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1.
Versatile Syntheses of Hemi‐Cryptophanes and a Metallo‐Cryptophane from a Hexa‐Functionalized C3v‐Symmetrical Tribenzotriquinacene (TBTQ) Derivative
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Jun Wei Zhi‐Min Li Xiao‐Jie Jin Prof. Xiao‐Jun Yao Prof. Xiao‐Ping Cao Prof. Hak‐Fun Chow Prof. Dietmar Kuck 《化学:亚洲杂志》2015,10(5):1150-1158
A number of three‐fold C3v‐symmetrical tribenzotriquinacene (TBTQ) cavitands were synthesized by a “metamorphosis‐to‐half” strategy, employing six‐fold etherification reactions between the hexakis(chloromethyl)‐TBTQ intermediate 2 a and various 5‐functionalized resorcinols. X‐ray structure analyses of single crystals of the cavitands revealed limited rotational flexibility of the resorcinol bridging units, which enables an apical, nearly co‐axial orientation of the three functional groups and, as a consequence, the construction of nanoscale cage‐like molecules via covalent or coordination bonding. On this basis, two TBTQ‐based hemicryptophanes were prepared from the TBTQ cavitands via covalent bond formation in good yields. A dumbbell‐shaped TBTQ‐based metallo‐cryptophane was also synthesized in 34 % yield by a solvothermal reaction between cadmium nitrate and two equivalents of the TBTQ‐cavitand triacid, as confirmed by single‐crystal X‐ray diffraction and MALDI‐ToF mass spectrometry. 相似文献
2.
Vignesh Athiyarath Kana M. Sureshan 《Angewandte Chemie (International ed. in English)》2020,59(36):15580-15585
To synthesize a fully organic 1D polymer in a novel twist‐stacked topology, we designed a peptide monomer HC≡CCH2‐NH‐Ile‐Leu‐N3, which crystallizes with its molecules H‐bonded along a six‐fold screw axis. These H‐bonded columns pack parallelly such that molecules arrange head‐to‐tail, forming linear non‐covalent chains in planes perpendicular to the screw axis. The chains arrange parallelly to form molecular layers which twist‐stack along the screw axis. Crystals of this monomer, on heating, undergo single‐crystal‐to‐single‐crystal (SCSC) topochemical azide–alkyne cycloaddition (TAAC) polymerization to yield an exclusively 1,4‐triazole‐linked polymer in a twist‐stacked layered topology. This topologically defined polymer shows better mechanical strength and thermal stability than its unordered form, as evidenced by nanoindentation studies and thermogravimetric analysis, respectively. This work illustrates the scope of topochemical polymerizations for synthesizing polymers in pre‐decided topologies. 相似文献
3.
Reaction between an aqueous ethanol solution of tin(II) chloride and that of 4‐propanoyl‐2,4‐dihydro‐5‐methyl‐2‐phenyl‐3 H‐pyrazol‐3‐one in the presence of O2 gave the compound cis‐dichlorobis(4‐propanoyl‐2,4‐dihydro‐5‐methyl‐2‐phenyl‐3 H‐pyrazol‐3‐onato) tin(IV) [(C26H26N4O4)SnCl2]. The compound has a six‐coordinated SnIV centre in a distorted octahedral configuration with two chloro ligands in cis position. The tin atom is also at a pseudo two‐fold axis of inversion for both the ligand anions and the two cis‐chloro ligands. The orange compound crystallizes in the triclinic space group P 1 with unit cell dimensions, a = 8.741(3) Å, b = 12.325(7) Å, c = 13.922(7) Å; α = 71.59(4), β = 79.39(3), γ = 75.18(4); Z = 2 and Dx = 1.575 g cm–3. The important bond distances in the chelate ring are Sn–O [2.041 to 2.103 Å], Sn–Cl [2.347 to 2.351 Å], C–O [1.261 to 1.289 Å] and C–C [1.401 Å] the bond angles are O–Sn–O 82.6 to 87.7° and Cl–Sn–Cl 97.59°. The UV, IR, 1H NMR and 119Sn Mössbauer spectral data of the compound are reported and discussed. 相似文献
4.
