哈尔滨市平房区碘缺乏病的自我考评结果分析

对哈尔滨市平房区7～10岁学龄儿童尿碘、甲状腺肿及用户碘盐进行调查，其结果为：尿碘中位数为315μg／L，＜50μg／L者占5．7％，＜100μg／L者占10．6％；甲状腺肿大率为21．80％；盐碘中位数为46．4×10-6，＜20×10－6者占3．9％，按照WHO、UNICEF、ICCIDD三个国际组织提供的考核评估标准，尿碘、盐碘水平已达标，但甲状腺肿大率未达标。     

大网格吸附剂提取新抗生素M－90的研究

本文研究用大网格吸附剂从发酵液中提取抗生素Ｍ－９０的吸附与解吸过程。包括：吸附剂、解吸剂的选择，加盐对吸附情况的影响，以及吸附条件和解吸条件的筛选等。结果表明，ＣＡＤ－４５为最佳吸附剂，吸附最佳ｐＨ为８．０；流速选择０．５ｍｌ／分；加３％ＮａＣｌ对吸附有利，最佳解吸剂为ｐＨ６．０９５％乙醇。在本实验条件下，当吸附液中Ｍ－９０浓度为２３０Ｕ／ｍｌ左右时，ＣＡＤ－４５对Ｍ－９０的吸附量达２．２２万Ｕ／ｍｌ吸附剂，吸附率为９６．８２％，解吸率为９３．７８％，收率为９０．８０％。     

镧对中国对虾卵子孵化和无节幼体变态的影响

研究了Ｌａ对中国对虾胚能和无节幼体生长的影响。实验结果表明，对胚肥发育期为单，二细胞的卵子，Ｌａ的最佳浓度范围为０．３０－１．８０ｍｇ／Ｌ，提高孵化率３３．％－４９．１％；对发育阶段为多细胞期的卵子，最佳浓度范围为０．９０－１．８０ｍ，ｇ＝Ｌ，提高孵化度１７．１％－２３．５％。     

依诺沙星在混合粘合剂碳糊电极上的电化学特性

制备了混合粘合剂碳糊电极。在０．０１５ｍｏｌ／Ｌ，磷酸－０．１０ｍｏｌ／ＬＫＣｌ溶液中，依诺沙星在该电极上于－１．２６Ｖ处产生一灵敏的阴极溶出伏安峰。在－０．９０Ｖ富集９０ｓ后，依诺沙星的线性范围为３．１×１０＾－７－１．２×１０＾－５ｍｏｌ／Ｌ，检测下限为９．４２×１０＾－８ｍｏｌ／Ｌ，所提出的方法用于尿液和血清中依诺沙星测定，回收率在９６％－１０３％之间。     

襄樊市学龄儿童碘营养现状调查

按东西南北中五个方位抽取了襄樊市７０所小学２８００名８－１０岁儿童进行了碘营养状况调查。以解诊和Ｂ超法检查甲状腺肿大率为主要指标,盐碘含量、尿碘水平为重要参考指标。结果表明：８－１０岁儿童甲肿率触诊法和Ｂ超法分别为１０．２５％和８．２５％,两者符合率为９６．６４％,甲肿率均超过５％,尿碘中位数为４３９．８１μｇ／Ｌ,尿碘值大于１００μｇ／Ｌ得占９６．６７％;儿童家中食盐含碘中位数为３１．３０＊１０     

乳化剂OP存在下微分电位溶出法同时测定铅铜的研究

在乳化剂ＯＰ存在下及０．３ｍｏｌ／Ｌ ＨＣｌ介质中，铅，铜在峰电位－０．５５Ｖ及－０．３４Ｖ处分别有一灵敏的溶出峰。详细探讨了溶出分析的最佳条件。本方法已用于发酵酒，配制酒，蒸馏酒及饮料中铅，铜的直接测定，回收率为９０．６％－１１０％，ＲＳＤ为０．２％－８．２％，检出限为０．０２５－０．００５４μｇ／２０ｍＬ范围。     

包头市青山区8～10岁儿童碘缺乏病甲状腺肿大率及尿碘监测分析

调查了内蒙古青山区８～１０岁儿童碘缺乏病甲状腺肿大率，结果表明，甲状腺肿大率为１９．６％，且以城乡结合部居住儿童为高，监测了其尿碘，尿碘水平１００μｇ／Ｌ以下者为１１．２％，其中５０μｇ／Ｌ者了有发现，据此情况，今后仍要强化防治工作。     

碘的凝胶色谱测定方法

建立了碘折凝胶色谱测定方法。色谱条件为：Ｓｈｉｍ－ｐａｃｋ ＤＩＯＬ－１５０柱；流动相甲醇０．０１ｍｏｌ／Ｌ Ｈ３ＰＯ４（１０：９０）流速为１．２ｍＬ／ｍｉｎ；柱温为３５℃，检测波长为２２４ｎｍ；线性范围是０．０１０－１．０ｍｇ／Ｌ，相关系数为０．９９９３，检测限为０．００１ｍｇ／Ｌ，相对标准偏差为１．２％－４．６％；回收率为９１％－９８％。所建立的方法已用于食盐，尿，系带等样品的测试，均取得较好     

