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Alkynes were dicarboalkoxylated efficiently and stereoselectively in high yields reacting for about 2h under atmospheric pressure of carbon monoxide at room temperature using a catalytic amount of PdCl2, and a stoichiometric amount of CuCl2. 相似文献
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Brian W. Moran 《合成通讯》2013,43(23):3413-3418
Abstract 4-N-Arylamino-1-butanol derivatives are produced via a palladium-catalyzed tetrahydrofuran ring-opening reaction. This reaction occurs during the reduction of aromatic nitro groups with polymethylhydrosiloxane (PMHS) and potassium fluoride in the presence of hydrogen peroxide. This represents a novel route for the synthesis of 4-N-arylamino-1-butanols. 相似文献
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A series of α- and β-ferrocenyl thiophene derivatives have been synthesized via Pd-catalyzed Stille coupling reaction of tributylstannylferrocene with varied bromosubstituted thiophene compounds. 相似文献
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鹅去氧胆酸是天然的初级胆汁酸,是鸡、鸭和鹅等家禽胆汁中的主要有机成分,具有杀菌、抗炎和溶解胆结石等作用,是临床上治疗胆固醇结石的药物之一,也是合成临床上治疗胆结石疾病用量最大的药物熊去氧胆酸的原料。鹅去氧胆酸在医药方面的应用价值促使其制备方法逐步完善。近年来,关于鹅去氧胆酸衍生物的研究越来越多,相关研究也延伸到生物医药、分子识别和功能材料等多个领域,尤其在生物医药领域,鹅去氧胆酸衍生物显示出广阔的应用前景。本文系统地综述了鹅去氧胆酸的提取、合成与化学修饰方法,以及鹅去氧胆酸衍生物的合成、性质及应用,并展望了其发展前景。 相似文献
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Lappaconitine l, a bisnorditerpenoid alkaloid, was isolated from many plants ofAconitum and Delphinium species such as A. barbatum var. puberulum, A.sinomontanuml' 2. It is now used in the clinical practice as an analgesic in China', andantiarrhythmic drugs in Uzbekistan4' 5. In our attempts to prepare the 10-oxygenatedderivatives by treating lappaconitine I with HIO. followed by bromination, unexpectedby-products were obtained in modest yields. This communication described the isolationan… 相似文献
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A simple and rapid method for the preparation of a series of novel quinoxaline derivatives in the presence of Ag+ is reported. 相似文献
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通过一步法将纳米Pd负载于二维氮化碳纳米片(g-C3N4)上,制得一种新型的二维纳米催化剂Pd/g-C_3N_4NSs(1),其结构和形貌经TEM,XRD和XPS表征。以卤代苯与取代苯硼酸的Suzuki-Miyaura反应为探针反应,研究了1的催化性能。结果表明:1催化活性较好,TOF为53 000 h-1,部分产物收率高于99%,循环使用3次,其催化性能基本不变。 相似文献
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Ameen Ali Abu‐Hashem 《Journal of heterocyclic chemistry》2014,51(4):1020-1026
2‐Mercapto‐6‐[(pyridin‐4‐ylmethylene)‐amino]‐3H‐pyrimidin‐4‐one 1 was synthesized from Schiff base reaction of 6‐amino‐2‐thiouracil with isonicotinaldehyde. The reaction of 1 with hydrazonyl chloride 2a , 2b , 2c , 2d afforded the novel pyrimidin‐4‐one 3a , 3b , 3c , 3d . Compounds 3a , 3b , 3c , 3d reacted with methyl iodide to give 4a , 4b , 4c , 4d . Subsequently, reaction of 4a , 4b , 4c , 4d with triethylamine as a catalyst in dry chloroform yielded tetraaza‐spiro[4.5]deca‐2, 8‐dien‐7‐one 5a , 5b , 5c , 5d . In addition, reaction of 1 with acrylonitrile gave pyrimidin‐propionitrile 6 . The cyclization of 6 by reacting with sodium ethoxide to give pyrimido [2, 1‐b] [1,3] thiazin‐6‐one 7 . The refluxing of 1 with bromine in acetic acid yielded 2‐bromo‐pyrimidin‐4‐one 8 . The latter compound 8 reacted with sodium azide gave tetrazolo‐pyrimidine 10 . The chemical structures of the newly synthesized compounds were characterized by IR, 1H NMR, 13C NMR, and mass spectral analysis. 相似文献
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对钯催化羰基衍生物α位的芳基化反应的研究进展做了论述, 重点介绍了酮羰基化合物α-芳基化反应、酰胺类化合物α-芳基化反应和酯类化合物α-芳基化反应的研究进展. 此外, 对钯催化酮α-芳基化反应在γ-Lycorane合成中的应用和钯催化酰胺α-芳基化反应在Cherylline, Latifine及Physovenine等天然产物合成中的应用也进行了专门介绍. 相似文献
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Matthias Beller Markus Eckert Wahed A. Moradi Helfried Neumann 《Angewandte Chemie (International ed. in English)》1999,38(10):1454-1457
One-step synthesis of substituted hydantoins can be achieved by the palladium-catalyzed “ureidocarbonylation” of aldehydes with urea derivatives and carbon monoxide [Eq. (1)]. This surprisingly selective protocol converts substituted ureas into 1,5- and 1,3,5-substituted hydantoins in yields of up to 93 %. 相似文献
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Synthesis of novel bis-(3-methyl-5-nitro-2-oxo-2,3-dihydro-2λ 5benzo[1,3,2]oxazaphosphol-2yl)substituted aryl methanes was accomplished by Pudovik reaction. Addition of equimolar quantities of 2-methylamino-4-nitro phenol (1) and ethanol to PCl3 afforded cyclic condensation product. On reaction with respective aldehydes followed by treatment with phosphorus(III) monochloride of 1, and on subsequent reaction at reflux temperature, this rearranged from P(III) to P(V) state. Their structures were determined by IR, 1H NMR, 13C NMR, 31P NMR, and mass spectral data. 相似文献
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以氨基酸(1a~1c)为原料,经两步反应合成了3个N-酰基-D-苯甘氨酸甲酯(4a~4c);D-2-氯苯甘氨酸和3,5-二甲基苯甲酰氯或D-4-氯苯甘氨酸和3,5-二硝基苯甲酰氯分别经缩合反应合成了N-3,5-二甲基苯甲酰基-D-2-氯苯甘氨酸(6)或N-3,5-二硝基苯甲酰基-D-4-氯苯甘氨酸(7)。其中4b,4c,6和7为新化合物,其结构经1H NMR,IR和元素分析表征。分别以胺-酯交换法和缩合反应将4a,4c,6和7固定在氨丙基硅胶表面,制得4种新型的"刷型"手性固定相4a',4c',6'和7'。研究结果表明,以缩合法制备的6'和7'的手性选择体负载量相对较高,分别为0.24 mmol·g-1和0.33 mmol·g-1。以胺-酯交换法制备的4a'和4c'的负载量分别为0.11 mmol·g-1和0.10 mmol·g-1。用4-二甲基氨基吡啶和1-羟基苯并三唑为催化剂能避免N-酰基-D-苯甘氨酸甲酯在固定化反应中的消旋化。初步评价了6'的分离性能,结果显示6'在以乙腈-水为流动相时有较好的对映体选择性。 相似文献