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V. L. Gein M. I. Kazantseva L. F. Gein P. A. Slepukhin 《Russian Journal of Organic Chemistry》2014,50(2):240-243
Reactions of alkyl acetoacetates, aromatic aldehydes, ammonium acetate, and 1,3-cyclohexanedione afford alkyl 4-aryl-2-methyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxylates. The structure of compounds obtained was established with the help of IR, 1H NMR, and mass spectra and by X-ray diffraction analysis. 相似文献
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Ethyl ethoxymethylenemalonate reacts with cyanothioacetamide andN-methylmorpholine to giveN-methylmorpholinium 3-cyano-5-ethoxycarbonyl-6-oxopyridine-2-thiolate. Alkylation of the latter yieldsS-alkyl derivatives.
Translated fromIzvestiya Akademii Nauk. Seriya Khimicheskaya, No. 1, pp. 196–197, January, 1999. 相似文献
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The title compound (C22H27NO3) was obtained by the reaction of 4-methylbenzal- dehyde, dimedone, ethyl acetoacetate and ammonium acetate in water in the presence of triethyl- benzylammonium chloride (TEBA). The crystal is of orthorhombic, space group Pbcn with a = 18.242(2), b = 15.651(1), c = 14.207(2) (A), V = 4056.15(64) (A)3, Mr = 353.45, Z = 8, Dc = 1.158 g/cm3, μ = 0.076, λ(MoKα) = 0.71073 (A) and F(000) = 1520. The final R = 0.0453 and wR = 0.0436 for 1156 observed reflections with I > 2((Ⅰ). X-ray analysis revealed that the pyridine ring is of boat conformation and the six-member ring fused with it adopts half-chair conformation. 相似文献
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1 INTRODUCTION The 1,4-dihydropyridines (1,4-DHPs) are biologi- cally interesting compounds and have been developed extensively in pharmacology. 1,4-DHP derivatives are used therapeutically in the treatment of cardio- vascular disorders, especially hypertension and coro- nary heart disease such as angina pectoris, atheros- clerosis, etc. The DHPs have emerged as one of the most important classes of drugs for the treatment of gastrointestinal disease, Raynaud?s disease, pulmonary hyper… 相似文献
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The reactions of 3- or 4-hydroxybenzaldehydes with cyanothioacetamide and Meldrum's acid in the presence ofN-methylmorpholine affordedN-methylmorpholinium 5-cyano-4-(3-or 4-hydroxyphenyl)-2-oxo-1,2,3,4-tetrahydropyridine-6-thiolates, respectively. The resulting
compounds were used in the synthesis of substituted 6-alkylthio-1,2,3,4-tetrahydropyridin-2-ones.
Translated fromIzvestiya Akademii Nauk. Seriya Khimicheskaya, No. 12, pp. 2333–2336. December, 1999. 相似文献
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V. L. Gein M. I. Kazantseva A. A. Kurbatova 《Russian Journal of Organic Chemistry》2011,47(6):886-888
Cyclohexane-1,3-dione reacted with substituted benzaldehydes and N-arylacetoacetamides in the presence of ammonium acetate under solvent-free conditions (150–160°C, 10–20 min) to give the
corresponding 4,N-diaryl-2-methyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxamides. The product structure was determined by IR and 1H NMR spectroscopy and mass spectrometry. 相似文献
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The reaction of dimedone, N-aryl-substituted acetoacetic acid amides, aryl aldehydes, and ammonium acetate gives 4,N-diaryl-2,7,7-trimethyl-5-oxo-1,4,5,6,7,8-hexahydro-3-quinoline carboxamides. 相似文献
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芳亚苄基丙二腈;二甲基环己二酮;无催化剂条件下2-氨基-3-氰基-4-芳基-7;7-二甲基-5-氧代-5;6;7;8-四氢-4H-苯并吡喃的合成 相似文献
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S. G. Krivokolysko V. D. Dyachenko V. P. Litvinov 《Chemistry of Heterocyclic Compounds》1999,35(4):455-458
Condensation of isovaleric aldehyde with cyanothioacetamide and acetylacetone or its enamine produces 5-acetyl-3-cyano-4-isobutyl-6-methyl-3,4-dihydropyridine-2(1H)-thione,
from which 5-acetyl-3-cyano-4-isobutyl-6-methylpyridine-2(1H)-thione and the corresponding substituted 2-alkylthio-1,4-dihydropyridines
are prepared.
