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1.
K. Kantminene G. Mikul'skene O. Hormi Z. I. Beresnevicius 《Chemistry of Heterocyclic Compounds》2002,38(4):422-428
Tetrahydro-1H,7H-benzo[ij]quinolizine-1,7-diones have been obtained by the cyclization of N-alkoxyphenyl-N-(2-carboxyethyl)--alanines. Fission of the ester bond occurs on cyclization of N-(4-ethoxyphenyl)-N-(2-carboxyethyl)--alanine, but the cyclization of the 3,4-dialkoxyphenyl derivative leads to the formation of 9-alkoxy-8-hydroxy-2,3,5,7-tetrahydro-1H,7H-benzo[ij]quinolizine-1,7-diones. The corresponding dioximes and diphenylhydrazones were obtained. 相似文献
2.
2-Hydroxy-4-oxo-4-(2,3,5,6-tetrafluoro-4-methoxyphenyl)-but-2-enoic acid methyl ester (1) was synthesized by the reaction of pentafluoroacetophenone with dimethyl oxalate in the presence of sodium methylate. Subsequently, reactions of compound 1 with aniline, o-phenylenediamine, and o-aminophenol were investigated. In addition, the thermal cyclization of ester 1 was studied and led to the formation of 5,6,8-trifluoro-7-methoxy-4-oxo-4H-chromene-2-carboxylic acid methyl ester (6) due to nucleophilic substitution of the 3-fluoro group. Hydrolysis of compound 1 and subsequent cyclization by treatment with SOCl2 gave 5-(2,3,5,6-tetrafluoro-4-methoxyphenyl)-furan-2,3-dione (3). Thermal decarbonylation of compound 3 under mild conditions resulted in the formation of 3-(2,3,5,6-tetrafluoro-4-methoxyphenyl)-propene-1,3-dione (4) which dimerized to pyranone 5. 相似文献
3.
Benzyl 5,6-dihydroxyindole-2-carboxylate 3 and the free acid 4 were synthesized by oxidative cyclization of dopa benzyl ester with ceric ammonium nitrate and subsequent removal of the benzyl group by hydrogenation. 相似文献
4.
Milda M. Burbuliene Olegas Bobrovas Povilas Vainilavicius 《Journal of heterocyclic chemistry》2006,43(1):43-47
5.
Milda M. Burbuliene Rita Dobrovolskaite Povilas Vainilavicius 《Journal of heterocyclic chemistry》2006,43(6):1557-1561
6.
The reaction of tert-butyl (3-indolyl)carbinol with potassium cyanide yielded a nitrile which was reduced to-tert-butyltryptamine. 1-Methyl-4-tert-butyl--carboline was prepared by cyclization of the acetyl derivative of this amine with subsequent dehydrogenation. An attempt to obtain this compound through 4-(3-indolyl)-5,5-dimethyl-2-hexanone was unsuccessful.See [1] for communication II.Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 5, pp. 621–622, May, 1971. 相似文献
7.
Two isomers of 2,3-dimethyl-1-thiahydrindane and two isomers of 4-methyl-1-thiadecali were obtained by the reaction of cyclohexene episulfide with crotylmagnesium bromide and subsequent cyclization of the resulting 2-(-methyl--propenyl)-1-cyclohexanethiol by the action of 75% sulfuric acid and UV irradiation.See [3] for communication IV.Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 5, pp. 622–625, May, 1972. 相似文献
8.
Richard A. Bunce James E. Schammerhorn LeGrande M. Slaughter 《Journal of heterocyclic chemistry》2007,44(5):1051-1057
9.
10.
