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N,N’-二羧甲基-2-甲基苯并咪唑内翁盐的合成及晶体结构 总被引:1,自引:0,他引:1
以2-甲基苯并咪唑为原料,合成了一个新型的苯并咪唑二羧酸衍生物,基结构通过IR,1HNMR,元素分析和X-射线单晶衍射法确定.X射线衍射单晶结构分析表明,固态时标题化合物通过分子间氢键形成一维无限链状结构,这些一维无限链状结构又通过链与链间的苯并咪唑环的π-π堆积作用形成二维结构.标题化合物的晶体属单斜晶系,P21/c空间群;Mr568.54,a=19.821(3),b=7,.4501(11),c=20.093 (3)A,β=116.479(3)°,v=2655.8(3)A3,z=4,Dc=1.422 mg· m-3,F(000)=1200,最终偏离因子R=0.0675,wR=0.2187. 相似文献
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近年来,氮杂大环冠醚因可以作为生物膜活性物质的模型化合物、NMR成像造影剂、重金属解毒剂,及其金属配合物可改变入射光波长等性质已引起国内外广泛的注意[1].作者曾用NMR法、电位法对标题化合物的配合性质进行了研究[2,3],并发现这些配体在水溶液中不稳定,易发生水解.当水溶液的pH为7.0时,水解逐渐发生.配体1是最不稳定的,即使在酸性溶液中,数小时后也开始水解.按已发表的合成法[4],大环醚双内酯的产率低,实验重复性差,且原始产物通常为奶油状棕色粘性物,难以纯化.本文报道N,N′-二羧甲基大环醚双内酯的合成改进方法. 相似文献
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双膦酸及其酯主要是以P-C-P键为特征的类似天然焦磷酸的一类低聚膦酸类化合物.因焦磷酸在体内易被酶水解,故将其P-O-P结构更换成P-C-P结构,便成为在体内不易被酶水解的稳定化合物.此类化合物具有良好的趋骨性(Seeing-bone)以及与金属离子较强的螯合作用,在治疗骨质疏松、关节炎、乳腺癌和骨癌引起的高钙血症等、有关钙代谢方面的疾病得到了广泛应用[1,2].关于此类化合物的合成文献有较多报道[3,4],但都相对复杂.为了寻找简单易行的合成方法,我们以胺、羧酸、水和三氯化磷为原料,一锅反应合成了目标化合物.并发现有些形成了环状膦酰胺类化合物,该法具有操作简单,原料易得等优点. 相似文献
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新型超分子化合物C6H20N2O64P2MO18·8H2O 的晶体结构及电催化作用 总被引:20,自引:0,他引:20
多酸是较好的受体分子,当它与有机电子给体作用时,可形成超分子化合物.90年代初这类化合物的研究才刚刚起步.作为一类新型电、磁、非线性光学材料极具开发价值[1].用氨基酸作为电子给体对生物活性研究意义重大[2],有关Keggin结构的超分子化合物已见报道[3],但标题化合物这类手性阴离子[4]与手性氨基酸所形成的杂多化合物及单晶结构尚未见文献报道. 相似文献
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0引言
60年代初,Weisz提出规整结构分子筛"择形催化"概念,继而发现它对催化裂化反应的惊人活性[1].金属有机膦酸化学因其在自组装化学、超分子化学、软化学和纳米化学等前沿领域的广泛研究而倍受广大化学工作者的关注[2],尤其是在吸附、催化、离子交换、非线性光学材料方面潜在极大的应用前景[3,4],因而设计和合成新型的有机膦酸及其金属化合物,并进一步探索其结构和性能之间的关系,对筛选出具有实际应用价值的新型结构材料具有重要的意义. 相似文献
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一缺位杂多阴离子XW11O(12-n)-39(X=P5+,Si4+,B3+,Ga3+)含硫有机膦衍生物的合成及结构表征 总被引:4,自引:0,他引:4
杂多化合物的衍生物由于具有潜在的多功能催化性能,长期以来一直受到人们的关注[1~3].将有机或有机金属基团引入杂多化合物中以修饰杂多阴离子的部分外部骨架结构,对研究杂多化合物的性质和应用及新型催化剂的开发具有重要意义[4,5].在杂多化合物表面引入适当的有机基团还可改善其溶解性能及其它物理性质,从而拓宽其应用范围.研究结果表明,这类化合物还具有很好的抗病毒和抗肿瘤活性[6,7].Klemperer等[8]合成的[(η5-C5H5)TiPW11O39]4-将多酸与金属有机化合物有机地融为一体,从而开辟了多酸金属有机化学的新领域.此后,相继合成了许多多酸型金属有机化合物[9],然而缺位杂多阴离子的有机膦衍生物的研究却鲜见报道[10]. 相似文献
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Bao-qing Shentu Ji-peng Li Zhi-xue Weng 《高分子科学》2006,(4):345-351
The effect of N,N,N',N'-tetraalkyl terephthalamide (TATA) on the non-isothermal crystallization and melting characteristics ofpolypropylene (PP) was studied. The addition of TATA can lead to the formation ofβ-crystal PP. With the increase in TATA concentration the degree of crystallinity for β-crystal PP increased significantly, and that for a-crystal PP decreased, which indicated that TATA effectively induced the formation of β-crystal PP. WAXD also revealed the existence of β-crystal PP after the introduction of TATA into PP. PP containing TATA crystallized at a temperature range of 5-10℃ higher than that of pure PP, and the half-crystallization time (t1/2) and Avrami exponent (n) of PP at the same cooling rate were decreased by the addition of TATA, indicating that TATA influenced the crystallization rate and crystallization growth mode of PP. The rate constant of crystallization of PP containing TATA (Zc) was larger than that of pure PP, which further indicated that the crystallization of PP was accelerated by the addition of TATA. 相似文献
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研究新型萃取剂从硝酸盐介质中萃取分离稀土元素对于后处理工艺具有重要意义。本文报道以甲苯为稀释剂,N,N,N′,N′-四丁基丙二酰胺(TBMA)从硝酸盐介质中萃取铈(Ⅲ)、镝(Ⅲ)、铒(Ⅲ)、镨(Ⅲ)、钐(Ⅲ)、铽(Ⅲ)、铥(Ⅲ)、镱(Ⅲ)的机理。考察了硝酸浓度、TBMA浓度、盐析剂浓度以及温度对上述三价镧系离子分配比的影响。得出萃合物的组成主要是三配体配合物M(NO3)3·3TBMA;计算出萃取反应的条件平衡常数、萃取平衡常数。温度效应研究表明萃取反应主要是焓驱动的。对萃取分离系数以及TBMA萃取三价镧系离子的规律进行了初步研究。 相似文献
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Screening of N,N‐bidentate and N,N,N‐tridentate pyridine‐based ligands in the catalytic allylic oxidation of cyclic olefins
