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1.
Wen‐Hui Xu Adnan J. Al‐Rehaily Muhammad Yousaf Mohammad S. Ahmad Shabana I. Khan Ikhlas A. Khan 《Helvetica chimica acta》2015,98(4):561-568
Two new furanoflavonoids, retamasins A and B ( 1 and 2 , resp.), along with five known flavonoids, 3 – 7 , were isolated from the aerial parts of Retama raetam. Their structures were determined on the basis of extensive spectroscopic (IR, MS, and 1D‐ and 2D‐NMR) analyses and by comparison with the literature data. This is the first report of the isolation of new furanoflavonoids 1 and 2 from Retama genus, while compounds 3, 5 , and 6 were found for the first time from R. raetam. Antioxidant and anti‐inflammatory activities of the isolated compounds were also evaluated. Compounds 2, 3 , and 5 – 7 exhibited potent inhibitions of iNOS activity with IC50 values of 2.9, 5.0, 3.1, 1.2, and 4.8 μg/ml, respectively. All compounds inhibited NF‐κB except 1 and 5 . Compound 6 was most active in inhibiting iNOS and NF‐κB activity, as well as in decreasing oxidative stress. 相似文献
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Ming Zhao Sin Ting Lau Xiao Qi Zhang Wen Cai Ye Po Sing Leung Chun‐Tao Che Zhi‐Xiu Lin 《Helvetica chimica acta》2011,94(11):2099-2105
Bruceine K ( 1 ), a pentacyclic C20‐quassinoid bearing a unique 12,20‐epoxy moiety, and bruceine L ( 2 ), along with the ten known compounds (6S,7E)‐6,9,10‐trihydroxy‐ and (6S,7E)‐6,9‐dihydroxymegastigma‐4,7‐dien‐3‐one ( 3 and 4 , resp.), cleomiscosins A–C, luteoline, quercetine, bruceantinol, pinoresinol, and thevetiaflavone, were isolated from the ripe fruits of Brucea javanica. Bruceines K ( 1 ) and L ( 2 ) were determined to be (1β,2α,11β,12β,14ξ,15β)‐12,20‐epoxy‐1,2,11,13,14,15‐hexahydroxypicras‐3‐en‐16‐one and (1β,2α,11β,12β,15β)‐13,20‐epoxy‐1,2,11,12‐tetrahydroxy‐16‐oxo‐15‐(senecioyloxy)picras‐3‐en‐21‐oic acid methyl ester (senecioic acid=3‐methylbut‐2‐enoic acid), respectively, on the basis of NMR (1H‐ and 13C‐NMR, DEPT, 1H,1H‐COSY, NOESY, HMQC, and HMBC) and ESI‐MS data. Among the known compounds, (6S,7E)‐6,9,10‐trihydroxy‐ and (6S,7E)‐6,9‐dihydroxymegastigma‐4,7‐dien‐3‐one ( 3 and 4 , resp.), cleomiscosin C, luteoline, quercetine, and thevetiaflavone were isolated for the first time from the Brucea plants. 相似文献
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Shi‐Fei Li Ying‐Tong Di Yue‐Hu Wang Cheng‐Jian Tan Xin Fang Yu Zhang Yong‐Tang Zheng Ling Li Hong‐Ping He Shun‐Lin Li Xiao‐Jiang Hao 《Helvetica chimica acta》2010,93(9):1795-1802
One new anthraquinone glycoside, 6‐O‐(α‐L ‐rhamnopyranosyl‐(1→6)‐β‐d‐ glucopyranosyl)emodin ( 1 ), and two new sesquilignans, seslignanoccidentaliols A ( 2 ) and B ( 3 ), were isolated from the whole plant of Cassia occidentalis. The structures of the new compounds were established by means of spectroscopic methods, especially 2D‐NMR data (1H,1H‐COSY, HMQC, HMBC, and ROESY), as well as HR‐ESI‐MS analysis. One previously reported sesquilignan, erythro‐guaiacylglycerol‐β‐O‐4′‐(5′)‐methoxylariciresinol, was revised to be seslignanoccidentaliol A ( 2 ). The 6‐O‐(α‐L ‐rhamnopyranosyl‐(1→6)‐β‐d‐ glucopyranosyl)emodin ( 1 ) exhibited moderate anti‐HIV‐1 activity with an EC50 value of 2.90 μg/ml and a therapeutic‐index (TI) value of 260. 相似文献
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Yu‐Xi Liu Shuang‐Gang Ma Xiao‐Jing Wang Nan Zhao Jing Qu Shi‐Shan Yu Jun‐Gui Dai Ying‐Hong Wang Yi‐Kang Si 《Helvetica chimica acta》2012,95(8):1401-1408
