Local Derivative-Free Approximation of Computationally Expensive Posterior Densities

Bayesian inference using Markov chain Monte Carlo (MCMC) is computationally prohibitive when the posterior density of interest, π, is computationally expensive to evaluate. We develop a derivative-free algorithm GRIMA to accurately approximate π by interpolation over its high-probability density (HPD) region, which is initially unknown. Our local approach reduces the waste of computational budget on approximation of π in the low-probability region, which is inherent in global experimental designs. However, estimation of the HPD region is nontrivial when derivatives of π are not available or are not informative about the shape of the HPD region. Without relying on derivatives, GRIMA iterates (a) sequential knot selection over the estimated HPD region of π to refine the surrogate posterior and (b) re-estimation of the HPD region using an MCMC sample from the updated surrogate density, which is inexpensive to obtain. GRIMA is applicable to approximation of general unnormalized posterior densities. To determine the range of tractable problem dimensions, we conduct simulation experiments on test densities with linear and nonlinear component-wise dependence, skewness, kurtosis and multimodality. Subsequently, we use GRIMA in a case study to calibrate a computationally intensive nonlinear regression model to real data from the Town Brook watershed. Supplemental materials for this article are available online.     

Bayesian Variable Selection for Logistic Models Using Auxiliary Mixture Sampling

This article presents a Markov chain Monte Carlo algorithm for both variable and covariance selection in the context of logistic mixed effects models. This algorithm allows us to sample solely from standard densities with no additional tuning. We apply a stochastic search variable approach to select explanatory variables as well as to determine the structure of the random effects covariance matrix.

Prior determination of explanatory variables and random effects is not a prerequisite because the definite structure is chosen in a data-driven manner in the course of the modeling procedure. To illustrate the method, we give two bank data examples.     

Adaptive Bayesian Nonstationary Modeling for Large Spatial Datasets Using Covariance Approximations

Gaussian process models have been widely used in spatial statistics but face tremendous modeling and computational challenges for very large nonstationary spatial datasets. To address these challenges, we develop a Bayesian modeling approach using a nonstationary covariance function constructed based on adaptively selected partitions. The partitioned nonstationary class allows one to knit together local covariance parameters into a valid global nonstationary covariance for prediction, where the local covariance parameters are allowed to be estimated within each partition to reduce computational cost. To further facilitate the computations in local covariance estimation and global prediction, we use the full-scale covariance approximation (FSA) approach for the Bayesian inference of our model. One of our contributions is to model the partitions stochastically by embedding a modified treed partitioning process into the hierarchical models that leads to automated partitioning and substantial computational benefits. We illustrate the utility of our method with simulation studies and the global Total Ozone Matrix Spectrometer (TOMS) data. Supplementary materials for this article are available online.     

A Pivotal Allocation-Based Algorithm for Solving the Label-Switching Problem in Bayesian Mixture Models

In Bayesian analysis of mixture models, the label-switching problem occurs as a result of the posterior distribution being invariant to any permutation of cluster indices under symmetric priors. To solve this problem, we propose a novel relabeling algorithm and its variants by investigating an approximate posterior distribution of the latent allocation variables instead of dealing with the component parameters directly. We demonstrate that our relabeling algorithm can be formulated in a rigorous framework based on information theory. Under some circumstances, it is shown to resemble the classical Kullback-Leibler relabeling algorithm and include the recently proposed equivalence classes representatives relabeling algorithm as a special case. Using simulation studies and real data examples, we illustrate the efficiency of our algorithm in dealing with various label-switching phenomena. Supplemental materials for this article are available online.     

SLTBL模型的Bayes分析

利用M arkov cha in M on te C arlo技术对可分离的下三角双线性模型进行B ayes分析.由于参数联合后验密度的复杂性,我们导出了所有的条件后验分布,以便利用G ibbs抽样器方法抽取后验密度的样本.特别地,由于从模型的方向向量的后验分布中直接抽样是困难的,我们特别设计了一个M etropolis-H astings算法以解决该难题.我们用仿真的方法验证了所建议方法的有效性,并成功应用于分析实际数据.     

Bayesian Methods for Wavelet Series in Single-Index Models

Single-index models have found applications in econometrics and biometrics, where multidimensional regression models are often encountered. This article proposes a nonparametric estimation approach that combines wavelet methods for nonequispaced designs with Bayesian models. We consider a wavelet series expansion of the unknown regression function and set prior distributions for the wavelet coefficients and the other model parameters. To ensure model identifiability, the direction parameter is represented via its polar coordinates. We employ ad hoc hierarchical mixture priors that perform shrinkage on wavelet coefficients and use Markov chain Monte Carlo methods for a posteriori inference. We investigate an independence-type Metropolis-Hastings algorithm to produce samples for the direction parameter. Our method leads to simultaneous estimates of the link function and of the index parameters. We present results on both simulated and real data, where we look at comparisons with other methods.     

