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TONG Dingyi DUAN Haifeng WANG Jiajun ZHANG Li CAO Jungang WEI Zhonglin LIN Yingjie 《高等学校化学研究》2014,30(1):4-8
Pyrene is one of significant fluorescent material and its fluorescence properties are excellent.It has been widely used for such as OLEDs,DSCs,LMOGs and so on[1-5].What's more,pyrene has been successfully applied to signaling the presence of metal ions,nucleic acids,proteins and so on[6-9].Thus,the development of the fluorescent dyes based on pyrene has been a research focus[10-12].However,the synthesis of many pyrene derivatives needed the high-cost coupling reaction such as Heck reaction and Suzuki reaction[1-3,10-12]. 相似文献
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LIJun-fen BAIGuan LINPei-hua TIANMei-lin DONGChuan LIDu-xin 《高等学校化学研究》2004,20(2):216-220
Five organic fluorescence dyes were synthesized by two- or three-step reactions. These synthetic meth-ods have an advantage of the simple processes, low costs and high yields. The compositions of the five compounds are characterized by IR, ^1H NMR, elemental analyses and fluorescence spectroscopies. The quantum yields of fluorescence were measured. 相似文献
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与传统半导体发光材料相比,荧光碳点作为一种新型的碳纳米发光材料,因其优异的生物相容性、良好的发光性能、简单的合成工艺、低廉的成本等优点而备受关注。荧光碳点在生物荧光标定、医学传感器、光诊疗剂以及发光器件等方面具有广阔的应用潜力。本文重点阐述了荧光碳点的合成方法、显微结构分析、荧光机理及应用的最新成果,希望为荧光碳点合成与应用研究的发展提供参考。 相似文献
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aza-BODIPY荧光染料是近10年发展起来并受到广泛关注的一类新型荧光化合物,它极有可能发展成可应用于光动力学治疗的光敏剂.本工作合成了5个aza-BODIPY 1a~1e,用IR,NMR,MS和元素分析对它们进行了表征.研究了它们的紫外吸收光谱与荧光发射光谱,结果表明1a~1e具有较高的摩尔吸光系数,在aza-BODIPY母环的3,5位或1,7位的苯环4位有供电子取代基时能使化合物的最大紫外吸收波长和荧光发射波长红移.测试了1a~1d的循环伏安曲线,根据各化合物的氧化还原电位讨论了它们的结构稳定性. 相似文献
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利用电化学方法在碱性条件下电解石墨棒, 通过常温下水合肼还原, 得到5~10 nm的荧光石墨烯量子点(Graphene Quantum Dots, GQDs). 通过透射电子显微镜(TEM)、原子力显微镜(AFM)对所制备的GQDs进行形貌表征, GQDs的粒子大小均一, 为单层石墨烯. 通过傅里叶变换红外光谱(FTIR)、荧光光谱(PL)、紫外可见吸收光谱(UV-vis)、X 射线衍射光谱(XRD)对所制备的GQDs进行性质测定, 发现GQDs可以发出黄色荧光, 量子产率为14%, 毒性低、具有良好的水溶性、荧光稳定性和生物兼容性, 可顺利进入细胞, 在肿瘤细胞的成像研究方面具有广泛的应用前景. 相似文献
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Takahiro Egawa Kazuhisa Hirabayashi Dr. Yuichiro Koide Chiaki Kobayashi Dr. Naoya Takahashi Dr. Tomoko Mineno Dr. Takuya Terai Dr. Tasuku Ueno Dr. Toru Komatsu Dr. Yuji Ikegaya Prof. Norio Matsuki Prof. Tetsuo Nagano Dr. Kenjiro Hanaoka 《Angewandte Chemie (International ed. in English)》2013,52(14):3874-3877
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Zuhai Lei Caixia Sun Peng Pei Shangfeng Wang Dandan Li Xin Zhang Fan Zhang 《Angewandte Chemie (International ed. in English)》2019,58(24):8166-8171
Small‐molecule organic fluorophores, spectrally active in the 900–1700 nm region, with tunable wavelength and sensing properties are sought‐after for in vivo optical imaging and biosensing. A panel of fluorescent dyes ( CX ) has been developed to meet this challenge. CX dyes exhibit the wavelength tunability of cyanine dyes and have a rigidified polymethine chain to guarantee their stability. They are chemo‐ and photo‐stable in an aqueous environment and have tunable optical properties with maximal absorbing/emitting wavelength at 1089/1140 nm. They show great potential in high‐contrast in vivo bioimaging and multicolor detection with negligible optical cross talk. Förster resonance energy transfer (FRET) between CX dyes was demonstrated in deep tissue, providing an approach for monitoring drug‐induced hepatotoxicity by detection of OONO?. This report presents a series of NIR‐II dyes with promising spectroscopic properties for high‐contrast bioimaging and multiplexed biosensing. 相似文献