Synthesis,Characterization and Photoluminescence of Lanthanide Metal‐organic Frameworks,Constructed from Triangular 4,4′,4″‐s‐triazine‐1,3,5‐triyl‐p‐aminobenzoate Ligands
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Eight isomorphous metal‐organic frameworks: [Ln2(TATAB)2(H2O)(DMA)6]·5H2O (Ln = Sm ( 1 ), Eu ( 2 ), Gd ( 3 ), Tb ( 4 ), Dy ( 5 ), Er ( 6 ), Tm ( 7 ), Yb ( 8 )); TATAB = 4,4′,4″‐s‐triazine‐1,3,5‐triyl‐p‐aminobenzoate, DMA = N,N‐dimethylacetamide), were synthesized by the self‐assembly of lanthanide ions, TATAB, DMA and H2O. Single‐crystal X‐ray crystallography reveals they are three dimensional frameworks with 2‐fold interpenetration. Solid‐state photoluminescence studies indicate ligand‐to‐metal energy transfer is more efficient for compounds 2 and 4 which exhibit intense characteristic lanthanide emissions at room temperature. 相似文献
5.
A 2‐fold parallel interpenetrated polymer, ZnCo(OH)(pheno)(p‐BDC)1.5·H2O ( 1 ) (pheno = phenanthrene‐9,10‐dione; p‐BDC = 1,4‐benzenedicarboxylate) has been prepared by hydrothermal synthesis and structurally characterized by IR, elemental analysis, ICP and single crystal X‐ray diffraction. Complex 1 crystallizes in the orthorhombic space group Pbca and affords a three‐dimensional (3D) six‐connected α‐Po network. The magnetic behavior for 1 was studied in the temperature range of 1.8‐300 K. 相似文献
6.
《国际化学动力学杂志》2018,50(9):651-658
The data on temperature, solvent, and high hydrostatic pressure influence on the rate of the ene reactions of 4‐phenyl‐1,2,4‐triazoline‐3,5‐dione ( 1 ) with 2‐carene ( 2 ), and β‐pinene ( 4 ) have been obtained. Ene reactions 1 + 2 and 1 + 4 have high heat effects: ∆Hr‐n ( 1 + 2 ) −158.4, ∆Hr‐n( 1 + 4 ) −159.2 kJ mol−1, 25°C, 1,2‐dichloroethane. The comparison of the activation volume (∆V≠( 1 + 2 ) −29.9 cm3 mol−1, toluene; ∆V≠( 1 + 4 ) −36.0 cm3 mol−1, ethyl acetate) and reaction volume values (∆Vr‐n( 1 + 2 ) −24.0 cm3 mol−1, toluene; ∆Vr‐n( 1 + 4 ) −30.4 cm3 mol−1, ethyl acetate) reveals more compact cyclic transition states in comparison with the acyclic reaction products 3 and 5 . In the series of nine solvents, the reaction rate of 1+2 increases 260‐fold and 1+4 increases 200‐fold, respectively, but not due to the solvent polarity. 相似文献
7.
F. Sbai M. Dakir A. Auhmani H. El Jamili M. Akssira A. Benharref A. Kenz M. Pierrot 《Acta Crystallographica. Section C, Structural Chemistry》2002,58(8):o518-o520
The stereochemistries of the title compounds, both C16H24Cl2O, have been established by X‐ray diffraction. In both structures, the seven‐membered ring adopts the same conformation, whereas the six‐membered ring shows an envelope conformation in the epoxydodecane structure and a boat conformation in the dodecan‐9‐one structure. 相似文献
8.
Linyan Yang Liangliang Xin Wen Gu Shengyun Liao Peiyao Du Jinlei Tian Yanping Zhang Rui Lv Xiaohua Wei Xin Liu Daizheng Liao 《中国化学》2014,32(3):227-232
A new coordination polymer, [Co2(L)2(4,4′‐bipy)]n·3nH2O ( 1 ) based on 5‐(3‐methyl‐5‐phenyl‐4H‐1,2,4‐triazol‐4‐yl)isophthalic acid (H2 L ) and 4,4′‐bipyridine (4,4′‐bipy) has been hydrothermally synthesized and characterized by single‐crystal X‐ray diffraction, XRPD, IR, and elemental analysis. Temperature‐dependent magnetic susceptibility and thermal degradation for 1 were also studied. The asymmetric unit of compound 1 consists of two crystallographically independent Co(II) ion, two L 2? ligand, one 4,4′‐bipy ligand, and three lattice water molecules. The 2D triangle networks were linked by the bridging 4,4′‐bipy ligand to give rise to a 2‐fold interpenetrated 3D architecture. The simplest cyclic motif of the 2D networks is a triangle ring consisting of three Co(II) cations and three L 2? ligands. So we can define Co(II) ions as 4‐connected nodes and the L 2? ligands as 3‐connected nodes. Thus, the 3D structure can be described as a 2‐fold parallel interpenetrated ins InS 3,4‐conn topology. 相似文献
9.
