Numerical simulation of lateral migration of red blood cells in Poiseuille flows

A spring model is applied to simulate the skeleton structure of the red blood cell (RBC) membrane and to study the RBC rheology in two‐dimensional Poiseuille flows using an immersed boundary method. The lateral migration properties of the cells in Poiseuille flows have been investigated. The simulation results show that the rate of migration toward the center of the channel depends on the swelling ratio and the deformability of the cells. We have also combined the above methodology with a fictitious domain method to study the motion of RBCs in a two‐dimensional micro‐channel with a constriction with an application to blood plasma separation. Copyright © 2010 John Wiley & Sons, Ltd.     

Red blood cell partitioning and blood flux redistribution in microvascular bifurcation

This paper studies red blood cell (RBC) partitioning and blood flux redistribution in microvascular bifurcation by immersed boundary and lattice Boltzmann method. The effects of the initial position of RBC at low Reynolds number regime on the RBC deformation, RBC partitioning, blood flux redistribution and pressure distribution are discussed in detail. It is shown that the blood flux in the daughter branches and the initial position of RBC are important for RBC partitioning. RBC tends to enter the higher-flux-rate branch if the initial position of RBC is near the center of the mother vessel. The RBC may enter the lower-flux-rate branch if it is located near the wall of mother vessel on the lower-flux-rate branch side. Moreover, the blood flux is redistributed when an RBC presents in the daughter branch. Such redistribution is caused by the pressure distribution and reduces the superiority of RBC entering the same branch. The results obtained in the present work may provide a physical insight into the understanding of RBC partitioning and blood flux redistribution in microvascular bifurcation.     

Three‐dimensional vortex simulation of unsteady flow in hydraulic turbines

On the basis of the Helmholtz decomposition, a grid‐free numerical scheme is provided for the solution of unsteady flow in hydraulic turbines. The Lagrangian vortex method is utilized to evaluate the convection and stretch of the vorticity, and the BEM is used to solve the Neumann problem to define the potential flow. The no‐slip boundary condition is satisfied by generating vortex sticks at the solid surface. A semi‐analytical regularization technique is applied to evaluate the singular boundary surface integrals of the potential velocity and its gradients accurately. The fast multipole method was extended to evaluate the velocity and velocity gradients induced by the discretized vortex blobs in the Lagrangian vortex method. The successful simulation for the unsteady flow through a hydraulic turbine's runner has manifested the effectiveness of the proposed method. Copyright © 2011 John Wiley & Sons, Ltd.     

Simulation of three‐dimensional flows over moving objects by an improved immersed boundary–lattice Boltzmann method

An improved immersed boundary–lattice Boltzmann method (IB–LBM) developed recently [28] was applied in this work to simulate three‐dimensional (3D) flows over moving objects. By enforcing the non‐slip boundary condition, the method could avoid any flow penetration to the wall. In the developed IB–LBM solver, the flow field is obtained on the non‐uniform mesh by the efficient LBM that is based on the second‐order one‐dimensional interpolation. As a consequence, its coefficients could be computed simply. By simulating flows over a stationary sphere and torus [28] accurately and efficiently, the proposed IB–LBM showed its ability to handle 3D flow problems with curved boundaries. In this paper, we further applied this method to simulate 3D flows around moving boundaries. As a first example, the flow over a rotating sphere was simulated. The obtained results agreed very well with the previous data in the literature. Then, simulation of flow over a rotating torus was conducted. The capability of the improved IB–LBM for solving 3D flows over moving objects with complex geometries was demonstrated via the simulations of fish swimming and dragonfly flight. The numerical results displayed quantitative and qualitative agreement with the date in the literature. Copyright © 2011 John Wiley & Sons, Ltd.     

Higher‐order‐accurate numerical method for temporal stability simulations of Rayleigh‐Bénard‐Poiseuille flows

For Rayleigh‐Bénard‐Poiseuille flows, thermal stratification resulting from a wall‐normal temperature gradient together with an opposing gravitational field can lead to buoyancy‐driven instability. Moreover, for sufficiently large Reynolds numbers, viscosity‐driven instability can occur. Two higher‐order‐accurate methods based on the full and linearized Navier‐Stokes equations were developed for investigating the temporal stability of such flows. The new methods employ a spectral discretization in the homogeneous directions. In the wall‐normal direction, the convective and viscous terms are discretized with fifth‐order‐accurate biased and fourth‐order‐accurate central compact finite differences. A fourth‐order‐accurate explicit Runge‐Kutta method is employed for time integration. To validate the methods, the primary instability was investigated for different combinations of the Reynolds and Rayleigh number. The results from these primary stability investigations are consistent with linear stability theory results from the literature with respect to both the onset of the instability and the dependence of the temporal growth rate on the wave angle. For the cases with buoyancy‐driven instability, strong linear growth is observed for a broad range of spanwise wavenumbers. The largest growth rates are obtained for a wave angle of 90°. For the cases with viscosity‐driven instability, the linear growth rates are lower and the first mode to experience nonlinear growth is a higher harmonic with half the wavelength of the fundamental.     