贵州省两县市6岁以下儿童营养健康状况调查

为了解学龄前儿童营养健康状况，进一步开展营养干预改善工作，对两县市的821名儿童进行了营养健康状况、患病情况等调查，结果表明儿童中低体重发生率为20％，生长迟缓发生率为28．9％，两者在2－6岁的儿童中发生率较高，调查前两周儿童呼吸系统疾病和腹泻的发生率也较高。提出了进一步改善儿童营养健康状况的建议措施。     

毛细管电泳法测定天麻注射液中天麻素含量

报道了一种快速，准确的天麻注射液中天麻素含量的毛细管电泳测定法。方法的线性范围为８０－１５００μｇ／ｍＬ，ＲＳＤ＝１．９０％（ｎ＝６）加入回收率为９８．９－１０６．８％。     

HEPT类化合物的QSAR研究

为定量结构／活性相关性研究提取了量子化学参数,拓扑指数Am,分子连接性指数^mxt及疏水性常数,同时应用正交变换和最佳变量子集算法（Leaps-and-Bonds)进行了变量压缩和选择,进而实施了多元回归分析,并由此结果进行了HEPT类化合物（1－[(2-hydroxyethoxy)methyl]-6-(phenylthio)-thymine derivatives)的结构／活性关系的理论解释,进行了人工神经网络法对于该类化合物的活性预测,其结构明显好于多元回归法。     

Effect of the pH of the medium on the chemical shifts in the PMR spectra and on the distribution of the π-electron density

The dependence of the chemical shifts of the ring protons on the pH of the medium for a number of 4-hydroxyquinoline derivatives was studied by means of PMR spectroscopy. The dipolar and uncharged hydroxy forms exist in equilibrium in aqueous solutions. The effect of intramolecular hydrogen bonding on the character of the dependence of the chemical shift on the pH of the medium in the case of 3-piperidinomethyl-4-hydroxyisoquinoline was investigated. The possibility of the separate protonation of the ring nitrogen and the side-chain nitrogen in 3-piperidinomethyl-4-hydroxyisoquinoline was established. The distribution of the -electron density in 4-hydroxyisoquinoline is in good agreement with its chemical behavior.Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 11, pp. 1546–1549, November, 1971     

Effect of the pH of the medium on the chemical shifts in the PMR spectra and on the distribution of the π-electron density

The dependence of the chemical shift of the ring protons on the pH of the medium for a number of 3-hydroxyquinoline derivatives was studied by PMR spectroscopy. The regions of ionization of the molecules, which correspond to the ranges of acidic, neutral, and alkaline media, were found. In D₂O, 3-hydroxyquinoline is present only in the uncharged hydroxy form. The presence of intramolecular hydrogen bonding in 4-dimethylaminomethyl-3-hydroxyquinoline has a substantial effect on the character of the dependence of the chemical shift on the pH of the medium; the existence of separate protonation of the nitrogen atoms of the ring and the side chain of 4-dimethylaminomethyl-3-hydroxyquinoline was established. The distribution of the -electron density in the 3-hydroxyquinoline molecule is in good agreement with its chemical behavior during electrophilic substitution.Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 11, pp. 1540–1545, November, 1971.     

液滴荧光传感与计算机联用技术在微量分析中的应用

通过在LS55型荧光-磷光-发光分光光度计上加装液滴产生及调节附件,采用计算机采集与分析处理数据,成功地研制了双通道液滴光化学传感装置.利用葡聚糖凝胶对复合维生素B中不同组分的选择性吸附来达到分离与同时检测的目的,并将其用于复合维生素B药片的分析,取得了满意的结果.     

On the theory underlying the Car-Parrinello method and the role of the fictitious mass parameter

The theory underlying the Car-Parrinello extended-Lagrangian approach to ab initio molecular dynamics (CPMD) is reviewed and reexamined using "heavy" ice as a test system. It is emphasized that the adiabatic decoupling in CPMD is not a decoupling of electronic orbitals from the ions but only a decoupling of a subset of the orbital vibrational modes from the rest of the necessarily coupled system of orbitals and ions. Recent work [J. Chem. Phys. 116, 14 (2002)] has pointed out that, due to the orbital-ion coupling that remains once adiabatic decoupling has been achieved, a large value of the fictitious mass mu can lead to systematic errors in the computed forces in CPMD. These errors are further investigated in the present work with a focus on those parts of these errors that are not corrected simply by rescaling the masses of the ions. It is suggested that any comparison of the efficiencies of Born-Oppenheimer molecular dynamics (BOMD) and CPMD should be performed at a similar level of accuracy. If accuracy is judged according to the average magnitude of the systematic errors in the computed forces, the efficiency of BOMD compares more favorably to that of CPMD than previous comparisons have suggested.