共查询到20条相似文献,搜索用时 15 毫秒
1.
V. A. Glushkov V. I. Karmanov E. V. Feshina G. A. Postanogova Yu. V. Shklyaev 《Chemistry of Heterocyclic Compounds》2001,37(1):103-108
1-Aroylmethyl-3,3-dialkyl-3,4-dihydroisoquinolines were synthesized by the Ritter reaction. The nitrosylation of these isoquinoline derivatives proceeds smoothly at the -enamine carbon atom to give monooximes of 3,3-dialkyl-3,4-dihydro-1-isoquinolyl aryl diketones. Loss of an acetyl group occurs in the nitrosylation of 1-(-acetylbenzyl)-3,3-dimethyl-3,4-dihydroisoquinoline. 相似文献
2.
The reaction of dialkylbenzylcarbinols with 3-cyanocoumarin in the presence of sulfuric acid gave 3,3-dialkyl-1-(3-coumarinyl)-3,4-dihydroisoquinoline. 相似文献
3.
N. N. Polygalova A. G. Mikhailovskii V. V. Udodov A. I. Mikhalev M. I. Vakhrin 《Chemistry of Heterocyclic Compounds》2007,43(8):1024-1028
It has been shown that the reaction of dialkylbenzylcarbinols with 3-cyano-2-pyridones and 2-chloro-3-cyanopyridines gives
the corresponding 3,3-dialkyl-1-(3-pyridyl)-3,4-dihydroisoquinolines.
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 8, pp. 1208–1212, August, 2007. 相似文献
4.
V. A. Glushkov Yu. S. Rozhkova M. I. Vakhrin Yu. V. Shklyaev 《Chemistry of Heterocyclic Compounds》2005,41(8):1022-1026
A three component “one-pot” condensation of 1,2-ethylenedioxybenzene and RCN nitriles with isobutylene oxide, isobutyraldehyde,
or cyclohexanecarboxaldehyde in the presence of conc. H2SO4 gives 1-R-3,3-dialkyl-6,7-ethylenedioxy-3,4-dihydroisoquinolines.
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 8, pp. 1198–1203, August, 2005. 相似文献
5.
V. A. Glushkov S. N. Shurov O. A. Maiorova G. A. Postanogova E. V. Feshina Yu. V. Shklyaev 《Chemistry of Heterocyclic Compounds》2001,37(4):444-452
The interaction of 1,2- or 1,4-dimethoxybenzene with isobutylene oxide and nitriles RCN leads to 1-R-6,7- or 1-R-5,8-dimethoxy-3,3-dimethyl-3,4-dihydroisoquinolines. In the case of 1,2-dimethoxybenzene and cyclohexene oxide the similar reaction is accompanied by rearrangement and 1-R-3,3-tetramethylene-3,4-dihydroisoquinolines are formed in low yield. On using cyanoacetic acid ester and any oxide derivatives of tetrahydroisoquinolylideneacetic acid are formed. 相似文献
6.
1-Substituted 3,3,4-trimethyl-3,4-dihydrobenzo[h]isoquinolines have been obtained by the reaction of 1,2-dimethyl-1-(2-naphthyl)-1-propanol with nitriles in conc. H2SO4. It was shown that the presence of a benzene ring annelated at positions 7 and 8 of the isoquinoline does not influence reaction of the 1-methyl derivative with isocyanate, however reactions of the 1-methylthio derivative with C and N nucleophiles are affected significantly. 相似文献
7.
B. B. Aleksandrov M. S. Gavrilov M. I. Vakhrin V. S. Shklyaev 《Chemistry of Heterocyclic Compounds》1985,21(6):662-665
A number of ethyl esters of 3,3-dialkyl-3,4-dihydroisoquinoline-1(2H), -- alkylacetic acids have been synthesized. The effect of replacement of -hydrogen by alkyl radicals on the azomethine-enamine tautomeric equilibrium was shown.Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 6, pp. 794–797, June, 1985. 相似文献
8.
2-R-7a-Methyl-3-(spirocyclohexa-2,5-dien-4-one)perhydro-1-indolines were obtained by the reactions of 1-(4-ethoxyphenyl)-2-methylcyclohexanol with nitriles (RCN) in dichloromethane in the presence of concentrated sulfuric acid. 相似文献
9.
Ausheva O. G. Glushkov V. A. Shurov S. N. Shklyaev Yu. V. 《Russian Chemical Bulletin》2001,50(9):1648-1656
The reactions of 1-(p-methoxyphenyl)-2-methylpropan-1-ol or -cyclohexyl-p-methoxybenzyl alcohol with nitriles RCN in concentrated sulfuric acid afforded 1-R-3,3-dialkyl-2-azaspiro[4.5]deca-1,6,9-trien-8-ones. The stability of the latter toward the dienone-phenolic rearrangement depends on the nature of the substituent R. The reaction mechanism was studied by the semiempirical quantum-chemical AM1 method. 相似文献
10.
