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1.
本文探讨1.5 T磁共振化学交换饱和转移(Chemical Exchange Saturation Transfer,CEST)成像的影响因素.通过试管模型和临床病例,采用GE Signa HDe 1.5 T磁共振成像(Magnetic Resonance Imaging,MRI)扫描仪分别进行不同矩阵、激励次数、翻转角、磁化传递翻转角的CEST成像对比分析,以及不同激励次数、磁化传递翻转角的Z谱分析,并从成像组织、成像设备、成像技术等方面对原始图信号、酰胺质子转移(Amide Proton Transfer,APT)信号及Z谱进行分析研究.实验结果表明1.5 T MRI扫描仪的CEST图像信噪比相对较低,且磁场稳定性及均匀度影响了CEST成像的效果.在其他参数不变的情况下,降低采集矩阵和增加激励次数与翻转角可以增加原始图像信噪比.磁化传递翻转角为105°时,CEST成像效果最好.激励次数为2、磁化传递翻转角为105°时,所得数据符合组织Z谱情况.模型Z谱在磁化传递频率为-294~-194 Hz范围可显示30%谷氨酸(Glu)、碘剂(I320)、纯水(H2O)、肌酸(Cr)的信号差异,与H2O差异最大处在-244~-214 Hz.原始图像信号30% I320明显高于Glu、H2O、Cr,Cr略低于Glu,APT图Cr略低于Glu.25例脑肿瘤的APT图呈高信号、12例脑梗塞的APT图呈低信号,CEST原始图像均可区分病变区域.有12例因采集时间、患者配合情况、环境及室温等影响导致CEST成像的失败.由此得出1.5 T场强下,CEST技术受到成像组织、设备、技术等因素的影响,需要进行多方面优化.在保证磁场稳定性及均匀度的情况下,优化参数的CEST成像和Z谱成像可以区分代谢物及其浓度.  相似文献   

2.
Proton T2 relaxation times were measured in 13 stroke patients and 13 aged-matched normal subjects at 2.1 T. Spectra were acquired from an 8-cc volume using the STEAM sequence with echo times (TE) of 30.4 ms and 270.0 ms and repetition time of 2.8 s. Transverse relaxation times were estimated using two-point calculations. Percentage volume of infarct in the STEAM voxel was measured on spin-echo MRI encompassing the infarct and correlated with the peak amplitude of N-acetylated compounds (NA). T2 values of NA, creatine, and choline resonances showed no significant difference between patients and controls. T2 for lactate in patients was 780 ± 257 ms, respectively (mean ± SE, n = 7). In stroke patients, high inverse correlation was found between the absolute NA signal and partial volume of normal brain contributing to each spectrum (p < .001, r = 0.97). Together with unchanged T2, this suggests that NAA largely disappears from infarcted tissue within 24 hr postinfarct.  相似文献   

3.
The nanometer sized particles of PbI2 were embedded in SiO2 films. X-ray diffraction and the TEM pictures showed the preservation of the bulk layered structure and symmetry. The PL spectrum of the nano-particles exhibited a pronounced blue shift of the exciton band due to quantum size effect. The Lead Iodide represents an exceptionally small exciton Bohr radius (aB = 19 Å) and a special case in which me mh. The prepared samples contained particles with mean radii, a, in the range aB < a < 3aB. Within this limit (with me mh), the experimental results suggest that the electron is localized nearly at the center of the particle, enabling the hole to move around it. Thus, the size confinement permits the creation of an acceptor-like exciton. The PL spectrum revealed additional states, associated with stoichiometric defects either at the interior or surface sites of the nano-particles. These defects act either as donor or acceptor states. The dynamics of the various recombination processes has been investigated by measuring the time resolved PL spectra. The results show a multiexponential behavior of the various recombination emission bands, indicating the occurrence of trapping and detrapping processes. Analysis of these results suggests that the existence of surface states give rise to these complex radiative decay processes. The correlation between donor-acceptor recombination emission bands in the aforementioned samples and lattice imperfections was examined, utilizing optically detected magnetic resonance (ODMR) spectroscopy. The results identified the following imperfection sites: an acceptor site associated with an isotropic Lead vacancy defect, [V]pb2+ and a donor site, associated with an anisotropic Iodine vacancy, [V0]Iodine.  相似文献   

