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《Tetrahedron》1988,44(9):2649-2655
The syntheses of 1,4-dideoxy-l,4-imino-L-ribitol and of 1,4-dideoxy-l,4-imino-D-talitol from D-mannose are described. 1,4-Dideoxy-l,4-imino-D-talitol is a specific and competitive inhibitor of human liver α-mannosidase and also blocks the lysosomal catabolism of asparigine-linked glycans of glycoproteins . 相似文献
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《结构化学》1989,(1)
<正> Quinoxaline 1,4-dioxide (QO2), C8HsN2O2, Mr=162.14,monoclinic, space group P21,a = 4.112(2), b = 7.402(3), c = 11.378(8) A,β= 94.69(5)°, V=345.1A3,Z= 2,Dc= 1.56 g/cm3, R= 0.032 for 409(I>3.0 O(I)) reflections. The QO2 molecule is planar with average N-O bond length of 1.291(5)A and average N-O bond order of 1.35. 2,3-Dimethylquinoxaline 1,4-dioxide (QM2O2), C10H10N2O2,Mr = 90.20, orthorhombic,space group Pbca,a =7.647(1), b = 14.943(3), c =15.656(5)A, V =1789.1 A3,Z = 8;Dc=1.41 g/cm3,R=0.030 for 655 (I> 3.0 σ(I)) reflections. The QM202 molecule is also planar with average N-O bond length of 1.301A, and average N-0 bond order of 1.31. 相似文献
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XU Xing-Youa MA Wei-Xinga GAO Jiana LIU Qing-Liangb a 《结构化学》2002,21(5):473-476
1 INTRODUCTION Macrocyclic ligands and their metal complexes have received much attention due to their applications in ion transport, ion separation and as models in biomimic researches[1~7]. The synthetic methods of macrocyclic ligands and their metal complexes are mainly divided into three kinds[8]. The first one is synthesizing free ligand, then forming the metal complexes; the second is template synthesis; and the third is synthesizing the end-off or side-off precursor ligand, then c… 相似文献
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Cetin Bayrak Halil Senol Sedef Sirtbasi Ertan Sahin Abdullah Menzek 《Tetrahedron》2018,74(40):5839-5849
Reactions of benzyne with ester derivatives of spiro[2.4]hepta-4,6-dien-1-ylmethanol were performed. By rearrangement reaction of cyclopropyl methanol units of ((1s*,1′R*,2R*,4′S*)-1′,4′-dihydrospiro[cyclopropane-1,9'-[1,4]methanonaphthalen]-2-yl) methyl 3,5-dinitrobenzoate (13) and its isomer (14), corresponding allyl chlorides were obtained. Two rearrangement products were obtained from bromination of compound 13 with an equivalent amount of Br2. A naphthalene derivative including allyl and CHO moiety was formed for reactions from compounds with epoxide of 13 and 14 with NaN3 by sequential rearrangements. Formations of products are discussed. 相似文献
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丁二烯可通过1,4加成或1,2加成进行聚合.1,4加成可能生成顺-1,4链节,也可能生成反-1,4链节;1,2加成则可能形成全同立构或间同立构的聚合物.一般游离基或离子型聚合的产物多半为包含各种链节的无规聚合物(见表1).例如用钠或钾聚合的 相似文献
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《有机化学》2016,(12)
1,4-二氢吡啶(1,4-DHPs)是具有广泛生理活性和应用价值的重要氮杂环化合物.随着绿色有机合成化学的发展,1,4-DHPs的绿色合成和新合成方法在近些年取得了一些重要研究成果,弥补了Hantzsch反应的传统合成途径的一些不足,如环境友好、合成效率、产物结构单一和反应类型匮乏等.对2010年以来Hantzsch反应的绿色合成和新合成方法进行综述,全面地介绍了Hantzsch反应中绿色溶剂、绿色催化剂和绿色合成技术的应用,以及基于新砌块发展出合成1,4-DHPs的新反应研究现状,系统地分析了Hantzsch反应的绿色合成及新型反应的合成策略特点,详细地阐述反应底物、反应条件和产率,进而从新反应的绿色合成化和手性合成等方面对该领域的研究方向进行了探讨. 相似文献