Four new diketopiperazine alkaloids, rel‐(8R)‐9‐hydroxy‐8‐methoxy‐18‐epi‐fumitremorgin C ( 1 ), rel‐(8S)‐19,20‐dihydro‐9,20‐dihydroxy‐8‐methoxy‐9,18‐di‐epi‐fumitremorgin C ( 2 ), rel‐(8S,19S)‐19,20‐dihydro‐9,19,20‐trihydroxy‐8‐methoxy‐9‐epi‐fumitremorgin C ( 3 ), and (3S,8S,9S,18S)‐8,9‐dihydroxyspirotryprostatin A ( 4 ), together with the eight known compounds 5 – 12 , were isolated from the endophytic fungus Aspergillus fumigatus. The structures of the new compounds were determined by extensive spectroscopic methods including HR‐ESI‐MS, NMR, and CD experiments. Compound 12 showed weak inhibitory activity in vitro against the release of β‐glucuronidase in rat polymorphonuclear leukocytes induced by the platelet‐activating factor. None of the twelve compounds exhibited detectable cytotoxic activities toward five human tumor cell lines (HCT‐8, Bel‐7402, BGC‐823, A549, and A2780) in the MTT assay. 相似文献
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Tung‐Ying Wu Yuan‐Bin Cheng Fu‐Ting Cheng Yu‐Ming Hsu Thang Tran Dinh Fang‐Rong Chang Yang‐Chang Wu 《Helvetica chimica acta》2014,97(12):1714-1718
A phytochemical investigation of MeOH extract of Desmos cochinchinensis var. fulvescens Ban afforded two new compounds, 1β,7α‐dihydroxyeudesman‐4‐one ( 1 ) and 5αH‐megastigm‐7‐ene‐3α,4α,6β,9‐tetrol ( 2 ), together with nine known terpenoids. The structures of the new compounds were elucidated by 1D‐ and 2D‐NMR spectroscopic analysis. Their relative configurations were assigned by NOESY experiments. 相似文献
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A new dimeric lignan, named biplanispine A ( 1 ) which represents the first example of a dimeric 2,6‐diaryl‐3,7‐dioxabicyclo[3.3.0]octane skeleton from a Rutaceae plant, together with 13 known lignans 2 – 14 , was isolated from the bark of Zanthoxylum planispinum. Their structures were elucidated by spectroscopic methods, especially 2D‐NMR techniques. All isolated compounds were evaluated for their antibacterial activities by the disc diffusion method. Compounds 7 and 9 showed interesting antibacterial activities at 200 μg/disc; they were as effective as kanamycin sulfate at 10 μg/disc against Staphylococcus aureus and Bacillus subtilis. 相似文献
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Anti‐inflammatory Activity of Two New Indole Alkaloids from the Stems of Nauclea officinalis 下载免费PDF全文
De‐Li Chen Guo‐Xu Ma Min‐Jun He Yang‐Yang Liu Xiao‐Bing Wang Xin‐Quan Yang 《Helvetica chimica acta》2016,99(9):742-746
Two new indole alkaloid derivatives ( 1 , 2 ), together with six known indole alkaloids ( 3 – 8 ) were isolated from the 70% EtOH/H2O extract of the stem of Nauclea officinalis. Their structures were determined on the basis of extensive analyses of spectroscopic data (IR, MS, 1D‐ and 2D‐NMR). All the isolates were evaluated for their anti‐inflammatory activities on lipopolysaccharide (LPS)‐induced nitric oxide (NO) production in RAW 264.7, and all the compounds showed significant inhibitory activities with the IC50 values of 0.82, 6.45, 9.75, 1.34, 3.40, 2.69, 1.58, and 1.96 μm , compared to the positive drug control group aminoguanidine with an IC50 value of 1.80 μm , especially compound 1 had the most significant activity. 相似文献
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Y. Huang L. Chen B. He S.Y. Liu D.Q. Zeng Y.H. Wang L.W. Du W.W. Tang 《Arabian Journal of Chemistry》2021,14(7):103228
