多胺多羧酸双吡哆醇酯磁性金属螯合物及其弛豫性能研究

由二乙三胺五乙胺（ＤＴＰＡ）双酸酐和乙二胺四乙酸（ＥＤＴＡ）双酸酐与维生素Ｂ６族化全物吡哆醇（ＰＮ）或其衍生物合成了一系列新型的多胺多羧酸双吡哆醇酯衍生物及其钆、锰、铁等顺磁性金属螯合物，研究了其中钆和锰螯合物在体外水溶液中对水质子的给向弛豫性能，结果表明，所有配体和配合物均有很好的水溶性，且对光和空气稳定，螯合物的驰豫率（Ｔ１）与可与其母体螯全物相媲美，如钆－二乙三胺五乙酸二吡哆醇酯（ＧｄＤＴＰ     

两亲性聚酯配体及其钆（Ⅲ）配合物的合成和弛豫性能研究

通过二乙三胺五乙酸二酐（ＤＴＰＡＡ）分别与Ｌ－Ｎ，Ｎ－双（２－羟乙基）取代的丙氨酸、苯丙氨酸、缬氨酸、亮氨酸、异亮氨酸和Ｎ，Ｎ－双（２－羟乙基）甘氨酸共聚，制备了六个大分子聚酯配体及其轧（Ⅲ）配合物。对所合成的配体和钆配合物进行了表征，并测试了部分钆配合物的弛豫性能。     

大分子聚酯配体及其钆（Ⅲ）配合物的合成和核磁弛豫性能研究

通过二乙三胺五乙酸二酐（ＤＴＰＡＡ）分别与Ｎ－正丁基、正辛基、苄基、对甲苯磺酰基、苯基和对溴苯基取代二乙醇胺共聚，制得一系列大分子配体及其钆（ＩＩＩ）配合物．对所合成的配体和钆配合物进行了表征，并测试了部分钆配合物的核磁弛豫性能．     

肝靶向性磁共振成像造影剂——含D—半乳糖基的DTPA双酰胺钆…

通过二乙三胺五乙酸的双Ｎ－羟基琥珀酰亚胺活性酯与含氨基的乳糖或Ｄ－半乳糖衍生物反应，合成了８种含有Ｄ－半乳糖基的二乙三胺五乙酸非离子型配体，并进一步合成了其钆（Ⅲ）配合物，配体及配合物的结构经ＩＲ，＾１ＨＮＭＲ与元素分析表征，对配合物的体外驰豫性能和小鼠急性毒性作了初步研究，家兔在磁共振成像实验表明这种上类造影剂具有肝靶向的特性。     

DTPA—多甘醇—磷酸酯三元共聚物钆（Ⅲ）配合物的合成与表征

以二亚乙基三胺五惭酸双酐和二氯磷酸酯与多甘醇共缩聚，制得一系列三元共聚物的配体及其钆（Ⅲ）配全物，对配体和配合物进行了结构表征，并测试了配合物的弛豫效能。     

顺磁性聚酯金属配合物的合成及其驰豫性能的研究

本文通过二乙三胺五乙酸（ＤＴＰＡ）或乙二胺四乙酸（ＥＤＴＡ）的双酸酐与二元醇或二元酚进行聚合反应，制备了两个系列共１５种新的聚酯型大分子配体及其顺磁性金属配合物，用核磁、红外光谱以及元素分析表征了配体和配合物的结构。初步试验结果表明，与相应的小分子金属配合物相比，聚酯金属配合物具有较高的弛豫性能。     

聚酯—酰胺型MRI造影剂的合成及其弛豫性能研究

通过二乙三胺五乙酸双酸酐分别与乙醇胺、Ｌ—丝氨酸及其乙酯、Ｌ—酪氨酸及其甲酯、苄酯、正辛酯共聚，合成了七种大分子配体，制备了它们的Ｇｄ（Ⅲ）配合物，并进行了表征。测试其中五种水溶性配合物的弛豫性能。结果表明它们具有与Ｇｄ（ＤＴＰＡ）相当或更强的弛豫性能。     

Gd－DTPA氨基酸、短肽衍生物的合成及其磁共振成像造影性能的研究

合成了一系列二乙三胺五乙酸（ＤＴＰＡ）的疏水性氨基酸、短肽衍生物的Ｇｄ（Ⅲ）螯合物，研究了其磁共振成像造影性能。结果表明：螯合物的急性毒性与Ｇｄ－ＤＴＰＡ相当，自旋－晶格弛豫性能Ｒ＿１比Ｇｄ－ＤＴＰＡ略高。Ｇｄ－ＤＴＰＡ，氨基酸，短肽，急性毒性，自旋－晶格弛豫性能     