4.
A centimeter size single crystal of La2−xSrxCuO4+δ (volume=1.32 cm3) with xSr=0.08 has been grown by the travelling-solvent floating-zone (TSFZ) method using a double ellipsoidal-type optical furnace as the heat source. The crystallised phase was checked solvent free by X-ray powder diffraction experiments, the crystal dimensions and quality being investigated by X-ray and neutron Laüe techniques. Several rocking curves of the Bragg peaks were performed by neutron diffraction giving a full width at half maximum (FWHM) of 0.200° for (006) reflection and clearly showing the presence of twin domains as expected for such an orthorhombic structure. The superconducting critical temperature of the as-grown crystal under 2 oxygen bar was determined by SQUID measurements with Tc=18–20 K. Thermal treatments at different oxygen pressures were carried out showing no significant improvement of the transition sharpness and the Tc value. Normal state susceptibility was also measured from 6 to 800 K for two different field orientations and can be interpreted as an antiferromagnetic insulating state behaviour. The resistivity measurements display an insulating behaviour perpendicular to the CuO2 planes and a metallic behaviour in the planes, with a high anisotropy ratio Rc/Rb350 at room temperature and a zero resistivity achieved at 27 K in both directions. The specific heat measurements have revealed no anomalies in the temperature range 15–300 K.  相似文献   

5.
The spin-dependent tunneling of cobalt clusters embedded in Al2O3 or SiOx has been analyzed as a function of the frequency at room temperature. Two sets of samples, with one or several layers of clusters, have been produced by alternate physical deposition of the metal and the insulator. The impedance versus frequency curves were measured with and without an external magnetic field. The results suggest that when the distance between successive cluster layers is small, some correlations between the cluster positions are present.  相似文献   

6.
Visualization of short echo time (TE) metabolites in prostate magnetic resonance spectroscopic imaging is difficult due to lipid contamination and pulse timing constraints. In this work, we present a modified pulse sequence to permit short echo time (TE=40ms) acquisitions with reduced lipid contamination for the detection of short TE metabolites. The modified pulse sequence employs the conformal voxel MRS (CV-MRS) technique, which automatically optimizes the placement of spatial saturation planes to adapt the excitation volume to the shape of the prostate, thus reducing lipid contamination in prostate magnetic resonance spectroscopic imaging (MRSI). Metabolites were measured and assessed using a modified version of LCModel for analysis of in vivo prostate spectra. We demonstrate the feasibility of acquiring high quality spectra at short TEs, and show the measurement of short TE metabolites, myo-inositol, scyllo-inositol, taurine and glutamine/glutamate for both single and multi-voxel acquisitions. In single voxels experiments, the reduction in TE resulted in 57% improvement in the signal-to-noise ratio (SNR). Additional 3D MRSI experiments comparing short (TE=40 ms), and long (TE=130 ms) TE acquisitions revealed a 35% improvement in the number of adequately fitted metabolite peaks (775 voxels over all subjects). This resulted in a 42 ± 24% relative improvement in the number of voxels with detectable citrate that were well-fitted using LCmodel. In this study, we demonstrate that high quality prostate spectra can be obtained by reducing the TE to 40 ms to detect short T2 metabolites, while maintaining positive signal intensity of the spin-coupled citrate multiplet and managing lipid suppression.  相似文献   

