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1.
2-Isoxazolines are converted to corresponding 3-hydroxyketones which are used as precursors to produce new 3-unsubstituted 1,5-diaryl-2,4-pentanediones and -4-methoxy-2-pentanones. 相似文献
2.
《Tetrahedron letters》1986,27(27):3203-3204
A synthesis of 2R,3S,4R-dihydroxyproline is described in which an azide is introduced into C-2 positon of D-ribonolactone with retention of configuration. 相似文献
3.
Morio Asaoka Noboru Yanagida Keiji Ishibashi Hisashi Takei 《Tetrahedron letters》1981,22(43):4269-4270
Dehydration or dealkoxylation of the reaction products of various aldehydes, ketones, and acetals with 2-trimethylsiloxyfuran gave corresponding 4-ylidenebutenolides in good to high overall yields. 相似文献
4.
Diacetone-D-glucose 1 gives 3- O -methylxanthate 2 on reaction with NaH/Me I. Reductive deoxygenation of compound 2 by Bu3SnH gives the corresponding 3-deoxy glucose derivative 3 and on acid-catalyzed regioselective deprotection of C-5,6-acetonide gives the diol 4. The diol on oxidative cleavage with NaIO4 gives the aldehyde 5, which on further condensation with benzylamine followed by reduction with NaBH4 gives the amine 7. Z-Protection of the amine followed by methanolysis gives methyl furanoside 9. Reaction of 9 with methanesulfonyl chloride/Et3N gives the corresponding C-3-O-mesylate derivative 10. Catalytic hydrogenation of compound 10 (Pd/C/H2/MeOH 3 kg) gives bicyclic oxaazo compound 11, due to deprotection of the N-benzyl- and Z-protecting groups and intramolecular nucleophilic displacement of the C-2- O-mesylate by the C-5 amine in a one-pot reaction. Z-Protection of the amine 11 followed by acid-catalyzed hydrolysis gives acetal 13. Reduction of acetal by use of NaBH4 gives Z-prolinol 14. Selective oxidation of diol 14 by (2,2,6,6-tetramethylpiperidin-1-yl)-oxyl (TEMPO)/[(bis)(acetoxy)iodo]benzene (BAIB) and NaClO2/NaH2PO4, followed by Z-deprotection, gives the title compound I in 3.5% overall yield from D-glucose. 相似文献
5.
Synthesis of O2'-methyluridine, O2'-methylcytidine, N4,O2'-dimethylcytidine and N4,N4,O2'-trimethylcytidine from a common intermediate 总被引:5,自引:0,他引:5
A Nyilas J Chattopadhyaya 《Acta chemica Scandinavica. Series B: Organic chemistry and biochemistry》1986,40(10):826-830
A facile synthesis of the title compounds from a readily accessible precursor, 3',5'-O-bis-protected O4-(2-nitrophenyl)uridine, is described. 相似文献
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7.
LIU Fang-ming YU Jian-xin LU Wen-jie LIU Gang LIU Yu-ting Xu-Li TANG CHEN Yao-zu 《高等学校化学学报》1998,19(Z1):285
Many compounds containing the 1,3,4-oxadiazole and/or1,2,3(or 4)-triazole and thiadiazole ring system are reported to possess antibacterial[1], antiinflammatory[2], anticonrulsant[3],CNS stimulant[4] and pesticidal[5] activities and excellent anthelmintic properties[6,7]. In view of this and the results of the combined different nuclei system in a molecular always enhancing the therapeutic activities,the present work deals with the synthesis of the combined different pharmacologically active nuclei system mentioned above in a molecular through some new method. 相似文献
8.
G. Veinberg M. Vorona D. Musel R. Bokaldere I. Shestakova I. Kanepe E. Lukevics 《Chemistry of Heterocyclic Compounds》2004,40(6):816-822
4-Sulfonylazetidinones-2 were synthesized by the reaction of DBU and organic halides on the esters of penicillin sulfones. 4-Sulfonylthio- and 4-sulfothioazetindinones-2 were synthesized by nucleophilic substitution of the 2-benzothiazolylthio groups in 4-(benzothiazolylthio)azetidinones-2 using sodium sulfinates or sodium hydrogen sulfite. A study of their cytotoxic activities revealed the anticancer effect of compounds containing methylsulfonylthio-, 4-tolylsulfonylthio-, and 4-methoxycarbonylamino-phenylsulfonylthio-substituents at position 4 of the -lactam ring relative to a wide range of monolayer cultures of cancer cells in vitro. 相似文献
9.