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Zusammenfassung Die Untersuchungen über die Reaktion zwischen 2,5-Dihydroxy-1,4-dithianen und Aminen der allgemeinen Formel R–NH2 und R–NHNH2 wurden fortgesetzt. Aus 2,5-Dihydroxy-1,4-dithian (I) und Ammoniak bildet sich das trizyklische System des 2,5-Di-(N-2,5-endimino-1,4-dithianyl)-1,4-dithians. Dagegen reagiert 2,5-dimethyl-2,5-dihydroxy-1,4-dithian mit Ammoniak zu 2,5-Dimethyl-2,5-endimino-1,4-dithian. Weiters gibt I mit Thiosemikarbazid N-Thioureido-2,5-endimino-1,4-dithian. Um zu wasserlöslichen Derivaten des Ringsystems zu gelangen, die einer pharmakologischen und bakteriostatischen Untersuchung unterzogen werden können, wurden die zur Salzbildung fähigen Verbindungen N--Diäthylaminoäthyl-2,5-endimino-1,4-dithian und N-Isonicotinsäureamido-2,5-endimino-1,4-dithian hergestellt.Herrn Prof. Dr.F. Wessely zu seinem 60. Geburtstag in aufrichtiger Verehrung gewidmet. 相似文献
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The absolute rate constant for 1,4-benzoquinone (BQ) irreversibly trapping α-phenethyl radicals (3) has been determined as 4.4×106 M−1 s−1 at 43 °C using acyclic cis azoalkane 9c as a radical precursor. These reactants afford the hydroquinone mono ether 4 at 30 °C but a mixture of products at elevated temperature. 2,6-Di-tert-butyl-1,4-benzoquinone (DTBQ) also reacts with 3 but the cyclohexadienone products are thermally labile. 相似文献
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1INTRODUCTIONIthasbeenarousedmoreandmoreinterestsinces-tetrazinewasfirstsynthesizedbyHautgschin1900[1].Thesynthesisofdihydroderivativeof3,6-dimethyl-s-tetrazinewasreportedindetailbySkorianetz[2].UsingX-ray,Jennison[3]foundthat1,6-dihydro-s-tetrazinehashom… 相似文献
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The diffusion behavior of polystyrene with narrow molecular weight distribution at 20℃ in 1, 4-dioxane was investigated by the photon correlation spectroscopy. The cumulant method was employed for the analysis of the intensity-intensity autocorrelation function measured over a wide range of the scattering vector. The diffusion coefficient D was determined as the function of concentration C in the molecular weight range of 3. 0×104-1. 20×106. In a low concentration range, D was found to be linearly dependent on C, which has been found for some other systems. The dependence of D on molecular weight at infinite dilution can be written as an empirical formula D0 = kDM-γ M, the exponent γ(0. 576 ±0. 01) is in good agreement with the result of the scaling theory. 相似文献
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Zusammenfassung In Fortsetzung unserer Arbeiten wurde versucht, das 2,5-Endoxy-1,4-dithian als den Grundkörper dieses bicyclischen Ringsystems herzustellen. Die Bemühungen blieben bisher erfolglos; doch wurde eine einfache Darstellungsmethode für das 2,5-Dioxy-1,4-dithian gefunden. Die Reaktion dieser Verbindung mit Semicarbazid führt zu einem Derivat, das als erster Vertreter des Ringsystems eines 2,5-Endimino-1,4-dithians angesprochen wurde. Mit Phenylhydrazin entsteht dementsprechend das N-Anilido-2,5-endimino-1,4-dithian, während mit Anilin ein 2,5-Dianilido-1,4-dithian erhalten wurde. Die Reaktion mit -Methyl-phenylhydrazin wurde erörtert. Zur Konstitutionsbestimmung der erhaltenen Produkte wurden besonders die hydrierende Desulfurierung und die Diskussion der UR-Spektren herangezogen.Mit 3 Abbildungen. 相似文献