There are many nutrients and active substances in the residue of traditional Chinese medicine, which can be processed into organic fertilizer and returned to the field to improve the soil fertility. In this study, we found that Brucea javanica (L.) Merr. residue has herbicidal activity and can be used for weed control in the field, this prompted us to investigate the active constituents in it. The herbicidal activities of extracts of B. javanica residue were evaluated by conducting bioassays against gramineous weed, Eleusine indica (L.) Gaertn. and broad-leaved weed, Bidens pilosa L., respectively. It confirmed that ethyl acetate and n-butanol extracts possessed potent biological activities on seed germination and seedling growth of E. indica at 5 mg/mL. This prompted us to investigate the active constituents in the seeds residue. By the activity-guided fractionation, eight known compounds were isolated, which were bruceines D?F (1–3), pityriacitrin (4), 4-(9H-β-carbolin-1-yl)-4-oxobut-2-enoic acid methyl ester (5), protocatechuic acid (6), vanillic acid (7) and carisphthalate (8). Then, three quassinoids (1–3) were evaluated for their potential herbicidal effects in bioassay. Results showed that bruceines D?F have potential herbicidal activity against the test weeds. In the range of experimental concentration, bruceine D had obvious herbicidal effect on the two tested weeds. At the concentration of 31.25 μg/mL, bruceine D could completely inhibit the root growth of E. indica; at the concentration of 125 μg/mL, bruceine D can inhibit the seed germination and shoot elongation of E. indica and the shoot growth of B. pilosa, with the inhibition reached 100%. In addition, at the same concentration (250 μg/mL), bruceines D?F could completely affected shoot elongation of B. pilosa. These results showed that B. javanica residue is a potential source of botanical herbicide development, which has great agricultural economic value, at the same time, the reuse of B. javanica residue realizes the transformation of waste into treasure, rational utilization of resources and sustainable development. 相似文献
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Xi‐Tao Yan Yan Ding Wei Li Ya‐Nan Sun Seo‐Young Yang Young‐Sang Koh Young‐Ho Kim 《Helvetica chimica acta》2014,97(2):283-289
Two new phenolic compounds, (Z)‐5′‐hydroxyjasmone 5′‐O‐{6″‐O‐[(E)‐caffeoyl]‐β‐D ‐glucopyranoside} ( 1 ) and quercetin‐7‐O‐β‐D ‐glucuronide methyl ester ( 2 ), along with ten known phenolic compounds, 3 – 12 , were isolated from the aerial parts of Artemisia iwayomogi. Their structures were elucidated by spectroscopic methods, including 1D‐ and 2D‐NMR, and HR‐ESI‐TOF‐MS techniques. The inhibitory effects of compounds 1 – 12 on the LPS‐stimulated production of IL‐12 p40, IL‐6, and TNF‐α in bone marrow‐derived dendritic cells were evaluated. 相似文献
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Guo‐Xu Ma Xiao‐Yan Huang Hua‐Nian Dai Xiao‐Qing Zhong Yan‐Lin Zhou Zuo‐Lin Su Ying‐Zi He Jun‐Shan Yang Jing‐Quan Yuan Xu‐Dong Xu 《Helvetica chimica acta》2016,99(6):482-486
Two new triterpenoid glycosides, 3α,19α,23α‐trihydroxy‐2‐oxo‐12‐ursen‐28‐O‐β‐d ‐glucopyranoside ( 1 ) and 3α,19α,23α‐trihydroxy‐2‐oxoolean‐12‐en‐28‐O‐β‐d ‐glucopyranoside ( 2 ) as well as three known compounds, 2α,3α,19α‐trihydroxyolean‐12‐en‐28‐O‐β‐d ‐glucopyranoside ( 3 ), 2α,3α,19α,23‐tetrahydroxy‐12‐ursen‐28‐O‐β‐d ‐glucopyranoside ( 4 ), and 2α,3β,19α,23‐tetrahydroxyurs‐12‐en‐28‐oic acid ( 5 ) were isolated from 75% EtOH extract of Rosa cymosa. Their structures were elucidated by extensive spectroscopic methods. All the isolated compounds displayed moderate inhibitory activity against LPS‐induced NO production in macrophages. 相似文献
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Separation of flavonoids from Millettia griffithii with high‐performance counter‐current chromatography guided by anti‐inflammatory activity 下载免费PDF全文
Huan Tang Bo Wu Kai Chen Heying Pei Wenshuang Wu Liang Ma Aihua Peng Haoyu Ye Lijuan Chen 《Journal of separation science》2015,38(3):523-529