Alexey Marchuk Florian J. Pucher Friedrich W. Karau Prof. Dr. Wolfgang Schnick 《Angewandte Chemie (International ed. in English)》2014,53(9):2469-2472
Phosphorus nitride imide, PN(NH), is of great scientific importance because it is isosteric with silica (SiO2). Accordingly, a varied structural diversity could be expected. However, only one polymorph of PN(NH) has been reported thus far. Herein, we report on the synthesis and structural investigation of the first high‐pressure polymorph of phosphorus nitride imide, β‐PN(NH); the compound has been synthesized using the multianvil technique. By adding catalytic amounts of NH4Cl as a mineralizer, it became possible to grow single crystals of β‐PN(NH), which allowed the first complete structural elucidation of a highly condensed phosphorus nitride from single‐crystal X‐ray diffraction data. The structure was confirmed by FTIR and 31P and 1H solid‐state NMR spectroscopy. We are confident that high‐pressure/high‐temperature reactions could lead to new polymorphs of PN(NH) containing five‐fold‐ or even six‐fold‐coordinated phosphorus atoms and thus rivalling or even surpassing the structural variety of SiO2. 相似文献
10.
Arthur D. Hendsbee Jason D. Masuda Adam Pirko 《Acta Crystallographica. Section C, Structural Chemistry》2009,65(12):m466-m468
The title complex salt, [Fe(C5H5)(C13H10S2)]PF6·0.33C3H6O, obtained from an acetone–diethyl ether–dichloromethane mixture at 280 (2) K, has three cationic molecules (A–C), three hexafluoridophosphate counter‐anions and one acetone solvent molecule in the asymmetric unit. Two of the three cations contain FeCp (Cp is cyclopentadienyl) inside the fold of the heterocycle. The dihedral angles between the planes of the external (complexed and uncomplexed) benzene rings in the thianthrene molecule are 146.5 (2)° for FeCp‐out‐of‐fold molecule A, and 139.0 (3) and 142.5 (2)° for the two FeCp‐in‐fold molecules B and C, respectively. The complexed Cp and benzene rings in each molecule are almost parallel, with a dihedral angle between the planes of 0.2 (5)° for molecule A, 2.8 (5)° for B, and 2.19 (4) and 6.86 (6)° for the disordered Cp ring in C. 相似文献
11.
《Angewandte Chemie (Weinheim an der Bergstrasse, Germany)》2017,129(14):3983-3987
Recently, a facile method for the synthesis of size‐monodisperse Pt, Pt3Sn, and PtSn intermetallic nanoparticles (iNPs) that are confined within a thermally robust mesoporous silica (mSiO2) shell was introduced. These nanomaterials offer improved selectivity, activity, and stability for large‐scale catalytic applications. Here we present the first study of parahydrogen‐induced polarization NMR on these Pt‐Sn catalysts. A 3000‐fold increase in the pairwise selectivity, relative to the monometallic Pt, was observed using the PtSn@mSiO2 catalyst. The results are explained by the elimination of the three‐fold Pt sites on the Pt(111) surface. Furthermore, Pt‐Sn iNPs are shown to be a robust catalytic platform for parahydrogen‐induced polarization for in vivo magnetic resonance imaging. 相似文献
12.
Xiaogang Yang Dongsheng Li Feng Fu Long Tang Jiyuan Yang Lili Wang Yaoyu Wang 《无机化学与普通化学杂志》2008,634(14):2634-2638
The reaction of ZnII nitrate with maleic acid (H2mal) / fumaric acid (H2fum) and 4,4′‐dipyridyl disulfide (4‐pds) resulted under same conditions in two distinct interpenetrated compounds, namely [Zn(4‐dps)2(H2O)2]·2Hmal ( 1 ) and [Zn(4‐dps)(fum)] ( 2 ). In 1 , Hmal anion adopts bridging mode based on hydrogen bonding, affording a 2‐fold parallel interpenetrated 3D→3D α‐Po net hydrogen‐bonded framework, in which 1D double‐stranded chains are formed, and then extended to a 3D supramolecular architecture combining second‐sphere hydrogen‐bonded interactions. For 2 , fum dianion takes on bis‐dentate bridging coordination fashion, furnishing a 2‐fold interpenetrated 2D→2D (4,4) layered coordination network, in which the tetrahedral ZnII atoms are interlinked by 4‐dps and fum. Additionally, the compound 2 shows strong fluorescence in the solid state at room temperature. 相似文献
13.
