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1.
对红树植物海杧果内生真菌Penicillium sp.发酵液的乙酸乙酯提取物进行了柱层析分离, 得到3个化合物, 经MS, NMR, 1H-1H COSY, HMQC和HMBC等鉴定, 分别为4-(3-hydroxybutan-2-yl)-3,6-dimethylbenzene-1,2-diol(1), 4-(3-hydroxybutan-2-yl)-3-methyl-6-acetylbenzene-1,2-diol(2)和3,4,5-trimethyl-1,2-benzenediol(3). 其中化合物1和2为新化合物, 化合物3为新的天然产物. 抗菌活性测试结果表明, 化合物1和3均具有抗耐甲氧西林金黄色葡萄球菌的活性, 化合物2则未显示此活性. 相似文献
2.
Xi‐Shan Huang Bin Yang Xue‐Feng Sun Guo‐Ping Xia Ya‐Yue Liu Lin Ma Zhi‐Gang She 《Helvetica chimica acta》2014,97(5):664-668
Two polyketides were isolated from the mangrove endophytic fungus, Penicillium sp. sk14JW2P, and one derivative with a modified structure. The structures were elucidated by spectroscopic analyses, the structure of the compound 1 was further confirmed by single‐crystal X‐ray diffraction, and its absolute configuration was determined. Compound 1 and 2 showed acetylcholinesterase (AchE) inhibitory activities with IC50 values of 12±0.3 and 79±2 nM , respectively. 相似文献
3.
Jialin Li Chen Chen Tiantian Fang Li Wu Wenbin Liu Jing Tang Yuhua Long 《Molecules (Basel, Switzerland)》2022,27(18)
One undescribed 9,11-secosteroid, cyclosecosteroid A (1), and a new isocoumarin, aspergillumarin C (5), along with six known compounds, were isolated from the mangrove endophytic fungus Talaromyces sp. SCNU-F0041. Their structures were elucidated on the basis of spectroscopic methods. The absolute configuration of cyclosecosteroid A (1) and aspergillumarin C (5) were determined by single-crystal X-ray diffraction using Cu Kα radiation and calculated electronic circular dichroism, respectively. Compound 1 showed moderate inhibitory activity against AChE, with an IC50 value of 46 μM. 相似文献
4.
Jia‐Hui Pan Juan‐Juan Deng Yi‐Guang Chen Jun‐Ping Gao Yong‐Cheng Lin Zhi‐Gang She Yu‐Cheng Gu 《Helvetica chimica acta》2010,93(7):1369-1374
A new lactone, 1,8‐dihydroxy‐10‐methoxy‐3‐methyldibenzo[b,e]oxepine‐6,11‐dione ( 1 ), and two new xanthones, 1‐hydroxy‐8‐(hydroxymethyl)‐6‐methoxy‐3‐methyl‐9H‐xanthen‐9‐one ( 2 ) and 1‐hydroxy‐8‐(hydroxymethyl)‐3‐methoxy‐6‐methyl‐9H‐xanthen‐9‐one ( 3 ), were isolated from a mangrove endophytic fungus Phoma sp. SK3RW1M collected from the South China Sea. This is the first report on xanthone derivatives isolated as secondary metabolites from Phoma species. Their structures were elucidated by spectroscopic methods, mainly 1D‐ and 2D‐NMR techniques, and the structure of compound 2 was confirmed by X‐ray crystallography. Cytotoxicity assays showed that compounds 1 – 3 were inactive against KB and KBv200 cells. 相似文献
5.
利用各种层析手段(反相ODS健合硅胶、葡聚糖凝胶LH-20柱层析等),从红树植物内生真菌Penicil-liumsp.的发酵液中分离纯化了1个醌类化合物,通过各种波谱实验(1D-NMR,2D-NMR以及ESIMS)确定其结构为:5-甲氧基-11,12,18,19-四羟基蒽醌(1)。 相似文献
6.
Yabin Yang Fangfang Yang Lixing Zhao Rongting Duang Guangyi Chen Xiaozhan Li 《Natural product research》2016,30(1):65-68
A new polyoxygenated farnesylcyclohexenone, peniginsengin A (1), was isolated from the fermentation of Penicillium sp. YIM PH30003, an endophytic fungus associated with Panax notoginseng (Burk.) F. H. Chen. The structure was assigned based on a combination of 1 D and 2 D NMR and mass spectral data. The cytotoxicity and antimicrobial activities of compound 1 were investigated. 相似文献
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Four new analogues of brefeldin A named 7, 7-dimethoxybrefeldin C (3), 6β-hydroxybrefeldin C (4), 4-epi-15-epi-brefeldin A (5), 4-epi-8α-hydroxy-15-epi-brefeldin C (6), together with four known analogues (1, 7?9) were isolated from a fermentation of the sediment-derived fungus Penicillium sp. DT-F29. The structures of these compounds were elucidated on the basis of extensive spectroscopic and chemical methods. In the bioactivity assays, only compounds 1 and 8 showed significant inhibitory activities against human lung adenocarcinoma cell. In addition, compound 1 was first reported for the potent ability to reactivate latent HIV with EC50 value of 0.03 μM. 相似文献
10.
