Exact Results for Topological Strings on Resolved <Emphasis Type="Italic">Y</Emphasis><Superscript><Emphasis Type="Italic"> p</Emphasis>,<Emphasis Type="Italic">q</Emphasis></Superscript> Singularities

We obtain exact results in α′ for open and closed A-model topological string amplitudes on a large class of toric Calabi-Yau threefolds by using their correspondence with five dimensional gauge theories. The toric Calabi-Yaus that we analyze are obtained as minimal resolution of cones over Y ^p,q manifolds and give rise via M-theory compactification to SU(p) gauge theories on . As an application we present a detailed study of the local case and compute open and closed genus zero Gromov-Witten invariants of the orbifold. We also display the modular structure of the topological wave function and give predictions for higher genus amplitudes. The mirror curve in this case is the spectral curve of the relativistic A ₁ Toda chain. Our results also indicate the existence of a wider class of relativistic integrable systems associated to generic Y ^p,q geometries.     

An over-expression system for characterizing <Emphasis Type="Italic">Ppt1</Emphasis> function in <Emphasis Type="Italic">Drosophila</Emphasis>

Background  

The infantile onset form of Neuronal Ceroid Lipofuscinoses (INCL) is the earliest and most severe form of NCL, with neurological symptoms that reflect massive neurodegeneration in the CNS and retina. INCL is due to recessively inherited mutations at the CLN1 locus. This locus encodes the evolutionarily conserved enzyme palmitoyl-protein thioesterase 1 (PPT1), indicating an essential role for protein palmitoylation in normal neuronal function.     

Differentiating the Absolutely Continuous Invariant Measure of an Interval Map <Emphasis Type="Italic">f</Emphasis> with Respect to <Emphasis Type="Italic">f</Emphasis>

Let the map f:[−1,1]→[−1,1] have a.c.i.m. ρ (absolutely continuous f-invariant measure with respect to Lebesgue). Let δρ be the change of ρ corresponding to a perturbation X=δf○f⁻¹ of f. Formally we have, for differentiable A,but this expression does not converge in general. For f real-analytic and Markovian in the sense of covering (−1,1) m times, and assuming an analytic expanding condition, we show thatis meromorphic in C, and has no pole at λ=1. We can thus formally write δρ(A)=Ψ(1).     

<Emphasis Type="Italic">lin-12</Emphasis> Notch functions in the adult nervous system of <Emphasis Type="Italic">C. elegans</Emphasis>

Background  

Notch signaling pathways are conserved across species and traditionally have been implicated in cell fate determination during embryonic development. Notch signaling components are also expressed postdevelopmentally in the brains of adult mice and Drosophila. Recent studies suggest that Notch signaling may play a role in the physiological, rather than developmental, regulation of neurons. Here, we investigate a new non-developmental role for Caenorhabditis elegans lin-12 Notch signaling in neurons regulating the spontaneous reversal rate during locomotion.     

Study of <Emphasis Type="Italic">N</Emphasis> = <Emphasis Type="Italic">Z</Emphasis> nuclei in variation-after-projection framework

Variation-after-projection (VAP) calculations in conjunction with the Hartree- Bogoliubov (HB) ansatz have been carried out for A = 68-88, N = Z nuclei. In this framework, the yrast spectra with , B(E2) transition probabilities and deformation parameter ( ) have been obtained. A pairing interaction for like particles as well as protons and neutrons has been included in the model for a two-body interaction.Received: 28 April 2003, Revised: 20 March 2004, Published online: 14 September 2004PACS: 21.10.-k Properties of nuclei; nuclear energy levels - 21.60.-n Nuclear structure models and methods - 27.50. + e      

<Emphasis Type="Italic">parkin</Emphasis> counteracts symptoms in a <Emphasis Type="Italic">Drosophila</Emphasis> model of Parkinson's disease

Background

Parkinson's disease, a prevalent neurodegenerative disease, is characterized by the reduction of dopaminergic neurons resulting in the loss of motor control, resting tremor, the formation of neuronal inclusions and ultimately premature death. Two inherited forms of PD have been linked to mutations in the α-synuclein and parkin genes. The parkin protein functions as an ubiquitin ligase targeting specific proteins for degradation. Expression of human α-synuclein in Drosophila neurons recapitulates the loss of motor control, the development of neuronal inclusions, degeneration of dopaminergic neurons and the ommatidial array to provide an excellent genetic model of PD.