A self‐contrast approach to evaluate the inhibitory effect of chrysosplenetin,in the absence and presence of artemisinin,on the in vivo P‐glycoprotein‐mediated digoxin transport activity
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Bei Yang Li‐Ping Ma Wei Ma Shi‐Jie Wei Hong‐Yan Ji Hou‐Gang Li Hong‐Wan Dang Cheng Liu Xiu‐Li Wu Jing Chen 《Biomedical chromatography : BMC》2016,30(10):1582-1590
In this study, we used a self‐contrast method, which excluded the individual difference, to evaluate the inhibitory effect of chrysosplentin (CHR) in the presence or absence of artemisinin (ART) on the P‐glycoprotein (P‐gp) transport activity. A sensitive and rapid UHPLC–MS/MS method was applied for quantification of digoxin, a P‐gp‐specific substrate, in rat plasma. A pharmacokinetic study was carried out: first after an oral administration of digoxin at a dose of 0.09 mg/kg (first period), followed by a 20‐day wash‐out, then after another administration of digoxin (second period). During the second period, test compounds were orally given three times per day for seven consecutive days. Results showed that the t1/2 of digoxin in all the groups had no significant difference between the first and second periods. The AUC0–24, Cmax, tmax, and Clz/F of the negative control and ART alone groups showed no difference. However, the AUC0–24 and Cmax in the CHR alone, CHR–ART (1:2) and verapamil (positive control) groups showed 2.34‐, 3.04‐, 1.79‐, and 1.81‐, 1.99‐, 2.06‐fold increases along with 3.50‐, 3.84‐ and 4.76‐fold decreases for CLz/F, respectively. The tmax in the CHR–ART (1:2) group increased 3.73‐fold. In conclusion, our self‐contrast study suggested that CHR, especially when combined with ART in a ratio of 1:2, inhibited P‐gp activity while ART alone has no effect. Copyright © 2016 John Wiley & Sons, Ltd. 相似文献
14.
《中国化学》2018,36(7):594-598
Using coinage metal (Cu(II), Ag(I)) hinges, two sets of heterometallic molecular capsules with analogous open‐ended cavities were prepared based on the half‐sandwich rhodium fragments. In the case of [Rh4Cu4] cages, up to six‐fold‐stacked host‐guest structures were formed by varying the cavity's dimensions. Moreover, the series of capsules were demonstrated to self‐fine‐tune to form multi‐heteroguest arrays via favourable donor‐acceptor π interactions and Ag‐π interactions, as evidenced from single‐crystal X‐ray analysis. 相似文献
15.
Rastislav Serbin Yaroslav R. Bazel Marcel Torok Josef Havel Ioseph S. Balogh Zholt O. Kormosh Gabriela Holéczyová Vasil Andruch 《中国化学会会志》2009,56(6):1168-1174
A new, simple, rapid, sensitive, efficient and low‐cost spectrophotometric procedure for the determination of gold was developed. The method is based on the reaction of [AuCl4]? with 2‐[2‐(4‐dimethylaminophenyl)‐vinyl]‐1,3,3‐trimethyl‐3H‐indolium reagent to form a colored ion associate extractable by various organic solvents. The molar absorptivity of the ion associates is in the range (5.7–9.2) × 104 L mol?1 cm?1 depending on the extractant. Butyl acetate was chosen as the extractant. The optimum reaction conditions were established: pH 2–4, concentration of the dye reagent (0.8–1.5) × 10?4 mol L?1. The determination of gold is not hindered even by a 1000‐fold concentration of Ni and Co; a 500‐fold concentration of Pb and Zn; a 100‐fold concentration of Bi, Cu, Cd, Pt, Rh and Ru; or a 20‐fold concentration of Ag. The established method was applied to the determination of gold in model samples and enriched polymetallic ores. 相似文献
16.
Production of Hydrogen by Glycerol Photoreforming Using Binary Nitrogen–Metal‐Promoted N‐M‐TiO2 Photocatalysts
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The need for renewable energy focuses attention on hydrogen obtained by using sustainable and green methods. The sustainable compound glycerol can be used for hydrogen production by heterogeneous photocatalysis. A novel approach involves the promotion of the TiO2 photocatalyst with a binary combination of nitrogen and transition metal. We report the synthesis and spectroscopic characterization of the new N‐M‐TiO2 photocatalysts (M=none, Cr, Co, Ni, Cu), and the photocatalytic reforming of glycerol to hydrogen under ambient conditions and near‐UV or visible light versus benchmark P25 TiO2. In units of activity μmol m?2 h?1, N‐Ni‐TiO2 is five‐fold more active than P25, and N‐Cu‐TiO2 is 44‐fold more active. The photocatalytic activity of N‐M‐TiO2 increases from Cr to Co and Ni, whereas the photoluminescence decreases; the change in activity is due to the modulation of charge recombination. 相似文献
17.
