共查询到20条相似文献,搜索用时 15 毫秒
1.
H. Enginar P. Unak F. Yurt Lambrecht F. Z. Biber 《Journal of Radioanalytical and Nuclear Chemistry》2004,260(2):339-349
An estrogen derivative 1-(3, 17-α-estradiolyl propin-1-yl-3-(1,4,8,11-tetraazacyclotetradecyl)-propanate (ESTACPA) was synthesized.
The product was purified by HPLC and characterized by NMR and IR spectroscopy. The synthesized compound was labeled with 99mTc. The biodistribution studies were performed on female Albino Wistar rats. The rats were sacrificed and their organs were
removed. The radioactivities of the organs were counted using a gamma-counter. The activity per gram tissue was calculated
and time versus activity curves were generated. The 99mTc-ESTACPA uptake by the uterus and ovary such as ER-rich tissues, were observed. The pancreas and stomach also showed a significant
uptake.
This revised version was published online in July 2006 with corrections to the Cover Date. 相似文献
2.
H. Enginar P. Ünak F. Yurt F. Zümrüt Biber 《Journal of Radioanalytical and Nuclear Chemistry》2002,251(3):473-479
An oestrogen derivative 3,17-a-oestradiolyl propyl 1,4,8,11-tetraazacyclotetradecanyl-1-(4-methylbenzoic acid)ester (ESTCPTA) that is 3,17-a-oestradiolyl propinol coupled to 1-(4-methylbenzoic acid)1,4,8,11-tetraazacyclotetradecane (CPTA) was synthesized in five steps. The product was purified by recrystallization in ethyl alcohol, and analysed by NMR and IR spectroscopy. ESTCPTA was labeled with 99mTc and radio thin layer chromatography (RTLC) and radio-paper electrophoresis were used to determine the radiochemical yields. Specific activity was approximately 23.7 GBq/mmol and the labeling yield was over 95%. The biodistribution studies were performed on female Albino Wistar rats. The rats were sacricified by ether narcotization at certain time intervals and the activity of the organs was counted by a gamma counter. The activity per gram tissue was calculated and time activity curves were generated. 相似文献
3.
F. Yurt P. Unak F. Zümrüt Biber 《Journal of Radioanalytical and Nuclear Chemistry》2002,251(2):241-244
Sertraline is an antidepressant drug. Sertraline was labeled with 131I by using iodogen method. Labeling yield was 85–90% and specific activity was approximately 64.75 GBq/mmol. The purification of radioiodinated Sertraline was performed by Sep Pak C-18 plus and the radiochemical purity was determined to be over 99%. Biodistribution studies were carried out by male Albino Wistar rats. The percentage of injected radioactivity per gram of tissue was calculated, and these data versus time curves were generated for organs and brain regions. The results showed that 131I labeled Sertraline may be a promising radiopharmaceutical for the investigation of serotonin 5-HT receptor functions of brain. 相似文献
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Clarke C Cowley AR Dilworth JR Donnelly PS 《Dalton transactions (Cambridge, England : 2003)》2004,(16):2402-2403
Attachment of a thioamide tethering group provides a modification of the well-known pyridylhydrazine based route to radiolabelling of biomolecules (the HYNIC system) and gives a proligand which gives stable, well-defined chelated derivatives with both Re(v) oxo and Re(III) diazenide cores. Both display previously unknown bonding modes for the pyridylthiocarbazide ligands. 相似文献
6.
The use of calcium carbide (in the presence of H2O) as a source of acetylene in the reaction with methyl 2-amino-4,6-O-benzylidene-2-deoxy-β-d-glucopyranoside under superbasic conditions (KF, KOH, DMSO, 130 °C, 3 h) led to the corresponding vinyl ether in 78% yield. The vinylation does not affect other reaction centers. Replacement of water with deuterium oxide in the reaction mixture gave a stable deuterated analog of this vinyl ether in 72% yield. The one-step isotopic enrichment was practically quantitative (isotopic purity >96%). Introduced deuterium atoms can be used as a convenient label in further transformations.