Results

To investigate the role of parkin, we have generated transgenic Drosophila that conditionally express parkin under the control of the yeast UAS enhancer. While expression of parkin has little consequence, co-expression of parkin with α-synuclein in the dopaminergic neurons suppresses the α-synuclein-induced premature loss of climbing ability. In addition directed expression of parkin in the eye counteracts the α-synuclein-induced degeneration of the ommatidial array. These results show that parkin suppresses the PD-like symptoms observed in the α-synuclein-dependent Drosophila model of PD.

Conclusion

The highly conserved parkin E3 ubiquitin ligase can suppress the damaging effects of human α-synuclein. These results are consistent with a role for parkin in targeting α-synuclein to the proteasome. If this relationship is conserved in humans, this suggests that up-regulation of parkin should suppress α-synucleinopathic PD. The development of therapies that regulate parkin activity may be crucial in the treatment of PD.

     

<Emphasis Type="Italic">K</Emphasis><Subscript><Emphasis Type="Italic">e</Emphasis>3</Subscript> decays and CKM unitarity

We present a detailed numerical study of the K_e3 decays to in chiral perturbation theory with virtual photons and leptons. We describe the extraction of the CKM matrix element |V_us| from the experimental K_e3 decay parameters. We propose a consistency check of the K ⁺ _e3 and K⁰_e3 data that is largely insensitive to the dominating theoretical uncertainties, in particular the contributions of . Our analysis is highly relevant in view of the recent high statistics measurement of the K ⁺ _e3 branching ratio by E865 at Brookhaven which does not indicate any significant deviation from CKM unitarity but rather a discrepancy with the present K⁰_e3 data.Received: 22 January 2004, Published online: 30 April 2004Work supported in part by IHP-RTN, Contract No. HPRN-CT2002-00311 (EURIDICE) and by Acciones Integradas, Project No. 19/2003 (Austria), HU2002-0044 (MCYT, Spain)     

Measurement of high-<Emphasis Type="Italic">Q</Emphasis><Superscript>2</Superscript> charged current cross sections in <Emphasis Type="Italic">e</Emphasis><Superscript> + </Superscript><Emphasis Type="Italic">p</Emphasis> deep inelastic scattering at HERA

