药物对福氏志贺氏菌代谢抑制的微量热法研究

药物抑制细菌生长的热化学研究是当今热化学法研究的一个活跃领域．在这项研究中，Boling[1]、Nordmark[2]、屈松生[3]等人已做了不少有意义的工作．在前人工作的基础上，我们用热活性检测系统测定了福氏志贺氏菌属中五株细菌在药物抑制下生长的完整的热谱曲线．按指数生长模型计算出细菌代谢抑制下的生长速车常数，并用计算机拟会出生长速率常数与不同浓度药物之间的关系式，进一步得到生长速率常数为零（临界生长参数[4]）时的用药物浓度．此项研究工作的开展对于深入研究药物对细菌的抑制作用，筛选对某细菌抑制的特效药提供了一种新的…     

微量量热法研究淀粉酶催化反应

酶催化水解反应;热动力学;微量量热法研究淀粉酶催化反应     

2－杂萘满并喹啉的合成及抑菌活性的微量量热法研究

２－杂萘满并喹啉的合成及抑菌活性的微量量热法研究刘永军，丁养军，刘英（曲阜师范大学化学系曲阜２７３１６５）关键词２－杂萘满酮，抑菌活性，微量量热２－杂萘满酮具有（Ｉ）所示的化学结构，最常见的杂原子为Ｏ、Ｓ、Ｎ，关于Ｓｅ原子报道不多，分别俗称异色满酮、...     

微量量热法研究肌动蛋白的聚合及顺铂的影响

肌动蛋白（actin）是细胞微丝系统的结构蛋白·单体G一肌动蛋白与聚合产物F一肌动蛋白间的相互转变与细胞的运动、形态和信息传递相关＊．实际上，微丝系统处在一个动态平衡状态．即G和F不断相互转换以适应细胞功能要求．在外源性物质影响下，这个动态平衡可能被影响而产生相应的药理、毒理作用．罗世荣等问报导在荧光显微镜下观察到，顺铂（抗癌药）及其类似物会诱导微丝的重组和解聚．但机理有待研究·目前虽然有许多方法被用来研究肌动蛋白的聚合过程问，但对聚合全过程的确切描述尚无充分的实验数据，对聚合热动力学过程的研究至今尚…     

微量热法研究PCMB对精氨酸酶的抑制作用

利用微量热法研究了对－氯汞苯甲酸（ＰＣＭＢ）对精氨酸的酶促水解反应的抑制作用，确定它于竞争性不可逆抑制剂，在２９８．１５Ｋ和ＰＨ为９．４时ＰＣＭＢ与精氨酸酶作用的二级速度常数ｋ＋０＝９２．１７Ｌ／（ｍｏｌ．ｓ）。同时用ＰＣＭＢ作为修饰剂探讨了精氨酸酶的活性中心性质，推测该水解酶至多含有３个与酶活性有关的半胱氨酸残基，但主些残基不属于精氨酸酶的活性中心。     

流动微量量热法测量油砂的比表面积

目前固体比表面积的测定主要是通过测量吸附到固体表面的吸附质的量来实现的。当固体表面积很小时；因为吸附量少，不易测准，精密度差。Groszek用流动微量量热法测量了一些不同种类的固体的比表面积，并与其它方法的数据比较，证明量热法数据可靠、且精密度     

微量吸附量热法研究氧化物催化剂的酸碱性质

利用微量吸附量热技术定量地表征了Eu₂O₃、CeO₂、MgO、ZnO、Al₂O₃和NiO等氧化物表面酸碱中心的强度和数量,结果表明,样品的NH₃和CO₂起始吸附热与其Sanderson电负性相关.     

MgFeO氧化物催化剂酸碱性质的微量吸附量热研究

ＭｇＦｅＯ氧化物催化剂酸碱性质的微量吸附量热研究屠迈，沈俭一，陈懿（南京大学化学化工学院，２１００９３）全面描述固体酸碱催化剂表面酸碱性质应当包括测定酸碱中心的类型（即Ｂ型和Ｌ型）、强度和数量或强度分布，这些性质与其催化性能有密切的联系。从固体表面吸...     

微生物最适生长酸度的微量热法研究

The bacterial growth thermogram curves under different acidities were determined. From these thermogram curves, the growth rate constants(k) at different acidities were calculated and the equation correlating of k with PH could be established. From these k-pH equations,the optimum acidity of bacteria growth could be obtained. These models provide a good method for the study of the metabolism of bacteria.     