An approach of dynamic mesh adaptation for simulating 3‐dimensional unsteady moving‐immersed‐boundary flows

In this paper, we present an approach of dynamic mesh adaptation for simulating complex 3‐dimensional incompressible moving‐boundary flows by immersed boundary methods. Tetrahedral meshes are adapted by a hierarchical refining/coarsening algorithm. Regular refinement is accomplished by dividing 1 tetrahedron into 8 subcells, and irregular refinement is only for eliminating the hanging points. Merging the 8 subcells obtained by regular refinement, the mesh is coarsened. With hierarchical refining/coarsening, mesh adaptivity can be achieved by adjusting the mesh only 1 time for each adaptation period. The level difference between 2 neighboring cells never exceeds 1, and the geometrical quality of mesh does not degrade as the level of adaptive mesh increases. A predictor‐corrector scheme is introduced to eliminate the phase lag between adapted mesh and unsteady solution. The error caused by each solution transferring from the old mesh to the new adapted one is small because most of the nodes on the 2 meshes are coincident. An immersed boundary method named local domain‐free discretization is employed to solve the flow equations. Several numerical experiments have been conducted for 3‐dimensional incompressible moving‐boundary flows. By using the present approach, the number of mesh nodes is reduced greatly while the accuracy of solution can be preserved.     

Three‐dimensional numerical simulation of compound meandering open channel flow by the Reynolds stress model

Turbulent flow in a compound meandering open channel with seminatural cross sections is one of the most complicated turbulent flows as the flow pattern is influenced by the combined action of various forces, such as centrifugal force, pressure, and shear stresses. In this paper, a three‐dimensional (3D) Reynolds stress model (RSM) is adopted to simulate the compound meandering channel flows. Governing equations of the flow are solved numerically with finite‐volume method. The velocity fields, wall shear stresses, and Reynolds stresses are calculated for a range of input conditions. Good agreement between the simulated results and measurements indicates that RSM can successfully predict the complicated flow phenomenon. Copyright © 2008 John Wiley & Sons, Ltd.     

An immersed boundary method for simulation of inviscid compressible flows

In this paper, an immersed boundary method for simulating inviscid compressible flows governed by Euler equations is presented. All the mesh points are classified as interior computed points, immersed boundary points (interior points closest to the solid boundary), and exterior points that are blanked out of computation. The flow variables at an immersed boundary point are determined via the approximate form of solution in the direction normal to the wall boundary. The normal velocity is evaluated by applying the no‐penetration boundary condition, and therefore, the influence of solid wall in the inviscid flow is taken into account. The pressure is computed with the local simplified momentum equation, and the density and the tangential velocity are evaluated by using the constant‐entropy relation and the constant‐total‐enthalpy relation, respectively. With a local coordinate system, the present method has been extended easily to the three‐dimensional case. The present work is the first endeavor to extend the idea of hybrid Cartesian/immersed boundary approach to compressible inviscid flows. The tedious task of handling multi‐valued points can be eliminated, and the overshoot resulting from the extrapolation for the evaluation of flow variables at exterior points can also be avoided. In order to validate the present method, inviscid compressible flows over fixed and moving bodies have been simulated. All the obtained numerical results show good agreement with available data in the literature. Copyright © 2014 John Wiley & Sons, Ltd.     

2‐D transmitral flows simulation by means of the immersed boundary method on unstructured grids

Interaction between computational fluid dynamics and clinical researches recently allowed a deeper understanding of the physiology of complex phenomena involving cardio‐vascular mechanisms. The aim of this paper is to develop a simplified numerical model based on the Immersed Boundary Method and to perform numerical simulations in order to study the cardiac diastolic phase during which the left ventricle is filled with blood flowing from the atrium throughout the mitral valve. As one of the diagnostic problems to be faced by clinicians is the lack of a univocal definition of the diastolic performance from the velocity measurements obtained by Eco–Doppler techniques, numerical simulations are supposed to provide an insight both into the physics of the diastole and into the interpretation of experimental data. An innovative application of the Immersed Boundary Method on unstructured grids is presented, fulfilling accuracy requirements related to the development of a thin boundary layer along the moving immersed boundary. It appears that this coupling between unstructured meshes and the Immersed Boundary Method is a promising technique when a wide range of spatial scales is involved together with a moving boundary. Numerical simulations are performed in a range of physiological parameters and a qualitative comparison with experimental data is presented, in order to demonstrate that, despite the simplified model, the main physiological characteristics of the diastole are well represented. Copyright © 2002 John Wiley & Sons, Ltd.     