Cross sections for e ⁺ p charged current deep inelastic scattering at a centre-of-mass energy of have been determined with an integrated luminosity of collected with the ZEUS detector at HERA. The differential cross sections , and for are presented. In addition, has been measured in the kinematic range and . The predictions of the Standard Model agree well with the measured cross sections. The mass of the W boson propagator is determined to be from a fit to . The chiral structure of the Standard Model is also investigated in terms of the (1-y)² dependence of the double-differential cross section. The structure-function has been extracted by combining the measurements presented here with previous ZEUS results from e ^- p scattering, extending the measurement obtained in a neutrino-nucleus scattering experiment to a significantly higher Q ² region.Received: 17 July 2003, Published online: 12 November 2003 ^a supported by the Natural Sciences and Engineering Research Council of Canada (NSERC) ^b supported by the German Federal Ministry for Education and Research (BMBF), under contract numbers HZ1GUA 2, HZ1GUB 0, HZ1PDA 5, HZ1VFA 5 ^c supported by the MINERVA Gesellschaft für Forschung GmbH, the Israel Science Foundation, the U.S.-Israel Binational Science Foundation and the Benozyio Center for High Energy Physics ^d supported by the German-Israeli Foundation and the Israel Science Foundation ^e supported by the Italian National Institute for Nuclear Physics (INFN) ^f supported by the Japanese Ministry of Education, Culture, Sports, Science and Technology (MEXT) and its grants for Scientific Research ^g supported by the Korean Ministry of Education and Korea Science and Engineering Foundation ^h supported by the Netherlands Foundation for Research on Matter (FOM) ⁱ supported by the Polish State Committee for Scientific Research, grant no. 620/E-77/SPUB-M/DESY/P-03/DZ 247/2000-2002 ^j partially supported by the German Federal Ministry for Education and Research (BMBF) ^k supported by the Fund for Fundamental Research of Russian Ministry for Science and Education and by the German Federal Ministry for Education and Research (BMBF) ^l supported by the Spanish Ministry of Education and Science through funds provided by CICYT ^m supported by the Particle Physics and Astronomy Research Council, UK ⁿ supported by the US Department of Energy ^o supported by the US National Science Foundation ^p supported by the Polish State Committee for Scientific Research, grant no. 112/E-356/SPUB-M/DESY/P-03/DZ 301/2000-2002, 2 P03B 13922 ^q supported by the Polish State Committee for Scientific Research, grant no. 115/E-343/SPUB-M/DESY/P-03/DZ 121/2001-2002, 2 P03B 07022     

Conformational analysis of <Emphasis Type="Italic">o</Emphasis>-allylphenol by density functional and IR spectroscopy methods

The two-dimensional cyclic potential energy surfaces for internal rotation of the allyl substituent and its vinyl fragment in o-allylphenol (o-APh) depending on the OH group orientation relative to the allyl substituent were constructed by a B3LYP/6-31G method. It is shown that o-APh exists in the gas phase as a mixture of eight non-planar rotamers (A, B, C, D, E, F, G, and H) and their eight optical isomers (A ₁, B ₁, C ₁, D ₁, E ₁, F ₁, G ₁, and H ₁). An intramolecular H-bond (IHB) O–H...π occurs only in four rotamers (A, B, A ₁, and B ₁). The content of such rotamers in the gas phase is 47.2% (as calculated by the B3LYP/cc-pVTZ method). Taking into account the solvation effect in the polarizable continuum model (PCM) for a solution of o-APh in cyclohexane decreases the total content of rotamers with an IHB (A and B) to 37.7%. The ratio of rotamers with OH groups bonded by an IHB and with free OH groups that is predicted theoretically agrees with the value measured experimentally from IR spectra of o-APH in CCl₄ solution.     

Surface superconductivity and<Emphasis Type="Italic">H</Emphasis><Subscript><Emphasis Type="Italic">c3</Emphasis></Subscript> in UPt<Subscript>3</Subscript>

Ginzburg-Landau (GL) theory is used to study surface superconductivity for UPt₃ for various order parameter symmetries (OPS), andH _c3 is found for all principal directions of the surface normal\(\hat n\) and the field [1]. Assuming specular reflection, and allowing for reorientation of the antiferromagnetic symmetry breaking field in the models withE _1g ,E _2g ,E _1u , orE _2u symmetry, the experiments of Keller et al. [2] with\(\hat n = \hat a\) can be qualitatively explained for all OPS except possiblyA _1u ⊕B _1u . The implied GL parameters then predict qualitatively different and OPS dependent behavior for\(\hat n = \hat a^* \) and\(\hat n = \hat c\). Study ofH _c3 for these surfaces would give strong clues about the OPS of UPt₃.     

<Emphasis Type="Italic">SU</Emphasis>(3)-Instantons and <Emphasis Type="Italic">G</Emphasis><Subscript>2</Subscript>,<Emphasis Type="Italic">Spin</Emphasis>(7)-Heterotic String Solitons

Necessary and sufficient conditions to the existence of a hermitian connection with totally skew-symmetric torsion and holonomy contained in SU(3) are given. A formula for the Riemannian scalar curvature is obtained. Non-compact solution to the supergravity-type I equations of motion with non-zero flux and non-constant dilaton is found in dimension 6. Non-conformally flat non-compact solutions to the supergravity-type I equations of motion with non-zero flux and non-constant dilaton are found in dimensions 7 and 8. A Riemannian metric with holonomy contained in G₂ arises from our considerations and Hitchin’s flow equations, which seems to be new. Compact examples of SU(3),G₂ and Spin(7) instanton satisfying the anomaly cancellation conditions are presented.     