Millettia griffithii is a unique Chinese plant located in the southern part of Yunnan Province. Up to now, there is no report about its phytochemical or related bioactivity research. In our previous study, the n‐hexane crude extract of Millettia griffithii revealed significant anti‐inflammatory activity at 100 μg/mL, inspiring us to explore the anti‐inflammatory constituents. Four fractions (I, II, III, and A) were fractionated from n‐hexane crude extract by high‐performance counter‐current chromatography with solvent system composed of n‐hexane/ethyl acetate/methanol/water (8:9:8:9, v/v) and then were investigated for the potent anti‐inflammatory activity. Fraction A, with the most potent inhibitory activity was further separated to give another four fractions (IV, V, VI, and B) with solvent system composed of n‐hexane/ethyl acetate/methanol/water (8:4:8:4, v/v). Compound V and fraction B exhibited remarkable anti‐inflammatory activity with nitric oxide inhibitory rate of 80 and 65%, which was worth further fractionation. Then, three fractions (VII, VIII, and IX) were separated from fraction B with a solvent system composed of n‐hexane/ethyl acetate/methanol/water (8:1:8:1, v/v), with compound VIII demonstrating the most potent inhibitory activity (80%). Finally, the IC50 values of compound V and VIII were tested as 38.2 and 14.9 μM. The structures were identified by electrospray ionization mass spectrometry and1H and 13C NMR spectroscopy. 相似文献
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Bo Kyeong Yoon Zheng Yi Lim Won-Yong Jeon Nam-Joon Cho Jeong Hoon Kim Joshua A. Jackman 《Molecules (Basel, Switzerland)》2020,25(22)
Brucea javanica oil (BJO) is widely used in traditional Chinese medicine to treat various types of cancer and inflammatory diseases. There is significant interest in understanding the medicinal activities of BJO and its molecular components, especially quassinoids, and in exploring how they can be incorporated into nanomedicine delivery strategies for improved application prospects. Herein, we cover the latest progress in developing different classes of drug delivery vehicles, including nanoemulsions, liposomes, nanostructured lipid carriers, and spongosomes, to encapsulate BJO and purified quassinoids. An introduction to the composition and medicinal activities of BJO and its molecular components, including quassinoids and fatty acids, is first provided. Application examples involving each type of drug delivery vehicle are then critically presented. Future opportunities for nanomedicine delivery strategies in the field are also discussed and considered within the context of translational medicine needs and drug development processes. 相似文献
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Ching‐Yao Chang 《中国化学会会志》2011,58(3):286-289
The first total synthesis of the linear diarylheptanoid 1‐(4″‐methoxyphenyl)‐7‐(4′‐hydroxyphenyl)‐(E)‐hept‐2‐ene, which has a uniquely nonconjugated olefin, was achieved. The synthetic route employed an olefin cross‐metathesis as a key step. Beginning with commercially available 3‐(4‐hydroxyphenyl)propan‐1‐ol, the final product was made in three steps with a 52% yield. 相似文献
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Hatem A. Abdel‐Aziz Khalid A. Al‐Rashood Kamal Eldin H. ElTahir Hany S. Ibrahim 《中国化学会会志》2011,58(7):863-868