An immersed boundary/wall modeling method for RANS simulation of compressible turbulent flows

In this paper, an immersed boundary (IB) method is developed to simulate compressible turbulent flows governed by the Reynolds‐averaged Navier‐Stokes equations. The flow variables at the IB nodes (interior nodes in the immediate vicinity of the solid wall) are evaluated via linear interpolation in the normal direction to close the discrete form of the governing equations. An adaptive wall function and a 2‐layer wall model are introduced to reduce the near‐wall mesh density required by the high resolution of the turbulent boundary layers. The wall shear stress modified by the wall modeling technique and the no‐penetration condition are enforced to evaluate the velocity at an IB node. The pressure and temperature at an IB node are obtained via the local simplified momentum equation and the Crocco‐Busemann relation, respectively. The SST k ? ω and S‐A turbulence models are adopted in the framework of the present IB approach. For the Shear‐Stress Transport (SST) k ? ω model, analytical solutions in near‐wall region are utilized to enforce the boundary conditions of the turbulence equations and evaluate the turbulence variables at an IB node. For the S‐A model, the turbulence variable at an IB node is calculated by using the near‐wall profile of the eddy viscosity. In order to validate the present IB approach, numerical experiments for compressible turbulent flows over stationary and moving bodies have been performed. The predictions show good agreements with the referenced experimental data and numerical results.     

Three‐dimensional immersed boundary conditions for moving solids in the lattice‐Boltzmann method

This paper establishes the range of validity for a previously published three‐dimensional moving solid boundary condition for the lattice‐Boltzmann method. This method was reasonably formulated from a mass and momentum balance perspective, but was only verified for a small range of (primarily two‐dimensional) problems. One of the advantages of this boundary condition is that it offers resolution at the sub‐grid scale, allowing for accurate and stable calculation of the force and torque for solids which are moving through a lattice, even for small solid sizes relative to the computational grid size. We verify the boundary condition for creeping flows by comparison to analytical solutions that include both the force and the torque on fixed and moving spheres, and then follow this with comparisons to experimental and empirical results for both fixed as well moving spheres in inertial flows. Finally, we compare simulation results to numerical results of other investigators for the settling of an offset sphere and the drafting–kissing–tumbling of two sedimenting spheres. We found that an accurate calculation of the collision‐operator weighting used to obtain sub‐grid‐scale resolution was necessary in order to prevent spikes in the velocities, forces, and moments when solid objects cross‐computational cells. The wide range of comparisons collected and presented in this paper can be used to establish the validity of other numerical models, in addition to the one examined here. Published in 2007 by John Wiley & Sons, Ltd.     

Three‐dimensional modeling of non‐hydrostatic free‐surface flows on unstructured grids

A three‐dimensional numerical model is presented for the simulation of unsteady non‐hydrostatic shallow water flows on unstructured grids using the finite volume method. The free surface variations are modeled by a characteristics‐based scheme, which simulates sub‐critical and super‐critical flows. Three‐dimensional velocity components are considered in a collocated arrangement with a σ‐coordinate system. A special treatment of the pressure term is developed to avoid the water surface oscillations. Convective and diffusive terms are approximated explicitly, and an implicit discretization is used for the pressure term to ensure exact mass conservation. The unstructured grid in the horizontal direction and the σ coordinate in the vertical direction facilitate the use of the model in complicated geometries. Solution of the non‐hydrostatic equations enables the model to simulate short‐period waves and vertically circulating flows. Copyright © 2015 John Wiley & Sons, Ltd.     

A hybrid vortex method for the simulation of three‐dimensional flows

This paper presents an integral vorticity method for solving three‐dimensional Navier–Stokes equations. A finite volume scheme is implemented to solve the vorticity transport equation, which is discretized on a structured hexahedral mesh. A vortex sheet algorithm is used to enforce the no‐slip boundary condition through a vorticity flux at the boundary. The Biot–Savart integral is evaluated to compute the velocity field, in conjunction with a fast algorithm based on multipole expansion. This method is applied to the simulation of uniform flow past a sphere. Copyright © 2007 John Wiley & Sons, Ltd.     

