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A. P. Gulya V. I. Tsapkov D. Poirier K. Aruksandei E. Pakhontsu 《Russian Journal of General Chemistry》2010,80(7):1351-1354
2-[(2-Hydroxyphenylimino)methyl]phenol (H2L1) and 1-[(2-hydroxyphenylimino)methyl]naphthalen-2-ol (H2L2) reacted with copper(II) acetate hydrate and sulfanilamide (Sf1), sulfathiazole (Sf2), sulfaethidole (Sf3), sulfadiazine (Sf4), and sulfadimidine (Sf5) in ethanol to give mixed-ligand copper chelates with the composition Cu(Sf1–5)(L1–2) · n H2O (n = 1, 2). All these complexes are monomeric. Salicylaldehyde imines (H2L1 and H2L2) behave as doubly deprotonated tridentate O,N,O ligands, whereas sulfanilamides (Sf1–5) are unidentate ligands. Thermolysis of the synthesized complexes includes dehydration at 70–90°C, followed by complete thermal
decomposition (290–380°C). The complexes [Cu(Sf1)(L1)] · 2H2O and [Cu(Sf3)(L1)] · H2O at a concentration of 10−4 M inhibited growth and reproduction of 100% of human myeloid leukemia cells (HL-60). The inhibitory effect was 90 and 75%,
respectively, at a concentration of 10−5 M, whereas no antitumor activity was observed at a concentration of 10−6 M. 相似文献
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