共查询到20条相似文献,搜索用时 15 毫秒
1.
Samir Kumar Mandal 《Tetrahedron》2008,64(49):11050-11057
A radical-promoted synthesis of 3,4-dihydroisocoumarins has been achieved in moderate to good yields using titanocene(III) chloride (Cp2TiCl) as the radical initiator. The total synthesis of four naturally occurring dihydrocoumarins hydrangenol, phyllodulcin, macrophyllol and thunberginol G has been accomplished using the radical technology. Cp2TiCl was prepared in situ from commercially available titanocene dichloride (Cp2TiCl2) and Zn-dust in THF under argon. 相似文献
2.
Asymmetric synthesis of α-methylene bis-γ-butyrolactone has been synthesized using titanocene(III) chloride as a radical source. Titanocene(III) chloride (Cp2TiCl) was prepared in situ from commercially available titanocene dichloride (Cp2TiCl2) and zinc dust in THF. 相似文献
3.
Sumit Saha 《Tetrahedron》2010,66(24):4278-3130
Enantioselective synthesis of two anti-tumor antibiotics, (−)-methylenolactocin and (−)-protolichesterinic acid, has been achieved through titanocene(III) chloride mediated radical cyclization reaction starting from commercially available d-mannitol. Titanocene(III) chloride (Cp2TiCl) was prepared in situ from commercially available titanocene dichloride (Cp2TiCl2) and zinc dust in THF. 相似文献
4.
Samir Kumar Mandal 《Tetrahedron letters》2006,47(10):1599-1601
Titanocene(III) chloride (Cp2TiCl) mediated 8-endo radical cyclizations towards the synthesis of eight-membered cyclic ethers have been described. Titanocene(III) chloride was prepared in situ from commercially available titanocene dichloride (Cp2TiCl2) and activated zinc dust in THF. 相似文献
5.
Samir Kumar Mandal 《Tetrahedron letters》2005,46(36):6115-6117
Free radical-promoted conjugate addition of activated bromo compounds to α,β-unsaturated ketones and reactive α,β-unsaturated esters has been described using titanocene(III) chloride (Cp2TiCl) as the radical initiator. Cp2TiCl was prepared in situ from commercially available Cp2TiCl2 and activated zinc dust in THF. 相似文献
6.
Samir Kumar Mandal 《Tetrahedron》2007,63(46):11341-11348
Titanocene(III) chloride (Cp2TiCl) mediated 7-exo and 8-endo radical cyclizations of epoxides towards the synthesis of 7- and 8-membered cyclic ethers have been described. Titanocene(III) chloride was prepared in situ from commercially available titanocene dichloride (Cp2TiCl2) and activated zinc dust in THF. 相似文献
7.
Samaresh Jana 《Tetrahedron letters》2005,46(7):1155-1157
A novel and efficient methodology has been developed for the construction of synthetically important tri-substituted tetrahydrofuran derivatives from bromo-alkenes and bromo-alkynes by radical cyclization reactions using the radical initiator Cp2TiCl, generated in situ from commercially available titanocene dichloride and Zn dust in tetrahydrofuran under argon. 相似文献
8.
Samaresh Jana 《Tetrahedron letters》2006,47(33):5949-5951
Aromatic carbonyl compounds undergo smooth intramolecular radical cyclization with alkenes or alkynes using titanocene(III) chloride to furnish the corresponding benzopyrans. The radical initiator, Cp2TiCl, was prepared in situ from commercially available titanocene dichloride (Cp2TiCl2) and zinc dust in THF under argon. 相似文献
9.
Moumita Paira 《Tetrahedron letters》2007,48(18):3205-3207
A simple and efficient methodology has been developed for the one-pot preparation of α-methylene-γ-butyrolactones by free-radical induced Barbier-type reaction of methyl 2-(bromomethyl)acrylate and aldehydes followed by in situ lactonization. The radical initiator titanocene(III) chloride (Cp2TiCl) was easily generated in situ from commercially available Cp2TiCl2 and activated zinc dust in THF. Ketones remained unaffected under the reaction conditions. 相似文献
10.
