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1.
I. P. Romanova A. T. Gubaidullin I. A. Litvinov S. G. Fattakhov V. S. Reznik O. G. Sinyashin 《Russian Chemical Bulletin》2000,49(7):1195-1201
X-ray diffraction study demonstrated that the molecular and crystal structures of the complexes of 1,3-diallyl-5-[3-(diphenylphosphino)propyl]-1,3,5-triazine-2,4,6(1H,3H,5H)-trione (1) with PdCl2 are determined to a large degree by intra- and intermolecular short contacts between different-polarity groups of the complex
molecules. The strength and the existence of the complexes may be affected by the solvents from which the crystals are grown.
Published inIzvestiya Akademii Nauk. Seriya Khimicheskaya, No. 7, pp. 1199–1204, July, 2000. 相似文献
2.
Franois Chau Jean-Claude Malanda Ren Milcent 《Journal of heterocyclic chemistry》1997,34(5):1603-1606
The 5-aryl(or methyl)-3-phenylcarbamoyl-1,3,4-oxadiazol-2(3H)-ones 2 , in the presence of sodium hydride in anhydrous dimethylformamide, were transformed into 1-benzamido(or acetamido)-3,5-diphenyl-1,3,5-triazine-2,4,6-trione derivatives 7 in poor yields. However, compounds 7 were obtained in better yields when the sodium salts of 5-aryl(or methyl)-1,3,4-oxadiazol-2(3H)-ones 1 were treated with two equivalents of aryl(or ethyl)isocyanates. Acidic hydrolysis of 1-acetamido-3,5-diphenyl-1,3,5-triazine-2,4,6-trione ( 7i ) provided the corresponding free N-amino derivative 9 . Nitrous deamination of 9 gave the known 3,5-diphenyl-1,3,5-triazine-2,4,6-trione ( 11 ). This cyclic transformation is the first one to be reported providing 1,3,5-triazine-2,4,6-trione derivatives. 相似文献
3.
V. E. Semenov A. E. Nikolaev A. V. Kozlov Yu. Ya. Efremov Sh. K. Latypov V. S. Reznik 《Russian Journal of Organic Chemistry》2008,44(6):882-890
Reactions of 1,3-bis(ω-bromoalkyl)-substituted uracils, quinazoline-2,4-dione, and 5-methyl-1,3,5-triazine-2,4,6-trione and 1,3-bis(m-bromomethylbenzyl)-5-bromouracil with amines (aliphatic amines, benzylamines, naphthylmethanamine, and anisidine) gave a series of macrocyclic compounds having one pyrimidine or triazine fragment and an azapolymethylene bridge connecting the N1 and N3 atoms of the heteroring. The bridging nitrogen atom in some macrocyclic compounds was subjected to quaternization with methyl p-toluenesulfonate. 相似文献
4.
T. A. Tseitler G. V. Zyryanov D. S. Kopchuk I. S. Kovalev V. L. Rusinov O. N. Chupakhin 《Russian Journal of Organic Chemistry》2014,50(6):783-785
Direct arylation of 1,3,5-triazine-2,4(1H,3H)-dione with mesitylene afforded a novel fused heterocyclic system, 8,10-dimethyl-1,10b-dihydro[1,3,5]triazino[2,1-a]isoindole-2,4,6(3H)-trione. 相似文献
5.
The solid-phase synthesis of 1,3-disubstituted and 1,3,5-trisubstituted 1,3,5-triazine-2,4,6-triones from MBHA and Wang resin is described. Reaction of resin-bound amino acids with isocyanates yield resin-bound ureas, which further react with chlorocarbonyl isocyanate in toluene at 65 degrees C to selectively afford the resin-bound 1,3-disubstituted 1,3,5-triazine-2,4,6-triones. Selective alkylation at the N-5 position of the resin-bound 1,3-disubstituted 1,3,5-triazine-2,4,6-triones was accomplished by treatment with alkyl halides in the presence of 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU). The desired products were cleaved from their solid support and obtained in good yield and purity. The method can be employed in production of toltrazuril analogue libraries for identification of new anticoccidial agents. 相似文献
6.
Keitaro Senga Joze Kobe Roland K. Robins Darrell E. O'Brien 《Journal of heterocyclic chemistry》1975,12(5):893-898
The synthesis of a new series of alkylxanthine analogs containing a bridgehead nitrogen atom is reported. 1,3-Dialkylpyrazolo[1,5-a]-1,3,5-triazine-2,4-diones, were prepared by the treatment of 3-methylpyrazolo[1,5-a]-1,3,5-triazine-2,4-dione (3) with the corresponding alkyl iodide. Similarly, the reaction of 3-methyl-7-phenylpyrazolo[1,5-a]-1,3,5-dialkyl-7-phenylpyrazolo[1,5-a]-1,3,5-triazine-2,4-diones. The starting materials, 3 and 17 , were prepared via the reaction of an appropriate 3-aminopyrazole with ethoxycarbonyl isothiocyanate. Several 8-bromo derivatives were prepared by direct bromination of the 1,3-dialkylpyrazolo[1,5-a]-1,3,5-triazine-2,4-diones. 相似文献
7.
