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1.
The facile and efficient multigram synthesis of (±)-tropan-2-one 1 was achieved in six steps (65% overall yield) from N-methyl-3-oxopyridyl hydroiodide 3. 相似文献
2.
Zhong Hong YAN Chun Hao YANG Xi Han WU Yu Yuan XIEDivision of Chemistry Shanghai Second Medical University Shanghai Sate Key Laboratory of Drug Research Shanghai Institute of Materia Medica Shanghai Institutesfor Biological Sciences Shanghai 《中国化学快报》2004,(4)
The first and facile synthesis of (±)syringaresinol was described. 相似文献
3.
An efficient synthesis of (±)-cycloillicinone was accomplished in five steps from sesamol. The title compound was obtained via a biomimetic Diels–Alder cycloaddition between illicinone A and β-trans-ocimene as the key step. 相似文献
4.
Initial formation of tetrahydrocarboline 3 from tryptophan methyl ester 1 and aldehyde 2 by Pictet–Spengler reaction, followed by treatment with trichlorocyanuric acid, provides a facile and efficient route for a one-pot synthesis of β-carbolines with excellent yields. 相似文献
5.
One‐step synthesis of biologically active (±)‐confluentin is described from commercially available orcinol with trans,trans‐farnesal in the presence of ethylenediamine diacetate as a catalyst. Further conversion of synthetic confluentin to highly potent anti‐HIV agent, (±)‐daurichromenic acid, is accomplished by formylation and oxidation in two steps. 相似文献
6.
An efficient Baeyer–Villiger rearrangement of cyclobutanone derivatives was investigated. One-pot synthesis of keto-δ-lactone from the Baeyer–Villiger rearrangement products was developed. Meanwhile, the synthetic useful γ-lactone and butenolide derivatives could be easily prepared. 相似文献
7.
The synthesis of macrolides1 is currently under intensive investigations because of their diverse biological and physiological activities. The recent developments in their synthetic strategies made the task easier for synthesis of several naturally occurring rnacrolides. 相似文献
8.
A total synthesis of (±)-boschnialactone ( 1 ) and (±)-tertahydroanhydrodesoxyaucubigenin ( 2 ) is described and trisubstitued cyclopentenoid 3 is a key intermediate. 相似文献
9.
Erich L. Grimm Sylvain Levac Michel L. Coutu 《Phosphorus, sulfur, and silicon and the related elements》2013,188(1-4):501-502
Abstract A new synthetic approach to medium-sized rings has been accomplished via intramolecular cyclization of a sulfone-stabilized carbanion. This strategy was applied to the total synthesis of (±)-parvifoline. 相似文献
10.
The natural furocoumarin dehydroxyglaupalol and two analogs were prepared by reaction of the appropriate 4-hydroxy-coumarin with 3-chloro-3-methylbutyne in basic medium, followed by catalytic hydrogenation of the exo double bond. 相似文献
11.
The syntheses of (±)-curcuphenol 1, (±)-curcudiol 2, (±)-curcuhydroquinone 3, and (±)-curcuquinone 4 have been achieved. The key steps involved in the syntheses were the Reformatsky reaction and hydrogenation reaction. 相似文献
12.
《中国化学快报》1997,(11)
Eversinceβ-vetivoneanditscongenerswererecognizedtohavespiro[4,5]decaneratherthanthehydroazuleneskeleton,[1]themembersofthisclasshavebecomeafavoritetargetforsynthesis.Herein.weshowafacileconversionofthemajorphotoproductformedinthereactionofmethyl2,4-dioxopentancate(1)with1,5-dimethyl-6-methylenecyclochexene(2)[2]intovetispiranederivatives,hinesol(3),ametaboliteofAtractylodeslancea[3,4],andagarospirol(4)foundinAquilariaagollocha,[5]inracemicforms,respectively.WhenanEtoAsolutionof1and2wasintema… 相似文献
13.
14.
A general synthetic approach has been developed for the synthesis of a key intermediate (6) that can be elaborated into several ophthalmic prostaglandins and their derivatives. Using these strategy, we have obtained (±)-bimatoprost (1) and its analog, (±)-homobimatoprost (5). 相似文献
15.
《Tetrahedron》1987,43(4):779-784
The aliphatic portion of (±)-zearalenone has been synthesised by a new simple route starting from 2,3-dihydropyran and 2-acetyl-γ-butyrolactone by employing dithiane for C-C bond formation. The final condensation of this segment with the aromatic part and subseqnet transformations led to (±)-zearalenone. 相似文献
16.
A. M. Moiseenkov A. V. Lozanoya A. A. Surkova A. V. Buevich V. V. Veselovsky 《Russian Chemical Bulletin》1996,45(7):1753-1759
The racemic forms of natural Omnoterpenoids, (±)-furodizinin and (±)-furodizin, were synthesized by cationic cyclization of the or -furylmethyl derivatives of linalool, geraniol and nerol.A. M. Moiseenkov (1936–1992), an outstanding Russian organic chemist, would have been sixty on July 6, 1996, He contributed significantly to the chemistry of terpenoids. The scientific heritage of A, M. Moiseenkov is rich and diversified. This work is devoted to the walizWon of one of his ideas. For the preliminary communication see Ref. 1.DeceasedTranslated fromIzvestiya Akademii Nauk. Seriya Khimicheskaya, No. 7, pp. 1842–1847, July, 1996. 相似文献
17.
Combretastatin (1) is a new plant product isolated recently by Pettit et al 1. from the South African tree, Combretum caffrum that possesses central nervous system antineoplastic activity and is being evaluated against several of National Cancer Institute's key evaluation systems. The structure of 1 was established on the basis of its spectral properties and confirmed by X-ray analysis. However, the absolute configuration and the synthesis of 1 have not been reported so far. As combretastatin is present in the plant in only 0.0008% and the isolation technique is much tedious, there is an urgent need for the synthesis of 1 for further evaluation of its activity. This prompted us t o report the first synthesis of (±)1. 相似文献
18.
The first synthesis of (±) Altaicadisporolactane 1 is described starting from succinic anhydride. 相似文献
19.
LIU Hong-xing CHEN Xi-hui HUANG Chu-sheng ** . Institute of Applied Chemistry Guangxi Teachers College Nanning P. R. China . College of Chemical Engineering Guangxi University Nanning P. R. China) 《高等学校化学研究》2003,19(4)
IntroductionMonoterpenoid acid 7a,which is a componentof some traditional medicines such as Gymnocladuschinensis baillon in a glycoside form[1— 3 ] ,has re-cently been isolated from Artemisia sieberi in Iran ina free form[4] .The structure ofthe compound7a has been es-tablished to be( E) - 2 ,6- dimethyl- 6- hydroxy- 2 ,7-octadienoic acid by chemical and spectroscopic anal-yses.Its methyl ester derivative7b was isolatedfrom the antibacterial extracts of the leaves ofPiper aduncum as well[5]… 相似文献
20.
A concise route for the syntheses of (±)-cherylline and latifine dimethyl ether is reported. The key steps involved are Michael addition of veratrole with p-methoxy nitrostyrene (for cherylline), anisole with 2,3-dimethoxy nitrostyrene (for latifine), and reduction of nitro intermediate, followed by Pictet–Spengler cyclization. 相似文献