微波辐射法合成2-(4-取代苯乙烯基)苯并噻唑

甲基苯并噻唑;芳香醛;微波辐射法合成2-(4-取代苯乙烯基)苯并噻唑     

2-取代吡啶半菁染料的无溶剂微波合成及光谱性质的理论研究

在微波促进无溶剂条件下, 由N-甲基-2-甲基吡啶碘盐与取代芳香醛在哌啶作用下合成了一系列2-取代的吡啶半菁染料, 产物结构由元素分析, ¹H NMR, MS, IR, UV得到确认. 该方法操作简便, 收率高. 在此基础上, 对N-甲 基-2-(p-N,N-二甲氨基-苯乙烯基)吡啶半菁染料的光谱性质进行了理论计算.     

微波辐射下8-取代嘌呤核苷的绿色合成

8-溴嘌呤核苷与亲核试剂在水溶液中,于400W,95℃微波辐射5min合成了10种8-取代嘌呤核苷,收率72%～92%,其结构经1HNMR和13CNMR表征。     

两步法无催化剂高效合成2-取代苯并咪唑

芳香醛与NaHSO3加成得到羟基磺酸盐,加入邻苯二胺或取代邻苯二胺在乙醇中回流反应,空气氧化直接得到2-取代苯并咪唑. 在合成的15个化合物中,产率均超过80%. 其中化合物2-(4-氯苯基)-6-甲氧基-1H-苯并咪唑尚未见报道. 所有产物结构经元素分析、IR、1H NMR分析技术得到确证. 合成方法无需任何催化剂,操作简单,条件温和,环境友好.     

微波辐射下2-取代苯并咪唑衍生物库的平行合成

以邻苯二胺及相应羧酸为原料,于多聚磷酸存在下,由微波辐射平行合成了一个小型2-取代苯并咪唑衍生物库,反应时间由常规加热的几小时到几天缩短为20min,且产率较高。经元素分析和1H NMR确证了产物结构。     

2-苯乙烯基喹啉染料的无溶剂微波合成

在微波促进无溶剂条件下,由2-甲基喹啉与取代芳香醛在醋酐作用下合成了一系列2-苯乙烯基喹啉染料,该法操作简便、收率高.经元素分析, 1H NMR, MS, IR和UV确证了产物的结构.     

微波辐射下合成5-芳亚甲基-2,3-二芳基-4-噻唑啉酮类化合物

在水介质中,以四丁基溴化铵(TBAB)作催化剂,微波辐射下使芳醛与4-噻唑啉酮反应合成一系列5-芳亚甲基-2,3-二芳基-4-噻唑啉酮类化合物.该反应具有反应时间短、产率高、环境友好、后处理简便等优点.所有化合物均经IR,MS,1H NMR和元素分析确定.同时用X射线衍射法测定了化合物4a的晶体结构.     

无溶剂微波照射下2－取代苯并咪唑的合成

用PPA作催化剂，在无溶剂微波照射下合成了10种2－取代苯并咪唑，为该类化 合物的合成提供了一种新方法。与常规方法相比，反应时间大大缩短，产率与传统 合成方法相当。     

关于单取代环己烷的纯直立键构象体

１．论文名称ＯｎＰｕｒｅＡｘｉａｌＭｏｎｏｓｕｂｓｔｉｔｕｔｅｄＣｙｃｌｏｈｅｘａｎｅｓ２．发表刊物Ｊ．Ａｍ．Ｃｈｅｍ．Ｓｏｃ．，１９９８，１２０，１２１４５．３．研究者ＢｅｎＣｏｒｎｅｔ，ＭａｔｈｅｗＤａｖｉｓ，ＳｈａｏｘｉｏｎｇＷｕ，ＮｅｙｓａＮ...     

微波无溶剂法合成香草醛氨基酸席夫碱

氨基酸席夫碱是制备特殊生物活性物质的重要中间体。氨基酸席夫碱中的亚胺(C=N)结构与亚磷酸烷基酯加成的化合物具有良好的抗植物病毒,除草,杀菌等性能[1-3]。氨基酸席夫碱中的羟基,羧基和亚胺等多个活性基团,可以与多种金属离子配位,其配合物具有抗菌,抗病毒,抗癌等性能[4-9],     

One-Pot Synthesis of Substituted Cyclohexanes from Condensation of Aldehyde and Methylketone

Six-carbonringsareusuallypreparedfromDiels-Alder[2rr 4tt]cyclicaddition,DieckmanncondensationorintramolecularMichaelcondensati0n.H0wever,inmostofthecases,thepreparati0nofsubstitUtedcyclohexaneshastounderg0areacti0nsequence.Toreachthisbyaone-stepreaction,sofar,isstillapr0bleminsyntheticorganicchehastry.ThisletterintendstogiveapreliminaryrePortonanewmethodtosynthesizesubstitUtedcyclohexanesthroughsingle-stepintermolecularcondensation0fanaldehydeandamethylketoneinthepresenceofanalkali.Thereact…     