Bayesian Analysis of Geostatistical Models With an Auxiliary Lattice

The Gaussian geostatistical model has been widely used for modeling spatial data. However, this model suffers from a severe difficulty in computation: it requires users to invert a large covariance matrix. This is infeasible when the number of observations is large. In this article, we propose an auxiliary lattice-based approach for tackling this difficulty. By introducing an auxiliary lattice to the space of observations and defining a Gaussian Markov random field on the auxiliary lattice, our model completely avoids the requirement of matrix inversion. It is remarkable that the computational complexity of our method is only O(n), where n is the number of observations. Hence, our method can be applied to very large datasets with reasonable computational (CPU) times. The numerical results indicate that our model can approximate Gaussian random fields very well in terms of predictions, even for those with long correlation lengths. For real data examples, our model can generally outperform conventional Gaussian random field models in both prediction errors and CPU times. Supplemental materials for the article are available online.     

Reparameterized and Marginalized Posterior and Predictive Sampling for Complex Bayesian Geostatistical Models

This article proposes a four-pronged approach to efficient Bayesian estimation and prediction for complex Bayesian hierarchical Gaussian models for spatial and spatiotemporal data. The method involves reparameterizing the covariance structure of the model, reformulating the means structure, marginalizing the joint posterior distribution, and applying a simplex-based slice sampling algorithm. The approach permits fusion of point-source data and areal data measured at different resolutions and accommodates nonspatial correlation and variance heterogeneity as well as spatial and/or temporal correlation. The method produces Markov chain Monte Carlo samplers with low autocorrelation in the output, so that fewer iterations are needed for Bayesian inference than would be the case with other sampling algorithms. Supplemental materials are available online.     

Efficient Bayesian Inference for Multivariate Probit Models With Sparse Inverse Correlation Matrices

We propose a Bayesian approach for inference in the multivariate probit model, taking into account the association structure between binary observations. We model the association through the correlation matrix of the latent Gaussian variables. Conditional independence is imposed by setting some off-diagonal elements of the inverse correlation matrix to zero and this sparsity structure is modeled using a decomposable graphical model. We propose an efficient Markov chain Monte Carlo algorithm relying on a parameter expansion scheme to sample from the resulting posterior distribution. This algorithm updates the correlation matrix within a simple Gibbs sampling framework and allows us to infer the correlation structure from the data, generalizing methods used for inference in decomposable Gaussian graphical models to multivariate binary observations. We demonstrate the performance of this model and of the Markov chain Monte Carlo algorithm on simulated and real datasets. This article has online supplementary materials.     

Bayesian Case Influence Measures for Statistical Models With Missing Data

We examine three Bayesian case influence measures including the φ-divergence, Cook’s posterior mode distance, and Cook’s posterior mean distance for identifying a set of influential observations for a variety of statistical models with missing data including models for longitudinal data and latent variable models in the absence/presence of missing data. Since it can be computationally prohibitive to compute these Bayesian case influence measures in models with missing data, we derive simple first-order approximations to the three Bayesian case influence measures by using the Laplace approximation formula and examine the applications of these approximations to the identification of influential sets. All of the computations for the first-order approximations can be easily done using Markov chain Monte Carlo samples from the posterior distribution based on the full data. Simulated data and an AIDS dataset are analyzed to illustrate the methodology. Supplemental materials for the article are available online.     

Sampling Schemes for Bayesian Variable Selection in Generalized Linear Models

Bayesian approaches to prediction and the assessment of predictive uncertainty in generalized linear models are often based on averaging predictions over different models, and this requires methods for accounting for model uncertainty. When there are linear dependencies among potential predictor variables in a generalized linear model, existing Markov chain Monte Carlo algorithms for sampling from the posterior distribution on the model and parameter space in Bayesian variable selection problems may not work well. This article describes a sampling algorithm based on the Swendsen-Wang algorithm for the Ising model, and which works well when the predictors are far from orthogonality. In problems of variable selection for generalized linear models we can index different models by a binary parameter vector, where each binary variable indicates whether or not a given predictor variable is included in the model. The posterior distribution on the model is a distribution on this collection of binary strings, and by thinking of this posterior distribution as a binary spatial field we apply a sampling scheme inspired by the Swendsen-Wang algorithm for the Ising model in order to sample from the model posterior distribution. The algorithm we describe extends a similar algorithm for variable selection problems in linear models. The benefits of the algorithm are demonstrated for both real and simulated data.     

A Computational Approach for Full Nonparametric Bayesian Inference Under Dirichlet Process Mixture Models

Widely used parametric generalized linear models are, unfortunately, a somewhat limited class of specifications. Nonparametric aspects are often introduced to enrich this class, resulting in semiparametric models. Focusing on single or k-sample problems, many classical nonparametric approaches are limited to hypothesis testing. Those that allow estimation are limited to certain functionals of the underlying distributions. Moreover, the associated inference often relies upon asymptotics when nonparametric specifications are often most appealing for smaller sample sizes. Bayesian nonparametric approaches avoid asymptotics but have, to date, been limited in the range of inference. Working with Dirichlet process priors, we overcome the limitations of existing simulation-based model fitting approaches which yield inference that is confined to posterior moments of linear functionals of the population distribution. This article provides a computational approach to obtain the entire posterior distribution for more general functionals. We illustrate with three applications: investigation of extreme value distributions associated with a single population, comparison of medians in a k-sample problem, and comparison of survival times from different populations under fairly heavy censoring.     