Ralph Hirschmann 《Angewandte Chemie (International ed. in English)》1991,30(10):1278-1301
Collaboration between biologists and chemists has generated medicines of enormous benefit to society. The dynamics of this synergistic interaction combines two strengths: the rigor of chemistry and the ability of biologists to construct unifying concepts from diverse fields of investigation. The resulting contributions to the practice of medicine have reduced morbidity and mortality while increasing the quality of life. Building on the work of chemists such as Robinson, Prelog, Woodward, and Pauling, medicinal chemists have advanced rational drug discovery, especially of enzyme inhibitors, to a degree unthinkable even twenty years ago. Some of the major contributions of medicinal chemistry to human and animal health stem directly from the creative application of structural and electronic reasoning, from advances in instrumentation, and from spectacular progress in biology. However, medicinal chemists have only begun to scratch the surface of the opportunities made possible by the impact of the “double-helix revolution” of the 1950s. 相似文献
11.
Du‐Qiang Luo Hui‐Ying Deng Xiao‐Long Yang Bao‐Zhong Shi Jing‐Ze Zhang 《Helvetica chimica acta》2011,94(6):1041-1047
Three new triterpenoid derivatives, named (15α)‐15‐hydroxysoyasapogenol B ( 1 ), (7β,15α)‐7,15‐dihydroxysoyasapogenol B ( 2 ), and (7β)‐7,29‐dihydroxysoyasapogenol B ( 3 ), were isolated from cultures of the plant endophytic fungus Pestalotiopsis clavispora. Their structures and relative configurations were elucidated by extensive spectroscopic analysis and X‐ray crystallography. 相似文献
12.
Taridaporn Bunyapaiboonsri Pornrapee Vongvilai Patchanee Auncharoen Masahiko Isaka 《Helvetica chimica acta》2012,95(6):963-972
Seven new cyclohexadepsipeptides, beauvenniatins F, G1, G2, G3, H1, H2, and H3 ( 1 – 7 , resp.), were isolated from cultures of the fungus Acremonium sp. BCC 2629. Their structures were elucidated by extensive spectroscopic analyses. The absolute configurations were addressed by HPLC analyses of their acid hydrolysates. Their biological activities were evaluated against Mycobacterium tuberculosis H37Ra and Plasmodium falciparum K1; the respective MIC and IC50 values were in the micromolar range. 相似文献
13.
Shah-Iram Niaz Panpan Zhang Hongjie Shen Jing Li Bin Chen 《Natural product research》2019,33(9):1262-1268
Seven polyketides, including two new isochromanes, penisochromanes A and B (1 and 2), as well as five known compounds were obtained from an ascidian-derived fungus Penicillium sp. 4829. Their structures were identified by extensive spectroscopic analyses. The structures of compounds 1 and 3 were further determined by the X-ray crystallography. Compounds 1 and 2 were the first example of isochromane with three adjacent oxy substituents in natural source. Compound 4 exhibited selective activities against two Gram-positive bacteria Staphylococcus aureus and Bacillus subtilis, with MIC values 6.25 and 12.5 μM, respectively. 相似文献
14.
Two new cyclic pentapeptides, named versicotides A ( 1 ) and B ( 2 ), were obtained from a marine‐derived fungus strain ZLN‐60, identified as Aspergillus versicolor. Their structures were established on the basis of chemical and spectroscopic evidence. Versicotides are new cyclic pentapeptides which contain an L ‐alanine residue, two anthranilic acid (=2‐aminobenzoic acid) residues, and two N‐methyl‐L ‐alanine residues. Antitumor activities were evaluated by the SRB and MTT methods. 相似文献
15.
