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1.
Wei Wang Lie-Ping Wang Ming-Zhen Mao Chao Xue Hai-Yang Wang 《Phosphorus, sulfur, and silicon and the related elements》2016,191(10):1362-1367
A series of novel O,O-Dialkyl-2-[3-bromo-1-(3-chloropyridin-2-yl)-1H-pyrazole-5-carbonyloxy](aryl) methy-lphosphonates I-1–14 were designed and synthesized. The structures of all the title compounds were confirmed by 1H-NMR, 13C-NMR, 31P-NMR, IR and elemental analysis. Their insecticidal activities against Mythimna separata and Plutella xylostella were evaluated. The results of bioassays indicated that the title compounds exhibited 20–80% larvicidal activity against Mythimna separata at 1000 mg/L. 相似文献
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Fifteen new thiazol-2-amine derivatives containing the 2,4-difluorophenyl unit and 1H-1,2,4-triazole moiety were synthesized. Their structures of all these new compounds have been confirmed by 1H NMR spectra and elemental analysis. The antifungal and plant-growth-regulatory activities of the title compounds are discussed. 相似文献
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Abstract A series of novel α-amino phosphonate derivatives containing both pyridine and 1,2,3-triazole moieties 4 were synthesized via a multi-step reaction. First, the condensation of 5-amino-1-[(6-chloropyridin-3-yl) methyl]-4-cyano-1H-1,2,3-triazole with various aromatic aldehydes in the presence of magnesium perchlorate afforded imines 3 in moderate yields; second, imines 3 reacted with dialkyl phosphites or triphenyl phosphite to give the title compounds 4 in moderate to good yields. Their structures were elucidated by spectroscopic data (IR, 1H NMR, 31P NMR, ESI-MS) and elemental analysis. The preliminary bioassay (in vitro) indicated that some of the title compounds 4 possessed moderate herbicidal activities against dicotyledonous plants (Brassica campestris L) at a concentration of 100 mg/L. However, compounds 4 did not exhibit herbicidal activities against Brassica campestris L at a concentration of 10 mg/L. Supplemental materials are available for this article. Go to the publisher's online edition of Phosphorus, Sulfur, and Silicon and the Related Elements to view the free supplemental file. GRAPHICAL ABSTRACT 相似文献
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Four compounds have been synthesized and characterized by1H NMR spectroscopy and elemental analyses, among which 1-(4,5-dihydro-3-phenyl-pyrazol-1-yl)-2-(1H-1,2,4-triazol-1-yl)ethanone 3a was further confirmed by X-ray crystallographic analysis. The biological activities of these compounds were tested, with the result that they displayed moderate fungicidal activities. In addition, a MO calculations using density functional theory (DFT) at B3LYP/6-31G* level have also been carried out, and the structure–activity relationships for these compounds are discussed. 相似文献
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Wei Wang Min-Zhen Mao Xiao-Guang Zhang Xiao-Rui Zheng Xiao-Ying Huang 《Phosphorus, sulfur, and silicon and the related elements》2018,193(3):164-167
A series of novel ethyl 2-(5-methyl-3-arylisoxazole-4-carboxamido)-4-alkylthiazole-5-carboxylates I-1-6 were synthesized. The structures of all target compounds were characterized by 1H NMR, 13C NMR, IR, MS and elemental analyses. Their fungicidal and herbicidal activities were evaluated. The results of preliminary bioassays show that the title compounds I-4 possess 20–50% inhibition against most of the tested plants at the dosage of 150 g ai/ha, while the title compounds I-1-5 possess 32–58% inhibition against FusaHum graminearum, Thanatephorus cucumeris, Botrytis cinereapers and Fusarium oxysporum in vitro at the concentration of 100 mg/L. 相似文献
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通过α-卤代芳基乙酮和5-[(1H-1,2,4-三唑-1-基)甲基]-4-苯基-2H-1,2,4-三唑-3(4H)-硫酮反应, 合成了11个新的2-{5-[(1H-1,2,4-三唑-1-基)甲基]-4-苯基-4H-1,2,4-三唑-3-硫基}-1-芳基乙酮类化合物. 其结构经元素分析, IR, 1H NMR等确证, 并用X射线单晶衍射测定了化合物6f的晶体结构. 生物活性测试结果表明, 部分化合物具有一定的杀菌活性. 相似文献
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S. Yu. Bylikin S. A. Pogozhikh V. N. Khrustalev Vad V. Negrebetsky A. G. Shipov Yu. E. Ovchinnikov Yu. I. Baukov 《Russian Chemical Bulletin》2000,49(1):140-147
RacemicN-(chlorodimethylgermylmethyl)-4-phenyl-2-pyrrolidone and the first optically active amide derivatives containing the asymmetrical
carbon atom and the five-coordinate germanium atom,viz.,N-(chlorodimethylgermylmethyl)- andN-(bromodimethylgermyl-methyl)-N-[(S)-1-phenylethyl] acetamides, were synthesized. Their structures were established by X-ray diffraction analysis. The geometric
characteristics of the trigonal-bipyramidal valence environment about the germanium atoms are compared with those of analogous
enantiomeric silicon compounds and the related five-coordinate germanium compounds. The barriers to permutational isomerization
of the title compounds were determined by dynamic1H NMR spectroscopy. It was found that these barriers are higher than those of the corresponding silicon analogs.