The Representation of Isometric Operators on <Emphasis Type="Italic">C</Emphasis><Superscript>(1)</Superscript>(<Emphasis Type="Italic">X</Emphasis>)

In this paper,we introduce a new norm on C ⁽¹⁾(X), which is induced by a hexagon on R ², and prove that every isometric operator on C ⁽¹⁾(X) can be induced by a homeomorphism of X, where X is a connected subset of R.     

<Emphasis Type="Italic">X</Emphasis>(3872) and other possible heavy molecular states

We perform a systematic study of the possible molecular states composed of a pair of heavy mesons such as , , in the framework of the meson exchange model. The exchanged mesons include the pseudoscalar, scalar and vector mesons. Through our investigation, we find the following results. (1) The structure X(3764) is not a molecular state. (2) There exists strong attraction in the range r<1 fm for the system with J=0,1. If future experiments confirm Z ⁺(4051) as a loosely bound molecular state, its quantum number is probably J ^P =0⁺. Its partner state Φ ^**0 may be searched for in the π ⁰ χ _c1 channel. (3) Vector meson exchange provides strong attraction in the channel together with pion exchange. A bound state solution may exist with a reasonable cutoff parameter Λ∼1.4 GeV. X(3872) may be accommodated as a molecular state dynamically although drawing a very definite conclusion needs further investigation. (4) The molecular state may exist.     

Reconstruction of some cosmological models in <Emphasis Type="Italic">f</Emphasis>(<Emphasis Type="Italic">R</Emphasis>,<Emphasis Type="Italic">T</Emphasis>) cosmology

In this paper, we reconstruct cosmological models in the framework of f(R,T) gravity, where R is the Ricci scalar and T is the trace of the stress-energy tensor. We show that the dust fluid reproduces ΛCDM, phantom–non-phantom era and phantom cosmology. Further, we reconstruct different cosmological models, including the Chaplygin gas, and scalar field with some specific forms of f(R,T). Our numerical simulation for the Hubble parameter shows good agreement with the BAO observational data for low redshifts, z<2.     

Jet production in <Emphasis Type="Italic">pA</Emphasis> and <Emphasis Type="Italic">AA</Emphasis> collisions in the perturbative QCD pomeron model

Inclusive cross-sections for gluon jet production are studied numerically in the perturbative QCD pomeron model for pA and central AA collisions at high energies. Two forms for the inclusive cross-sections, with and without emission from the triple pomeron vertex, are compared. The difference was found to reduce to a numerical factor for momenta below the saturation momentum Q _s. Above Q _s no difference was found at all. For pA collisions the gluon spectrum was found to be at momenta k below Q _s and above it. For central AA collisions it was found to be at momenta k below Q _s and above it. At large k the spectrum goes like , flattening with energy. The multiplicities turned out to be proportional to A ^0.7 for pA collisions and A for central AA collisions with a good precision. In the latter case they are becoming more peaked at the center with the growth of energy. Their absolute values are high and grow rapidly with energy in accordance with the high value of the BFKL intercept.Received: 12 October 2004, Revised: 22 November 2004, Published online: 21 January 2005     

Basic configuration of a single-wall carbon nanotube <Emphasis Type="Italic">Y</Emphasis> junction of <Emphasis Type="Italic">D</Emphasis><Subscript>3<Emphasis Type="Italic">h</Emphasis></Subscript> symmetry: Structure and classification

The structure of single-wall carbon nanotube Y junctions of symmetry D_3h containing topological defects in the form of six heptagons or three octagons located immediately in the junction region of each pair of nanotubes forming the Y junctions is investigated, and their classification is suggested. It is shown that the pairs of heptagons in a Y junction formed by nanotubes of the “zigzag” type can be arranged in two ways and can be transformed into one another by using the (6, 7, 7, 6) ? (7, 6, 7, 6) Stone-Wales transformation and that the octagon and pairs of heptagons in a Y junction formed by nanotubes of the “armchair” type can be transformed into one another by introducing or removing a C₂ cluster. A method for constructing such Y junctions is suggested.     