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Dr. Elodie Heyer Pauline Lory Dr. Jérôme Leprince Dr. Mathieu Moreau Prof. Anthony Romieu Prof. Massimo Guardigli Prof. Aldo Roda Dr. Raymond Ziessel 《Angewandte Chemie (International ed. in English)》2015,54(10):2995-2999
The preparation of highly water‐soluble and strongly fluorescent diketopyrrolopyrrole (DPP) dyes using an unusual taurine‐like sulfonated linker has been achieved. Exchanging a phenyl for a thienyl substituent shifts the emission wavelength to near λ=600 nm. The free carboxylic acid group present in these new derivatives was readily activated and the dyes were subsequently covalently linked to a model protein (bovine serum albumin; BSA). The bioconjugates were characterized by electronic absorption, fluorescence spectroscopy and MALDI‐TOF mass spectrometry, thus enabling precise determination of the labeling density (ratio DPP/BSA about 3 to 8). Outstanding values of fluorescence quantum yield (30 % to 59 %) for these bioconjugates are obtained. The photostability of these DPP dyes is considerably greater than that of fluorescein under the same irradiation conditions. Remarkably low detection limits between 80 and 300 molecules/μm2 were found for the BSA bioconjugates by fluorescence imaging with a epifluorescence microscope. 相似文献
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Benjamin W. Lewis Niels Bisballe Marco Santella Peter A. Summers Jean-Baptiste Vannier Marina K. Kuimova Bo W. Laursen Ramon Vilar 《Chemistry (Weinheim an der Bergstrasse, Germany)》2021,27(7):2523-2536
Four-stranded G-quadruplex (G4) DNA is a non-canonical DNA topology that has been proposed to form in cells and play key roles in how the genome is read and used by the cellular machinery. Previously, a fluorescent triangulenium probe ( DAOTA-M2 ) was used to visualise G4s in cellulo, thanks to its distinct fluorescence lifetimes when bound to different DNA topologies. Herein, the library of available triangulenium probes is expanded to explore how modifications to the fluorescent core of the molecule affect its photophysical characteristics, interaction with DNA and cellular localisation. The benzo-bridged and isopropyl-bridged diazatriangulenium dyes, BDATA-M2 and CDATA-M2 respectively, featuring ethyl-morpholino substituents, were synthesised and characterised. The interactions of these molecules with different DNA topologies were studied to determine their binding affinity, fluorescence enhancement and fluorescence lifetime response. Finally, the cellular uptake and localisation of these optical probes were investigated. Whilst structural modifications to the triangulenium core only slightly alter the binding affinity to DNA, BDATA-M2 and CDATA-M2 cannot distinguish between DNA topologies through their fluorescence lifetime. It is argued theoretically and experimentally that this is due to reduced effectiveness of photoinduced electron transfer (PET) quenching. This work presents valuable new evidence into the critical role of PET quenching when using the fluorescence lifetime of triangulenium dyes to discriminate G4 DNA from duplex DNA, highlighting the importance of fine tuning redox and spectral properties when developing new triangulenium-based G4 probes. 相似文献
