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1.
AbstractAn alternative and concise total synthesis of (3?R, 4S)-4-Hydroxylasiodiplodin has been reported from inexpensive and commercially available 6-heptenal and Orsellinic acid starting materials. The key steps involved in the synthesis are Wittig reaction, Sharpless epoxidation, Yamaguchi esterification and ring-closing metathesis (RCM). 相似文献
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Lakshmi Narayana Sharma Konidena Suresh Kumar Chettu Praveena Mukkavilli Krishna Reddy Valluru Kameswara Rao N.S. Annapurna Nowduri Raghu Babu Korupolu 《中国化学会会志》2019,66(2):226-230
A new total synthesis of [R]‐Patulolide A from readily available (R)‐propylene epoxide obtained using the asymmetric synthetic approach is reported. The key reactions involved are ozonolysis and Yamaguchi macrolactonization, resulting in the ring system. 相似文献
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Venkata Naresh Vema Y. Bharathi kumari Sridhar Musulla RamaKrishnam Raju Addada Srinivasa Rao Alapati 《Tetrahedron letters》2018,59(47):4165-4167
Greensporone C, a new 14-membered resorcylic acid lactone, has been synthesized from inexpensive and commercially available starting materials. This convergent synthesis utilizes Cross metathesis using the Grubbs Hoveyda catalyst, alkylation of 1,3-dithiane and Yamaguchi macrolactonization as key steps. 相似文献
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J.S. Yadav Saibal Das J. Satyanarayana Reddy N. Thrimurtulu A.R. Prasad 《Tetrahedron letters》2010,51(31):4050-4052
The first total synthesis of (3R),(5R)-5-hydroxy-de-O-methyllasiodiplodin and its epimer is reported from malic acid. The adopted approach is highly convergent and stereoselective. The strategy utilizes syn selective reduction and ring-closing metathesis as key steps. 相似文献
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S. T. Malinovskii V. P. Tashchi M. Z. Krimer A. B. Kamenskii Yu. G. Putsykin 《Russian Chemical Bulletin》1995,44(4):695-698
The synthesis and X-ray structural study of 1-(4-chlorophenyl)-3-(5-methyl-1,3-dioxan-5-yl)-(1,2), (3,4)-diepoxybutane are described.Translated fromIzvestiya Akademii Nauk. Seriya Khimicheskaya, No. 4, pp. 715–718, April, 1995. 相似文献
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《Tetrahedron letters》1986,27(39):4735-4736
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S Stadlbauer K Ohmori F Hattori K Suzuki 《Chemical communications (Cambridge, England)》2012,48(67):8425-8427
Concise synthesis of (-)-epicatechin and its 3-O-gallate is described, illustrating efficacy of the new strategy for catechin-class polyphenols based on assembly of lithiated fluorobenzene and epoxy alcohol followed by a pyran cyclization. 1,3,5-Trifluorobenzene serves as the A-ring equivalent for functionalization and the pyran annulation. 相似文献
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G. Yu. Ishmuratov A. V. Bannova E. R. Latypova R. R. Muslukhov A. A. Smol′nikov R. F. Talipov 《Chemistry of Natural Compounds》2012,48(5):789-790
A modified stereospecific synthesis of potentially biologically and pharmacologically active methyl (1R,2R,3E,5R)-3-(hydroxyimino)-5-methyl-2-(1-methylethyl)cyclohexanecarboxylate from (R)-4-menthen-3-one was developed using sequential 1,4-conjugate addition of Norman reagent catalyzed by CuI?CBF3?Et2O?CCuCl2 and ozonolysis?Creduction of the intermediate (R,R,R)-vinylmenthone by hydroxylamine hydrochloridein MeOH. 相似文献
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《Tetrahedron letters》1987,28(27):3059-3060
The synthesis of mevalonolactone stereospecifically labeled at carbon 5 is described combining chemical reactions with an enzymatic reduction step. 相似文献
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Faouzi Aloui 《Tetrahedron letters》2009,50(30):4321-37
3-(Diphenylphosphino)hexahelicene is synthesised in good yield and purity, via a three-step sequence involving a palladium-catalysed Mizoroki-Heck coupling reaction and classical oxidative photocyclisation. Mononuclear ruthenium and palladium complexes of 3-(diphenylphosphino)hexahelicene are prepared and characterised. 相似文献
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《Tetrahedron letters》1988,29(36):4625-4628
The chiral mevinic acid analogues [(15) and (16)] have been prepared from the yeast reduction product (2) by homologation and selenolactonistion and subsequently converted into both enantiomers of Goniothalamin [(17) and (18)]. 相似文献
13.
Kitazaki T Tasaka A Hosono H Matsushita Y Itoh K 《Chemical & pharmaceutical bulletin》1999,47(3):360-368
A new route for the synthesis of the optically active antifungal azole TAK-187, 2-[(1R,2R)-2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-tria zol-1- yl)propyl]-4-[4-(2,2,3,3-tetrafluoropropoxy)phenyl]-3(2H,4H)-1,2,4 - triazolone, was established. The key synthetic intermediate, 2-[(1R)-2-(2,4-difluorophenyl)-2-oxo-1-methylethyl]-4-[4-(2,2,3,3- tetrafluoropropoxy)phenyl]-3(2H,4H)-1,2,4-triazolone (8), was prepared starting from the esters (11a, b) of (S)-lactic acid in a stereocontrolled manner. This optically active propiophenone derivative 8 was converted to the one carbon-elongated (1R,2S)-diol 7, which was then reacted with 1H-1,2,4-triazole to yield TAK-187. This newly developed route was applied to the synthesis of the analogs (25a, b--28a, b) containing an imidazolone or imidazolidinone nucleus. 相似文献
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I. V. Mineeva 《Russian Journal of Organic Chemistry》2013,49(6):838-842
A simple and efficient asymmetric synthesis of (5S,7R)-7-hydroxydodecano-5-lactone, a component of the giant danaine butterfly Idea leuconoe pheromone, and formal syntheses of (+)-(3R,5R)-3-hydroxydecano-5-lactone, verbalactone, and Tolypothrix pentaether have been accomplished starting from methyl (3R,5R)-3,5-dihydroxydecanoate. The latter is obtained from methyl 3-[(tributylstannyl)methyl]but-3-enoate using Keck allylation in the key step of the construction of its carbon skeleton. 相似文献
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Here we present new routes for the efficient syntheses of 6,5'-(S)- and 6,5'-(R)-cyclouridine. The syntheses utilize readily accessible uridine as a starting material. This route to the R diastereomer is significantly more efficient than previous synthetic efforts, allowing us to obtain large amounts of pure material for future biological testing. 相似文献
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Total synthesis of (3R, 5R)-(+)-3-hydroxy-5-decanolide (1) and massoialactone (2), and formal synthesis of verbalactone (3), have been reported. 相似文献
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1INTRODUCTIONSeveralimportantapproachestothesynthesisandpropertiesofchiralγ alkyloxybutenolideshaveatractedmuchatentionowingt... 相似文献