脉冲输入免疫因子的HBV模型的稳定性和持久性分析

提出了一个数学模型,用于研究脉冲投放免疫因子对HBV传染病动力学的影响.通过利用脉冲微分不等式和比较定理,证明了HBV模型的无病周期解的存在性,给出了无病周期解的全局渐近稳定性和系统的持续性的充分条件.研究结果表明:短的投放周期或适当的免疫因子投放量可以导致HBV的清除.     

The analysis of an epidemic model on networks

The paper consider an epidemic model with birth and death on networks. We derive the epidemic threshold R₀ dependent on birth rate b, death rate d (natural death) and μ from the infectious disease and natural death, and cure rate γ. And the stability of the equilibriums (the disease-free equilibrium and endemic equilibrium) are analysed. Finally, the effects of various immunization schemes are studied and compared. We show that both targeted, and acquaintance immunization strategies compare favorably to a proportional scheme in terms of effectiveness. For active immunization, the threshold is easier to apply practically. To illustrate our theoretical analysis, some numerical simulations are also included.     

Analysis on dynamics of a population model with predator–prey-dependent functional response

We consider a reaction–diffusion population model with predator–prey-dependent functional response. Firstly, we discuss the conditions which ensure the model has a unique positive constant solution. Secondly, we investigate the dynamical properties of the model, including the large time behaviors of the nonconstant solutions and the local and the global asymptotic stability of the positive constant solution.     

Persistence and global stability in a delayed predator–prey system with Michaelis–Menten type functional response

A delayed three-species predator–prey food-chain model with Michaelis–Menten type functional response is investigated. It is proved that the system is uniformly persistent under some appropriate conditions. By means of constructing suitable Lyapunov functional, sufficient conditions are derived for the global asymptotic stability of the positive equilibrium of the system.     

Dynamics and steady-state analysis of an unstirred chemostat model with internal storage and toxin mortality

This study proposes and analyzes a reaction–diffusion system describing the competition of two species for a single limiting nutrient that is stored internally in an unstirred chemostat, in which each species also produces a toxin that increases the mortality of its competitors. The possibility of coexistence and bistability for the model system is studied by the theory of uniform persistence and topological degree theory in cones, respectively. More precisely, the sharp a priori estimates for nonnegative solutions of the system are first established, which assure that all of nonnegative solutions belong to a special cone. Then it turns out that coexistence and bistability can be determined by the sign of the principal eigenvalues associated with specific nonlinear eigenvalue problems in the special positive cones. The local stability of two semi-trivial steady states cannot be studied via the technique of linearization since a singularity arises from the linearization around those steady states. Instead, we introduce a 1-homogeneous operator to rigorously investigate their local stability.     

Threshold dynamics for a cholera epidemic model with periodic transmission rate

A cholera epidemic model with periodic transmission rate is presented. The basic reproduction number is defined. It is shown that the disease-free equilibrium is globally asymptotically stable and the cholera eventually disappears if the basic reproduction number is less than one. And if the basic reproduction number is greater than one, there exists a positive periodic solution which is globally asymptotically stable. Numerical simulations are provided to illustrate analytical results.     

Bifurcation analysis in an approachable haematopoietic stem cells model

A haematopoietic stem cells model (HSC) with one delay is considered. At first, we investigate the stability and existence of Hopf bifurcations by analyzing the distribution of the roots of associated characteristic equation. Then an explicit formula for determining the stability and the direction of periodic solutions bifurcating from Hopf bifurcations is derived, using the normal form theory and center manifold argument. Finally, some numerical simulations are carried out for supporting the analytic results.     

Stability analysis for an epidemic model with stage structure

An epidemic model with stage structure is formulated. The period of infection is partitioned into the early and later stages according to the developing process of infection, and the infectious individuals in the different stages have the different ability of transmitting disease. The constant recruitment rate and exponential natural death, as well as the disease-related death, are incorporated into the model. The basic reproduction number of this model is determined by the method of next generation matrix. The global stability of the disease-free equilibrium and the local stability of the endemic equilibrium are obtained; the global stability of the endemic equilibrium is got under the case that the infection is not fatal.     

抗生素调节的单种群chemostat模型研究

构建并分构了抗生素调节的单种群chemosta模型 ,得到了依赖于抗生素输入浓度的微生物种群绝灭和一致持续生存的充分条件 .     