2,2′,2″-(2,4,6-Trioxo-1,3,5-triazinane-1,3,5-triyl) triacetonitrile (or tris-(cyanomethyl)-isocyanurate) and 1,3,5-tris((1/2H-tetrazol-5-yl)methyl)-1,3,5-triazinane-2,4,6-trione (or tris-(5-tetrazolylmethyl)-isocyanurate) were synthesized with new methods. High yields, simple methodology, and cheapness are advantages of the methods. Furthermore, 1,3,5-tris((1/2H-tetrazol-5-yl)methyl)-1,3,5-triazinane-2,4,6-trione was synthesized in the less hazardous condition. The compounds were characterized by elemental analysis, IR, 1HNMR, 13CNMR and mass spectroscopic analysis. In addition, DSC/TGA measurements were carried out to determine the thermal behavior of the final product. 相似文献
8.
A. V. Shastin T. I. Godovikova T. S. Pivina N. I. Golovina G. V. Shilov Yu. A. Strelenko B. L. Korsunskii V. P. Lodygina 《Russian Chemical Bulletin》2006,55(6):1060-1065
The structure of 2,4,6-tris[di(tert-butoxycarbonyl)methylidene]hexahydro-1,3,5-triazine was studied by quantum chemistry, NMR and IR spectroscopy, and X-ray
diffraction. This compound exists exclusively in the hexahydro-1,3,5-triazine form both in solution and in the solid phase,
although due to the loss of the aromatization energy, this structure should be less stable than a 1,3,5-triazine structure.
The formation of strong intramolecular hydrogen bonds confirmed by NMR and IR spectroscopy and X-ray diffraction data may
be a main reason for stabilization of the hexahydro-1,3,5-triazine isomer.
Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 6, pp. 1022–1026, June, 2006. 相似文献
9.
Eight new multinuclear FeIII and CrIII complexes involving the tetradentate Schiff bases N,N′‐bis(salicylidene)ethylenediamine (salenH2) or N,N′‐bis(salicylidene)benzene‐1,2‐diamine (salophH2) and the two new ligands 4,4′,4″,4′′′,4′′′′,4′′′″‐[1,3,5‐triazine‐2,4,6‐triyltris(nitrilomethylidyne‐4,1‐phenyleneoxy‐1,3,5‐triazine‐6,2,4‐triyldiimino)]hexakis[benzoic acid] ( 4 ) or 5,5′,5″,5′′′,5′′′′,5′′′″‐[1,3,5‐triazine‐2,4,6‐triyltris(nitrilomethylidyne‐4,1‐phenyleneoxy‐1,3,5‐triazine‐6,2,4‐triyldiimino)]hexakis[benzene‐1,3‐dicarboxylic acid] ( 5 ) were synthesized (Schemes 1 and 2) and characterized by means of 1H‐NMR and FT‐IR spectroscopy, elemental analysis, LC/MS analysis, AAS (atomic‐absorption spectrum) analysis, thermal analyses, and magnetic‐susceptibility measurements. The complexes can also be characterized as low‐spin distorted‐octahedral FeIII and CrIII complexes bridged by carboxylato moieties. 相似文献
10.
Heating of 6-amino-1,3-dimethyluracil with hexafluoroacetone and ethyl trifluoropyruvate benzoylimines in DMF in the presence of Et3N results in 1,3-dimethyl-7-phenyl-5,5-bis(trifluoromethyl)-1,2,3,4,5,8-hexahydropyrimido[4,5-d]pyrimidine-2,4-dione and 5-benzoylamido-1,3-dimethyl-5-trifluoromethyl-1,2,3,4,5,6-hexahydropyrrolo[2,3-d]pyrimidine-2,4,6-trione, respectively. 相似文献
11.
I. P. Romanova S. G. Fattakhov A. A. Nafikova I. I. Vandyukova R. R. Shagidullin N. M. Azancheev V. S. Reznik O. G. Sinyáshin 《Russian Chemical Bulletin》1998,47(9):1812-1819
The reactions of phosphine derivatives of diallyl isocyanurates with palladium(ii) dichloride lead to the formation of complexes, whose structure, composition, and stability depend on the length of the methylene
chain between the isocyanurate and diphenylphosphine fragments in the ligand. 1,3-Diallyl-5-[5′-(diphenylphosphino)pentyl
and 10′-(diphenyl-phosphino)decyl] isocyanurates with PdCl2 form monomeric L2PdCl2
trans-complexes in which P atoms of the ligands participate in coordination with the metal. 1,3-Diallyl-5-[2′-(diphenylphosphino)ethyl]
isocyanurate with PdCl2 forms a dimeric (LPdCl2)2 complex, which decomposes in a solution to the monomer including solvent molecule into the coordination sphere of the metal.