V. A. Glushkov V. I. Karmanov Yu. V. Shklyaev 《Chemistry of Heterocyclic Compounds》2005,41(4):475-480
3,3,-Dialkyl-1-cyano-3,4-dihydroisoquinolines were prepared by Beckmann defragmentation of ethyl α-(3,3-dialkyl-3,4-dihydroisoquinol-1-yl)-α-hydroximinoacetates and they take part in a Ritter reaction to form substituted bis-1,1′-(3,4-dihydroisoquinolines).__________Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 4, pp. 558–563, April, 2005. 相似文献
11.
Yu. V. Shklyaev R. R. Ismagilov Yu. S. Rozhkova A. A. Fatykhov I. B. Abdrakhmanov A. G. Tolstikov 《Russian Chemical Bulletin》2004,53(4):906-910
Reactions of 1,2,3- or 1,2,4-trimethylbenzene with isobutyraldehyde and ethyl cyanoacetate (ECA) or reactions of the corresponding 1-aryl-2-methylpropan-1-ols with ECA afforded isomeric 3,3,5,6,7-, 3,3,6,7,8-, 3,3,5,7,8-, and 3,3,5,6,8-pentamethyl-3,4-dihydroisoquinolines. Isomerization is explained as the ring opening of a spiran intermediate in two possible ways followed by the Jacobsen rearrangement. 相似文献
12.
13.
《Green Chemistry Letters and Reviews》2013,6(3):353-402
Abstract Condensation of indole with aromatic aldehydes has been carried out without using any catalyst and solvent to give bis(indolyl)methanes. 相似文献
14.
Glushkov V. A. Ausheva O. G. Shurov S. N. Shklyaev Yu. V. 《Russian Chemical Bulletin》2002,51(5):894-896
1-R-3,3-Dimethyl-2-azaspiro[4.5]deca-1,6,9-trien-8-ones were synthesized through three-component condensation of anisole, isobutyraldehyde, and a corresponding nitrile in dichloromethane in the presence of concentrated sulfuric acid. 相似文献
15.
G. A. Smirnov P. B. Gordeev S. V. Nikitin G. V. Pokhvisneva T. V. Ternikova O. A. Luk´yanov 《Russian Chemical Bulletin》2015,64(5):1057-1061
Synthetic procedures towards methylene-bis(1-oxy-3,3-dialkyl-1-triazene 2-oxides), the first representatives of a new class of promising exogenous nitric oxide (NO) donors, which can release NO in living organisms, were developed. Synthesis involves the reactions of salts of 1-hydroxy-3,3-dialkyl-1-triazene 2-oxides with either dibromomethane or 1-chloromethoxy-3,3-dialkyl-1-triazene 2-oxides. 相似文献
16.
Phenyl groups were used as silicon-protecting groups in the synthesis of bis-(3,3-dinitrobutyl)polysiloxanes. The addition of diphenylsilane to acrolein dimethyl acetal, followed by reactions with methyllithium and phosphorus tribromide gave bis(3-bromobutyl)diphenylsilane. Sodium nitrite displacement gave bis(3-nitrobutyl)diphenylsilane, and oxidative nitration gave bis(3,3-dinitrobutyl)diphenylsilane. Dephenylation with bromine and hydrolysis gave cyclic polysiloxanes. 相似文献
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19.
Indanones 3 were prepared from the reaction of indanone (1) with corresponding benzaldehyde derivatives 2, as described in the literature. Then, indenones 3 were subjected to KOtBu-catalyzed Michael addition with malononitrile to give a mixture of diastereomers 5 with a low conversion and no diastereoselection. Utilization of phase-transfer catalyst such as benzyltriethylammonium chloride or N-benzylcinchonidinium chloride had a positive effect on both conversion and diastereoselection. The structure of diastereomers 5 was determined by spectroscopic methods (NMR, IR). 相似文献
20.
Santhisudha Sarva Jayaprakash Soora Harinath Siva Prasad Sthanikam Selvarajan Ethiraj Mohanasrinivasan Vaithiyalingam Suresh Reddy Cirandur 《中国化学快报》2016,27(1):16-20
A series of bioactive bis(indolyl)methanes are synthesized by one-pot green reaction of indole with various substituted aldehydes by microwave irradiation under solvent free conditions. The antibacterial activity against Staphylococcus aureus and anti-inflammatory activity of the synthesized bis(indolyl)-methanes are evaluated in vitro and compared to standard drugs tetracycline and diclofenac, respectively. The majority of the compounds showed good antibacterial and anti-inflammatory activity. Interestingly, compounds 3j, 3i, 3k and 3g exhibited much higher anti-inflammatory activity than the standard diclofenac drug and thus qualify for clinical trials to be used as an anti-inflammatory compound. 相似文献