New Polyphenols and Triterpene from the Pseudobulbs of Pleione Formosana

Three new polyphenolic compounds including a dihydrophenanthrene, pleioanthrenin ( 1 ), two bibenzyls, pleiobibenzynin A ( 2 ) and B ( 3 ), and a new cycloartane triterpenoid, (24R)‐cyclomargenyl p‐coumarate ( 4 ), together with eight known compounds, were isolated from the pseudobulbs of Pleione formosana. The structures of the new compounds were elucidated by extensively spectroscopic analysis.     

Constituents from Rubia Ustulata Diels and R. Yunnanensis Diels and Their Antiplatelet Aggregation Activity

A new anthraquinone glycoside, rubiayannone‐A ( 1 ), and a new coumarin, rubilatin‐A ( 2 ), together with twenty‐two known compounds were isolated and characterized from the roots of Rubia ustulata. A new anthraquinone, 2‐carbomethoxyanthraquinone ( 3 ), and rubiayannone‐A, 2‐formylanthraquinone were obtained from the roots of R. yunnanensis. The structures of those compounds were elucidated by spectroscopic methods. The antiplatelet aggregation activity of the isolated compounds 1, 4～6 were also discussed.     

Three New Polyoxygenated Steroids from Two Species of the South China Sea Gorgonian Muricella flexuosa and Menella verrucosa Brundin

Three new polyoxygenated steroids, muricesteroid ( 1 ), and menellsteroids A ( 2 ) and B ( 3 ), were isolated from two species of the South China Sea gorgonian Muricella flexuosa and Menella verrucosa Brundin , respectively. The structures of these new compounds were elucidated on the basis of extensive spectroscopic analysis, chemical methods and comparison with known related compounds.     

Phenolic Compounds from Scorzonera tomentosa L.

From the subaerial parts of S. tomentosa L. (Asteraceae), two new dihydroisocoumarins, compounds 1 and 2 , a new phthalide, 3 , and a new stilbene derivative, 4 , were isolated, together with four known compounds, (±)‐hydrangenol ( 5 ), (?)‐hydrangenol 4′‐O‐β‐glucoside ( 6 ), (±)‐hydramacrophyllol A ( 7 ), and (±)‐hydramacrophyllol B ( 8 ). All secondary metabolites were identified on the basis of physicochemical, spectroscopic, and mass‐spectrometric data. The known compounds 5 – 8 were isolated for the first time from this species.     

Cytotoxic Constituents from the Stem Bark of Zanthoxylum Pistaciiflorum

Two new esters, methyl 4‐(prenyloxy)dihydrocinnamate and methyl 4‐(geranyloxy)dihydrocinnamate, together with fourteen known compounds have been isolated from the stem bark of Zanthoxylum pistaciiflorum. The structures of two new compounds were determined through spectral analyses. Among the isolates, four compounds exhibited effective cytotoxicities against P‐388 and HT‐29 cell lines in vitro.     

Three new 3,4-seco-cycloartane triterpenes from Gardenia sootepensis

The plants in the genus Gardenia (Rubiaceae) have long been used as traditional medicines in China. In this study, two new 3,4-seco-cycloartane triterpenes, sootepin J (1) and sootepin K (2), and a novel nor-3,4-seco-cycloartane triterpenes, sootepin L (3), together with two known compounds (4–5), were isolated from the methanolic extract of the leaves and twigs of Gardenia sootepensis. The structures of the new compounds were elucidated by combinations of 1D, 2D NMR experiments and HR-MS data, while the known compounds were identified by comparison of the NMR data with previously published data.     

Two New Pseudoguaianolides from the Flowers of Parthenium hysterophorus

Chemical investigation on two samples of the flowers of Parthenium hysterophorus afforded two new pseudoguaianolides (one from each sample) together with several known constituents. The structures of the new compounds were established by extensive spectroscopic (1D‐ and 2D‐NMR) studies. The X‐ray crystallographic analysis of one of these compounds was also accomplished.     

Terpenoids from Loxocalyx urticifolius

Two new diterpenoids, loxocalyxin A ( 1 ) and 13‐epiloxocalyxin A ( 2 ), and two new sesquiterpenoids, loxocalyxins B and C ( 3 and 4 , resp.), together with three known compounds, were isolated from the MeOH extract of the whole plant of Loxocalyx urticifolius Hemsl . The structures of the new compounds were established by means of spectroscopic analysis including one‐ and two‐dimensional NMR spectroscopy. All new structures were confirmed by X‐ray crystallographic analysis. Their absolute configurations were established.     

Two New Diterpenes from Solidago canadensis

Two new clerodane‐type diterpenes, solidagocanins A and B ( 1 and 2 , resp.), as well as two known compounds, mellein ( 3 ) and physcion ( 4 ), were isolated from the aerial parts of Solidago canadensis. The structures of the new compounds were elucidated by spectroscopic analyses, including 2D‐NMR techniques.     

Chemical Constituents from the Leaves of Litsea Acutivena

Continuous investigation of the CHCl₃‐soluble and n‐hexane fractions of the leaves of Litsea acutivena Hayata (Lauraceae) led to the isolation of one new butanolide, acutilactone ( 1 ), one new lactone, 4‐nonacosyl‐dihydrofuran‐2‐one ( 2 ), together with 15 known compounds. The known compounds included one butanolide, one norisoprenoid, one quinone, two steroids, one triterpenoid, one coumarin, two fatty acids, one amide, and five other compounds. The structures of these compounds were determined by means of spectral analyses.     

