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In an effort to find highly efficient ligands for hepatic asialoglycoprotein receptor(ASGPR),four cluster galac-tosides with different scaffolds were synthesized in this paper.The affinity of these compounds for ASGPR wasanalyzed by binding study in vitro.The results showed that trivalent cluster galactosides behaved better than diva-lent analogues and the cluster galactosides with aryl groups on their scaffolds presented better binding affinity thanthose with aliphatic chain scaffolds. 相似文献
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XiaoRuZHANG YingXiaLI ShiDongCHU KunYuYU HuaShiGUAN 《中国化学快报》2003,14(11):1130-1132
The Ugi four-component reaction (U-4CR) was utilized to prepare divalent and trivalent cluster mannosides. Thus, two target compounds 6 and 8 were obtained efficiently using carboxymethyl 2, 3, 4, 6-tetra-O-acety-α-D-mannopyranoside 4 as acid component, and 1, 6-hexanediamine or tris(2-aminoethyl)amine as the multivalent scaffolds. 相似文献
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Synthesis of Oligomeric Mannosides and Their Structure‐Binding Relationship with Concanavalin A 下载免费PDF全文
Chen‐Wei Li Kai‐Wei Hon Bhaswati Ghosh Po‐Han Li Hsien‐Ya Lin Po‐Han Chan Prof. Chun‐Hung Lin Prof. Yu‐Chie Chen Prof. Kwok‐Kong Tony Mong 《化学:亚洲杂志》2014,9(7):1786-1796
Small glycodendrimers with α‐mannosyl ligands were synthesized by using copper‐catalyzed azide–alkyne coupling chemistry and some of these molecules were used as multivalent ligands to study the induction of concanavalin A (Con A) precipitation. The results showed that the monovalent mannose ligand could induce the precipitation of Con A. This unexpected finding initiated a series of studies to characterize the molecular basis of the ligand–lectin interaction. The atypical precipitation is found to be specific to the mannose, fluorescein moiety (FITC), and Con A. Apparently the mannose ligand binds to Con A through hydrogen‐bonding interactions, whereas the binding of FITC is mediated by hydrophobic forces. 相似文献
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糖簇分子和糖树状分子及其生物学活性 总被引:2,自引:0,他引:2
糖簇分子和糖树状分子是近年来发展起来的一类新型糖缀合物,其目的是模拟天然存在的“多元效应”。本文主要综述了目前已知糖簇分子和糖树状分子所具有的生物活性及其潜在的应用领域。 相似文献
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QiMingMU CuiHuaXUE GuoLinZHANG 《中国化学快报》2003,14(12):1211-1214
A novel type of chiral molecular clefts consisting of a rigid deoxycholic acid methyl ester backbone and chiral unsymmetrically disubstituted urea side chain have been designed and synthesized. All these new receptors 3a-c and the corresponding key intermediates la-c and 2a-c are new compounds, their structures were confirmed by ^1HNMR, IR, MS spectra and elemental analysis. These molecular clefts showed binding ability for halide anions. 相似文献
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Daniela P. Santos Marcio F. Bergamini Arnold G. Fogg Maria Valnice B. Zanoni 《Mikrochimica acta》2005,151(1-2):127-134
Glassy carbon electrodes were coated with films of poly(glutamic acid) (PG), and the modified electrode proved to be very effective in the oxidation of caffeic acid. The performance of the film was also tested with ascorbic acid, coumaric acid, ferulic acid, sinapic acid and chlorogenic acid. At pH 5.6, all the hydroxycinnamic acids yield a higher peak current intensity when oxidized after incorporation in the PG-modified electrode, and only the oxidation of ascorbic acid exhibits overpotential reduction. At pH 3.5 only caffeic and chlorogenic acid are incorporated in the modified electrode and exhibit a well-defined oxidation wave at +0.51 V and +0.48 V, which is the base for their determination. Linear calibration graphs were obtained from 9 × 10−6 mol L−1 to 4 × 10−5 mol L−1 caffeic acid by linear voltammetric scan and from 4 × 10−6 mol L−1 to 3 × 10−5 mol L−1 by square wave voltammetric scan. The method was successfully applied to the determination of caffeic acid in red wine samples without interference from other hydroxycinnamic acids or ascorbic acid. 相似文献
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He Binglin 《高等学校化学研究》1989,(4)
Tetranuclear Rh-Co bimetallic cluster was synthesized and characterized by IR and XPS. The properties of the anchored catalysts, its stability and the ligand effect were also studied. The experimental results show that the optimal conditions for the hydroformylation of hexene-1 are as follows: the temperature is 80℃, reaction time 8 h, pressure 5. 88×105 Pa, and molar ratio of H2/CO 1. 2/1. 0. Functional groups attached to the donor atom(N) possess more or less some influence on the catalytic behavior. Compared with the homogeneous cluster, the polymer-supported bimetallic cluster is more stable. After the catalytic reaction, the structure of the anchored catalysts was not destroyed. X-ray photoelectron spectroscopy characterization indicates that there is a weak interaction between the polymer support and the active metals. 相似文献
