共查询到20条相似文献,搜索用时 15 毫秒
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I. A. Litvinov V. A. Mamedov O. N. Kataeva 《Chemistry of Heterocyclic Compounds》1994,30(9):1012-1014
X-ray analysis was used to determined the structure of 1-phenyl-2-chloro-3-(m-nitrophenyl)-2,3-epoxypropanone, obtained by reacting phenacyl dihydrochloride with metanitrobenzaldehyde under Darzen's reaction conditions. The bulky m-nitrophenyl and benzoyl substituents were located in the trans position relative to the chloroepoxide fragment, which was found to stabilize when the m-nitrophenyl substituent was introduced.A. E. Arbuzov Institute of Organic and Physical Chemistry, Kazan Scientific Center, Russian Academy of Sciences, Kazan 420083. Translated from Khimiya Geterotsiklicheskikh Soedinennii, No. 9, pp. 1172–1175, September, 1994. Original article submitted May 5, 1994. 相似文献
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2,3-Dichloroquinoxaline and some of its derivatives have been reacted with malononitrile and ethyl cyanoacetate to yield a variety of 3-chloro-2-(cyanomethylene)- 1,2-dihydroquinoxaline derivatives. The reaction of 3-chloro-2-(dicyanomethylene)-1,2- dihydroquinoxaline (2e) with pyridine and its methyl derivatives led to the zwitterionic structures 6a-6c. The structures of the newly synthesized compounds were assigned by spectroscopic data and elemental analyses. 相似文献
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Anica Markovac Ambalal R. Patel Maurice P. MontagneLa Arthur B. Ash 《Journal of heterocyclic chemistry》1977,14(1):147-148
The preparation of 4-(3-nitrophenyl)-2-pieoline (3) was accomplished in one step by the Zecher-Krohnke ring-closure reaction. Compound 3 is the starling material for 2-lormyl-4-(3-arninophenyl)pyridine thiosemicarbazone (4-APPT), a promising antineoplastie agent. 相似文献
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The photoprocesses of nifedipine, a 4-(2-nitrophenyl)-1,4-dihydropyridine, and nimodipine and nitrendipine, two 3-nitrophenyl Hantzsch-type analogues, were studied by steady-state and time-resolved methods. The intramolecular photoreduction of nifedipine into its nitrosophenyl product takes place within a few ns. The quantum yield of conversion is Φred = 0.3 and does not depend significantly on the oxygen concentration and solvent properties. Formation of the fully reduced 4-(2-aminophenyl)-1,4-dihydropyridine as minor product is indicated by fluorescence spectroscopy. The photoreduction of nimodipine and nitrendipine is inefficient, Φred = 0.002 in acetonitrile, but markedly enhanced in the presence of donors such as triethylamine (TEA) and 2-propanol, e.g. for TEA Φred is up to 0.03. The triplet states of nimodipine and nitrendipine were characterized. They react intermolecularly with TEA and 2-propanol, forming radicals as intermediates and eventually several reduction products. 相似文献
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Selective openings of the ring B of the derivative hexapyrroloindol in basic conditions confirm the rearrangement of the tryptophan to aminoarylpyrrol, analogously to the step catalyzed by the enzyme prnB in the biosynthesis of pyrrolnitrin. 相似文献
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M. A. Sibiryakova G. F. Muzychenko T. P. Kosulina K. S. Pushkareva 《Chemistry of Heterocyclic Compounds》2006,42(7):875-881
The interaction has been investigated of 1-(4-nitrophenyl)pyrrolin-2-one with aromatic aldehydes in acetic anhydride in the
presence of catalytic amounts of pyridine. 1-(4-Nitrophenyl)pyrrolinium perchlorate has been synthesized and was put into
a condensation reaction with aromatic aldehydes. As a result 5-arylidene-1-(4-nitrophenyl)pyrrolin-2-onium perchlorates were
obtained.
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 7, pp. 1015–1021, July, 2006. 相似文献
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Liang He Yang Hui Guo Ya Ping Wang Xiang Jing Wang Ji Zhang Wen Sheng Xiang 《中国化学快报》2012,23(5):518-520
A novel and practical synthetic route is presented for the preparation of methyl-(E)-2-(3-(3-(2-(7-chloro-2-quinolinyl)ethenyl) phenyl)-3-oxopropyl)benzoate,the key intermediate of Montelukast,a leukotriene antagonist.The main diarylpropane framework was prepared via a polarity conversation reaction resulting in an acyl anion equivalent followed by a nucleophilic substitution reaction.The overall yield of this approach was 61%.This method is simple for operation and suitable for industrial production. 相似文献
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Xu Qin Li Yun Xu Yang Wei Li Wang Bin Hu Hui Min Xue Tian Yi Zhang Xue Tao Zhang 《中国化学快报》2011,22(7):765-767
A practical chemical synthesis of L-carmtine(1) has been accomplished from(R)-3-chloro-1,2-propanediol((R)-4),which is a main by-product originated from(R,R)-Salen Co(Ⅲ) catalyzed hydrolytic kinetic resolution(HKR) of(±)-epichlorohydrin.(R)-4 was utilized as a chiral starting material to prepare the key intermediate cyclic sulfite((R)-S).The new synthetic approach demonstrated an efficient utilization of organic by-product for the asymmetric synthesis of bioactive compounds. 相似文献
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N. N. Kolos V. D. Orlov D. Arisa O. V. Shishkin Yu. T. Struchkov N. P. Vorob'eva 《Chemistry of Heterocyclic Compounds》1996,32(1):78-85
By the reaction of 4-nitro-1,2 phenylenediamine with 1-(p-R-phenyl)-3-(4-nitrophenyl)propenones, Michael adducts with a 1:2 composition have been obtained. A stagewise scheme is proposed for the formation of these compounds. The structure of one of the products has been established by means of x-ray structure analysis.Deceased 相似文献
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Vashkevich E. V. Potkin V. I. Kozlov N. G. Skakovskii E. D. 《Russian Journal of Organic Chemistry》2003,39(11):1587-1592
By reaction of Z-3-(2-naphthyl)-3-chloro-2-propenal and aromatic amines 1-(2-naphthyl)-3-iminoaryl-1-propenylarylamines were prepared which at heating in the glacial acetic acid afforded the corresponding 2-(2-naphthyl)quinolines. 相似文献
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Benzo- and pyridoannulated 1,2-dithiole-3-thiones react with compounds containing an activated methyl group such as 1-methyl-3,4-dihydropyrrolo[1,2-a]pyrazine and 2-methylpyridines to furnish substituted 1,2-dithiol-3-ylidenes. 相似文献