Separation of the alkaloids deoxypeganine,peganol, and deoxyvasicinone by the HPLC method

Institute of Chemistry of Plant Substances Academy of Sciences of the Uzbek SSR, Tashkent. Scientific Center for Chromatography, Academy of Sciences of the Uzbek SSR. Institute of the Chemistry and Physics of Polymers, Academy of Sciences of the Uzbek SSR, Tashkent. Iranslated from Khimiya Prirodnykh Soedinenii, No. 2, pp. 297–298, March–April, 1991.     

4',4”- and 4',5”-di-sec-butyl-2,3:11,12-dibenzo-18-crown-6 — An ionophore for magnesium in natural and model systems

The ionophoric properties of the di-sec-butyl derivatives of dibenzo-18-crown-6 have been studied in natural and model membranes. It has been shown that the di-sec-butyl substituents in the benzene rings of dibenzo-18-crown-6 impart to the cyclopolyether the properties of an ionophore for magnesium. The Mg²⁺/Ca²⁺ selectivity of the cyclopolyether investigated was 4.8 according to results obtained on artifical membranes and mitochondria.Institute of Biochemistry, Academy of Sciences of the Uzbek SSR, Tashkent. Institute of Bioorganic Chemistry, Academy of Sciences of the Uzbek SSR, Tashkent. Translated from Khimiya Prirodnykh Soedinenii, No. 2, pp. 234–239, March–April, 1981.     

Inhibition of transport (Na+, K+)-ATPase by cardenolides of the strophanthidin group and a study of the structure-activity relationship

Summary A comparative study of the inhibiting action on transport (Na⁺,K⁺)-ATPase of 15 derivatives of strophanthidin and four rhamnosides of other aglycones have been made on the microsomal fraction of the cells of the rat cerebral cortex.It has been shown that the method of determining the activity of cardiotonic substances by determining the lethal dose and the enzyme test give completely comparable results. Both biological methods objectively reflect the characteristic features of the chemical structure of the cardenolides.Institute of Biochemistry, Academy of Sciences of the Uzbek SSR, Tashkent. Institute of the Chemistry of Plant Substances, Academy of Sciences of the Uzbek SSR, Tashkent. Translated from Khimiya Prirodnykh Soedinenii, No. 2, pp. 188–194, March–April, 1976.     

Isolation and antibiotic properties of cis-hexadeca-4,7,10,13-tetraenoic acid from the algaScenedesmus obliquus UA-2-6

Summary By the method of checking antibiotic activity, conditions have been selected for the isolation of cis-hexadeca-4,7,10,13-tetraenoic acid from the fatty-acid fractions of the lipids ofScenedesmus obliquus UA-2-6. Its structure has been confirmed and it has been established that this acid possesses a broad spectrum of antibiotic action.Institute of Microbiology, Academy of Sciences of the Uzbek SSR, Tashkent. Institute of the Chemistry of Plant Substances, Academy of Sciences of the Uzbek SSR, Tashkent. Translated from Khimiya Prirodnykh Soedinenii, No. 3, pp. 379–385, May–June, 1978.     

Immunomodulating activity of gossypol derivatives

Information is given on the immunosuppressive activity of a number of gossypol derivatives, and it is shown that practically all the compounds studied are immunotropic. The structural-functional relationship and the dose-dependent nature of the action of the substances obtained are shown.A. S. Sadykov Institute of Bioorganic Chemistry, Uzbek SSR Academy of Sciences, Tashkent. Tashkent State Medical Institute, Uzbek SSR Ministry of Health. Translated from Khimiya Prirodnykh Soedinenii, No. 5, pp. 647–650, September–October, 1988.     

Difference-perturbation spectra of iodotyrosines and iodothyronines in polyethyleneglycols

The difference-perturbation absorption spectra of monoiodotyrosine, diiodotyrosine, triiodothyronine, and thyroxine with low- and high-molecular-mass polyethyleneglycols as perturbants have been measured and characterized. The SDP spectra, and their intensity and the position of the main maximum depend on the number of iodine atoms and the state of ionization of the hydroxyl in accordance with their electron-accepting properties.Institute of Physiology, Uzbek SSR Academy of Sciences, Tashkent. Institute of Biochemistry, Uzbek SSR Academy of Sciences, Tashkent. Translated from Khimiya Prirodnykh Soedinenii, Vol. 6, pp. 840–845, November–December, 1989.     