A series of 3,4‐bis‐chalcone‐N‐arylpyrazoles 3a‐h was prepared conveniently from diacetyl pyrazoles 2a,b . All reactions were carried out under conventional thermal heating and/or microwave irradiation. The structure of the latter functionally pyrazoles was confirmed under the bases of their IR, mass, 1H NMR and 13C NMR. The X‐ray diffraction of compound 3e not only confirmed the chemical structure of 3a‐h , but also showed the E configuration of their chalcone moieties. Treatment of compound 3e with phenyl hydrazine in presence of acetic acid afforded the tri‐pyrazle 4 . The anti‐inflammatory activity of the newly synthesized compounds was investigated. Some of these compounds showed a moderate activity when compared with indomethacin as a reference drug. The combination between chalcone and pyrazole moieties revealed a variable effect in anti‐inflammatory activity. 相似文献
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Serge Michalet Laëtitia Payen‐Fattaccioli Chantal Beney Pascale Cégiéla Christine Bayet Gilbert Cartier Diderot Noungoué‐Tchamo Etienne Tsamo Anne‐Marie Mariotte Marie‐Geneviève Dijoux‐Franca 《Helvetica chimica acta》2008,91(6):1106-1117
Phytochemical investigation of barks of Christiana africana led to the identification of cyclopeptide alkaloids, flavonoids, coumarinolignans, iridoids, sesquiterpenoids, and triterpenes. This plant was classified so far in the Tiliaceae family. This study was started while the genomic study of numerous specimens was described in order to establish new criteria for Malvales botanical classification. In the present work, twenty components were identified, belonging to the three major classes of secondary metabolites: alkaloids, phenols, and terpenes. In the first class, cyclopeptides are well‐known compounds in Rhamnaceae and Sterculiaceae. Their presence in Malvaceae (in APG2 sensus) suggests a possible chemical link between the ex‐Tiliaceae and the Malvaceae. 相似文献
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The four new lariciresinol‐based lignan glycosides, (?)‐lariciresinol 4′‐(6″‐O‐feruloyl‐β‐D ‐glucopyranoside) ( 1 ), (?)‐lariciresinol 4′‐(4″,6″‐di‐O‐feruloyl‐β‐D ‐glucopyranoside) ( 2 ), 5,5′‐dimethoxylariciresinol 4′‐(4″,6″‐di‐O‐feruloyl)‐β‐D ‐glucopyranoside) ( 3 ), and 4‐O‐[α‐(1,2‐dihydroxyethyl)syringyl]‐5,5′‐dimethoxylariciresinol 4′‐(4″,6″‐di‐O‐feruloyl‐β‐D ‐glucopyranoside) ( 4 ), together with two known ones, lariciresinol 4′‐β‐D ‐glucopyranoside) ( 5 ) and tortoside B ( 6 ), were isolated from the BuOH extract of Rhus javanica var. roxburghiana roots, and their structures were established by means of various spectroscopic techniques. 相似文献
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Thayana da C. Alves Mariele R. S. Gonçalves Francyne C. S. Correia Virgínia C. da Silva Paulo T. de Sousa Jr. Mário G. de Carvalho Raimundo Braz‐Filho Evandro L. Dall'Oglio 《Helvetica chimica acta》2014,97(11):1469-1474
From the hexane and MeOH extracts of Annona coriacea Mart . (Annonaceae) seeds, two novel acetogenins, coriapentocins A and B ( 1 and 2 , resp.) were isolated. The known acetogenin bullacin ( 3 ) was also isolated from the hexane extract. The structures of compounds 1 – 3 were elucidated by NMR and MS analysis, and relative configurations were established by comparison with literature data. 相似文献
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Phytochemical studies on a stem of Hopea utilis (Dipterocarpaceae) resulted in the isolation of two new resveratrol derivatives, namely hopeaside E ( 1 ; resveratrol trimer) and hopeaside F ( 2 ; resveratrol pentamer), together with ten known resveratrol derivatives, 3 – 12 . The structures of the new compounds were elucidated by spectroscopic analyses, including NMR experiments, and their absolute configurations were determined on the basis of a comparative configurational analysis using the β‐D ‐glucopyranosyl group and chiroptical data. The absolute configuration of (+)‐balanocarpol ( 3 ) was also determined by acid‐catalyzed skeletal conversion. 相似文献