Avarietyofbiologicalactivitiesofsome4H-l,3,2-benzodioxaphosphorin2-sulfideshavebeenreported,forexampletheinsecticideSalithionl.Thecyclicphosphonothionateshavebeenpreparedbyintermolecularcondensationofphosphorodichloridothioateswithsalicylalcoholoritsderivativesinthepresenceofabase=,andbyintramolecularcyclizationreactionofthesalicylalasthestartingmaterial3.However,theintramolecularcyclizationreactionofthe2-hydrobenzophenonesandstereochemicalstudieshavenotbeenreported.Wenowdescribeanewsynthesis… 相似文献
10.
Norbert De Kimpe Wim De Cock Marian Keppens Dirk De Smaele Andrea Mszros 《Journal of heterocyclic chemistry》1996,33(4):1179-1183
A variety of heterocycles, including 3,4-disubstituted-2-imino-4-thiazolines, 3,4-disubstituted-4-methoxy-2-iminothiazolidines, 2,4-disubstituted-thiazoles, 2-amino-4-substituted-thiazoles and 1,5-disubstituted-4-imidazolin-2-ones, were synthesized from α-chloromethyl and α-bromomethyl ketimines by condensation with potassium thiocyanate, thiourea, ammonium thiocyanate and potassium cyanate. 相似文献
11.
2-Phenyl-1, 2, 3-triazole-4-formylhydrazine (2) was prepared by hydrazinolysis of the corresponding ester 1. Reaction of 2 with CS2/KOH gave the oxadiazole derivatives (3) which via, Mannich reaction with different dialkyl amines furnished 3-N, N-dialkyl derivatives (4a-c). Also, condensation of 2 with appropriate aromatic acid in POCl3 yielded oxadiazole derivatives (5a-c), or with aldehydes and ketones afforded hydrazones (6a-c). Cyclization of (6a-c) with acetic anhydride gave the desired dihydroxadiazole derivatives (7a-c). On the other hand, reaction of dithiocarbazate (8) with hydrazine hydrate gave the corresponding triazole derivative (9) which on treatment with carboxylic acids in refluxing POCl3 yielded s-triazole[3,4-b]-1, 3, 4-thiadiazole derivatives (10a-b). The structures of all the above compounds were confirmed by means of IR, 1H NMR, MS and elemental analysis. 相似文献
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13.
本文报道了七个新的2,4,5-三氧-1,3,2,4-二氮二磷杂环戊烷衍生物的制备, 产物的结构经IR, ^1H和^31P NMR, MS以及元素分析证实, 并利用^31P NMR和GC-MS区分了化合物的顺式和反式异构体。 相似文献
14.
2,2,4,4—四对羟甲基酚氧基—6,6—二苯基三聚磷腈的合成 总被引:10,自引:0,他引:10
通过Friedel-Crafts反应,将本基引入到六氯环三磷腈上,然后由亲核取代反应和氢化还原反应,合成了2,2,4,4-四对羟甲基酚氧基-6,6-二苯基三聚磷腈,探索了各步的合成、分离方法,并对化合物的结构进行了表征. 相似文献
15.
4-Trifluoromethyl-1,2-dihydropyrimidines were synthesized in moderate yields by the one-pot reaction of 4-ethoxy-1,1,1-trifluoro-3-buten-2-one, aldehydes and ammonia catalyzed by zinc chloride under mild conditions. 相似文献
16.
Tse-Lok Ho 《合成通讯》2013,43(9):761-764
4-Acetyl-2-carene obtained from 3-carene undergoes methylation, ozonolysis, and lead tetraacetate oxidation resulting in cis-dihydrochrysanthemolactone. 相似文献
17.
L. D. Smirnov K. M. Dyumaev N. I. Shuikin I. F. Bel'skii 《Russian Chemical Bulletin》1962,11(12):2148-2149
Summary A new method was proposed for the synthesis of 2,4,6-trialky1-3-hydroxypyridines by the reactions of 3,5-dialkyl-2-acylfurans with ammonia. 相似文献
18.
Magdesieva N. N. Koloskova N. M. Le Ngi Nguyen 《Chemistry of Heterocyclic Compounds》1977,13(11):1177-1180
A preparative method was worked out for the synthesis of 3,4,6-triaryl-2-pyrones by 1,3-dipolar cycloaddition of selenium arylacylmethylides to diphenylcyclopropenone.Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 11, pp. 1475–1478, November, 1977. 相似文献
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20.
dl-4-Hydroxymethyi-2-buten-4-olide(4) has been synthesized from furfural (5) through a sequence of reactions as shown in Scheme of the text. 相似文献