Unusual Desilanolysis of 1,1-Dimethyl-1-(trimethylsiloxy)-3-phenylpropyne

Russian Journal of General Chemistry -     

1-Trimethoxysilylmethyl-and 1-(2,8,9-trioxa-5-aza-1-silabicyclo[3.3.3]undecan-1-ylmethyl)-1,1-dimethyl-2-(3-alkoxy-3-oxopropyl)hydrazinium halides

Previously unknown 1,1-dimethyl-1-trimethoxysilylmethyl-2-(3-alkoxy-3-oxopropyl)hydrazinium and 1,1-dimethyl-1-(2,8,9-trioxa-5-aza-1-silabicyclo[3.3.3]undecan-1-ylmethyl)-2-(3-alkoxy-3-oxopropyl)-hydrazinium halides were synthesized, and physiological activity of 2-(3-ethoxy-3-oxopropyl)-1,1-dimethyl-1-(2,8,9-trioxa-5-aza-1-silabicyclo[3.3.3]undecan-1-ylmethyl)hydrazinium chloride and bromide was studied.     

Selective Noncatalytic Hydration of N-(1,1-Dimethyl-2-propynyl)-acetamide to N-(1,1-Dimethyl-2-oxopropyl)acetamide

Russian Journal of Organic Chemistry -     

3,3-Dimethyl-1-(trifluoromethylsulfonyl)-1,3-azasilolidine

Russian Journal of General Chemistry -     

Synthesis and Reactions of 1,1-Dimethyl-3-oxobutyl-isothiocyanate (DMO-ITC)

In this review an attempt has been made to compile all the existing comprehensive literature for the synthesis of 1,1-Dimethyl-3-oxobutyl-isothiocyanate (DMO-ITC) and its reactions with the compounds having different functional groups, such as amines, diamines, amino alcohols, amino phenols, amino thiophenols, amino nitriles, amino acids, and hydrazines. The peculiar behavior of the DMO-ITC is due to its sensitivity toward acids and gives different products when the reaction occurs in the absence and presence of an acid. The pH of the reaction condition also plays an important role. Normally, DMO-ITC gives pyrimidinethione derivatives when treated with amines, but reactions become interesting when the compounds have an amino group as well as the other functional group (NH 2 , OH, SH, CN, COOH) at ortho position, providing condensed bicyclic, tricyclic, or poly heterocycles with ring nitrogen and/or sulfur is of biological importance. The reaction of DMO-ITC with ethylene diamine, o -phenylenediamines, 1,2-diaminoanthraquinone, o -diaminonaphthalenes, N -aminoethyladenosine, 2-amino ethanol, o -aminophenols, o -aminothiophenols, o -aminobenzonitriles, and o -aminobenzoic acids gave imidazopyrimidinethione, pyrimidobenzimidazolethiones, pyrimidoanthraquinonimidazolethione, pyrimidonaphthoimidazolethiones, furanopurinimidazopyrimidinethione, oxazolopyrimidinethione, oxafluorenethiones, thiafluorenethiones, thioxophenanthreneones, and thiaphenanthreneones derivatives respectively. But similar reactions were not seen with o -diaminoheterocycles. Hydrazines derivatives gave seven-membered heterocycles, that is, triazepinethiones derivatives. The synthesis of the heterocycles are well defined in separate sections according to the update references.     

Synthesis of 2-and 5-(1,1-Dimethyl-1,2,5,6-tetrahydropyridinium-3-yl)oxadiazoline Iodides