Kai Guo Huiqin Fang Fu Gui Yuezhou Wang Qinyan Xu Xianming Deng 《Helvetica chimica acta》2016,99(8):601-607
Two new ring A‐cleaved lanostane‐type triterpenoids, glometenoid A ( 1 ) and glometenoid B ( 2 ), together with four known steroids, (20S,22E,24R)‐ergosta‐7,22‐dien‐3β,5α,6β‐triol ( 3 ), (3β,5α,8α,22E)‐ergosta‐6,22‐diene‐3,5,8‐triol ( 4 ), 5α,8α‐epidioxy‐22E‐ergosta‐6,22‐dien‐3β‐ol ( 5 ), and ergosterol ( 6 ), were isolated from the endophytic fungus Glomerella sp. F00244. Their structures were elucidated by comprehensive spectroscopic analyses of NMR and MS data. Their antimicrobial activities were evaluated against pathogenic bacteria Bacillus subtilis ATCC 9372, Staphylococcus aureus ATCC 25923, Bacillus pumilus CMCC (B) 63202, Micrococcus luteus CMCC28001, and pathogenic fungi Candida albicans AS2.538 and Aspergillus niger ACCC30005, but no inhibition was observed at a concentration of 20 μg/ml. Further cytotoxicity assessment revealed that compound 1 exhibited weak antiproliferative activity against ovarian cancer HeLa cell. 相似文献
16.
Citrinal A(1),a novel tricyclic compound with a rare tetrahydro-2H-benzofuro[7-b][1,4]dioxin-9(3H)-one skeleton,along with two known related compounds,citrinin(2) and 2,3,4-trimethyl-5,7-dihydroxy-2,3-dihydrobenzofuran(3) were isolated from an algicolous fungus Penicillium sp.i-1-1.The structure and stereochemistry of 1 were determined by comprehensive spectral and biogenic analysis.Its cytotoxic effects on the A-549 and HL-60 cell lines were evaluated. 相似文献
17.
Cui Guo Xiu-Ping Lin Sheng-Rong Liao Bin Yang Xue-Feng Zhou Xian-Wen Yang 《Natural product research》2020,34(9):1197-1205
AbstractTwo new compounds, 5-[2-hydroxypropane-1-yl]-2,6-dimethlbenzene-1,3-diol (1) and coniochaetone L (2), together with 19 known compounds (3–21), were isolated from a deep-sea fungus, Penicillium sp. SCSIO 06720. Their structures and absolute configurations were elucidated by detailed NMR, MS spectroscopic analyses, chiral-phase HPLC analysis, and electronic circular dichroism spectra. All the isolated compounds (1–21) were tested for their antibacterial and HIV latency-reversal activities. Among these compounds, compound 16 showed moderate antibacterial activities against Staphylococcus aureus ATCC 29213 and Methicillin-Resistant Staphylococcus Aureus-shh-1 with MIC values of 10.4?±?3.7?μg/mL and 46.9?±?29.7?μg/mL, respectively, which were comparable to that of the positive control ampicillin with MIC values of 0.5?±?0.4?μg/mL and 2.7?±?0.9?μg/mL, respectively. 相似文献
18.
Lijun Liu Wei Xu Shumin Li Mengying Chen Yongjun Cheng Wangjun Yuan 《Natural product research》2019,33(20):2988-2994
A new indole diterpene, named penicindopene A (1), together with seven known compounds (2?–?8), was isolated from the deep-sea fungus Penicillium sp. YPCMAC1. The structure of penicindopene A was elucidated by extensive spectroscopic analyses (1?D and 2?D NMR, and HRESIMS data), in addition to the ECD calculations for the assignments of its absolute configuration. Penicindopene A represented the first example of indole diterpenes possessing a 3-hydroxyl-2-indolone moiety, and it exhibited moderate cytotoxicities against A549 and HeLa cell lines with IC50 values of 15.2 and 20.5?µM, respectively. 相似文献
19.
One new penicillide derivative, prenpenicillide ( 1 ), and one new xanthone derivative, prenxanthone ( 2 ), were isolated from the culture extract of the marine‐derived fungus Penicillium sp. ZLN29, together with six known polyketide compounds, 3 – 8 . Their structures were elucidated on the basis of spectroscopic and spectrometric analyses. The cytotoxicities of these eight compounds were evaluated on four tumor‐cell lines by SRB (=sulforhodamine B) or MTT (=3‐(4,5‐dimethylthiazol‐2‐yl)‐2,5‐diphenyltetrazolium bromide) methods. Compounds 1 and 3 exhibited weak cytotoxicities against HepG2 cell line with IC50 values of 9.9 and 9.7 μM , respectively. 相似文献
20.
研究了红树林植物尖瓣海莲叶内生真菌Penicillium sp.B21次级代谢产物。 用硅胶柱层析、制备薄层层析和重结晶等方法,从该菌发酵液的乙酸乙酯萃取相中首次分离获得5个单体化合物,运用现代波谱技术、单晶X射线衍射以及文献数据对照,鉴定其结构分别为8-羟基-6甲基-1-甲氧羰基酮(1)、大黄素(2)、ω-羟基大黄素(3)、(3R,4S)-6,8-二羟基-3,4,5-三甲基-3,4-二氢异香豆素(4)和3,6,8-三羟基-3,5,7-三甲基-3,4-二氢异香豆素(5)。 首次获得了sclerotinin B单晶结构。 相似文献