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1.
Aromatic hydrazides reacted with 4-aryl-2-hydroxy-4-oxobut-2-enoic and 2-hydroxy-5,5-dimethyl- 4-oxohex-2-enoic acids to give 4-aryl-2-(2-aroylhydrazinylidene)-4-oxobutanoic and 5,5-dimethyl-2-(aroylhydrazinylidene)- 4-oxohexanoic acids. The products were found to exist in solution as mixtures of Z/E-hydrazinylidene and cyclic dihydropyrazole tautomers, and they underwent intramolecular cyclization to 5-aryland 5-tert-butyl-3-(aroylhydrazinylidene)furan-2(3H)-ones by the action of acetic anhydride. 相似文献
2.
O. A. Komarova N. M. Igidov N. N. Koryagina A. S. Makarov Yu. S. Toksarova A. E. Rubtsov 《Russian Journal of Organic Chemistry》2011,47(1):109-114
Hydrazones derived from substituted benzophenones and fluorenone reacted with 4-aryl-2-hydroxy-4-oxobut-2-enoic and 2-hydroxy-5,5-dimethyl-4-oxohex-2-enoic acids to give the corresponding 2-(2-ylidenehydrazino) derivatives which may be used as initial compounds for the synthesis of 3-hydrazono-3H-furan-2-ones. The obtained but-2-enoic and hex-2-enoic acid derivatives in solution may exist as Z- and E-isomeric enehydrazine tautomers or hydrazone tautomers with syn or anti orientation of substituents with respect to the double C=N bond. 相似文献
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Mukovoz P. P. Dankovtseva E. S. Mukovoz V. P. Abramova V. V. Chigrineva N. A. Danilova E. A. 《Russian Journal of General Chemistry》2019,89(2):224-229
Russian Journal of General Chemistry - Two-stage condensation of cycloalkyl ketones with dimethyl oxalate or alkyl acetates with dialkyl oxalates and cycloalkyl ketones produced disodium... 相似文献
6.
I. V. Ukrainets O. V. Gorokhova K. V. Andreeva 《Russian Journal of Organic Chemistry》2014,50(1):63-65
Treatment of 1-(2-cyanoethyl)-4-hydroxy-N-(hydroxyalkyl)-2-oxo-1,2-dihydroquinoline-3-carboxamides with a solution of hydrogen chloride in aqueous acetic acid ensures selective transformation of the cyano group into amide or carboxy with simultaneous acetylation of the hydroxyalkyl fragments. 相似文献
7.
1-(3-R-adamantan-1-yl)-2-[(triphenyl-λ5-phosphanylidene)hydrazinylidene]ethanone reacted with 4-aryl(hetaryl)-2,4-dioxobutanoic acids to give 2-{2-[2-(3-R-adamantan-1-yl)-2-oxoethylidene]hydrazinyl}-4-aryl(hetaryl)-4-oxobut-2-enoic acids which were shown to exist in solution as mixtures of Z- and E-isomeric enehydrazine tautomers. The products underwent cyclization to 3-{[2-(3-R-adamantan-1-yl)-2-oxoethylidene]- hydrazinylidene}-5-aryl(hetaryl)furan-2(3H)-ones. 相似文献
8.
Denisova E. I. Lipin D. V. Parkhoma K. Yu. Devyatkin I. O. Shipilovskikh D. A. Chashchina S. V. Makhmudov R. R. Igidov N. M. Shipilovskikh S. A. 《Russian Journal of Organic Chemistry》2021,57(12):1955-1960
Russian Journal of Organic Chemistry - New substituted 2-[2-(4-nitrobenzoyl)hydrazinylidene]-4-oxobut-2-enoic acids have been synthesized by condensation of 4-nitrobenzohydrazide with... 相似文献
9.
I. V. Ukrainets S. G. Taran P. A. Bezuglyi S. N. Kovalenko A. V. Turov N. A. Marusenko 《Chemistry of Heterocyclic Compounds》1993,29(9):1044-1047
Preparative methods for the synthesis of 1-R-2-oxo-3-(4-oxo-3H-quinazolin-2-yl)-4-hydroxyquinolines based on ethyl esters or nitrites of 1-R-2-oxo-4-hydroxyqidnoline-3-carboxylic acids and anthranilamide or ethyl anthranilate correspondingly were proposed. The antithyroid activity of the compounds synthesized was studied.For Communication 17, see [1].Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 9, pp. 1223–1226, September, 1993. 相似文献
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I. V. Ukrainets L. V. Sidorenko O. S. Golovchenko 《Chemistry of Heterocyclic Compounds》2007,43(11):1434-1439
1-R-4-Hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxylic acids 2-nitrobenzylidenehydrazides are reduced to the corresponding
quinoline-3-carboxamides by zinc in glacial acetic acid but in refluxing triethylphosphite they are converted to the symmetrical
N,N′-di(4-hydroxy-2-oxo-1,2-dihydro-3-quinolinoyl)hydrazines. A study of the antitubercular activity of the synthetic compounds
has been carried out.