B-P-O系催化剂表面酸性的吸附量热研究

制备了不同P／B比的W-P-O系催化剂，XRD和Raman光谱表明各样品中P和B都处于四面体结构中，但Raman光谱显示P／B＜1的样品表面有B的三配位物相B2O3。存在．用吸附量热法考察了NH3、H2O及二甲醚（DME）等探针分子的吸附行为，研究了样品的表面酸性，NH3在P／B＞1的样品上发生解离吸附，而在P／B＜1的样品上，其起始吸附热与在γ-Al2O3上的相似．进一步的研究表明，二甲醚可以作为合适的探针分子表征B-P-O系催化剂的表面酸性．     

Microcalorimetric Study of the Screening Specific Promoter Bacteria of Nutrient Drug

The power vs. time curves of the promoter bacteria of a nutrient drug were determined by using a 2277 Thermal Activity Monitor (Sweden). A new experimental model of bacterial growth were established. The growth rate constant, heat output and optimum concentration of specific promoter bacterial of nutrient drug were calculated.This revised version was published online in November 2005 with corrections to the Cover Date.     

Study of a Biological Oscillation System by a Microcalorimetric Method

The power–time curves of a biological oscillation system were determined for different temperatures, acidities and carbon sources, by using a 2277 thermal activity monitor. The apparent activation energy and order of the oscillation reaction were calculated from the induction period (t _in) and the first oscillation period (t _p). The regularity of the biological oscillation system is discussed. This revised version was published online in July 2006 with corrections to the Cover Date.     

黄芪促菌作用的微量热法研究

黄芪促菌作用的微量热法研究李志萍，杭瑚，陆懋荪于秀芳，张洪林袁久荣（青岛大学化学系青岛２６６０７１）（曲阜师范大学化学系曲阜）（山东中医学院中药系济南）关键词黄芪，促菌作用，量热法前文［１～３］已报道合成药物及中草药黄连对细菌生长的抑制作用。本文研究...     

微量热法测定细菌的临界生长温度

In this paper, we have determined the multiplication rate constanis (k) of Shigella flexneri and E. coli. at different temperatures and in different culture media by means of a microcalorimeter. From these results a linear equation as k~(1/2)=a+bT can be established for the bacterial growth. The corresponding linear equation for S. flexneri is k~(1/2)=-1.2823+0.0047122 T(r=0.971), so its eritica lgrowth temperature T_0 is equal to 272.1 K. The linear equation for E coli is k~(1/2)=-1.6390+0.005948 T (r=0.994), T_0=275.5 K. The experimental results indicate that the critial growth temperature of E. coli. is nearly a constant (T_0=273.9 K) in different culture media, which is very informative for the study on microorganism growth.     

化学药物(复杂有机物)系统命名的步骤与方法

理解并掌握药物化学名是药学专业学生和药师在药物化学学习和药学服务工作中经常遇到的难题。本文在广泛查阅文献资料的基础上系统、详细地总结化学药物系统命名的步骤和方法,同时对《有机化合物命名原则(2017)》与《有机化学命名原则(1980)》进行对比,并结合2个代表药进行解释说明。该步骤和方法具有系统、详细的特点,对药学专业学生和药师理解并掌握药物化学名具有较大的帮助作用。     

A Microcalorimetric Study of Water Vapor Sorption on Morphine Sulphate

Water vapor sorption on morphine sulphate was studied in a twin double sorption microcalorimeter at 25°C. The vapor sorption isotherm and the differential heats of sorption were determined simultaneously from dry condition to a water activity of 0.99. Two well resolved hydration steps were obtained on the sorption isotherm at water activities of 0.01 and 0.22 corresponding to the formation of dihydrate and pentahydrate of morphine sulphate. They were accompanied by constant values of the differential heats of sorption: –24 kJ mol^–1(H₂O) for the dihydrate formation and –10 kJ mol^–1(H₂O) for the pentahydrate formation.The calorimetrically obtained sorption isotherms were compared with the results of Karl Fisher titrations of morphine sulphate samples equilibrated at different water activities. The appearance of a liquid phase in the morphine sulphate at high water activities is discussed on the basis of the obtained differential heats of sorption and measured heat capacities of morphine sulphate at different water activities.This revised version was published online in November 2005 with corrections to the Cover Date.