相似文献7.
The reaction of catalytic and thermal addition of acrylic acid to tetracyclo[4.4.12,5.17,10.01,6]dodec-3-en and its 8-methyl-substituted derivative was studied. The reaction is intended for the synthesis of corresponding
acrylates, which are reactive monomers suitable for producing high-molecular compounds. 相似文献
8.
Luís J. Moreno López Manuel Callejón Mochón Juán C. Jiménez Sánchez Alfonso Guiraúm Pérez 《Mikrochimica acta》1996,124(3-4):187-194
A method for the determination of salicylaldehyde (2 × 10–6–10–4
M) by differential-pulse polarography, based on the in situ formation of its Girard-P derivative in aqueous solution at pH 2.5, is proposed. The relative standard deviation was 1.5% (ten determinations of 4 × 10–5
M level). The applicability of this method was checked in synthetic samples containing salicyl alcohol,o-aminophenol, 2-methylphenol, salicylic acid and 4-aminobenzoic acid. 相似文献
9.
Ahmed H. Orabi 《International journal of environmental analytical chemistry》2019,99(8):741-766
In this research work, the separation of Uranium from phosphate medium via adsorption prior to its fluorometric determination was carried out onto a newly synthesised adsorbent made via impregnation of urea onto cellulose (UIC). The full characterisation of the synthetic extractant (UIC) was carried out by various instrumental techniques such as elemental analysis, FTIR, TGA, XRD and SEM analysis. Various factors that may affect the quality of adsorbing U (VI) ions using synthesised Urea-impregnated cellulose had been investigated. The maximum adsorption capacity (82 mg/g) for U (VI) has been verified by the Langmuir isotherm model. The thermodynamics and kinetics of the adsorption process indicated that the uranium sorption onto synthesised Urea-impregnated cellulose was an exothermic and pseudo-second-order process. The tolerance limits for the common cations which are actually found with uranium in the phosphate solutions and may show sorption behaviour on the synthesised UIC resin were calculated and gave a high tolerance limit. Contrary to previously reported studies, several ameliorations have resulted including an elevated selectivity and adsorption capacity of uranium from phosphate medium. The optimised method was applied with good accuracy results for determination of uranium in reference and different phosphate rock types bearing uranium. 相似文献
10.
V. V. Murhekar Anupam Mathur G. Prabhakar Barakha P. Karkhanis Neelam S. Pilkhwal B. K. Tiwari D. Padmanabhan Grace Samuel S. S. Sachdev 《Journal of Radioanalytical and Nuclear Chemistry》2014,302(2):883-888
Board of Radiation and Isotope Technology, India is a manufacturer and supplier of therapeutic doses of the 131I-meta-iodobenzylguanidine to various nuclear medicine centers in India. The therapeutic dosage of radiopharmaceutical involves a single variable dose of >3.7 GBq activity. Since the radiopharmaceutical produced is mainly by isotope exchange, which yields a low specific activity product, the determination of its accurate mass is a critical parameter for its safe administration in patients. In view of this, a suitable high performance liquid chromatography (HPLC) method has been developed for the determination of specific activity with high precision. Also, quantification of stability in terms of the % radiochemical purity of the formulation >370 MBq/mL supplied, under different storage conditions over time was carried out using the developed HPLC method. 相似文献
11.
Miao Liu Xiao Lin Xiaoqing Song Yang Cui Peiwen Li Xuebin Wang Junbo Zhang 《Journal of Radioanalytical and Nuclear Chemistry》2013,298(3):1659-1663
In the present study, proline dithiocarbamate (PRODTC) ligand was radiolabeled with the [99mTc≡N]2+ core successfully to obtain the 99mTcN-PRODTC complex with high radiochemical purity. No decomposition of the complex at room temperature was observed over a period of 6 h. Its partition coefficient indicated that it was a hydrophilic complex. The electrophoresis results showed that the complex was negative. The biodistribution of 99mTcN-PRODTC in mice bearing S 180 tumor showed that the complex accumulated in the tumor with a certain uptake. The tumor/blood and tumor/muscle ratios reached 2.19 and 4.54 at 2 h post-injection, suggesting it would be a promising candidate for tumor imaging. 相似文献
12.