《Journal of heterocyclic chemistry》2018,55(9):2172-2177
A series of novel tetraethylene glycol tethered heteronuclear bis‐isatin derivatives 7a – l were designed, synthesized, and evaluated for their in vitro anti‐mycobacterial activities against Mycobacterium tuberculosis (MTB) H37Rv and multidrug‐resistant TB (MDR‐TB) as well as cytotoxicity in VERO cell line. All hybrids exhibited potential anti‐mycobacterial activities against MTB H37Rv and MDR‐TB, and acceptable cytotoxicity. Among them, the heteronuclear bis‐isatin 7l [minimum inhibitory concentration (MIC): 16 and 16 μg/mL] was found to be most active against MTB H37Rv and MDR‐TB strains, which was 2‐fold and >8‐fold, respectively, more potent than were the first‐line anti‐tubercular agents rifampicin (MIC: 32 μg/mL) and isoniazid (MIC: >128 μg/mL) against MDR‐TB, also demonstrated acceptable cytotoxicity profile (CC50: 62.5 μg/mL), could act as a starting point for further optimization. 相似文献
18.
Niels J. Hauwert Tamara A. M. Mocking Daniel DaCostaPereira Ken Lion Yara Huppelschoten Henry F. Vischer Iwan J. P. DeEsch Maikel Wijtmans Rob Leurs 《Angewandte Chemie (International ed. in English)》2019,58(14):4531-4535
Spatiotemporal control over biochemical signaling processes involving G protein‐coupled receptors (GPCRs) is highly desired for dissecting their complex intracellular signaling. We developed sixteen photoswitchable ligands for the human histamine H3 receptor (hH3R). Upon illumination, key compound 65 decreases its affinity for the hH3R by 8.5‐fold and its potency in hH3R‐mediated Gi protein activation by over 20‐fold, with the trans and cis isomer both acting as full agonist. In real‐time two‐electrode voltage clamp experiments in Xenopus oocytes, 65 shows rapid light‐induced modulation of hH3R activity. Ligand 65 shows good binding selectivity amongst the histamine receptor subfamily and has good photolytic stability. In all, 65 (VUF15000) is the first photoswitchable GPCR agonist confirmed to be modulated through its affinity and potency upon photoswitching while maintaining its intrinsic activity, rendering it a new chemical biology tool for spatiotemporal control of GPCR activation. 相似文献
19.
Anion‐Responsive Tunable Bulk‐Phase Homochirality and Luminescence of a Cationic Framework
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Biplab Manna Biplab Joarder Aamod V. Desai Avishek Karmakar Dr. Sujit K. Ghosh 《Chemistry (Weinheim an der Bergstrasse, Germany)》2014,20(39):12399-12404
Reaction of a linear bi‐chelating N‐donor achiral ligand with ZnII afforded a homochiral cationic framework with six‐fold one‐dimensional helical chains. The compound showed selective anion exchange behavior with interesting anion‐responsive tunable bulk‐phase homochirality. The cationic framework also presented anion‐driven variable luminescence and sorption behavior. 相似文献
20.
《Angewandte Chemie (Weinheim an der Bergstrasse, Germany)》2017,129(38):11707-11711
We describe two water‐soluble ruthenium complexes, [ 1 ]Cl2 and [ 2 ]Cl2, that photodissociate to release a cytotoxic nicotinamide phosphoribosyltransferase (NAMPT) inhibitor with a low dose (21 J cm−2) of red light in an oxygen‐independent manner. Using a specific NAMPT activity assay, up to an 18‐fold increase in inhibition potency was measured upon red‐light activation of [ 2 ]Cl2, while [ 1 ]Cl2 was thermally unstable. For the first time, the dark and red‐light‐induced cytotoxicity of these photocaged compounds could be tested under hypoxia (1 % O2). In skin (A431) and lung (A549) cancer cells, a 3‐ to 4‐fold increase in cytotoxicity was found upon red‐light irradiation for [ 2 ]Cl2, whether the cells were cultured and irradiated with 1 % or 21 % O2. These results demonstrate the potential of photoactivated chemotherapy for hypoxic cancer cells, in which classical photodynamic therapy, which relies on oxygen activation, is poorly efficient. 相似文献