Acoustic Measures of Symptoms in Abductor Spasmodic Dysphonia

Speech of patients with abductor spasmodic dysphonia (ABSD) was analyzed using acoustic analyses to determine: (1) which acoustic measures differed from controls and were independent factors representing patients' voice control difficulties, and (2) whether acoustic measures related to blinded perceptual counts of the symptom frequency in the same patients. Patients' voice onset time for voiceless consonants in speech were significantly longer than the controls (p = 0.015). A principle components analysis identified three factors that accounted for 95% of the variance: the first factor included sentence and word duration, frequency shifts, and aperiodic instances; the second was phonatory breaks; and the third was voice onset time. Significant relationships with perceptual counts of symptoms were found for the measures of acoustic disruptions in sentences and sentence duration. Finally, a multiple regression demonstrated that the acoustic measures related well with the perceptual counts (r² = 0.84) with word duration most highly related and none of the other measures contributing once the effect of word duration was partialed out. The results indicate that some of the voice motor control deficits, namely aperiodicity, phonatory breaks, and frequency shifts, which occur in patients with ABSD, are similar to those previously found in adductor spasmodic dysphonia. Results also indicate that acoustic measures of intermittent disruptions in speech, voice onset time, and speech duration are closely related to the perception of symptom frequency in the disorder.     

Iron in Parkinson's Disease Revisited

Hyperfine Interactions - Mössbauer studies of fresh frozen samples taken at autopsy from different parts of the human brain (globus pallidus (GP), substantia nigra (NS), and hippocamp (Hip))...     

Acoustic voice analysis in patients with Parkinson''s disease treated with dopaminergic drugs

To quantify several acoustic features of the voice in patients withParkinson's disease (PD), 41 patients and 28 age and sex-matched controls were studied. PD severity was assessed with the Unified PD Rating Scale (UPDRS) and the Hoehn and Yahr staging. The Computerized Speech Lab 4300 program (Kay Elemetrics) was used. Two seconds of a sustained /a/ and a sentence were captured with a microphone and laryngograph equipment. Measures included fundamental frequency (FO), frequency perturbation (fitter), intensity perturbation (shimmer), and harmonic/noise ratio (H/N) of the vowel /a/, and frequency and intensity variability of a sentence, phonational range, dynamic range at the natural frequency, maximum phonational time and s/z ratio. All subjects underwent indirect laryngoscopy and/or laryngeal fibroscopy. When compared with controls, PD patients showed higher jitter, lower H/N ratio, lower frequency and intensity variability of the sentence, and lower phonational range and reported a higher frequency of the presence of low voice-intensity, monopitch, voice arrests, and struggle. These features seem to be unaffected by the duration and severity of the disease.     

Can we really ‘read’ art to see the changing brain? A review and empirical assessment of clinical case reports and published artworks for systematic evidence of quality and style changes linked to damage or neurodegenerative disease

The past three decades have seen multiple reports of people with neurodegenerative disorders, or other forms of changes in their brains, who also show putative changes in how they approach and produce visual art. Authors argue that these cases may provide a unique body of evidence, so-called ‘artistic signatures’ of neurodegenerative diseases, that might be used to understand disorders, provide diagnoses, be employed in treatment, create patterns of testable hypotheses for causative study, and also provide unique insight into the neurobiological linkages between the mind, brain, body, and the human penchant for art-making itself. However—before we can begin to meaningfully build from such emerging findings, much less formulate applications—not only is such evidence currently quite disparate and in need of systematic review, almost all case reports and artwork ratings are entirely subjective, based on authors' personal observations or a sparse collection of methods that may not best fit underlying research aims. This leads to the very real question of whether we might actually find patterns of systematic change if fit to a rigorous review—Can we really ‘read’ art to illuminate possible changes in the brain? How might we best approach this topic in future neuroscientific, clinical, and art-related research? This paper presents a review of this field and answer to these questions. We consider the current case reports for seven main disorders—Alzheimer's and Parkinson's disease, frontotemporal and Lewy body dementia, corticobasal degeneration, aphasia, as well as stroke—consolidating arguments for factors and changes related to art-making and critiquing past methods. Taking the published artworks from these papers, we then conduct our own assessment, employing computerized and human-rater-based approaches, which we argue represent best practice to identify stylistic or creativity/quality changes. We suggest, indeed, some evidence for systematic patterns in art-making for specific disorders and also find that case authors showed rather high agreement with our own assessments. More important, through opening this topic and past evidence to a systematic review, we hope to open a discussion and provide a theoretical and empirical foundation for future application and research on the intersection of art-making and the neurotypical, the changed, and the artistic brain.     