7.
Cluster model calculations have been performed for CHx, x = 0−3, chemisorbed on Ni(100) and Ni(111). The predicted chemisorption energies, at the present level of theory, based on bond-prepared clusters for Ni(100) are for carbon 150 kcal/mol, for CH 136 kcal/mol, for CH2 91 kcal/mol and for CH3 46 kcal/mol. The corresponding energies for Ni(111) are for CH 120 kcal/mol, for CH2 88 cal/mol and for CH3 49 kcal/mol. These chemisorption energies lead to similar stabilities for all CHx fragments on both Ni(100) and Ni(111). Large basis sets and multi-reference correlation treatments are found to be very important in particular for the multiply bonded species. The vibrational C-H stretching frequencies predicted for CHx on Ni(111) are for CH 3054 cm−1 (2980 cm−1), for CH2 3204 cm−1 and for CH3 2709 cm−1 (2680 cm−1), where the available experimental values are given in parent The predicted ionization spectra of adsorbed CHx are also in general agreement with experimental findings.  相似文献   

8.
High-pressure electrical conductivity studies have been carried out with poly(p-phenylene)s with oxyethylene side-chains (PPP(EO)x/y), which were blended with LiCF3SO3. Measurements were performed at pressures up to 280 MPa and at different temperatures. The influences of salt concentration, side-chain length, temperature, and plasticizer content on the relative conductance and activation volume are investigated. The temperature-dependent conductivity of the sample is non-Arrhenius and exhibits Williams–Landel–Ferry (WLF) behavior. The logarithm of relative conductance for PPP(EO)x/y/LiCF3SO3 decreases almost linearly with increasing pressure but increases with salt concentration and side-chain length. As temperature increases, the activation volume becomes smaller but remains positive for PPP(EO)x/y/LiCF3SO3. At higher salt concentrations and longer side-chain lengths, a smaller activation volume for the ion motion is found. These results can be interpreted such that PPP(EO)x/y/LiCF3SO3 behaves like a true polymer electrolyte where ion transport is mediated by segmental motions of the EO side-chains. The addition of tetraethylene glycol dimethyl ether (TEGDME) as a plasticizer increases the activation volume but reduces the conductance.  相似文献   

9.
Polycrystalline samples of M-type hexaferrites BaFe12−2xRuxZnxO19 and BaFe12−2xRuxCoxO19 with 0x0.45 have been prepared by a classical sintering method. The evolutions with x of the cell parameters, the saturation magnetization and the magnetic transition temperature have been measured; in this range of small doping ratios, saturation magnetization and Curie temperature of substituted hexaferrites remain close to those of the undoped BaFe12O19. X-ray diffraction measurements on oriented powders show that a change of magnetocrystalline anisotropy from axial to planar occurs in both cases for a small substituting ratio xc=0.375. Microwave electromagnetic characteristics have been studied on the ceramic samples from 0.1 to 10 GHz. The behaviour of the magnetic losses (μ″) corroborates the anisotropy change when doping; a convolution of the dissipation mechanisms (domain wall motions and gyromagnetism) is obtained for xc. The level of the magnetic losses is discussed in relation with others substituted Ba-hexaferrites.  相似文献   

10.
《Surface science》1988,200(2-3):361-367
The inelastic mean free paths, λ, of electrons in polycrystalline Ag and Cu samples were determined for electron energies in the range 250–1500 eV by means of elastic peak electron spectroscopy (EPES). In this method the coefficient of elastic scattering of electrons, ηe, is measured. ηe is also calculated theoretically for different assumed values of λ. The value of λ giving the best agreement between the measured and calculated ηe is taken as the experimental one. the ηe measurements were performed for Ag and Cu samples cleaned by mechanical scraping only and for samples cleaned by ion bombardment in order to estimate the eventual influence of surface roughness on the ηe values. Additionally, different methods to calculate ηe theoretically are compared.  相似文献   