The transmission of meningococcal infection: a mathematical study

The most common type of bacterial meningitis in the developed countries is caused by Neisseria meningitidis bacteria, which cause meningococcal meningitis. Case fatality rate can be between 3% and 10% in developed countries and as high as 20% in African countries. During epidemics in sub-Saharan countries, the so-called meningitis belt, the case fatality rate can peak to 70% or higher. Some people who have bacterial meningitis experience some form of after effects: epilepsy, damaged eyesight, hearing loss, brain damage. There is no immunity after infection. Approximately on average 10% of the population at any time carry the germs for days, weeks, or months. Carriers can infect other individuals by close contacts, even though they do not become ill themselves. An age-structured mathematical model is formulated that enables the understanding of the dynamics of the infection transmission. The model is used to study the conditions for the stability of the disease-free steady state (which imply extinction of the disease) and the existence of an endemic state (which leads to persistence of the disease in the population). The results of the model are applied to identify the contribution of the carriers to the transmission of the disease. Final epidemiological conclusions are given.     

A discrete epidemic model for SARS transmission and control in China

Severe acute respiratory syndrome (SARS) is a rapidly spreading infectious disease which was transmitted in late 2002 and early 2003 to more than 28 countries through the medium of international travel. The evolution and spread of SARS has resulted in an international effort coordinated by the World Health Organization (WHO).

We have formulated a discrete mathematical model to investigate the transmission of SARS and determined the basic reproductive number for this model to use as a threshold to determine the asymptotic behavior of the model. The dependence of the basic reproductive number on epidemic parameters has been studied. The parameters of the model have been estimated on the basis of statistical data and numerical simulations have been carried out to describe the transmission process for SARS in China. The simulation results matches the statistical data well and indicate that early quarantine and a high quarantine rate are crucial to the control of SARS.     

A discrete hierarchical model of intra-specific competition

A discrete hierarchical model with either age, size, or stage structure is derived. The resulting scalar equation for total population level is then used to study contest and scramble intra-specific competition. It is shown how equilibrium levels and resilience are related for the two different competition situations. In particular, scramble competition yields a higher population level while contest competition is more resilient if the uptake rate as a function of resource density is concave down. The conclusions are reversed if the uptake rate is concave up.     

The dynamics of an age-structured TB transmission model with relapse

This paper deals with the global dynamics for a tuberculosis transmission model with age-structure and relapse. The time delay in the progression from the latent individuals to becoming the infectious individuals is also considered in our model. We perform some rigorous analyses for the model, including presenting an explicit formula for the basic reproduction number of the model, addressing the persistence of the solution semiflow and the existence of a global attractor. Based on these analyses, we establish some results about stability and instability of the solutions for our model. At end, the model is applied to describe tuberculosis transmission in China. The number of the total population and the number of the annual newly reported TB cases both match the statistical data well. The number of the total population, the latent individuals, the infectious individuals, the Purified Protein Derivative (PPD) positive rate, and the prevalence rate from 2020 to 2035 all are presented.     

Uniform persistence of asymptotically periodic multispecies competition predator–prey systems with Holling III type functional response

In this paper, we studied the persistence of the asymptotically periodic multispecies competition predator–prey system with Holling III type functional response. Further, by use of the Standard Comparison Theorem, we improved the results of paper [C. Chen, F. Chen, Conditions for global attractivity of multispecies ecological competition-predator system with Holling III type functional response, Journal of Biomathematics 19(2) (2004) 136–140].     

Spatiotemporal dynamics analysis and optimal control method for an SI reaction-diffusion propagation model

In the new social media era, it is becoming increasingly important to explore the propagation rules for rumors in social networks. This article is concerned with investigating a diffusive susceptible-infected rumor propagation model with a nonlinear propagation function in a spatially heterogeneous environment. We establish the uniform persistence and analyze the asymptotic behavior of the rumor-spreading steady state for the spatially heterogeneous model when one of the diffusion coefficients tends to zero. Moreover, to better reflect the effect of a time delay on the process of rumor propagation, we establish a spatially homogeneous model with a time delay and prove the existence and local stability of the corresponding equilibrium point. Furthermore, the optimal control in the spatially homogeneous environment case is derived. Finally, several numerical simulations are performed to verify the theoretical results in both spatially heterogeneous and spatially homogeneous systems.     

An analysis of a mathematical model of trophoblast invasion

We present a mathematical model that describes the initial stages of placental development during which trophoblast cells begin to invade the uterine tissue. We then carry out a mathematical analysis of a simpler submodel that describes the final stages of normal embryo implantation and suggests that as the timescale of interest increases, the dominant migratory mechanism of the trophoblasts switches from chemotaxis to nonlinear random motion.     

具有时滞Michaelis-Menten型功能性反应的有放养的捕食链非自治扩散系统的一些性态

本文讨论了有放养的时滞Michaelis Menten型功能性反应的捕食链 .应用微分不等式和V函数法 ,在一定条件下讨论了该系统的一致持久性 ,得到了概周期解的存在唯一性及其全局吸引性 .