E. N. Ulomskiy N. R. Medvedeva A. V. Shchepochkin O. S. Eltsov V. L. Rusinov O. N. Chupakhin E. G. Deeva O. I. Kiselev 《Chemistry of Heterocyclic Compounds》2011,47(9):1164-1169
The reaction of 3-R-5-amino-1,2,4-triazoles with the ethyl ester of 2-fluoroacetoacetic acid gave 2-R-fluoro[1,2,4]triazolo[1,5-a]pyrimidin-7(4H)-ones. The reaction of a 3-R-1,2,4-triazolyl-5-diazonium salt with the ethyl ester of 2-fluoroacetoacetic acid and subsequent
cyclization of the triazolylhydrazones lead to 7-R-3-fluoro[1,2,4]triazolo[5,1-c][1,2,4]triazin-4(1H)-ones. 相似文献
11.
E. O. Chukhadzhyan A. R. Gevorkyan El. O. Chukhadzhyan K. G. Shakhatuni F. S. Kinoyan G. A. Panosyan 《Chemistry of Heterocyclic Compounds》2004,40(1):29-36
The ability of the 4-hydroxy-2-butynyl group to participate as ,-unsaturated fragment in base-catalyzed intramolecular cyclization was established. 2,2-Dialkyl-4-hydroxymethylbenzo[f]isoindolinium and 2,2-dialkyl-4-hydroxymethylisoindolinium salts were obtained by the cyclization of dialkyl(4-hydroxy-2-butynyl)(3-phenylpropargyl)- or dialkyl(4-hydroxy-2-butynyl)(3-alkenylpropargyl)ammonium salts. 相似文献
12.
E. G. Knysh A. N. Krasovskii P. M. Kochergin P. M. Shabel'nik 《Chemistry of Heterocyclic Compounds》1972,8(3):364-367
Naphth[1,2-d]imidazo[3,2-b]-3-thiazolidone and its methyl homolog were synthesized by the reaction of 2-mercaptonaphth[1,2-d]imidazole with chloroacetic and -chloropropionic acids with subsequent cyclization of the naphth[1,2-d]imidazole-2-mercaptoacetic acids. The reactions of the first of them at the methylene group with aldehydes, nitroso compounds, and benzenediazonium salts were studied; the corresponding arylidene and azomethine derivatives of naphthimidazo-3-thiazolidone and the arylhydrazones of naphth[1,2-d]imidazo[3,2-b]thiazoline-2,3-dione were obtained. The arylidene derivatives of naphthimidazo-3-thiazolidone were also obtained by the reaction of naphthimidazole-2-mercaptoacetic acid or its methyl ester with aldehydes or (in one step) by the reaction of 2-mercaptonaphth[1,2-d]imidazole with chloroacetic acid and carbonyl compounds.See [1] for communication LXXI.Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 3, pp. 399–402, March, 1972. 相似文献
13.
The heretofore unknown sym-octahydro-4,9-dioxopyrido[2,3-g]quinoline was synthesized by carboxyethylation of dimethyl 2,5-diaminoterephthalate with -propiolactone with subsequent hydrolysis of the resulting 2,5-bis(-carboxyethylamino)terephthalic acid ester and cyclization of 2,5-bis(-carboxyethylamino)terephthalic acid. The structure of the product was confirmed by the UV and IR spectra and also by reduction to the known sym-octahydropyrido [2,3-g]quinoline.See [7] for preliminary communication.Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 11, pp. 1535–1537, November, 1970. 相似文献
14.
A number of 6- and 8-nitroindolizines were synthesized by quaternization of isomeric 2-methylnitropyridines by -halo ketones and subsequent cyclization.Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 7. pp. 922–926, July, 1976. 相似文献
15.
Sylvain Aubry Stphane Pellet‐Rostaing Marc Lemaire Ren Faure 《Journal of heterocyclic chemistry》2006,43(1):139-148
16.