普通话常规重音分布规则的研究

采用心理统计方法对中等规模语料库进行分析，探讨句法、韵律及其声学相关物之间的关系，根据汉语口语常规重音分布的规律，研究普通话常规重音分布规则及其在实际话语中应用的先后次序，最终建立适用于汉语文语转换系统的常规重音分布规则系统。     

Acoustic analysis of induced vocal stressby means of cognitive workload tasks

The purpose of this study was to determine the acoustic effects on voice of three tasks of cognitive workload and their possible relationship to stress. Acoustic analysis was used to measure stress and workload in four experimental tasks and two experiments. In the first experiment, subjects performed cognitive workload tasks under a stressful condition, performing the tasks as rapidly as possible without errors and with the knowledge that any errors committed would reduce their grade in a course. The second condition was to perform the same tasks but without the condition of stress related to the final grade. Four testing conditions were included. One was a baseline measure in which subjects spelled the Spanish alphabet. The second was the reading of a tongue twister, the third was the reading of a tongue twister with delayed auditory feedback, and the fourth was spelling the Spanish alphabet in reverse order. In each condition the subjects prolonged the vowel /a/ for, approximately 5 sec. All subjects performed a test to determine their overall level of anxiety. The results suggest that in conditions of experimentally induced stress there is an increase in the fundamental frequency (F₀) relative to baseline, an increase in jitter and shimmer, an increase in the high-frequency harmonic energy, and a decrease in spectral noise.     

Acoustic Signal Typing for Evaluation of Voice Quality in Tracheoesophageal Speech

SUMMARY: Because of the aperiodicity of many tracheoesophageal voices, acoustic analysis of the tracheoesophageal voice is less straightforward than that of the normal voice. This study presents the development and testing of an acoustic signal typing system based on visual inspection of a narrow-band spectrogram that can be used by researchers for classification of voice quality in tracheoesophageal speech. In addition to this classification system, a selection of acoustic measures [median fundamental frequency, standard deviation of fundamental frequency, jitter, percentage of voiced (%Voiced), harmonics-to-noise ratio (HNR), glottal-to-noise excitation (GNE) ratio, and band energy difference (BED)] was computed to provide more insight into the acoustic components of tracheoesophageal voice quality. For clinical relevance, relationships between the acoustic signal types and an overall judgment of the voice were investigated as well. Results showed that the four acoustic signal types form a good basis for performing more acoustic analyses and give a good impression of the overall quality of the voice.     

Effects of Bilateral Subthalamic Nucleus Stimulation and Medication on Parkinsonian Speech Impairment

This study aimed to assess quantitatively the effect of bilateral subthalamic nucleus (STN) stimulation and medication on hypokinetic parkinsonian dysarthria. Twelve Italian patients (11 males and 1 female) with idiopathic Parkinson's disease (mean age 60.29+/-7.50 years) and bilateral STN implantation were studied. Neurological assessments and acoustic recordings were performed in four clinical conditions combining stimulation and medication to assess the degree of motor disabilities and speech impairment. Acoustic analysis was performed by means of the Multidimensional Voice Program and the Advanced Motor Speech Profile (Kay Elemetrics, Lincoln Park, NJ). None of the evaluated parameters deteriorated after STN deep brain stimulation. STN stimulation significantly improved motor performances and vocal tremor and provided a major stability to glottal vibration. Effect of stimulation on these parameters was superior to that of levodopa. No significant variations were observed in perceptual evaluation and in acoustic parameters related to prosody, articulation, and intensity after either stimulation or medication. The improvement of acoustic parameters related to glottal vibration and voice tremor was not accompanied by a substantial effect on speech intelligibility. STN stimulation was more effective on global motor limb dysfunctions than on dysarthria, but we did not report negative consequences on speech.     