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This minireview highlights recent advances of research dedicated to photoswitchable fluorescent nanoparticles and their applications. Recently, several strategies have been developed to synthesize nanoparticles with optically switchable emission properties: either fluorescence on/off or dual‐alternating‐color fluorescence photoswitching. The underlying mechanisms of fluorescence photoswitching enable many different types of photoswitchable fluorescent nanoparticles to change fluorescence colors, thus validating the basis of the initial photoswitching design. Among all possible applications, the usage of photoswitchable fluorescent nanoparticles to empower super‐resolution fluorescence imaging and to label biological targets was subsequently reviewed. Finally, we summarize the important areas regarding future research and development on photoswitchable fluorescent nanoparticles. 相似文献
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近年来,荧光成像技术为人们研究活体细胞及组织内的化学生物学过程提供了有效的研究工具,可以无损、实时、原位地以高时空分辨率实现对目标物进行生物荧光成像与分析。荧光成像技术在生物学、环境监测、临床诊断和药物发现等诸多研究领域发挥着越来越重要的作用。生物荧光成像技术的最新进展对发展新型小分子荧光染料及探针提出了更高的要求。激发和发射波长位于近红外光区(600~900 nm)的荧光染料及探针由于具有光毒性低、生物分子自发荧光干扰小、光散射低、组织穿透能力强等优点,非常适合用于生物荧光成像领域。通过将罗丹明分子中O桥原子用Si代替,得到了一类新型的探针分子--硅杂蒽类荧光探针。这类染料分子在保留了氧杂蒽荧光染料优越的光学性质的同时,光谱发生明显红移,满足了近红外荧光检测的要求,具有良好的生物相容性。本文综述了近年来基于硅杂蒽及其衍生物荧光探针的合成及在金属离子、pH值、小分子、生物酶等检测方面的研究进展,并且简要阐述了基于硅杂蒽类探针分子的识别检测机理以及其在生物成像等方面的应用。 相似文献
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Faiz Ullah Sami Ullah Muhammad Farhan Ali Khan Muhammad Mustaqeem Rizwan Nasir Paracha Muhammad Fayyaz ur Rehman Fariha Kanwal Syed Shams ul Hassan Simona Bungau 《Molecules (Basel, Switzerland)》2022,27(19)
Fluorescent molecules absorb photons of specific wavelengths and emit a longer wavelength photon within nanoseconds. Recently, fluorescent materials have been widely used in the life and material sciences. Fluorescently labelled heterocyclic compounds are useful in bioanalytical applications, including in vivo imaging, high throughput screening, diagnostics, and light-emitting diodes. These compounds have various therapeutic properties, including antifungal, antitumor, antimalarial, anti-inflammatory, and analgesic activities. Different neutral fluorescent markers containing nitrogen heterocycles (quinolones, azafluoranthenes, pyrazoloquinolines, etc.) have several electrochemical, biological, and nonlinear optic applications. Photodynamic therapy (PDT), which destroys tumors and keeps normal tissues safe, works in the presence of molecular oxygen with light and a photosensitizing drugs (dye) to obtain a therapeutic effect. These compounds can potentially be effective templates for producing devices used in biological research. Blending crown compounds with fluorescent residues to create sensors has been frequently investigated. Florescent heterocyclic compounds (crown ether) increase metal solubility in non-aqueous fluids, broadening the application window. Fluorescent supramolecular polymers have widespread use in fluorescent materials, fluorescence probing, data storage, bio-imaging, drug administration, reproduction, biocatalysis, and cancer treatment. The employment of fluorophores, including organic chromophores and crown ethers, which have high selectivity, sensitivity, and stability constants, opens up new avenues for research. Fluorescent organic compounds are gaining importance in the biological world daily because of their diverse functionality with remarkable structural features and positive properties in the fields of medicine, photochemistry, and spectroscopy. 相似文献
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罗丹明以其良好的光稳定性、光物理性质和荧光效应得到了人们的极大重视。 基于罗丹明的螺环衍生物与被检测物质作用开环而产生荧光响应的特性,将两个或多个罗丹明母体单元构筑到包含特异性的识别单元的探针分子中,形成多枝的罗丹明酰肼类荧光探针,不仅可以弥补单分子探针的某些功能缺陷,而且可以使其具有更高灵敏度、更高选择性和可靠性,更加有利于分析检测。 本文着重从设计原理、识别性能、应用范围等方面介绍了多枝罗丹明探针在Hg2+、Cu2+、Fe3+和Al3+等离子检测中发展趋势,并展望了这类荧光探针在活细胞金属离子光学成像的应用前景。 相似文献