A. I. Markosyan R. A. Kuroyan S. V. Dilanyan M. S. Aleksanyan A. A. Karapetyan Yu. T. Struchkov 《Chemistry of Heterocyclic Compounds》2000,36(5):574-578
The reaction of 4-amino-3-ethoxycarbonyl-1,2-dihydrospiro(naphthalene-2,1-cyclopentane) with benzoyl isothiocyanate led to the corresponding 4-(N-benzoylthioureido) derivative, the cyclization of which gave 4-oxo-2-thioxo-1,2,3,4,5,6-hexahydrospiro(benzo[h]qquinazoline-5,1-cyclopentane). Condensation of the latter with hydrazine hydrate gave 2-hydrazino-3,4,5,6-tetrahydrospiro(benzo[h] quinazoline-5,1-cyclopentane), which formed 6-oxo-1H-7,8-dihydrospiro(benzo[h] triazolo[3,4-b] quinazoline7,1-cyclopentane) in reaction with orthoformice ester. Methylation of the product with methyl iodide led to its 2-methyl derivative.Communication 1, see ref. [1].Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 5, pp. 658–662, May, 2000. 相似文献
17.
The cyclization of hydrazones obtained by coupling of diazonium salts with ethyl-acetyl--phthalimidovalerate gives ethyl 5-substituted-3-(2-phthalimidoethyl)indole-2-carboxylates, the successive hydrolysis and decarboxylation of which make it possible to obtain 5-substituted tryptamines. The synthesized hydroxyethyl ester of serotonin was found to have pronounced antiradiation action.See [1] for communication C.Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 11, pp. 1496–1501, November, 1974. 相似文献
18.
3,4-Dihydroisoquinoline-Reissert-compounds were alkylated to 1-benzyl- and 1-picolyl-derivatives, which in turn could selectively be hydrolized yielding various carboxylic acids, among others certain amino acids related to 3,4-deoxynorlaudanosoline carboxylic acid (DNLCA). These on treating with ethanolic KOH underwent cyclization to dibenzoquinolizine- and isoquinonaphthyridine-13a-carboxylic acids. Alternatively this cyclization also could be achieved by a more convenient one-pot procedure starting from the same dihydro-Reissert-compounds. Thermal decarboxylation afforded among others the alangia alkaloids alangimarine and dihydroalangimarine. 相似文献
19.
G. Veinberg R. Bokaldere K. Dikovskaya M. Vorona D. Mucel' Kh. Kazhoka I. Turovskis I. Shestakova I. Kanepe I. Domracheva E. Lukevics 《Chemistry of Heterocyclic Compounds》1998,34(11):1266-1275
By the interaction of heterocyclic thiols with sulfoxides of 6,6-dihydro- and 6-chloropenicillanates, derivatives of 4-heteryldithio-2-azetidinones have been synthesized, as well as products of their cyclization to form 2-heterylthiomethyl-and 2-halomethyl-substituted penicillanates and an ester of 3-chloro-3-methyl-7-chlorocepham-4-carboxylic acid. Also, the desulfurization of 6-chloropenicillanate by Raney nickel has been accomplished. For the substances that have been synthesized, a direct relationship has been established between the intensity of their cytotoxic actionin vitro with respect to tumor cells and the influence of these compounds on the intracellular generation of nitric oxide radicals.Latvian Institute of Organic Synthesis, Riga LV-1006, Translated from Khimiya Geterosiklicheskikh Soedinenii, No. 11, pp. 1494–1503, November, 1998. 相似文献
20.
We recently developed a convenient route to hexahydronaphthalenols such as 5 (R=CO2CH3 or CH3) starting from m-toluic acid (1)1. The key features of the route involved reduction-alkylation of the toluic acid to the dihydro derivative 2 2, subsequent deprotection and oxidation of the side chain primary alcohol, and acid-catalyzed cyclization of the resulting aldehyde 4. In the case of the dimethylnaphthalenols 5 (R=CH3), conversion of the angular carboxylic function to the methyl group was effected prior to cyclization via reduction of the p-toluenesulfonic ester of the neopentyl alcohol 3 (R=CH2OH) using lithium triethylborohydride3. 相似文献