The reactions of 1,3-diallyl-5-[4′-(diphenylphosphino)butyl] isocyanurate and 1,3-diallyl-5-[6′-(diphenylphosphino)hexyl]
isocyanurate with PdCl2 give monomeric chelate LPdCl2 complexes in which one of the allyl groups of the isocyanurate cycle participates in coordination with the central ion along
with the phosphorus atom.
Translated fromIzvestiya Akademii Nauk. Seriya Khimicheskaya, No. 9, pp. 1859–1865, September, 1998. 相似文献
12.
《Mendeleev Communications》2023,33(4):448-450
Spirocyclization of morpholinium 3-[(aryl)(1,3-dimethyl-2,4,6-trioxohexahydropyrimidin-5-yl)methyl]-6-methyl-2-oxo-2H-pyran-4-olate by the action of sodium acetate-N-bromosuccinimide system in ethanol at room temperature results in spiro[furo[3,2-c]pyran-2,5’-pyrimidine] derivatives in 92–98% yields, the protocol allowing to avoid column chromatography purification. This new highly efficient and facile procedure is a convenient way to substituted unsymmetrical spiro scaffold containing pyrimidine-2,4,6-trione and 2,3-dihydro-4H-furo[3,2-c]pyran-4-one fragments promising for biomedical applications. 相似文献
13.
Ouro Adetchessi Daniel Desor Isabelle Forfar Christian Jarry Jean Michel Leger Michel Laguerre Alain Carpy 《Journal of heterocyclic chemistry》1997,34(2):429-434
The reaction of 2-amino-2-oxazolines with ethoxycarbonyl isocyanate was investigated in order to access to fused 1,3,5-triazine-2,4-diones with a potential 5-HT2 antagonist activity. The reaction leads to 2,3,6,7-tetrahydro-4H-oxazolo[3,2-a]-1,3,5-triazine-2,4-diones and to 1-carbethoxy-3-(2-iminooxazolidine)ureas. During the carbamoylation the regioselectivity seems to be related to the strong nucleophilic character of the endo nitrogen atom of 2-amino-2-oxazolines. The structures of two compounds were studied by X-ray crystallography. N-Substituted compounds have been prepared by alkylation of the 2,3,6,7-tetrahydro-7-phenoxymethyl-4H-oxazolo[3,2-a]-1,3,5-triazine-2,4-dione. 相似文献
14.
Reactions of 3-(Dimethylamino)-2,2-dimethyl-2H-azirines with Barbituric-Acid Derivatives The reaction of 3-(dimethylamino)-2,2-dimethyl-2H-azirine ( 1 ) and 5,5-disubstituted barbituric acids 5 in i-PrOH at ca. 70° gives 2-[5-(dimethylamino)-4,4-dimethyl-4H-imidazol-2-yl]alkanamides of type 6 in good yields (Scheme 1). The formation of 6 proceeds with loss of CO2; various reaction mechanisms with a zwitterionic 1:1 adduct B as common intermediate are discussed (Schemes 2 and 5). Thermolysis of product 6 leads to 2-alkyl-5-(dimethylamino)-4,4-dimethyl-4H-imidazoles 8 or the tautomeric 2-alkylidene derivatives 8 ′ via elimination of HNCO (Scheme 3). The latter undergoes trimerization to give 1,3,5-triazine-2,4,6-trione. No reaction is observed with 1,5,5-trisubstituted barbiturates and 1 in refluxing i-PrOH, but an N-alkylation of the barbiturate occurs in the presence of morpholine (Scheme 4). This astonishing reaction is explained by a mechanism via formation of the 2-alkoxy-2-(dimethylamino )aziridinium ion H which undergoes ring opening to give the O-alkylated 2-amino-N1,N1-dimethylisobutyramide I as alkylating reagent (Scheme 4). 相似文献
15.