New derivatives of 18-crown-6 containing a methylindanone fragment in the ring

New derivatives of 18-crown-6 containing a methylindanone fragment in the ring have been obtained by the acylation of dibenzo-18-crown-6 with unsaturated acids in the presence of polyphosphoric acid.Institute of Bioorganic Chemistry, Academy of Sciences of the Uzbek SSR, Tashkent. Translated from Khimiya Prirodnykh Soedinenii, No. 4, pp. 519–522, July–August, 1983.     

Stereospecific analysis of the triacylglycerols of a cottonseed oil hydrogenate and its fractions

A cottonseed oil hydrogenate has been fractionated into three fractions: high-melting, medium-melting, and liquid. It has been established that the fat of the second fraction, because of its physicochemical indices, consistency, and the distribution of the saturated fatty acyl radicals in the extreme positions of the TAG molecules, can be regarded as a cocoa butter substitute.Institute of the Chemistry of Plant Substances of the Uzbek SSR Academy of Sciences, Tashkent. Institute of Bioorganic Chemistry of the Uzbek SSR Academy of Sciences, Tashkent. Translated from Khimiya Prirodnykh Soedinenii, No. 4, pp. 509–513, July–August, 1987.     

Iodine-containing complexes of the Black Sea algaPhyllophora nervosa

Iodine-containing complexes have been isolated from a Black Sea red alga. Information is given showing their carbohydrate nature. The causes of the hydrophobic peptide-peptide interaction in the complex are discussed.Institute of the Chemistry of Plant Substances, Academy of Sciences of the Uzbek SSR, Tashkent. Physicochemical Institute, Academy of Sciences of the Ukrainian SSR, Odessa. Translated from Khimiya Prirodnykh Soedinenii, No. 6, pp. 772–776, November–December, 1983.     

Synthesis and anticholinesterase activites of a number of derivatives of the alkaloid lupinine

A series of new lupinine derivatives and their methiodides has been synthesized. It has been shown that they are powerful reversible inhibitors of acetylcholinesterase and butyrylcholinesterase.A. S. Sadykov Institute of Bioorganic Chemistry, Academy of Sciences of the Uzbek SSR, Tashkent. Translated from Khimiya Prirodnykh Soedinenii, No. 4, pp. 513–515, July–August, 1990.     

Effect of the irradiation of cotton seeds with pulses of concentrated light on the composition of the cottonseed oil

The presowing irradiation of cotton seeds with pulses of concentrated light (PCL) causes a change in a number of indices of the oil. When the seeds are stored, oxidative processes in them are intensified. In the oil of the harvested seeds some indices are restored.Institute of the Chemistry of Plant Substances of the Academy of Sciences of the Uzbek SSR, Tashkent, and S. V. Starodubtsev Institute of Technical Physics of the Academy of Sciences of the Uzbek SSR, Tashkent. Translated from Khimiya Prirodnykh Soedinenii, No. 6, pp. 777–780, November–December, 1980.     

Molecular and crystal structure of sophoridine N-oxide

The spatial structure of natural sophoridine N-oxide has been studied by x-ray structural analysis. It has been shown that when sophoridine is oxidized, rings B and C, which have the boat form, are deformed in the direction of the twist form.Institute of Bioorganic Chemistry of the Academy of Sciences of the Uzbek SSR, Tashkent, Institute of Crystallography of the Academy of Sciences of the USSR, Moscow, and V. I. Lenin Tashkent State University. Translated from Khimiya Prirodnykh Soedinenii, No. 5, pp. 588–596, September–October, 1981.     

Carbohydrates of Aerva lanata

F. N. Rusanov Botanical Garden, Uzbek SSR Academy of Sciences, Tashkent. Institute of Chemistry of Plant Substances, Uzbek SSR Academy of Sciences, Tashkent. Translated from Khimiya Prirodnykh Soedinenii, No. 3, pp. 425–426, May–June, 1989.     

