共查询到20条相似文献,搜索用时 46 毫秒
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过渡金属催化不对称C—H硼化反应是构建手性有机硼化合物最为有效的策略之一,具有原子和步骤经济性,在合成化学、药物化学和材料学等领域受到广泛关注.新型手性配体的设计与合成是过渡金属催化不对称C—H硼化反应成功的关键,根据手性配体的设计和发展过程,对近年来实现的过渡金属催化不对称C(sp2)—H和C(sp3)—H硼化反应的研究进展进行综述. 相似文献
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不对称η3-取代反应在有机合成及转化中具有重要的地位,广泛应用于天然产物及药物分子合成中.利用钯催化实现不饱和烃的不对称氢官能团化反应,因其广泛的底物普适性、高的原子经济性和立体选择性控制效果而受到诸多关注,也成为近年来该领域研究的热点.其中,相对于联烯和炔烃底物来说,钯催化的二烯和烯炔的不对称氢官能团化反应研究尚少,近年来才开始快速发展,实现了许多重要突破,并逐步发展成为一类具有高合成价值的策略.本文主要综述了自2020年以来该领域的最新研究进展,从共轭二烯、远程二烯及共轭烯炔等类型的底物出发,总结和概述了相关的研究现状、策略应用和反应机理. 相似文献
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Avishek Das Dr. Nitin T. Patil 《Chemistry (Weinheim an der Bergstrasse, Germany)》2022,28(20):e202104371
Transition metal-catalyzed enantioselective functionalization of ubiquitous C−H bonds has proven to be promising field as it offers the construction of chiral molecular complexity in a step- and atom-economical manner. In recent years, gold has emerged as an attractive contender for catalyzing such reactions. The unique reactivities and selectivities offered by gold catalysts have been exploited to access numerous asymmetric transformations based on gold-catalyzed C−H functionalization processes. Herein, this review critically highlights the major advances and discoveries made in the enantioselective C−H functionalization under gold catalysis which is accompanied by mechanistic insights at appropriate places. 相似文献
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Koji Kubota Keiichi Hayama Hiroaki Iwamoto Prof. Dr. Hajime Ito 《Angewandte Chemie (International ed. in English)》2015,54(30):8809-8813
The enantioselective borylative dearomatization of a heteroaromatic compound has been achieved using a copper(I) catalyst and a diboron reagent. This reaction involves the regio‐ and enantioselective addition of active borylcopper(I) species to indole‐2‐carboxylates, followed by the diastereoselective protonation of the resulting copper(I) enolate to give the corresponding chiral indolines, which bear consecutive stereogenic centers. 相似文献
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Marco Bandini Dr. Astrid Eichholzer 《Angewandte Chemie (International ed. in English)》2009,48(51):9608-9644
140 Years ago Adolf von Baeyer proposed the structure of a heteroaromatic compound which revolutionized organic and medical chemistry: indole. After more than a century, indole itself and the complexity of naturally occurring indole derivatives continue to inspire and influence developments in synthetic chemistry. In particular, the ubiquitous presence of indole rings in pharmaceuticals, agrochemicals, and functional materials are testament to the ever increasing interest in the design of mild and efficient synthetic routes to functionalized indole derivatives. This Review emphasizes the achievements in the selective catalytic functionalization of indoles (C? C bond‐forming processes) over the last four years. 相似文献
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Yu‐Ping He Hua Wu Qian Wang Jieping Zhu 《Angewandte Chemie (International ed. in English)》2020,59(5):2105-2109
We report herein the first examples of a palladium‐catalyzed enantioselective Cacchi reaction for the synthesis of indoles bearing a chiral C2‐aryl axis. In the presence of a catalytic amount of Pd(OAc)2 and (R,R)‐QuinoxP* ligand, reaction of N‐aryl(alkyl)sulfonyl‐2‐alkynylanilides with arylboronic acids under oxygen atmosphere afforded enantioenriched 2,3‐disubstituted indoles in high yields and enantioselectivity. The indole ring is constructed de novo in this process and a complexation‐induced chirality transfer is proposed to account for the observed enantioselectivity. 相似文献
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Zheng Huang Ohhyeon Kwon Haiyan Huang Aziz Fadli Xavier Marat Magali Moreau Prof. Dr. Jean‐Philip Lumb 《Angewandte Chemie (International ed. in English)》2018,57(37):11963-11967
Polyfunctional indoles bearing substituents at C5 and C6 are prevalent in natural products, pharmaceuticals, agrochemicals, and materials. Owing to the remoteness of the C5 and C6 positions, indoles of this family can be difficult to prepare, and often require multistep syntheses. Herein, we describe a concise process that converts simple derivatives of tyrosine into 5,6‐difunctionalized indoles by direct oxidation of C?H, N?H, and O?H bonds. Our work draws inspiration from the biosynthetic polymerization of tyrosine to make melanin pigments, but makes an important departure to provide well‐defined indole heterocycles. 相似文献
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John R. Coombs Prof. James P. Morken 《Angewandte Chemie (International ed. in English)》2016,55(8):2636-2649
Terminal alkenes are readily available functional groups which appear in α‐olefins produced by the chemical industry, and they appear in the products of many contemporary synthetic reactions. While the organic transformations that apply to alkenes are amongst the most studied reactions in all of chemical synthesis, the number of reactions that apply to nonactivated terminal alkenes in a catalytic enantioselective fashion is small in number. This Minireview highlights the cases where stereocontrol in catalytic reactions of 1‐alkenes is high enough to be useful for asymmetric synthesis. 相似文献
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Dr. Yasunori Toda Takayuki Yoshida Kaoru Arisue Prof. Dr. Kazuaki Fukushima Dr. Hiroyoshi Esaki Ayaka Kikuchi Prof. Dr. Hiroyuki Suga 《Chemistry (Weinheim an der Bergstrasse, Germany)》2021,27(41):10578-10582
Chiral Lewis acid-catalyzed asymmetric alcohol addition reactions to cyclic carbonyl ylides generated from N-(α-diazocarbonyl)-2-oxazolidinones featuring a dual catalytic system are reported. Construction of a chiral quaternary heteroatom-substituted carbon center was accomplished in which the unique heterobicycles were obtained in good yields with high stereoselection. The alcohol adducts were successfully converted to optically active oxazolidine-2,4-diones by hydrolysis. Mechanistic studies by DFT calculations revealed that alcohols could be activated by Lewis acids, enabling enantioselective protonation of the carbonyl ylides. 相似文献
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Prof. Mikel Oiarbide Prof. Claudio Palomo 《Chemistry (Weinheim an der Bergstrasse, Germany)》2021,27(40):10226-10246
Catalyst-controlled functionalization of unmodified carbonyl compounds is a relevant operation in organic synthesis, especially when high levels of site- and stereoselectivity can be attained. This objective is now within reach for some subsets of enolizable substrates using various types of activation mechanisms. Recent contributions to this area include enantioselective transformations that proceed via transiently generated noncovalent di(tri)enolate-catalyst coordination species. While relatively easier to form than simple enolate congeners, di(tri)enolates are ambifunctional in nature and so control of the reaction regioselectivity becomes an issue. This Minireview discusses in some detail this and other problems, and how noncovalent activation approaches based on metallic and metal free catalysts have been developed to advance the field. 相似文献