11.
用密度泛函理论的B3LYP方法,分别以6-311++g(df,3pd),6-311g(3d,3p)和6-311++g(3df,3pd)为基函数对NF分子、NF+和NF-离子基态进行几何优化和频率计算,并进行单点能扫描计算.用最小二乘法拟合得到NFX(X=-1,0,+1)分子离子基态的Murrell-Sorbie势能函数.利用得到的解析势能函数计算出的NF分子和NF+离子基态光谱常数(Be,αe,ωe,ωeχe)与实验值符合很好.首次得到NF-离子基态的光谱常数(Be,αe,ωe,ωeχe)和力常数(f2,f3,f4),为NF-离子基态的后期研究提供理论参考.  相似文献   

12.
Variation of the complex permeability with frequency of Ni1−xZnxFe2O4 (x=0.5, 0.6 and 0.7) prepared by a combustion method has been measured over a wide range of frequency, up to 1.8 GHz. Zn content improves permeability but moves the onset of resonance to lower frequencies.

The influence on some properties of samples prepared by the insertion of small amounts of Ruthenium, Yttrium and rare-earth cations into the Ni0.5Zn0.5MxFe2−xO4 ferrite has been also investigated. Relative losses and Curie temperature of all the samples have been measured. Ferrites substituted with Ru and Gd improve microwave behavior compared to non-substituted samples.  相似文献   


13.
Li (i=1, 2 and 3) X-ray production cross sections have been measured for 14 elements in the atomic number range 55≤Z≤81 at 15.73 keV. The values of Li subshell fluorescence yields (ω1, ω2 and ω3) have been determined using the presently measured X-ray production cross sections and the theoretical Li subshell photoionization cross sections values, Coster–Kronig transition probabilities and radiative emission rates. The measured X-ray production (XRP) cross-sections and fluorescence yield values were compared with the theoretical and semi empirical values, respectively.  相似文献   

14.
A series of apatite-type La–Ge–O ceramics were prepared and their cation-defect at the 4f+6h sites and oxide ion-defect at 2a site were investigated. In LaxGe6O12+1.5x ceramics of x=6–12, the higher conductivities were obtained in the region of apatite composition, Lax(GeO4)6O1.5x−12 (x=8–9.33), and the highest conductivity was achieved for La9(GeO4)6O1.5 (x=9), where the number of cation (La3+) occupying the 4f+6h sites is 9 and the number of oxide ion occupying the 2a site is 1.5. The ceramics with cation- and oxide ion-defects were La9−0.66xSrx(GeO4)6O1.5 (x=0–1), La9−1.33xZrx(GeO4)6O1.5 (x=0–1), La9−xSrx(GeO4)6O1.5−0.5x (x=0–3), La9−xZrx(GeO4)6O1.5+0.5x (x=0–1), Lax(GeO4)3x−21(AsO4)27−3xO1.5 (x=0–3), Lax(GeO4)33−3x(AlO4)3x−27O1.5 (x=0–3), La9(GeO4)6−x (AlO4)xO1.5−0.5x (x=0–3), La9(GeO4)6−x(AsO4)xO1.5+0.5x (x=0–1), La9.33−xSrx(GeO4)6O2−0.5x (x=0–1.2) and Lax(GeO4)4.5(AlO4)1.5O1.5x−12.75 (x=8.8–9.83), which were prepared by the partial substitution of La3+and GeO44−of the basic apatite La9(GeO4)6O1.5 with Sr2+ or Zr4+ and AlO45− or AsO43−. Such substitutions lowered the conductivity of La9(GeO4)6O1.5. These results were discussed by the electrostatic interaction between Sr2+, Zr4+, AlO45− or AsO43− and oxide ion as a conductive species.  相似文献   