Translated fromIzvestiya Akademii Nauk. Seriya Khimicheskaya, No. 1, pp. 137–144, January, 2000. 相似文献
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Yun-Nan Yan Dan-Yan Lin Wen-Long Pan Xiu-Ling Li Yi-Qian Wan Yu-Liang Mai Hua-Can Song 《Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy》2009,74(1):233-242
Eight 2-(9-phenanthrenyl)-, 2-(9-anthryl)- and 2-(1-pyrenyl)-1-alkyl-benzimidazole compounds, three 2-(9-anthryl)-1-alkylphenanthroimidazole compounds and five 4,5-diphenyl-1-alkyl-2-(9-anthryl)imidazole compounds were synthesized by alkylation reactions of the corresponding benzimidazole, phenanthroimidazole or imidazole compounds. 2-(10-Bromo-9-anthryl)-1-alkyl-benzimidazole compounds were prepared by bromination reaction of 2-(9-anthryl)-1-alkylbenzimidazole compounds. All the synthesized compounds were characterized by elemental analysis, 1H NMR, 13C NMR, MS or HRMS; their absorption coefficients (), maximum absorption λamax, fluorescence emission maximum λem, Stokes shifts and fluorescence quantum yields (ΦF) in ethyl acetate were determined; their fluorescent lifetimes (T1 and T2) were measured in ethyl acetate and in solid state, respectively. The crystal structure of 2-(9-anthryl)-1-n-butyl-4,5-diphenylimidazole (12a) was determined to be triclinic, space group P-1 types, using single crystal X-ray crystallography technique. The results showed that these compounds exhibited moderate fluorescence-emission abilities and higher solubility in most organic solvents than their corresponding starting materials. The relationships between the optical behaviors and structures for these compounds were discussed. 相似文献
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为了寻找高效、安全、经济的除草活性化合物, 设计并合成了9个新的2-[2-(烷氧羰基苯氧羰基)苯氧基]-4,6-二甲氧基嘧啶类化合物, 其化学结构经IR, 1H NMR, LC/MS和元素分析确证. 初步生物活性测定结果表明, 该类化合物在有效成份2250 g/ha剂量时, 对苘麻(Abutilon theophrasti)、稗草(Echinochloa crus-galli)、狗尾草(Setaria viridis)等都具有良好的除草活性, 抑制率达90%以上. 其中5b, 5e, 5h在187.5 g/ha剂量时, 仍具有良好的除草活性, 抑制率达90%以上. 相似文献
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Xing Liu Yalou Wang Guanzhong Wu Jiangchuan Li Xiaoyan Wu 《Frontiers of Chemistry in China》2008,3(1):118-123
Based on the SAR (structure activity relationship) of TZDs (thiazolidinediones), 3-methyl-1-phenyl-2-pyrazoline-5-one was
selected as a substitute for TZD. Compounds of 3-methyl-1-phenyl-4-{4-[(5-methyl-2-phenyloxazol-4-yl)methoxy]benzylene(benzyl)}-2-pyrazol-5-one
were designed and synthesized to find some more hypoglycemic active agents and further investigate the SAR of this class of
compounds. Butanedione monoxime reacted with (substituted) benzaldehyde via cyclization and chlorination to give 4-(chloromethyl)-5-methyl-2-phenyloxazole derivatives, which condensed with 4-hydroxybenzaldehyde
or vanillin, and was followed by the Knoevenagel reaction with 3-methyl-1-phenyl-2-pyrazol-5-one to give compounds Ia-Ih.
Compounds Ia-Ih were hydrogenated with Pd-C to give IIa-IIh, and their hypoglycemic activity was evaluated with a glucose
oxidase kit and insulin load test on normal mice. Sixteen new target compounds were synthesized. All the compounds were characterized
by 1H NMR, IR, MS and elemental analysis. The preliminary pharmacological tests show that the compounds have good hypoglycemic
activity and can enhance the action of insulin, especially Ib, Id and If.