Properties of Prior and Posterior Distributions for Multivariate Categorical Response Data Models

In this article, we model multivariate categorical (binary and ordinal) response data using a very rich class of scale mixture of multivariate normal (SMMVN) link functions to accommodate heavy tailed distributions. We consider both noninformative as well as informative prior distributions for SMMVN-link models. The notation of informative prior elicitation is based on available similar historical studies. The main objectives of this article are (i) to derive theoretical properties of noninformative and informative priors as well as the resulting posteriors and (ii) to develop an efficient Markov chain Monte Carlo algorithm to sample from the resulting posterior distribution. A real data example from prostate cancer studies is used to illustrate the proposed methodologies.     

Applications of Hybrid Monte Carlo to Bayesian Generalized Linear Models: Quasicomplete Separation and Neural Networks

Abstract

The “leapfrog” hybrid Monte Carlo algorithm is a simple and effective MCMC method for fitting Bayesian generalized linear models with canonical link. The algorithm leads to large trajectories over the posterior and a rapidly mixing Markov chain, having superior performance over conventional methods in difficult problems like logistic regression with quasicomplete separation. This method offers a very attractive solution to this common problem, providing a method for identifying datasets that are quasicomplete separated, and for identifying the covariates that are at the root of the problem. The method is also quite successful in fitting generalized linear models in which the link function is extended to include a feedforward neural network. With a large number of hidden units, however, or when the dataset becomes large, the computations required in calculating the gradient in each trajectory can become very demanding. In this case, it is best to mix the algorithm with multivariate random walk Metropolis—Hastings. However, this entails very little additional programming work.     

Bayesian and Maximum Likelihood Estimation for Gaussian Processes on an Incomplete Lattice

This article proposes a new approach for Bayesian and maximum likelihood parameter estimation for stationary Gaussian processes observed on a large lattice with missing values. We propose a Markov chain Monte Carlo approach for Bayesian inference, and a Monte Carlo expectation-maximization algorithm for maximum likelihood inference. Our approach uses data augmentation and circulant embedding of the covariance matrix, and provides likelihood-based inference for the parameters and the missing data. Using simulated data and an application to satellite sea surface temperatures in the Pacific Ocean, we show that our method provides accurate inference on lattices of sizes up to 512 × 512, and is competitive with two popular methods: composite likelihood and spectral approximations.     

Cluster Algorithms for Spatial Point Processes with Symmetric and Shift Invariant Interactions

Abstract

In this article, Swendsen–Wang–Wolff algorithms are extended to simulate spatial point processes with symmetric and stationary interactions. Convergence of these algorithms is considered. Some further generalizations of the algorithms are discussed. The ideas presented in this article can also be useful in handling some large and complicated systems.     

Bounds on regeneration times and convergence rates for Markov chains

In many applications of Markov chains, and especially in Markov chain Monte Carlo algorithms, the rate of convergence of the chain is of critical importance. Most techniques to establish such rates require bounds on the distribution of the random regeneration time T that can be constructed, via splitting techniques, at times of return to a “small set” C satisfying a minorisation condition P(x,·)(·), xC. Typically, however, it is much easier to get bounds on the time τ_C of return to the small set itself, usually based on a geometric drift function , where . We develop a new relationship between T and τ_C, and this gives a bound on the tail of T, based on ,λ and b, which is a strict improvement on existing results. When evaluating rates of convergence we see that our bound usually gives considerable numerical improvement on previous expressions.     

基于Markov Chain Monte Carlo模型对医院出院病人调查表数据缺失的填补与分析

目的对医院出院病人调查表普遍存在的数据缺失进行填补与分析,以保证统计调查表的质量,为医院以及上级卫生部门了解现状,进行预策和决策提供技术支持和质量保证。方法运用SAS9.1,采用多重填补方法Markov Chain Monte Carlo(MCMC)模型对缺失数据进行多次填补并综合分析。结果MCMC填补10次的结果最优。结论(Multiple Imputation)MI方法在解决医院出院病人调查表数据缺失时有优势,发挥空间较大,且填补效率较高。     

Modeling shape distributions and inferences for assessing differences in shapes

The general class of complex elliptical shape distributions on a complex sphere provides a natural framework for modeling shapes in two dimensions. Such class includes many distributions, e.g., complex Normal, Watson, Bingham, angular central Gaussian and several others. We employ this class of distributions to develop methods for asserting differences in populations of shapes in two dimensions. Maximum likelihood and Bayesian methods for estimation of modal difference are developed along with hypothesis testing and credible regions for average shape difference. The methodology is applied in an example from biometry, where we are interested in detecting shape differences between male and female gorilla skulls.