Georgios Patias Ioannis Choinopoulos Spyros Koinis Marinos Pitsikalis 《Journal of polymer science. Part A, Polymer chemistry》2018,56(19):2192-2202
Seven (half-)titanocene alkoxide complexes, [Cp2TiCl(OEt)], [Cp2TiCl(O-2-Bu)], [Cp2TiCl(OCH2CF2CF2H)], [CpTiCl2(OEt)], [CpTiCl2(O-(S)-2-Bu)], [CpTiCl2(OCH2CF3)], and [Cp2TiCl(OCH2CF3)], were synthesized and employed in lactide coordination polymerization. These organotitanium (IV) compounds proved to be very efficient initiators for the ring-opening polymerization of enantiomeric l -lactide and racemic mixture of rac-lactide, leading to end-functionalized polymers. Kinetic studies illustrated that these compounds produce well-defined polymers in a controlled manner. This was further demonstrated by synthesizing poly(l -lactide-b-hexyl isocyanate) diblock copolymer. The effect of the alkoxy end groups on the thermal behavior of the polymers was also studied by thermogravimetric analysis and differential scanning calorimetry. The polymers were characterized using size exclusion chromatography and proton nuclear magnetic resonance spectroscopy. The optical properties of the diblock copolymer were also investigated. © 2018 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2018 , 56, 2192–2202 相似文献
11.
G.A. Razuvaev V.N. Latyaeva L.I. Vishinskaya V.T. Bytchkov G.A. Vasilyeva 《Journal of organometallic chemistry》1975,87(1):93-99
The reaction of dicyclopentadienyltitanium dichloride with bis(triethylgermyl)mercury in benzene solution at 20° yields metallic mercury quantitatively, titanocene monochloride and triethylchlorogermane. The reaction of dicyclopentadienyltitanium dichloride with bis(triethylgermyl)cadmium leads to the formation of a complex of the following general composition: [Cp2TiCl2 - Cd(GeEt3)2]. The reactivity of this complex has been studied: in toluene solution at 20° it decomposes slowly to yield metallic cadmium, triethylchlorogermane and Cp2TiCl(GeEt3). 相似文献
12.
The mechanism of catalytic polymerization of acrylonitrile in the presence of titanocene dichloride under light have been investigated by UV, NMR and ESR spectroscopy. Results of photochemical reaction monitored by UV and NMR showed that titanocene dichloride (Cp2TiCl2) in dimethyl sulfoxide system can be decomposed by light irradiation to give cyclopentadiene. ESR studies show that cyclopentadienyl free radical in photopolymerization system of Cp2TiCl2-acrylonitrile can be trapped by two kinds of spin trapping agents, phenyl-N-tert-butylnitrone and 2-methyl-2-nitrosopropane, respectively. Therefore, the radical mechanism of catalytic polymerization of acrylonitrile in the presence of Cp2TiCl2 under light is further confirmed. 相似文献
13.
Titanocene(III) chloride (Cp(2)TiCl) mediated radical induced allylation of aldimines for the preparation of homoallyl amines is described. The radical was generated from the allyl bromide using Cp(2)TiCl as the radical source. Formal synthesis of C(4)-C(5')-linked 4'-deoxy aza-disaccharide is demonstrated and a study toward the bicyclic skeleton of alkaloids was also accomplished. The radical initiator Cp(2)TiCl was prepared in situ from commercially available titanocene dichloride (Cp(2)TiCl(2)) and Zn dust in THF under argon. 相似文献
14.
Dmitry F. Grishin Stanislav K. Ignatov Alexander A. Shchepalov Alexey G. Razuvaev 《应用有机金属化学》2004,18(6):271-276
The mechanism of the controlled radical polymerization of styrene and methyl methacrylate in the presence of dicyclopentadienyltitanium dichloride (Cp2TiCl2) was studied using quantum chemical calculations and electron spin resonance spectroscopy. It was established that the reduction of Cp2TiCl2 to Cp2TiCl during the macromolecule synthesis occurs through the living polymerization mechanism, which adjusts the growth of a polymeric chain. The geometrical structures of the molecular complexes between a growing macroradical and Cp2TiCl2 and transition states of radical inhibition steps were optimized and the thermodynamic and kinetic parameters of the elementary reactions were estimated for several feasible directions of the process. On this basis, the observed kinetic features of vinylic monomer polymerization with participation of organic compounds of titanium are discussed. Copyright © 2004 John Wiley & Sons, Ltd. 相似文献
15.