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Translated from Chemical Journal of Chinese Universities, 2007, 28(4): 672–677 [译自: 高等学校化学学报] 相似文献
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6-Triazolylpyridone derivatives were synthesized by coupling 4-(4-methoxyphenyl)-6-(1H-1,2,4-triazol-1-yl)-1-(3-chlorophenyl)pyridin-2(1H)-one with substituted benzenediazonium chlorides in the form of two isomers, which were separated by column chromatography and characterized by 1H and 13C NMR. Following the green approach, solvents were avoided as much as possible. The reaction monitoring was carried out by gas chromatography as well as thin-layer chromatography. The scope and limitation of the method are discussed. The structures of all the compounds have been assigned unambiguously on the basis of elemental analysis, infrared, and NMR spectral data and have been evaluated for antimicrobial and antitubercular activities. 相似文献
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通过3-取代-4-氨基-5-巯基-1,2,4-三唑(3a~3m)和2-溴-2-(1H–1,2,4-三唑-1-基)-4′-氯代苯乙酮(2)的缩合反应, 合成了13个新型3-取代-6-(4-氯苯基)-7-(1H-1,2,4-三唑-1-基)-1',2',4'-三唑[3,4-b]-1",3",4"-噻二嗪衍生物4a~4m. 化合物结构经元素分析, 1H NMR, IR和MS进行了表征. 抗菌试验表明所合成的化合物对细菌表现出中等程度的抑制活性. 相似文献
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Massenspektroskopische Untersuchungen an 2,5-Diaryl-1-(arylimino)-1λ4,2,5-thiadia-zolidin-3,4-dionen
Richard Neidlein Peter Leinberger Alfred Hotzel 《Journal of mass spectrometry : JMS》1977,12(10):628-630
The mass spectra of 2,5-diaryl-1-(arylimino)-1λ4,2,5-thiadiazolidin-3,4-diones have been examined. Some fragmentations are explained by rearrangement of the title compounds to 1,3-(diarylimino)-5-aryl-1λ4,2,5-thioxazolidin-4-ones and 1-oxo-2,5-diaryl-3-(arylimino)-1λ4,2,5-thiadiazolidin-4-ones. 相似文献
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Fifteen new ferrocene derivatives containing 1H‐1,2,4‐triazole moiety were synthesized in various yields by the condensation of ferrocenecarboxaldehyde with 1‐aryl‐3‐(1H‐1,2,4‐triazo‐1‐yl)‐propen‐1‐ones in toluene. Their structures have been confirmed by 1H NMR, IR, MS and elemental analysis. In addition, the crystal structure of 4l was determined. The antifungal and plant growth regulatory activities of the title compounds are discussed. Copyright © 2005 John Wiley & Sons, Ltd. 相似文献
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Liu Meng De-Qing Shi 《Phosphorus, sulfur, and silicon and the related elements》2013,188(9):2314-2323
A series of title compounds 2 were efficiently synthesized via the condensation of 1-phenyl-2-(1H-1,2,4-triazol-1-yl)ethanone oxime with various asymmetric thiophosphoryl chlorides in sodium hydroxide powder and acetonitrile system. The structures of title compounds 2 were confirmed by IR, 1H NMR, 31P NMR, EI-MS, and elemental analysis. The results of preliminary bioassays indicated that the title compounds 2 possessed good to moderate insecticidal activity against aphides at the dosage of 250 mg/L, and some of them exhibited moderate fungicidal activities at the concentration of 100 mg/L. 相似文献
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S. Yu. Bylikin S. A. Pogozhikh V. N. Khrustalev Vad V. Negrebetsky A. G. Shipov Yu. E. Ovchinnikov Yu. I. Baukov 《Russian Chemical Bulletin》1990,49(1):140-147
RacemicN-(chlorodimethylgermylmethyl)-4-phenyl-2-pyrrolidone and the first optically active amide derivatives containing the asymmetrical
carbon atom and the five-coordinate germanium atom,viz.,N-(chlorodimethylgermylmethyl)- andN-(bromodimethylgermyl-methyl)-N-[(S)-1-phenylethyl] acetamides, were synthesized. Their structures were established by X-ray diffraction analysis. The geometric
characteristics of the trigonal-bipyramidal valence environment about the germanium atoms are compared with those of analogous
enantiomeric silicon compounds and the related five-coordinate germanium compounds. The barriers to permutational isomerization
of the title compounds were determined by dynamic1H NMR spectroscopy. It was found that these barriers are higher than those of the corresponding silicon analogs.
Translated fromIzvestiya Akademii Nauk. Seriya Khimicheskaya, No. 1, pp. 137–144, January, 2000. 相似文献
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Gülhan Turan-Zitouni Ahmet Özdemir Zafer Asim Kaplancikli Pierre Chevallet Yagmur Tunali 《Phosphorus, sulfur, and silicon and the related elements》2013,188(12):2717-2724
The increasing clinical importance of drug-resistant fungal and bacterial pathogens has lent additional urgency to microbiological research and new antimicrobial compound development. For this purpose, new pyrazoline derivatives were synthesized and evaluated for antimicrobial activity. Some 1-[(N, N-disubstitutedthiocarbamoylthio)acetyl]-3,5-diaryl-2-pyrazolines derivatives were synthesized by reacting 1-(chloroacetyl)-3,5-diaryl-2-pyrazolines with appropriate potassium salts of secondary amine dithiocarbamic acids. The chemical structures of the compounds were elucidated by IR, 1 H-NMR, and FAB+-MS spectral data. Their antimicrobial activities against Staphylococcus aureus (B-767), Escherichia coli (B-3704), Pseudomonas aeruginosa (ATCC 27853), Proteus vulgaris (NRLL B-123), and Candida albicans (NRRL-27077) were investigated. The results showed that some of the compounds have notable activity against S. aureus and C. albicans. 相似文献