共查询到20条相似文献,搜索用时 15 毫秒
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Baihua Ye Nicolai Cramer 《Angewandte Chemie (Weinheim an der Bergstrasse, Germany)》2014,126(30):8030-8033
Directed Cp*RhIII‐catalyzed carbon–hydrogen (C H) bond functionalizations have evolved as a powerful strategy for the construction of heterocycles. Despite their high value, the development of related asymmetric reactions is largely lagging behind due to a limited availability of robust and tunable chiral cyclopentadienyl ligands. Rhodium complexes comprising a chiral Cp ligand with an atropchiral biaryl backbone enables an asymmetric synthesis of isoindolones from arylhydroxamates and weakly alkyl donor/acceptor diazo derivatives as one‐carbon component under mild conditions. The complex guides the substrates with a high double facial selectivity yielding the chiral isoindolones in good yields and excellent enantioselectivities. 相似文献
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Brian N. Laforteza Kelvin S. L. Chan Jin‐Quan Yu 《Angewandte Chemie (Weinheim an der Bergstrasse, Germany)》2015,127(38):11295-11298
The commonly used para‐nitrobenzenesulfonyl (nosyl) protecting group is employed to direct the C H activation of amines for the first time. An enantioselective ortho‐C H cross‐coupling between nosyl‐protected diarylmethylamines and arylboronic acid pinacol esters has been achieved utilizing chiral mono‐N‐protected amino acid (MPAA) ligands as a promoter. 相似文献
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Xiao Chen Dr. Keary M. Engle Dong‐Hui Wang Jin‐Quan Yu Prof. Dr. 《Angewandte Chemie (International ed. in English)》2009,48(28):5094-5115
Pick your Pd partners : A number of catalytic systems have been developed for palladium‐catalyzed C? H activation/C? C bond formation. Recent studies concerning the palladium(II)‐catalyzed coupling of C? H bonds with organometallic reagents through a PdII/Pd0 catalytic cycle are discussed (see scheme), and the versatility and practicality of this new mode of catalysis are presented. Unaddressed questions and the potential for development in the field are also addressed.
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Hana Prokopcov C.Oliver Kappe 《Angewandte Chemie (International ed. in English)》2009,48(13):2276-2286
New kid on the block : The cross‐coupling of thioorganic compounds with boronic acids under neutral conditions in the presence of catalytic palladium(0) and a stoichiometric amount of a copper(I) oxygenate has emerged as a very useful method for the construction of C C bonds (see scheme). This intriguing and mechanistically unprecedented base‐free coupling has distinct advantages, in particular when traditional Pd0‐catalyzed cross‐coupling is not possible.
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Christopher J. Teskey Andrew Y. W. Lui Michael F. Greaney 《Angewandte Chemie (Weinheim an der Bergstrasse, Germany)》2015,127(40):11843-11846
The first example of a transition‐metal‐catalyzed, meta‐selective C H bromination procedure is reported. In the presence of catalytic [{Ru(p‐cymene)Cl2}2], tetrabutylammonium tribromide can be used to functionalize the meta C H bond of 2‐phenylpyridine derivatives, thus affording difficult to access products which are highly predisposed to further derivatization. We demonstrate this utility with one‐pot bromination/arylation and bromination/alkenylation procedures to deliver meta‐arylated and meta‐alkenylated products, respectively, in a single step. 相似文献
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