Synthesis of Substituted Salicylanilides under Microwave Irradiation

Summary. Salicylanilides were prepared in 70–95% yields in 4–8min from phenyl salicylate or phenyl 4-methoxysalicylate and substituted anilines under microwave irradiation under solvent free conditions.Received October 17, 2002; accepted October 22, 2002 Published online July 3, 2003     

Synthesis of Substituted Salicylanilides under Microwave Irradiation

Salicylanilides were prepared in 70–95% yields in 4–8min from phenyl salicylate or phenyl 4-methoxysalicylate and substituted anilines under microwave irradiation under solvent free conditions.     

高效合成热力学不稳定的双取代环己烷

<正>环己烷是最常见并且最重要的环状结构单元之一,饱和环状结构可以提高分子的饱和度,有助于改善化合物物化特性和提高分子生物活性^{[1, 2]},而取代环己烷及其衍生物则由于广泛存在于天然产物和药物分子中受到合成化学家的关注。从构象上看,根据Barton规则,1,2-反式、1,3-顺式、1,4-反式双取代环己烷的两个取代基可同时处于椅式构象的平伏键,热力学稳定,容易合成;而1,2-顺式、     

微波固相合成苯并[a]吩噁嗪衍生物

首次在固相条件下微波辐射N,N-二烷基-4-亚硝基苯胺盐酸盐和2-萘酚衍生物快速合成苯并[a]吩嗪衍生物,得到苯并[a]吩嗪离子氯化物3a-3f,且收率较高.此外,N,N-二甲基-4-亚硝基苯胺盐酸盐和1,3-二羟基-2-萘甲酸乙酯的混合物在微波辐射下合成了一个新的激光染料9-二甲氨基-6-乙氧羰基-5H-苯并[a]的吩 嗪-5-酮4.     

Synthesis of Benzofuryl Substituted Unsymmetrical Ureas Under Microwave Irradiation

A series of 2-benzofuryl substituted unsymmetrical ureas were synthesized by reactions of benzofuroyl isocyanate, which was prepared from benzofuroyl azide by Curtius rearrangement, with various aromatic amines, 2-amino-5-(benzo-2-furyl)-1,3,4-thiadiazole, and 2-amino-5-aryloxymethylene-1,3, 4-thiadiazoles under microwave irradiation. Compared to conventional methods, this synthesis has the advantages of mild reaction conditions, easy handling, and high yields. The products have been characterized by analytical and spectral (IR and ¹ H NMR) data.     

The Synthesis and Polymerization of 1,3-Disubstituted Cyclohexanes

The synthesis of cis- and trans-1,3-diisocyanatocyclohexane is described. With water the cis-diisocyanate gave a bicyclic urea and a polyurea, which decomposed on heating to the bicyclic urea, and the trans-diisocyanate formed a polyurea. cis-1,3-Diisocyanatocyclohexane was polymerized using sodium cyanide as initiator to give soluble polymers which contained little or no residual isocyanato groups and hence cyclopolymerization had occurred. The polymers were thermally unstable and depolymerized quantitatively to monomer in the temperature range 270-370°. Two different structural units are possible for the cyclopolymer and the proportions of each unit were estimated by a quantitative aminolysis using di-n-butylamine. trans-1,3-Di-isocyanatocyclohexane did not polymerize under similar conditions.     

Catalytic Asymmetric Synthesis of Cyclohexanes by Hydrogen Borrowing Annulations

Hydrogen borrowing catalysis serves as a powerful alternative to enolate alkylation, enabling the direct coupling of ketones with unactivated alcohols. However, to date, methods that enable control over the absolute stereochemical outcome of such a process have remained elusive. Here we report a catalytic asymmetric method for the synthesis of enantioenriched cyclohexanes from 1,5‐diols via hydrogen borrowing catalysis. This reaction is mediated by the addition of a chiral iridium(I) complex, which is able to impart high levels of enantioselectivity upon the process. A series of enantioenriched cyclohexanes have been prepared and the mode of enantioinduction has been probed by a combination of experimental and DFT studies.     

Microwave Assisted One Pot Synthesis of Substituted 3-Formyl Benzoates Using Vilsmeier Reagent

A facile one pot conversion of alkyl diacylacetates to 2,6-dichloro-3-formyl benzoates using Vilsmeier reagent in a two pronged strategy - conventional heating and microwave irradiation method is reported. The reaction time has been brought down from hours to seconds in microwave irradiation method.