15.
The spectrum of hadronic molecules composed of heavy–antiheavy charmed hadrons has been obtained in our previous work. The potentials are constants at the leading order, which are estimated from resonance saturation. The experimental candidates of hadronic molecules, say X(3872), Y(4260), three Pc states and Pcs(4459), fit the spectrum well. The success in describing the pattern of heavy–antiheavy hadronic molecules stimulates us to give more predictions for the heavy–heavy cases, which are less discussed in literature than the heavy–antiheavy ones. Given that the heavy–antiheavy hadronic molecules, several of which have strong experimental evidence, emerge from the dominant constant interaction from resonance saturation, we find that the existence of many heavy–heavy hadronic molecules is natural. Among these predicted heavy–heavy states we highlight the DD* molecule and the ${D}^{(* )}{{\rm{\Sigma }}}_{c}^{(* )}$ molecules, which are the partners of the famous X(3872) and Pc states. Quite recently, LHCb collaboration reported a doubly charmed tetraquark state, Tcc, which is in line with our results for the DD* molecule. With the first experimental signal of this new kind of exotic states, the upcoming update of the LHCb experiment as well as other experiments will provide more chances of observing the heavy–heavy hadronic molecules.  相似文献   

16.
The forced swimming test (FST) is a useful paradigm that is relatively quick and simple to perform and has been utilized to predict antidepressant activity based on learned helplessness as a model of depression. To date, few studies have used proton magnetic resonance spectroscopy (1H-MRS) to assess antidepressant effects in rats. The purpose of this study was to assess desipramine (DMI) effects on the left dorsolateral prefrontal cortex (DLPFC) of the rats, which were randomly assigned to three groups (control, n=10; FST+saline, n=10; FST+DMI, n=10), using single-voxel localization technique. All 1H-MRS experiments were performed on a Bruker 4.7-T scanner with 400 mm bore magnet, allowing for acquisition of in vivo 1H point-resolved spectroscopy spectra (TR/TE=3000/30 ms, number of data points=2048, NEX=512, voxel volume=27 μl, scan time=25 min). Proton metabolites were quantified automatically using LCModel software and were expressed as ratios to total creatine (Cr+PCr). Major target metabolites such as N-acetyl aspartate (NAA)+N-acetylaspartylglutamate (NAAG), glutamate+glutamine (Glu+Gln), glycerophosphorylcholine+phosphorylcholine (GPC+PCho), myo-inositol (mIns) and taurine (Tau) were successfully quantified with Cramer–Rao lower boundary ≤10%. There were significantly higher mIns/(Cr+PCr) and mIns/(NAA+NAAG) ratios in the FST+saline group compared to the control group. In the FST+DMI group, both mIns/(Cr+PCr) and mIns/(NAA+NAAG) ratios were significantly decreased to the level similar to those in the control group. No other metabolite ratios were significantly different among the three groups. Our findings suggest a possible role of altered mIns level within the left DLPFC of the rat model for depression.  相似文献   

17.
The diagnosis of hippocampal sclerosis: Other techniques   总被引:5,自引:0,他引:5  
Pathologically, hippocampal sclerosis (HS) is characterized by neuronal loss and gliosis affecting particularly the pyramidal neurons of CA1, CA3, and CA4 with relative sparing of the CA2 neurons. This can be identified in vivo with magnetic resonance (MR) imaging techniques that can reveal both morphological and signal abnormalities. The morphological changes are atrophy and loss of the normal internal architecture of the hippocampus as seen in coronal section. There is also T1- and T2-weighted signal abnormality in the hippocampus. Quantitative techniques are very good at measuring any single one of these features, but the spectrum of HS includes cases in which a single feature can occasionally be misleading. Also, quantitation focuses entirely on the hippocampus, and it is becoming clear that HS may exist in the presence of other brain pathology that may affect proper management of the patient. Therefore, quantitative measures should always be interpreted in the context of optimised imaging sequences and visual inspection. For routine clinical purposes, the relative reliance on quantitation (hippocampal volume or T2 measurements) depends entirely on the yield of visual inspection in any institution. This, in turn, depends on whether optimised imaging is performed and on the familiarity of the reporting specialist with the MRI features of HS. A technique which approaches 95–100% compared with pathology is essential in any epilepsy centre, and optimised visual analysis can achieve this. There are some cases where quantitation of a single feature can be misleading, so visual analysis should always be performed, and complements any quantitative study.  相似文献   