ＩｎｔｒｏｄｕｃｔｉｏｎＲｅｃｅｎｔｌｙ ,ｔｈｅｉｎｃｒｅａｓｉｎｇｄｅｍａｎｄｆｏｒｅｆｆｅｃｔｉｖｅｔｒｅａｔ ｍｅｎｔｏｆｎｅｕｒｏｄｅｇｅｎｅｒａｔｉｖｅｄｉｓｅａｓｅｓ ,ｐａｒｔｉｃｕｌａｒｌｙＡｌｚｈｅ ｉｍｅｒ’ｓｄｉｓｅａｓｅ (ＡＤ) ,ｉｓｂｅｃｏｍｉｎｇｍｏｒｅａｎｄｍｏｒｅｕｒ ｇｅｎｔ.ＡｍｏｎｇｔｈｅｒｅｓｅａｒｃｈｅｓｉｎｔｈｅｒａｐｅｕｔｉｃｓｆｏｒＡＤ ,ｍａｎｙｍｕｓｃａｒｉｎｉｃｃｏｍｐｕｎｄｓｎｏｔｏｎｌｙａｒｅｂｅｎｅｆｉｃｉａｌｉｎｔｈｅｔｒｅａｔ ｍｅｎｔｏｆＡ…     

Zur Synthese von 1-(3,3-Dimethyl-2-norbornyl)-äthanon

An improved synthesis of the title compound (1) is described. The catalytical action of variousLewis acids on the sterically hinderedDiels-Alder reaction of mesityl oxide with cyclopentadiene has been investigated. The mixture ofendo- andexo-isomers of the unsaturated intermediate2 yielded pure1 on hydrogenation and isomerization by sodium methoxide. The proof of theexo-configuration of the acetyl group has been achieved by mass spectra and 100 MHz¹H-NMR spectra.

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Herrn Prof. Dr.M. Pailer mit den besten Wünschen zum 65. Geburtstag gewidmet.     

2,5-Dimethyl-4-(p-alkylbenzyl)pyridines

1,2,5-Trimethyl-4[p-methyl(ethyl, isopropyl) benzyl]-4-piperidole were obtained and converted to the similarly substituted pyridine bases.Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 12, pp. 1642–1645, December, 1970.     

2,3-二甲基-4-(2,2,2-三氟乙氧基)吡啶-1-氧化物的合成

以2,3-二甲基-4-硝基吡啶-1-氧化物为原料,合成兰索拉唑中间体2,3-二甲基-4-(2,2,2-三氟乙氧基)吡啶-1-氧化物（2）,其结构经¹H NMR确证。研究了溶剂、催化剂、碱和反应时间等因素对2收率的影响。结果表明：在最优反应条件(乙腈作溶剂,三氟乙醇2.0 eq.,碳酸钾2.5 eq.,在1 mol%TBAB水溶液中反应10 h)下,2收率超过85%。将实验规模放大到100 g级,工艺稳定。     

Synthesis and characterization of new hydrazinium(1+) fluorostannates(II)

Two new compounds, N₂H₅SnF₃ and N₂H₅Sn₂F₅, were obtained when the system N₂H₅FSnF₂H₂O was investigated. The solids were characterized by chemical analysis, vibrational spectra and X-ray powder diffraction patterns. Thermal decomposition studies of the compounds showed that they decompose through intermediates, the corresponding ammonium fluorostannates(II), to tin(II) fluoride.     

1,1-Dimethyl-1-silacyclohexa-2,4-dien-tricarbonyleisen Vorläufige Mitteilung

1,1-Dimethyl-2,3,4,5-tetraphenyl-1-silacyclohexa-2,4-diene is isomerized by iron pentacarbonyl to 1,1-dimethyl-2,3,4,5-tetraphenyl-1-silacyclohexa-2,5-diene. However, iron pentacarbonyl with 1,1-dimethyl-1-sila-cyclohexa-2,4-diene yields 1,1-dimethyl-1-silacyclohexa-2,4-diene-tricarbonyl-iron.     

Deposition of Silicon Carbide Thin Films from 1,1-Dimethyl-1-Silacyclobutane

1,1-Dimethyl-1-silacyclobutane was used as a single-source precursor to deposit SiC thin films on Si(100) and Si(111) by low-pressure chemical vapor deposition (LPCVD). Polycrystalline β-SiC thin films were grown at temperatures 1100 and 1200°C. At temperatures between 950 and 1100°C, amorphous thin films of silicon carbide were obtained. The films were studied by X-ray diffraction (XRD), infrared spectroscopy (IR), scanning electron microscopy (SEM), scanning transmission electron microscopy (STEM), and electron diffraction (ED).