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A variety of chiral N,N‐bidentate and N,N,N‐tridentate ligands based on the pyridine framework, namely C2‐symmetric dipyridylmethane and terpyridine, N‐(p‐toluensulfinyl)iminopyridines and two kinds of iminopyridines, has been assessed in the asymmetric copper(I)‐catalysed allylic oxidation of cyclic olefins. Catalytic activity and enantioselectivity were found to be highly dependent upon the framework of the ligands, which afforded cycloalkenyl benzoates in low to moderate yields and enantioselectivities. The best yields (up to 70%) and enantioselectivities (up to 53% enantiomeric excess) were obtained with an iminopyridine based on camphane and quinoline skeletons. Copyright © 2014 John Wiley & Sons, Ltd. 相似文献
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新的核苷衍生物N2,N3-亚乙烯基腺嘌呤核苷的合成 总被引:4,自引:0,他引:4
描述了一条有效的合成新的荧光核苷衍生物N2,N3-亚乙烯基腺苷的合成路线.实验中首先通过6步制备了N2,N3-亚乙烯基鸟苷,然后经过氯化,再氨化得到标题化合物.标题化合物和新的中间化合物的结构分别通过1H NMR, MS和HRMS进行了确证,标题化合物的荧光性质初步得到证实. 相似文献
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Arpan Mukherjee Tuhin Subhra Koley Ayan Chakraborty Dr. Kallol Purkait Dr. Arindam Mukherjee 《化学:亚洲杂志》2021,16(22):3729-3742
Half-sandwich RuII complexes, [(YZ)RuII(η6-arene)(X)]+, (YZ=chelating bidentate ligand, X=halide), with N,N and N,O coordination ( 1 – 9 ) show significant antiproliferative activity against the metastatic triple-negative breast carcinoma (MDA-MB-231). 3-aminobenzoic acid or its methyl ester is used in all the ligands while varying the aldehyde for N,N and N,O coordination. In the N,N coordinated complex the coordinated halide(X) is varied for enhancing stability in solution (X=Cl, I). Rapid aquation and halide exchange of the pyridine analogues, 2 and 3 , in solution are a major bane towards their antiproliferative activity. Presence of free −COOH group ( 1 and 4) make complexes hydrophilic and reduces toxicity. The imidazolyl 3-aminobenzoate based N,N coordinated 5 and 6 display better solution stability and efficient antiproliferative activity (IC50 ca. 2.3–2.5 μM) compared to the pyridine based 2 and 3 (IC50>100 μM) or the N,O coordinated complexes ( 7 – 9 ) (IC50 ca. 7–10 μM). The iodido coordinated, 6 , is resistant towards aquation and halide exchange. The N,O coordinated 7 – 9 underwent instantaneous aquation at pH 7.4 generating monoaquated complexes stable for at least 6 h. Complexes 5 and 6 , bind to 9-ethylguanine (9-EtG) showing propensity to interact with DNA bases. The complexes may kill via apoptosis as displayed from the study of 8 . The change in coordination mode and the aldehyde affected the solution stability, antiproliferative activity and mechanistic pathways. The N,N coordinated ( 5 and 6 ) exhibit arrest in the G2/M phase while the N,O coordinated 8 showed arrest in the G0/G1 phase. 相似文献
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Gaozhan Xie Victor Brosius Jie Han Dr. Frank Rominger Prof. Andreas Dreuw Dr. Jan Freudenberg Prof. Uwe H. F. Bunz 《Chemistry (Weinheim an der Bergstrasse, Germany)》2020,26(1):160-164
A series of quinoidal N,N′-diaryldiaza-N,N′-dihydropentacenes (Quino) was prepared in a two-step reaction, starting from quinacridone. Oxidation of Quino furnishes stable radical cations, isoelectronic to the radical anions of the azaacenes, whereas the dicationic species are isoelectronic to neutral azapentacenes. The spectroscopic properties of the diaryldiazapentacenes and their oxidized mono- and dications are equivalent to that of the dianion of tetraazapentacene (TAP), its radical anion and the neutral TAP. 相似文献
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《Analytical letters》2012,45(5):821-832
Abstract The flow injection analysis of benzoyl peroxide using N,N,N,N-tetramethyl-p-phenylenediamine (TMPDA, also known as Wurster's reagent) and a solvent system including the surfactant sodium dodecyl sulfate (SDS) and cerium(IV) as a catalyst at pH 6.0 at 612 nm was investigated. The method was applied to the analysis of acne cream and flour. The study included a 26-metal-ion search for other possible methods of catalysis and a buffer study of SDS and cetyltrimethyl ammonium bromide (CTAB). 相似文献