The oxidation elimination reaction between dicarbonyl titanocene and aryltin halides was studied by means of paramagnetic resonance spectroscopy. The radical intermediates containing Ti(III) were discovered from the ESR spectra to be (Cp2TiSnArnX3-n), Cp2Ti(CO)X, and Cp2TiX, and a radical mechanism for the reaction is proposed. © 1996 John Wiley & Sons, Inc. 相似文献
16.
The reaction of titanocene dichloride,Cp
2TiCl2 (Cp=5-C5H5), with one or two equivalents of sodium cyanodithioformate affords the new mono- or bis(dithiocarboxylato) derivativesCp
2TiCl(S2CCN) (1) andCp
2Ti(S2CCN)2 (2). Elimination of sulfur converts2 into the metallacyclicCp
2TiS2C2(CN)2 (3), which does not react with the diene isoprene, but can be reconverted into the appropriate titanocene dihalides by chlorine or bromine. 相似文献
17.
Paul Binger Patrik Müller Petra Philipps Barbara Gabor Richard Mynott Albert T. Herrmann Franz Langhauser Carl Krüger 《欧洲无机化学杂志》1992,125(10):2209-2212
Bis(trimethylphosphane)titanocene ( 1 ) reacts with 2-methylene-1,1-diphenylcyclopropane ( 2 ) to give red crystalline (η2-2-methylene-1,1-diphenylcyclopropane)(trimethylphosphane)titanocene ( 3 ). In solution complex 3 degrades smoothly to form the new Cp2Ti(PMe3) – C2 – Ti(PMe3)Cp2 complex 4 , the crystal structure of which has been elucidated by an X-ray analysis. 相似文献
18.
Jizhu Jin Cheol‐Hee Ahn Tsuneji Sano Toshiya Uozumi Masahide Murata Hiroyuki Ozaki Hideaki Hagihara 《Journal of polymer science. Part A, Polymer chemistry》2000,38(18):3355-3359
Three kinds of MgCl2‐supported trivalent titanocene catalyst (Cat. 1: Cp2TiCl2AlCl2/MgCl2, Cat. 2: CpCp*TiCl/MgCl2, Cat. 3: Cp2TiCl/MgCl2) were prepared and tested for propylene polymerization. It was found that Cat. 1, combined with ordinary alkylaluminum as cocatalyst, produced PP containing 31.8 wt % of isotactic PP in fairly good yield. On the other hand, Cats. 2 and 3 hardly showed any activity. The effects of diisopropyldimethoxysilane (DIPDMS) on isospecificity of the Cat. 1 also were investigated. The isotactic index (I.I.) of PP was improved drastically by the addition of DIPDMS as external donor and reached the value as high as 98.4%, even in the absence of any internal donors. © 2000 John Wiley & Sons, Inc. J Polym Sci A: Polym Chem 38: 3355–3359, 2000 相似文献
19.
The reduction of titanocene dithiocyanate in various solvents has been examined using the techniques of polarography, voltammetry, controlled potential electrolysis and cyclic voltammetry. In THF and CH2Cl2, Cp2Ti(NCS)2 undergoes successive one-electron transfer reactions, and by using a combination of electrochemical and EPR techniques it has been possible to confirm the stability of [Cp2Ti(NCS)2]? in these solvents. In DMF, however, an irreversible dimerization follows the first electron transfer. 相似文献
20.
Addition of various polyfluoroalkyl halides including 1,2-dihalopolyfluoroalkanes to1-octene is effected by using a catalytic amount of Cp_2TiCl_2(IV) and iron powder to give 1:1 adductsin excellent yields. The reaction is performed in EtOH or THF. A Cp_2TiCl(Ⅲ) mediatedradical mechanism is proposed. Radical reactivity of polyfluoroalkanes toward 1-octene was foundto be --CF_2I> -CF_2Br >-CF_2CCl_3. 相似文献