Two C-lactosyl lipids and the related C-galactosyl lipids have been synthesised and their binding to RCA120 plant lectin was compared with a second series of thiolactosylethoxyalkanes. The interactions were measured quantitatively in real time by surface plasmon resonance (BIAcore) at a range of concentrations and temperatures from 5 to 30 degrees C. The C-galactosyl lipid (1,3-dimethyl-5-[beta-D-galactopyranosyl]-5-(4-octadecyloxybenzyl)pyrimidine-2,4,6-trione) bound much more weakly with a K(A) = 8.86 x 10(5) than the corresponding C-lactosyl lipid (1,3-dimethyl-5-[beta-D-galactopyranosyl-(1 --> 4)-beta-D-glucopyranosyl]-5-(4-octadecyloxybenzyl)pyrimidine-2,4,6-trione) (K(A) = 2.31 x 10(7)). The influence of the linker region of the two different series of lactosyl lipids was clearly demonstrated by the differences in the binding to RCA120 lectin. The changes in kinetic values and in the enthalpic and entropic contribution to the free energy of binding reflected the importance of the linker and the hydrocarbon anchor holding the synthetic glycolipids in the neomembrane. 相似文献
16.
Georgiy V. Malkov Alexey V. Shastin Yakov I. Estrin Elmira R. Badamshina Yuriy M. Mikhailov 《Macromolecular Symposia》2010,296(1):107-111
The results of the kinetic study of melt and solution polymerization at the 1,3-dipolar cycloaddition reaction of the AB2 monomer – 2-azido-4,6-bis(prop-2-yn-1-yloxy)-[1,3,5]-triazine (ABPOT) are presented in this work as well as the results of the 13C-NMR characterization of the obtained hyperbranched poly([1,2,3]-triazole-[1,3,5]-triazine)s. It is established, that the first-shell substitution effect during polyaddition process and unusual high degree of branching (up to 0.9) of polymers synthesized in melt are held. 相似文献
17.
O. V. Kovalchukova A. V. Churakov S. B. Strashnova Al-Tahan Rana Abdulillah Abbas V. S. Sergienko D. N. Kuznetsov K. I. Kobrakov 《Russian Journal of Inorganic Chemistry》2013,58(4):395-399
Twelve new d-metal complexes with 5-[(4-nitrophenyl)hydrazo]pyrimidine-2,4,6-trione (HL1) and 4-methyl-5-[4-nitrophenylhydrazo]-2,6-dioxo-1,2,5,6-tetrahydropyridine-3-carbonitryl (HL2) have been synthesized and separated out in the crystalline state. The crystal and molecular structures of HL1 have been solved by X-ray diffraction analysis. The organic molecule exists in the crystalline state as a planar hydrazo tautomer stabilized by intramolecular hydrogen bonds. Metal coordination is bidentate chelate. The acid-base equilibria and complexation of the ligands in solutions have been studied, and the complexation constants have been found. 相似文献
18.
A. V. Shastin T. I. Godovikova B. L. Korsunskii 《Chemistry of Heterocyclic Compounds》1998,34(10):1195-1197
A study was carried out on electrophilic addition and hydrolytic dissociation of 2,4,6-tris[di(tert-butoxycarbonyl)methylene]hexahydro-1,3,5-triazine.
Chloro, bromo, and methyl derivatives of tris[di(tert-butoxycarbonyl)methyl]-1,3,5-triazine were synthesized for the first
time as well as 2,4,6-tris-(tert-butoxycarbonylmethyl)-1,3,5-triazine.
For Communication 1, see ref. [1].
N. D. Zelinskii Institute of Organic Chemistry, Russian Academy of Sciences, 117913 Moscow and Institute of Chemical Physics,
Russian Academy of Sciences at Chernogolovka, 142432 Chernogolovka, Moscow Oblast. Translated from Khimiya Geterotsiklicheskikh
Soedinenii, No. 10, pp. 1404–1407, October, 1998. 相似文献
19.
Masaaki Yoshifuji Yuichi Hirano Gregor Schnakenburg Rainer Streubel Edgar Niecke Shigekazu Ito 《Helvetica chimica acta》2012,95(10):1723-1729
1,3‐Di(tert‐butyl)‐2,4‐bis[2,4,6‐tri(tert‐butyl)phenyl]‐1,3‐diphosphacyclobutane‐2,4‐diyl was formed from [2,4,6‐tri(tert‐butyl)phenyl]phosphaacetylene and t‐BuLi. In addition, the X‐ray diffraction analysis was carried out, together with theoretical calculations of the structure and NMR data. 相似文献
20.
Amino acids were immobilised by attaching them via a carbamate linker to Wang resin. These intermediates were converted to 1-(1,3-benzoxazol-2-yl)alkanamines over three steps, followed by coupling with 4-alkyl-6-chloro-1,3,5-triazine-2-amines to furnish the desired N-[1-(1,3-benzoxazol-2-yl)alkyl]-6-alkyl-1,3,5-triazine-2,4-diamines. Physico-chemical property profiles were used to support design and development of a combinatorial library. The synthetic methodology described herein was validated with the production of a herbicide targeted library of 300 members. 相似文献