Alkaloids of Aconitum talassicum

Three new C-20 diterpene alkaloids (talassamine (I), talassimidine (II), and talassimine (III)) and the known alkaloid lappaconitine have been isolated from the epigeal part ofAconitum talassicum (Ranunculaceae). The structures of the new alkaloids proposed on the basis of spectral characteristics and chemical transformations have been confirmed by an x-ray structural analysis of talassimine.Institute of Chemistry of Plant Substances, Academy of Sciences of the Uzbek SSR, Tashkent. Translated from Khimiya Prirodnykh Soedinenii, No. 1, pp. 93–98, January–February, 1991.     

Alkaloids of the epigeal part of Aconitum talassicum. Structure of actaline

The epigeal part ofAconitum talassicum M. Pop. has yielded, in addition to five alkaloids known previously, kobusine, pseudokobusine, and the new alkaloid actaline. The structure of the latter has been established on the basis of an x-ray structural analysis. Actaline is the first C₂₀ diterpene alkaloid with a lycoctonine skeleton.Institute of the Chemistry of Plant Substances, Uzbek SSR Academy of Sciences, Tashkent. Translated from Khimiya Prirodnykh Soedinenii, Vol. 1, pp. 39–44, January–February, 1989.     

New Alkaloids from Aconitum vaginatum

Two new amide alkaloids, vaginatunine A and B ( 1 and 2 , resp.), and a new C₁₈‐diterpenoid alkaloid vaginatunine C ( 3 ), together with four known alkaloids, were isolated from the tubers of Aconitum vaginatum. Their structures were determined by means of spectroscopic analyses and comparison of the data with those reported previously.     

Flavonoid glycosides from Aconitum baicalense

Two known flavonoids, the 7-O-α-L-rhamnopyranosides of kaempferol and of quercetin, and also the new acylated glycoside quercetin 3-O-[O-(6-caffeoyl-β-D-glucopyranosyl)-(1→2)-β-D-glucopyranoside 7-O-α-L-rhamnopyranoside (czekanoside A) have been isolated from the epigeal part ofAconitum baicalense Turcz, ex Rapaics (A. Czekanovskyi Steinb.). Their structures have been demonstrated by the methods of IR, UV,¹H, and¹³C NMR spectroscopies and FAB mass spectrometry and also with the aid of acid hydrolysis.     

Flavonoid glycosides from Aconitum baicalense

Two known flavonoids, the 7-O--L-rhamnopyranosides of kaempferol and of quercetin, and also the new acylated glycoside quercetin 3-O-[O-(6-caffeoyl--D-glucopyranosyl)-(12)--D-glucopyranoside 7-O--L-rhamnopyranoside (czekanoside A) have been isolated from the epigeal part ofAconitum baicalense Turcz, ex Rapaics (A. Czekanovskyi Steinb.). Their structures have been demonstrated by the methods of IR, UV,¹H, and¹³C NMR spectroscopies and FAB mass spectrometry and also with the aid of acid hydrolysis.Deceased.Irkutsk Institute of Organic Chemistry, Siberian Branch, Russian Academy of Sciences. Translated from Khimiya Prirodnykh Soedinenii, No. 5, pp. 484–493, September–October, 1992.     

Diterpenoid Alkaloids from Aconitum tanguticum

A new 19,21‐secohetisan diterpenoid alkaloid, tangutisine B ( 1 ), was isolated from the aerial parts of Aconitum tanguticum (Maxim. ) Stapf. , together with pacidine, 14‐deacetylajadine. The structure of 1 was determined by an interpretation of 1D‐ and 2D‐NMR together with X‐ray crystallographic data. Bioactivities of the isolates were tested in the P‐388, Bel‐7402, Cox‐2, and caspase‐3 assays.     

Oxidation of the Norditerpenoid Alkaloids Isotalatisidine and 6-Epiforsticine

Inpreviousworksonmodificationsofnorditerpenoidalkaloids,wereportedsomeimportantreactionssuchasN-deethylationandpreparationsoftheimmesand7,17-secoderivatives'.NowwewishtorepoFtoxidationofthenorditerpenoidalkaloidsisotalatizidineand6-epiforsticine.Oxidationofnorditerpenoidalkalnidshavinganla-hydroxylgroupwithreagentssuchasKMnO.K,Fe(CN),,OsO.,Ag,OandNBSaffordedcompoundswithanO,Nmixedacetalsystems=.Thus,treatmentofisqtalatizidineIwithKMnO.inacetone-H,O(5;1)forIhgavetheknowncompoundnevade…     

Norditerpenoid alkaloids from Aconitum karakolicum Rapaics

Two new norditerpenoid alkaloids, acofamine A (1) and acofamine B (2) were isolated from the aerial parts of Aconitum karakolicum Rapaics. The structures of these compounds were established by spectroscopic methods.     

New Diterpenoid Alkaloids from Aconitum liangshanicum

One new C₁₉‐diterpenoid alkaloid, named liangshantine ( 1 ), and three new C₂₀‐diterpenoid alkaloids, liangshansines A–C ( 2 – 4 , resp.), as well as eight known compounds, were isolated from the roots of Aconitum liangshanicum. The structures of these new alkaloids were elucidated by spectroscopic methods.     

膝瓣乌头根中新去甲二萜生物碱的结构研究

从膝瓣乌头(AconitumgeniculatumFlectcher)根中分得3个新的乌头碱型去甲二萜生物碱。由光谱法(^1HNMR,^1^3CNMR和MS)确定其结构为膝乌宁碱甲(genicunineA)1,膝乌宁碱乙(genicunineB)2,膝乌宁碱丙(genicunineC)3。     

黄草乌中的新二萜生物碱

从黄草乌(Aconitum vilmorinianum Kom.)根中分离得到三个新C~1~9-二萜生物碱: 黄乌宁(vilmorinine, 1), 黄乌生(vilmorisine20和黄乌亭(vilmoritine, 3)。采用波谱分析及化学方法确定了它们的结构。     

德钦乌头二萜生物碱成分研究

研究了乌头属植物德钦乌头(Aconitum ouvrardianum)根部二萜生物碱类化学成分。采用了柱色谱、重结晶方法进行分离纯化,根据理化性质及波谱学数据确定化合物结构。从中分离得到5个二萜生物碱,分别鉴定为黄草乌碱丁(Ⅰ)、异塔拉乌头定(Ⅱ)、塔拉萨敏(Ⅲ)、查斯曼宁(Ⅳ)和denudatine(Ⅴ)。化合物Ⅴ为首次从该植物中分离得到的C-20型二萜生物碱。