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Gamma-aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the central nervous system of mammals and plays an important role in the suppression of neurons’ excitability. GABA is formed from the decarboxylation of glutamic acid (Glu), and both GABA and Glu could be considered as important biologically active food components. In the current study, we validated a HPLC method for concomitant detection of GABA and Glu in plant samples after derivatization with dansyl chloride. The validated method had high precision and a high recovery rate and was successfully used for GABA and Glu quantification in 55 plant foods (fruits, vegetables, legumes, cereals, pseudocereals, and nuts) and 19 medicinal plants. Vegetables were the most important dietary source of these amino acids, with the highest quantity of GABA found in potatoes—44.86 mg/100 g fresh weight (FW) and yellow cherry tomatoes—36.82 mg/100 g FW. The highest amount of Glu (53.58 mg/100 g FW) was found in red cherry tomatoes. Analyzed fruits were relatively poor in GABA and Glu, and European gooseberry was the richest fruit with 13.18 mg/100 g FW GABA and 10.95 mg/100 g FW Glu. Cereals, pseudocereals, nuts, and legumes contain much higher amounts of Glu than GABA. The obtained results enrich the available information on the content of gamma-aminobutyric and glutamic acids in plant foods and could be used for the development of GABA-enriched functional foods. 相似文献
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制备了水杨醛谷氨酸合镍修饰碳黑微电极,试验了修饰电极对一氧化氮的电催化氧化性能。试验结果表明,在pH 6.8的磷酸盐中,一氧化氮在该电极上的线性范围为4.0×10-8~1.0×10-5mol.L-1;检出限(3σ)为1.0×10-8mol.L-1。将此电极用于3种模拟样品的分析,并在此基础作回收率试验,测得RSD(n=8)值在1.9%~2.8%之间,回收率在97%~105%之间。在一氧化氮浓度1.0×10-6mol.L-1的水平上进行精密度试验,测得RSD(n=10)为2.2%。 相似文献
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CHEN Man-Sheng KUANG Dai-Zhi② ZHANG Chun-Hua DENG Yi-Fang LI Wei YANG Ying-Qun 《结构化学》2005,24(11):1249-1253
1 INTRODUCTION There is great interest in the study of organotin carboxylic ester compounds due to their consider- able biological activities and structural diversities[1~3]. Since Holmes, R. R.[4] first reported the hexameric drum organotin compound, many organotin carboxy- lic ester compounds with drum-shape have been syn- thesized in recent years[5, 6]. It has been revealed that organotin compounds containing carboxylate ligands with additional donor atoms that are available for coord… 相似文献
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《Analytical letters》2012,45(18):3430-3442
Abstract The voltammetric determination of rutin in 0.04 mol l?1 B‐R buffer (pH 4.0) by square wave voltammograms (+0.41 V vs. Ag/AgCl(sat.)) at a poly glutamic acid modified glassy carbon electrode was found to be several orders of magnitude lower than that on a bare glassy carbon electrode. Rutin can be preconcentrated on the films of poly glutamic acid and presented linear relationship from concentration of 7×10?7 to 1×10?5 mol l?1 in 0.04 mol l?1 B‐R buffer pH 4.0. The method was successfully applied to the determination of rutin in pharmaceutical formulation without any pretreatment. 相似文献
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Analysis of Glutamic Acid in Cerebrospinal Fluid by Capillary Electrophoresis with High Frequency Conductivity Detection 总被引:1,自引:0,他引:1
Hai Yun ZHAI Jun Mei WANG Xiao Li YAO Xue Cai TAN Pei Xiang CAI Zuan Guang CHEN* College of Chemistry Chemical Engineering Sun Yat-sen University Guangzhou Department of Chemistry Medical College Sun Yat-sen University Guangzhou The First Affiliated Hospital Sun Yat-sen University Guangzhou 《中国化学快报》2005,16(2):225-228
Glutamic acid(Glu)is the most important amino acid in the nerve center system1.It isessential to detect Glu in cerebrospinal fluids(CSF),because the level of Glu in CSF hasimplicated several diseases such as metabolic diseases or central nervous systemdisorders2.The measurement of Glu in CSF had been performed by high performanceliquid chromatography(HPLC)and capillary electrophoresis(CE)with inducedfluorescence detection3-7.Since Glu shows no fluorescence,different reagents had beenus… 相似文献
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18β-甘草次酸A环官能团化衍生物的合成及抗肿瘤活性 总被引:1,自引:0,他引:1
采用化学方法对18β-甘草次酸A环进行改造, 合成了一系列新型18β-甘草次酸A环官能团化衍生物. 对人白血病细胞株HL-60、K562、肝癌细胞BEL-7404及乳腺癌细胞MDA-MB-231的体外抗肿瘤活性筛选结果表明, 化合物5对4种肿瘤细胞系的抑制活性均强于18β-甘草次酸; 构效关系分析表明, A环内烯键的形成对抑制肿瘤细胞增殖有重要影响; 同时利用Hoechst33258和AO/EB染色, 在荧光显微镜下观察到了细胞凋亡小体的形成. 相似文献
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Yue Ying HE Cong Ming XIAO 《中国化学快报》2006,17(5):645-648
Polylactide (PLA), made from agriculture products, was one of biodegradable polymers1,2. Owing to its characters, PLA and its copolymers have received great interest in industrial and medical applications3-6, such as drug delivery systems, sutures, artifi… 相似文献