Structure elucidation and HPLC-MS/MS determination of a potential biomarker for estradiol administration in cattle 总被引:1,自引:0,他引:1
Patricia Regal Julio A. Seijas Alberto Cepeda Cristina Fente 《Analytical and bioanalytical chemistry》2013,405(29):9537-9546
Administration of hormonal compounds as growth promoters in livestock farming was banned by Council Directive 96/22/EC. However, this kind of substances is sometimes reported within the framework of European monitoring residue plans. Various analytical methods have been previously developed to screen for their misuse, and they are now especially efficient for monitoring the illegal administration of synthetic and semisynthetic hormones. Nevertheless, proving an exogenous administration of hormones from natural origin (i.e., estradiol-17β or progesterone) still remains a challenge for European authorities. These target compounds are indeed always present in the animal matrix, and the establishment of reference thresholds appears very difficult because of the extreme variability existing among animals. In 2011, a metabolomics study was performed on serum samples obtained from cows treated with estradiol-17β (or its ester estradiol benzoate) and from control animals using a high-performance liquid chromatography (HPLC)-LTQ-Orbitrap system. After appropriate data processing and multivariate statistical analysis (orthogonal partial least squares discriminant analysis), it was possible to highlight one potential biomarker candidate of estradiol treatments in bovine animals. Now, this biomarker has been structurally elucidated as a dipeptide, and its usefulness has been tested through a targeted HPLC-MS/MS method. Its presence in the previous samples has been confirmed and also in additional samples from estradiol-treated animals. 相似文献
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Synthesis of diphenyl cucurbit[6]uril (CB[6]) has been achieved via co-oligomerization of diphenyl glycoluril and unsubstituted glycoluril. The unsymmetrically substituted CB[6], Ph(2)CB[6], was further converted to a rotaxane incorporating bis(dinitrophenyl)spermine. [reaction: see text] 相似文献
15.
Quantitative determination of thiabendazole, as its methyl derivative, has been achieved by gas-liquid chromatography with flame ionization detection and a column of 10% of DC-200 on Gas-Chrom Q at 240 degrees. Determination was possible with 10 to 200 ng per mul of the methylated reaction mixture. For determining thiabendazole in fruits, clean-up of the crude extracts by liquid-liquid partition allows satisfactory elimination of interference and permits determination in concentrations down to 0.1 ppm. The recovery of thiabendazole added to fruits at the 0.5-ppm level ranges from 90.3 to 94.9%. The methyl derivative was identified as N-methylthiabendazole by its elementary composition, by its melting-point, and by ultraviolet, infrared, mass and nuclear magnetic resonance spectroscopy. 相似文献
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1,8-naphthalimide-labelled polyamidoamine dendrimer (PAMAM-N) was synthesized and used to stabilize Au and Ag nanoparticles,
which were characterized by UV-Vis absorption and fluorescence spectroscopies, and transmission electron microscopy. The dimensions
of Au and Ag nanoparticles protected by PAMAM-N were smaller and the size distribution was narrower when compared to those
of polyamidoamine dendrimer. The presence of chromophore fragment (1,8-naphthalimide) allowed the fluorescent labeling of
Au and Ag nanoparticles. 相似文献
19.
A procaterol derivative (6) having a piperidylmethanol group was synthesized by the nucleophilic reaction of a 5-formylcarbostyril derivative with pyridyllithium, followed by selective catalytic reductions to afford the erythro-isomer. Compound 6 showed non-selective beta-adrenoceptor agonist activities like those of l-isoproterenol in an in vivo assay using anesthetized dogs. 相似文献