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 11, pp. 1687–1692, November, 2007. 相似文献
13.
A. V. Tverdokhlebov Yu. M. Volovenko T. V. Shokol 《Chemistry of Heterocyclic Compounds》1998,34(1):44-50
A study has been made of the interaction of 2-[2-(benz)azolyl]3-keto-4-chlorobutanenitriles with primary aliphatic amines. This is a convenient method for the synthesis of 2-amino-3-[2-(benz)azolyl]-4(5H)-ketopyrroles.Tarasa Shevchenko Kiev University, Kiev 252601, Ukraine; e-mail dov@fosfor.kiev.ua. Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 1, pp. 50–57, January, 1998. 相似文献
14.
The title compounds when constructed from a-aminoxyacetic esters coupled with N-benzyloxycarbonyl-L-serine in the presence of N-ethoxycarbonyl-2-ethoxy L-2-(benzyloxyformamido)-3-hydroxypropionamidooxy acetates. Alternative coupling with N-benzyloxycarbonyl-L-serine 3,4-dihydro-4-oxo-l,2,3-benzotriazin triphenyl phosphine and dimethyl azodicarboxylate gave the fully protected monocyclic β-lactams. In the phenylacetic acid series hydrogenolytic deprotection led to decomposition. However, in the phenylpropionic series the hydrogenolysis product was sufficiently stable to allow acylation by the thiol ester route to the title compound. 相似文献
15.
I. A. Kizimova N. M. Igidov M. V. Dmitriev S. V. Chashchina R. R. Makhmudov A. I. Siutkina 《Russian Journal of General Chemistry》2019,89(12):2345-2352
Decyclization of N′-[5-R-2-oxofuran-3(2H)-ylidene]-2-(phenylamino)benzohydrazides under the action of heterocyclic amines leads to the formation of N-hetaryl-4-R-4-oxo-2-[2-(phenylamino)benzoyl]hydrazinylidenebutanamides. Antinociceptive and anti-inflammatory activity of the obtained compounds was studied. 相似文献
16.
B. B. Aleksandrov V. S. Shklyaev Yu. V. Shklyaev 《Chemistry of Heterocyclic Compounds》1992,28(3):314-315
4-R-2,2-dimethyl-1,2-dihydrobenzo[f]isoquinolines and (2,2-dimethyl-1,2-dihydrobenzo[f]isoquinolylidene-4)acetic acid derivatives have been prepared by Ritter reactions of substituted acetonitriles with 2-methyl-1-(1-naphthyl)propan-2-ol.Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 3, pp. 375–376, March, 1992. 相似文献
17.
G. S. Posyagin M. A. Vikhareva O. A. Bystritskaya A. E. Rubtsov P. G. Neifeld V. V. Zalesov 《Russian Journal of General Chemistry》2009,79(11):2367-2372
Polarographic reduction of 4-aryl-2-(1,2-diphenyl-2-oxoethylidenehydrazino)-4-oxo-2-butenoic acids in 2-propanol-water solutions
proceeds with the formation of two or three irreversible cathode waves and leads to 4-aryl-2-(1,2-diphenyl-2-hydroxyethylhydrazino)-4-hydroxybutanoic
acids. The latter suffer hydrolysis with the rupture of the C2-NH bond and the formation of 4-aryl-2,4-dihydroxybutanoic acids. 相似文献
18.
I. V. Ukrainets N. L. Bereznyakova G. P. Petyunin I. A. Tugaibei V. B. Rybakov V. V. Chernyshev A. V. Turov 《Chemistry of Heterocyclic Compounds》2007,43(6):729-739
An improved method for the preparation and purification of ethyl 2-hydroxy-4-oxo-4H-pyrido[1,2-a]-pyrimidine-3-carboxylates
is proposed. According to 1H and 13C NMR spectroscopic data the synthesized compounds exist in DMSO solution in the 2-hydroxy-4-oxo form while in the crystal
(at least for the case of the unsubstituted derivative) X-ray analysis shows that it occurs in the bipolar 2,4-dioxo form.
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 6, pp. 864–876, June, 2007. 相似文献
19.
Shipilovskikh S. A. Shipilovskikh D. A. Rubtsov A. E. 《Russian Journal of Organic Chemistry》2017,53(1):137-140
Russian Journal of Organic Chemistry - The reaction of ethyl 2-[2-oxo-5-phenylfuran-3(2H)-ylideneamino]-4,5,6,7-tetrahydro-1-benzothiophene- 3-carboxylate with primary amines (RNH2) in toluene... 相似文献
20.
I. V. Ukrainets A. A. Davidenko E. V. Mospanova L. V. Sidorenko E. N. Svechnikova 《Chemistry of Heterocyclic Compounds》2010,46(5):559-568
We have carried out the synthesis and a comparative analysis of the acidic properties of a large group of 4-R-2-oxo-1,2-dihydroquinoline-3-carboxylic
acids. Features of the recorded NMR spectra of these compounds are discussed together with their analgesic properties. 相似文献