Synthesis, methylation, and acylation of 1,2-dihydrodeoxyvasicinones and their homologs

2,3-Trimethylene- and 2,3-pentamethylene-1,2,3,4-tetrahydro-4-quinazolones and their 6-methyl and 6-bromo derivatives have been obtained by the reduction of deoxyvasicinone and its 6-methyl and 6-bromo derivatives and also their seven-membered homologs at the cycloalkane ring with sodium tetrahydroborate in ethanol. The alkylation and acylation reactions of the above-mentioned reducing compounds have been studied.Institute of Chemistry of Plant Substances, Academy of Sciences of the Uzbek SSR, Tashkent. Translated from Khimiya Prirodnykh Soedinenii, No. 5, pp. 659–663, September–October, 1990.     

Comparative study of the cytotoxins of the venom of the central asian cobraNaja naja oxiana by the intrinsic-fluorescence method

The intrinsic fluorescence of cytotoxin V_C1 and V_C5 from the venom of the Central Asian cobra due to the tyrosine residues and differing with respect to quantum yield for these two polypeptides because of the nonidentity of the microenvironments of the tyrosyl residues has been measured and characterized. The dependence of the quantum yield on the pH and the temperature also indicate this nonidentity.Institute of Bioorganic Chemistry, Academy of Sciences of the Uzbek SSR, Tashkent. Institute of Biochemistry, Academy of Sciences of the Uzbek SSR, Tashkent. Translated from Khimiya Prirodnykh Soedinenii, No. 2, pp. 226–228, March–April, 1986.     

Total synthesis of racemic diptocarpidine and diptocarpiline

Convenient methods for the synthesis of racemic diptocarpidine and racemic diptocarpiline have been proposed on the basis of the readily available 6-phthalimidohexyl bromide and hept-6-enoic acid.Institute of Chemistry, Bashkir Branch, Academy of Sciences of the USSR, Ufa. Institute of the Chemistry of Plant Substances, Academy of Sciences of the Uzbek SSR, Tashkent. Translated from Khimiya Prirodnykh Soedinenii, No. 1, pp. 76–82, January–February, 1988.     

Lipids of kenaf wastes

The total phospholipids of kenaf wastes have been characterized qualitatively and quantitatively. Kenaf wastes may serve as an additional source of raw material for obtaining the total phospholipids and a homogeneous PC.Institute of the Chemistry of Plant Substances, Academy of Sciences of the Uzbek SSR. Uzbek Experimental Station of Tannin Crops, Central Asian Division of the Lenin All-Union Academy of Agricultural Sciences, Tashkent. Translated from Khimiya Prirodnykh Soedinenii, No. 6, pp. 686–688, November–December, 1986.     

X-ray structural investigation of alkaloids. II. Molecular structure and absolute configuration of (?)-pseudokopsinine

Summary By a complete x-ray structural investigation, the structural formula of (–)-pseudokopsinine has been refined and its absolute configuration has been determined.Institute of Heteroorganic Compounds, Academy of Sciences of the USSR, Moscow. Institute of the Chemistry of Plant Substances, Academy of Sciences of the Uzbek SSR, Tashkent. Translated from Khimiya Prirodnykh Soedinenii, No. 2, pp. 197–206, March–April, 1976.     

Total synthesis of the racemic alkaloid diptocarpamine

A route for the synthesis of racemic diptocarpamine from hex-5-enoic acid has been developed.Institute of Chemistry, Bashkir Scientific Center of the Urals Branch, USSR Academy of Sciences, Ufa. Institute of the Chemistry of Plant Substances, Uzbek SSR Academy of Sciences, Tashkent. Translated from Khimiya Prirodnykh Soedinenii, No. 2, pp. 232–236, March–April, 1989.     

Structure of isosophoridine

A complete x-ray study of the structure of a stereoisomer of the alkaloid matrine -isosophoridine - has been made. Rings A and B have the cis type of linkage. Rings A, B, and C have the chair form and D the half-chair form.Institute of Bioorganic Chemistry, Academy of Sciences of The Uzbek SSR, Tashkent Institute Institute of Crystallography, Academy of Sciences of the USSR, Moscow and V. I. Lenin Tashkent State University. Translated from Khimiya Prirodnykh Soedinenii, No. 4, pp. 460–465, July–August, 1981. Original article submitted February 2, 1981.