Electrical classification of single red blood cell deformability in high-shear microchannel flows

A sensor that can efficiently and sequentially measure the deformability of individual red blood cell (RBC) flowing along a microchannel is described. Counter-electrode-type microsensors are attached to the channel bottom wall, and as RBCs pass between the electrodes, the time series of the electric resistance is measured. An RBC is deformed by the high shear flow to a degree dependent upon its elastic modulus. Hence, the profile of the resistance, which is unique to the shape of the RBC, can be analyzed to obtain the deformability of each cell. First, theoretical and experimental analyses were conducted to identify the specific AC frequency at which the effect of the electric double layer formed on the electrode surface is minimized. Measurements were then conducted upon samples of normal human RBCs and glutaraldehyde-treated (rigidified) RBCs to evaluate the feasibility of the present method. In addition, simultaneous visualization of RBC deformation was performed using a high-speed camera. Normal RBCs were observed to have a degree of deformation index (DI) of around 0.57, whereas the rigidified RBCs was DI = 0 in the microchannel. The experimental measurements showed a strong correlation between the half-width of the maximum of the resistance distribution and the DI of the RBC.     

Coupling the lattice‐Boltzmann and spectrin‐link methods for the direct numerical simulation of cellular blood flow

The implementation of a spectrin‐link (SL) red blood cell (RBC) membrane method coupled with a lattice‐Boltzmann (LB) fluid solver is discussed. Details of the methodology are included along with subtleties associated with its integration into a massively parallel hybrid LB finite element (FE) suspension flow solver. A comparison of the computational performance of the coupled LB–SL method with that of the previously implemented LB–FE is given for an isolated RBC and for a dense suspension in Hagen–Poiseuille flow. Validating results for RBCs isolated in shear and parachuting in microvessel flow are also presented. Copyright © 2011 John Wiley & Sons, Ltd.     

Computation of incompressible flows with immersed bodies by a simple ghost cell method

The incompressible Navier–Stokes equations are solved by an implicit pressure correction method on Cartesian meshes with local refinement. A simple and stable ghost cell method is developed to treat the boundary condition for the immersed bodies in the flow field. Multigrid methods are developed for both velocity and pressure correction to enhance the stability and convergence of the solution process. It is shown that the spatial accuracy of the method is second order in L₂ norm for both velocity and pressure. Various steady and unsteady flows over a 2D circular cylinder and a 3D sphere are computed to validate the present method. The capability of the present method to treat a moving body is also demonstrated. Copyright © 2008 John Wiley & Sons, Ltd.     

Three‐dimensional numerical modelling of free surface flows with non‐hydrostatic pressure

A three‐dimensional numerical model is developed for incompressible free surface flows. The model is based on the unsteady Reynolds‐averaged Navier–Stokes equations with a non‐hydrostatic pressure distribution being incorporated in the model. The governing equations are solved in the conventional sigma co‐ordinate system, with a semi‐implicit time discretization. A fractional step method is used to enable the pressure to be decomposed into its hydrostatic and hydrodynamic components. At every time step one five‐diagonal system of equations is solved to compute the water elevations and then the hydrodynamic pressure is determined from a pressure Poisson equation. The model is applied to three examples to simulate unsteady free surface flows where non‐hydrostatic pressures have a considerable effect on the velocity field. Emphasis is focused on applying the model to wave problems. Two of the examples are about modelling small amplitude waves where the hydrostatic approximation and long wave theory are not valid. The other example is the wind‐induced circulation in a closed basin. The numerical solutions are compared with the available analytical solutions for small amplitude wave theory and very good agreement is obtained. Copyright © 2002 John Wiley & Sons, Ltd.     

Simulations of magnetorheological suspensions in Poiseuille flow

Particle-level simulations are conducted to study magnetorheological fluids in plane Poiseuille flow. The importance of the boundary conditions for the particles at the channel walls is examined by considering two extreme cases: no friction and infinite coefficient of friction. The inclusion of friction produces Bingham fluid behavior, as commonly observed experimentally for MR suspensions. Lamellar structures, similar to those reported for electrorheological fluids in shear flow, are observed in the post-yield region for both particle boundary conditions. The formation of these lamellae is accompanied by an increase in the bulk fluid velocity. The slip boundary condition produces higher fluid velocities and thicker lamellar structures.