The Dirac Operator on <Emphasis Type="Italic">SU</Emphasis><Subscript><Emphasis Type="Italic">q</Emphasis></Subscript>(2)

We construct a 3⁺-summable spectral triple over the quantum group SU_q(2) which is equivariant with respect to a left and a right action of The geometry is isospectral to the classical case since the spectrum of the operator D is the same as that of the usual Dirac operator on the 3-dimensional round sphere. The presence of an equivariant real structure J demands a modification in the axiomatic framework of spectral geometry, whereby the commutant and first-order properties need be satisfied only modulo infinitesimals of arbitrary high order.Partially supported by Polish State Committee for Scientific Research (KBN) under grant 2 P03B 022 25.Regular Associate of the Abdus Salam ICTP, Trieste.     

Energy dependence of Cronin momentum in saturation model for <Emphasis Type="Italic">p</Emphasis> + <Emphasis Type="Italic">A</Emphasis> and <Emphasis Type="Italic">A</Emphasis> + <Emphasis Type="Italic">A</Emphasis> collisions

The energy dependence of the Cronin momentum for p + A and A + A collisions in the saturation model are calculated. This dependence is consistent with simple dimensional considerations and can be used to test the validity of the saturation model. It gives the possibility to distinguish the different variants of the saturation model with precise experimental data and to measure the x dependence of the saturation momentum.     

Friedmann Cosmology with Matter Creation in Modified <Emphasis Type="Italic">f</Emphasis>(<Emphasis Type="Italic">R</Emphasis>, <Emphasis Type="Italic">T</Emphasis>) Gravity

The theoretical and observational consequences of thermodynamics of open systems which allow matter creation, are investigated in modified f(R, T) (R is the Ricci scalar and T is the trace of energy-momentum tensor) theory of gravity within the framework of a flat Friedmann-Robertson-Walker line element. The simplest model f(R, T)=R+2f(T) with “gamma-law” equation of state p = (γ?1)ρ is assumed to obtain the exact solution. A power-law expansion model is proposed by considering the natural phenomenological particle creation rate ψ = 3β n H, where β is a pure number of the order of unity, n the particle number density and H is the Hubble parameter. A Big Rip singularity is observed for γ<0 describing phantom cosmology. The accelerated expansion of the Universe is driven by the particle creation. The density parameter shows the negative curvature of the Universe due to particle creation. The entropy increases with the evolution of the Universe. Some kinematics tests such as lookback time, luminosity distance, proper distance, angular diameter versus redshift are discussed in detail to observe the role of particle creation in early and late time evolution of the Universe.     

Radiative <Emphasis Type="Italic">K</Emphasis><Subscript><Emphasis Type="Italic">e</Emphasis>3</Subscript> decays revisited

Motivated by recent experimental results and ongoing measurements, we review the chiral perturbation theory prediction for decays. Special emphasis is given to the stability of the inner bremsstrahlung-dominated relative branching ratio versus the K _e3 form factors, and on the separation of the structure-dependent amplitude in differential distributions over the phase space. For the structure-dependent terms, an assessment of the order p ⁶ corrections is given, in particular, a full next-to-leading order calculation of the axial component is performed. The experimental analysis of the photon energy spectrum is discussed, and other potentially useful distributions are introduced.Received: 9 December 2004, Published online: 21 February 2005PACS: 13.20.Eb, 11.30.Rd, 12.39.Fe