T. G. Shevchenko Lugansk State Pedagogical Institute, Lugansk 348011, Ukraine; e-mail: kgb@lgpi.lugansk.ua; N. D. Zelinskii
Institute of Organic Chemistry of the Russian Academy of Sciences, Moscow 117913, Russia;
Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 4, pp. 516–519, April, 1999. 相似文献
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The title compound, methyl 4-(2,4-dichlorophenyl)-2,7,7-trimethyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxylate(C_(20) H_(21)Cl_2NO_3, 1) was synthesized and the crystal structure was —determined by single-crystal X-ray diffraction. It crystallizes in tetragonal system, space group P421 c with a = 16.076(3), b = 16.076(3), c = 14.750(2) ?, V = 3811.8(14) ?3, Z = 8, R = 0.0377 and wR = 0.0845. The interactions between compound 1 and bovine serum albumin(BSA) were investigated using fluorescence spectroscopy. The results revealed that compound 1 can effectively quench the intrinsic fluorescence of BSA by static quenching mechanism. The thermodynamic parameters revealed that the action forces between compound 1 and BSA were mainly van der Waals forces and hydrogen bonds. According to F?rster's non-radioactive energy transfer theory, the binding distance between compound 1 and BSA had been determined. Furthermore, the synchronous fluorescence showed that compound 1 has few effects on the microenvironment and conformation of BSA in the binding process. 相似文献
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A. D. Dyachenko S. M. Desenko V. D. Dyachenko 《Chemistry of Heterocyclic Compounds》2004,40(8):1017-1023
Treatment of monothiomalonodiamide with cyclohexylidenemalononitrile or cyclohexylidenecyanoacetic ester in the presence of sodium ethylate gave 6-amino-3-carbamoyl-5-cyano-3,4-dihydrospirocyclohexane-4-pyridine-2-thiol and 5-cyano-3-thiocarbamoyl-4-spirocyclohexanepiperidine-2,6-dione. Their alkylation and hydrolysis have been studied. 相似文献
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V. D. Dyachenko S. G. Krivokolysko V. P. Litvinov 《Chemistry of Heterocyclic Compounds》1996,32(9):1055-1057
By condensation of the anilide of acetoacetic acid, propionaldehyde, and cyanothioacetamide, 6-methyl-5-phenylcarbamoyl-3-cyano-4-ethylpyridine-2(IH)thione has been obtained. In an alkaline medium, this compound is alkylated, forming the corresponding substituted 2-pyridyl sulfides. From these pyridines, substituted thienoj2,3-blpyridines have been synthesized through the Thorpe-Ziegler reaction.T. G. Shevchenko Lugansk Pedagogical Institute, Lugansk 348011. N. D. Zelinskii Institute of Organic Chemistry, Moscow 117913. Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 9, pp. 1232–1234, September, 1996. Original article submitted May 13, 1996. 相似文献
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V. D. Dyachenko V. N. Nesterov S. G. Krivokolysko V. P. Litvinov 《Chemistry of Heterocyclic Compounds》1997,33(6):684-690
We have obtained 2-alkylthio-7,7-dimethyl-5-oxo-4-ethyl(isopropyl)-3-cyano-1,4,5,6,7,8-hexahydroquinolines by reaction of 5,5-dimethylcyclohexane-1,3-dione, propionic (or isobutyric) aldehyde, cyanothioacetamide, and alkyl halides. We have established the structure of 4-isopropyl-7,7-dimethyl-5-oxo-3-cyano-2-cyanomethylthio-1,4,5,6,7,8-hexahydroquinoline by x-ray diffraction.T. G. Shevchenko Lugansk State Pedagogical Institute, Lugansk 348011. A. N. Nesmeyanov Institute of Heteroorganic Compounds, Russian Academy of Sciences, Moscow 117813. N. D. Zelinskii Institute of Organic Chemistry, Russian Academy of Sciences, Moscow 117913. Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 6, pp. 785–792, June, 1997. 相似文献
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Condensation of isovaleraldehyde with cyanothioacetamide and ethyl acetoacetate (or its enamine) gives 3-cyano-5-ethoxycarbonyl-4-isobutyl-6-methyl-3,4-dihydropyridine-2(1H)-thione. This compound was used in the synthesis of substituted 1,4-dihydropyridin-2-yl sulfides.
Translated fromIzvestiya Akademii Nauk. Seriya Khimicheskaya, No. 1, pp. 166–168, January, 1999. 相似文献