稳定自由基与五氟丙酸稀土双核配合物的合成与性能研究

合成并表征５种以２－（４’－氯苯基）－４，４，５，５－四甲基－３－氧化－１－氧自由基米唑桥联的新型五氟丙酸稀土（Ｎｄ，Ｇｄ，Ｄｙ，Ｈｏ，Ｅｒ）双核配合物，由Ｎｄ（Ⅲ），Ｄｙ（Ⅲ），Ｈｏ（Ⅲ）和Ｅｒ（Ⅲ）四种配合物的超灵敏跃迁，讨论了配合物的共价性随稀土离子原子序数增加而减弱的原因，对Ｇｄ（Ⅲ）配合物的变温（４～３００Ｋ）磁化率数据通过用最小二乘法与理论磁化率拟合，得交换积分Ｊ为正值，表明配合物中Ｇ     

肝靶向性磁共振成像造影剂──含D-半乳糖基的DTPA双酰胺钆配合物的研究

通过二乙三胺五乙酸的双N-羟基琥珀酰亚胺活性酯与含氨基的乳糖或D-半乳糖衍生物反应,合成了8种含有D-半乳糖基的二乙三胺五乙酸非离子型配体,并进一步合成了其钆(Ⅲ)配合物. 配体及配合物的结构经IR、¹HNMR与元素分析表征,对配合物的体外弛豫性能和小鼠急性毒性作了初步研究. 家兔的磁共振成像实验表明这类造影剂具有肝靶向的特性.     

Furyl- and thienyl-silatranes and germatranes

We review our research on the synthesis and study of the physical and biological properties of furyl- and thienylgermatranes and -silatranes.Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 6, pp. 725–732, June, 1992.     

Review and patents and literature

The use of the insect cell/baculovirus expression system for producing recombinant proteins of bacterial, plant, insect, and mammalian origin has become widespread. The popularity of this eukaryotic expression system is due to many factors, including (1) potentially high protein expression levels, (2) ease and speed of genetic engineering, (3) ability to accommodate large DNA inserts, (4) protein processing similar to higher eukaryotic cells (e.g., mammalian cells), and (5) ease of insect cell growth (e.g., suspension growth). The following review of the literature discusses two engineering aspects of recombinant protein synthesis by insect cell cultures: bioreactor scale-up and insect cell line selection. Following this review patent abstracts and additional literature pertaining to expression of recombinant proteins in insect cell culture are listed.     

多环芳二酐型聚酯亚胺膜的透气性能

多环芳二酐型聚酯亚胺膜的透气性能李悦生，丁孟贤，徐纪平（浙江大学高分子科学与工程研究所，杭州，３１００２７）（中国科学院长春应用化学研究所）关键词聚醚酰亚胺，聚酯酰亚胺，膜，透气性通常的聚酰亚胺加工性能较差，在芳环二酐的苯环间引入醚键等柔性基团后，其...     

微量元素与疾病诊断治疗的研究现状及展望

对国内外微量元素与疾病的关系及其诊断治疗的研究现状及研究动向进行了综述，包括：微量元素与地方病、癌肿、心血管病、糖尿病、眼病、神经系统病等。参考文献72篇。     

Preparation and photolysis of poly-p-ethylacrylophenone and poly-p-chloroacrylophenone and their copolymers with styrene and methyl methacrylate

Poly-p-ethylacrylophenone (PPEtAP) and poly-p-chloroacrylophenone (PPClAP) and their copolymers with styrene (PEtAP/S) and (PClAP/S) and with methyl methacrylate (PEtAP/MMA) and (PClAP/MMA) were prepared. Quantum yields of main-chain scissions at 366 nm at room temperature in benzene solution are of the same order as those of the unsubstituted polyacrylophenone and its copolymers. Substitution with chlorine and ethyl group in the para position compared to the unsubstituted polyacrylophenone and its copolymers leads to an increase of the lifetime for the n–π^* excited triplet state, as is evident from the measured quenching constants of photolysis. The low-temperature emission spectra of the copolymers are similar to the spectra of the model compounds in a polymer film. For the homopolymer, however, the character of the emission spectrum changes considerably.     

Concentrations and distributions of trace and minor elements in Chinese and Canadian coals and ashes

A total of 35 trace and minor elements including some of environmental significance were determined in each of a selection of 15 Chinese and 6 Canadian thermal coals and their ashes by using the SLOWPOKE-2 nuclear reactor facility of the University of Toronto. The concentrations and distributions of these constituents among the coals and their combustion products (viz. ash and volatile matter) are presented together with an interpretation of their significance in relation to the large scale combustion of these coals as thermal fuels in industrialized countries such as China and Canada. The detailed results showed wide variations in trace impurity concentrations (up to a factor of 100 and more) among the coals studied with few large differences between those of Chinese and Canadian origin except that the rare earths, Sc, Th, U, I, and Se were much higher in the former, other halogens, As and Na were lower. Values for elemental enrichment factors (EF) relative to normal crustal abundances indicated that only As(EF=13), Br(5.7), I(16), S(230), Sb(11) and Se(320) were appreciably enriched in coal. During static ashing at 750°C most of the halogens, S and Se were volatilized whereas most other inorganic constituents were highly retained and concentrated in the ash by factors of 6 to 11.