New Anthraquinone and Iridoid Glycosides from the Stems of Hedyotis hedyotidea

Five new anthraquinone glycosides, hedanthrosides A–E ( 1 – 5 , resp.) and two new iridoid glycosides, hediridosides A and B ( 6 and 7 , resp.), along with two known anthraquinones and four known iridoids, were isolated from the stems of Hedyotis hedyotidea (DC.) Merr . The structures of the new compounds were elucidated on the basis of 1D‐ and 2D‐NMR, and HR‐MS analysis and chemical methods.     

Chisiamols A-F,Triterpenoids from Chisocheton siamensis

Six new apotirucallane‐type triterpenoids, chisiamols A – F ( 1 – 6 ), along with two known compounds, were isolated from the twigs of Chisocheton siamensis. The structures of compounds 1 – 6 were established on the basis of spectroscopic and chemical methods.     

Chemical Constituents from the Root Bark of Rodgersia Sambucifolia

A new demethylacetovanillochromene glycoside, 2,2‐dimethyl‐2H‐(8‐hydroxy‐6‐acetyl)‐[2,3‐b] pyran‐8‐O‐β‐D‐apiofuranosyl‐(1 →6)‐β‐D‐glucopyranoside ( 1 ), together with twenty‐three known compounds, have been isolated from the root bark of Rodgersia sambucifolia. These known compounds include two diterpenoids, three flavonoids, two catechins, four lignans, two benzenoids, two isocoumarins, two steroids and six monoterpene glycosides, which were determined by means of spectral analyses.     

Benzofuran Derivatives from Gerbera saxatilis

Three new substituted 2,3‐dihydro‐1‐benzofuran derivatives, compounds 1 – 3 , were isolated from two extracts of Gerbera saxatilis, together with twelve known constituents. The structures of the new compounds were established by means of detailed spectroscopic analysis and by comparison of analytical data with those reported for structurally related compounds.     

A new triterpenoid saponin and a diterpene glucoside from the seeds of Orychophragmus violaceus

One new triterpenoid saponin orychoside A (1) and one new diterpene glucoside orychoside B (12), together with eleven known compounds, were isolated from the seeds of Orychophragmus violaceus. The structures of the new compounds were elucidated on the basis of spectroscopic analysis. The known compounds were identified by comparison with data reported in the literature. All compounds were tested for their cytotoxic activities against the HepG2 and A549 cell lines in vitro. The new compound 1 exhibited potent cytotoxicity against the two cell lines with IC₅₀ values of 7.13 and 8.77 μM, respectively. Compounds 2, 5, 8 and 9 were found to possess obvious cytotoxicity.     

Chemical Constituents from the Root Bark of Formosan Zanthoxylum Ailanthoides

Two new N‐isobutylamides, hydroxy lanyuamide I ( 1 ) and hydroxy lanyuamide II ( 2 ), together with one hundred and ten known compounds, have been isolated from the root bark of Formosan Zanthoxylum ailanthoides. These known compounds include twenty coumarins, twenty‐one benzo[c]phenanthridines, ten quinoline derivatives, one aporphine, one purine, seven amides, twelve benzenoids, one lactone, four flavonoids, nine lignans, eight steroids, two chlorophylls, eleven terpenoids and three other compounds, which were determined by means of spectral analyses.     

Dihydrobenzofuran Norlignans from the Leaves of Cedrela sinensis A. Juss

Two new norlignans, cedralins A ( 1 ) and B ( 2 ), were isolated from the leaves of Cedrela sinensis. Their structures were established by extensive spectroscopic studies and chemical evidence. The absolute configurations of these compounds were determined by comparing their CD spectra with those of known compounds. In addition, their in vitro cytotoxic activity against two human‐cancer cell lines was evaluated.     

Two New Bis‐alkaloids from the Aerial Part of Piper flaviflorum

Two new bis‐alkaloids, flavifloramides A ( 1 ) and B ( 2 ), as well as two known alkaloids, N‐trans‐feruloyltyramine ( 3 ) and paprazine ( 4 ), were isolated from the aerial part of Piper flaviflorum. The structures of the new compounds were elucidated by spectroscopic analyses, including 2D‐NMR techniques.     

New Oligosaccharide Esters and Xanthone C‐Glucosides from Polygala telephioides

Three new oligosaccharide esters named telephioses D ( 4 ), E ( 5 ), and F ( 6 ), and two new xanthone C‐glucosides, telephioxanthones A ( 7 ) and B ( 8 ), together with five known oligosaccharide esters and mangiferin, were isolated from the whole plant of Polygala telephioides Willd . The structures of the new compounds were elucidated on the basis of spectral data.     

Nepetanal and nepetanoate: a new diterpene aldehyde and a benzene derivative ester from Nepeta juncea

One new tricyclic clerodane type diterpene aldehyde nepetanal (1) and one new benzene derivative nepetanoate (2) have been isolated from a plant Nepeta juncea together with two known compounds oleanolic acid (3) and ursolic acid (4). The structures of the isolated compounds were elucidated by means of modern spectroscopic techniques and comparison with literature data. Copyright © 2009 John Wiley & Sons, Ltd.