Acoustic analysis of voice in individuals with amyotrophic lateral sclerosis and perceptually normal vocal quality

Currently, early phonatory changes in amyotrophic lateral sclerosis(ALS) are not well understood. The aim of this study was to compare acoustic parameters of voice in ALS subjects who demonstrated perceptually normal vocal quality on sustained phonation with a control group. We hypothesized that objective analysis of voice would reveal significant differences on specific acoustic parameters of voice compared to the control group. Results revealed statistically significant differences between the two groups on measures related to frequency range and phonatory stability. The findings suggest that early bulbar signs affecting the laryngeal system may be present in patients with ALS before the occurrence of perceptually aberrant vocal characteristics.     

The Acoustic Characteristics of Professional Opera Singers Performing in Chorus Versus Solo Mode

In this study, members of a professional opera chorus were recorded using close microphones, while singing in both choral and solo modes. The analysis included computation of long-term average spectra (LTAS) for the two song sections performed and calculation of singing power ratio (SPR) and energy ratio (ER), which provide an indication of the relative energy in the singer's formant region. Vibrato rate and extent were determined from two matched vowels, and SPR and ER were calculated for these vowels. Subjects sung with equal or more power in the singer's formant region in choral versus solo mode in the context of the piece as a whole and in individual vowels. There was no difference in vibrato rate and extent between the two modes. Singing in choral mode, therefore, required the ability to use a similar vocal timbre to that required for solo opera singing.     

Acoustic concomitants of emotional expression in operatic singing: The case of lucia in Ardi gli incensi

Two excerpts from the cadenza in Ardi gli incensi from Donizetti's opera Lucia di Lammermoor were acoustically analyzed for five recorded versions of the cadenza by Toti dal Monte, Maria Callas, Renata Scotto, Joan Sutherland, and Edita Gruberova. These acoustic parameters of the singing voices were correlated with preference and emotional expression judgments, based on pairwise comparisons, made by a group of experienced listener-judges. In addition to showing major differences in the voice quality of the five “dive” studied, the acoustic parameters suggested which vocal cues affect listener judgments. Two component scores, based on a factorial-dimensional analysis of the acoustic parameters, predicted 84% of the variance in the preference ratings.     

Acoustic analysis of the singing and speaking voice in singing students

The singing power ratio (SPR) is an objective means of quantifying the singer's formant. SPR has been shown to differentiate trained singers from nonsingers and sung from spoken tones. This study was designed to evaluate SPR and acoustic parameters in singing students to determine if the singer-intraining has an identifiable difference between sung and spoken voices. Digital audio recordings were made of both sung and spoken vowel sounds in 55 singing students for acoustic analysis. SPR values were not significantly different between the sung and spoken samples. Shimmer and noise-to-harmonic ratio were significantly higher in spoken samples. SPR analysis may provide an objective tool for monitoring the student's progress.     

Experimental and theoretical investigation of the apomorphine Raman spectrum

Apomorphine (aporphine‐10,11‐diol, CA Registry Number 58004) is a non‐narcotic derivative of morphine discovered in 1869 by Mattheisen [1] and it is a well‐known potent short‐acting dopamine agonist at D1 and D2 dopamine receptors, typically used in the treatment of patients with advanced Parkinson's disease (PD). To identify the unknown vibrational spectrum of this compound, apomorphine bare salt and its commercial drug formulation (Apofin) were examined by means of Raman spectroscopy. In the Raman spectrum of apomorphine (both bare salt and commercial drug), two strong characteristic signals were found, which were assigned with the help of first‐principles calculations: the band at 1589 cm⁻¹ (assigned to the stretching mode of the B aromatic ring coupled with C H in‐plane bending) and the band at 1302 cm⁻¹ (assigned to O‐H in‐plane bending and CH₂ twisting and wagging vibrations). Copyright © 2009 John Wiley & Sons, Ltd.