18.
李德铭  方松科  童金山  苏健  张娜  宋桂林 《物理学报》2018,67(6):67501-067501
采用固相反应法制备Sm_(1-x)Ca_xFeO_3(x=0,0.1,0.2,0.3)样品,研究Ca~(2+)掺杂对SmFeO_3介电性能、铁磁性及磁相变温度的影响.X射线衍射图谱分析表明:所有样品的主衍射峰与SmFe03相符合且具有良好的晶体结构.随着x的增加,SmFeO_3样品的晶粒尺寸由原来的0.5μm逐渐增大到2μm.当f=1 kHz时,Sm_(1-x)Ca_xFeO_3(x=0.1,0.2,0.3)样品的ε_r分别是SmFe03的5倍、3倍和2.6倍,而tgσ增大一个数量级.在3T磁场作用下,SmFe03样品的M-H呈线性,随着x的增加,M-H逐渐趋向饱和,Sm_(1-x)Ca_xFeO_3(x=0.1,0.2,0.3)样品的M_r分别是SmFeO_3的20倍、31倍和68倍.X射线光电子能谱分析表明:Fe~(2+)和Fe3+共存于Sm_(1-x)Ca_xFeO_3样品中,Fe~(2+)/Fe~(3+)比例随着x的增加而增大,证明Ca~(2+)掺杂增加了Fe~(2+)的含量,形成Fe~(2+)—O~(2-)—Fe~(3+)超交换作用,增强SmFe03的铁磁特性.测量了Sm_(1-x)Ca_xFeO_3样品在外加磁场为1000 Oe(1 Oe=79.5775 A/m)的M-T变化关系,观测到其自旋重组温度(T_(SR))和尼尔温度(T_N)分别为438 K和687 K,发现SmFe03样品的T_(SR)和T_N均随着x的增加向低温方向移动,当x=0.3时,自旋重组现象消失.这主要是SmFeO_3样品磁结构的稳定性和Fe~(3+)—O~(2-)—Fe~(3+)及Sm~(3+)—O~(2-)—Fe~(3+)超交换三者共同作用的结果.  相似文献   

19.
Experimental evidence shows that in the magnetoresistive manganite Ca1−xYxMnO3, ferromagnetic (FM) polarons arises in an antiferromagnetic (AF) background, as a result of the doping with yttrium. This hypothesis is supported in this work by classical Monte Carlo calculations performed on a model where FM double exchange and AF superexchange compete.  相似文献   

20.

Purpose

In vivo magnetic resonance (MR) tracking of magnetically labeled bone marrow mesenchymal stem cells (BMSCs) administered via the mesenteric vein to rats with liver fibrosis.

Materials and Methods

Rat BMSCs were labeled with superparamagnetic iron oxide (SPIO) and the characteristics of the BMSCs after labeling were investigated. Eighteen rats with CCL4-induced liver fibrosis were randomized to three groups to receive SPIO-labeled BMSCs (BMSC-labeled group), cell-free SPIO (SPIO group), or unlabeled BMSCs (control group). MR imaging of the liver was performed at different time points, and signal-to-noise ratio (SNR) of the liver was measured. In vivo distribution of delivered BMSCs was assessed by histological analysis.

Results

Labeling of BMSCs with SPIO did not significantly alter cell viability and proliferation activity. In BMSC-labeled group, the liver SNR immediately decreased from 8.56±0.26 to 3.53±0.41 at 1 h post injection and remained at a significantly lower level till 12 days (P<.05 versus the level before). By contrast, the liver SNR of the SPIO group almost recovered to the preinjection level (P=.125) at 3 days after a transient decrease. In control group, the liver SNR demonstrated no significant difference at the tested time points. Additionally, Prussian blue-positive cells were mainly distributed in the liver parenchyma, especially in injured areas.

Conclusion

The magnetically labeled BMSCs infused through the mesenteric vein can be detected in the fibrotic liver of rats using in vivo MR imaging up to 12 days after injection.  相似文献   

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