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电化学方法研究环糊精与酮洛芬的包结行为 总被引:7,自引:0,他引:7
以电化学方法研究了各种环糊精及其衍生物对酮洛芬电化学行为的影响,测定了酮洛芬与β环糊精,羟丙基β-环糊精和甲基化-β-环糊精的包结常数及其温度对包结作用的影响,并由各包结物的热力学参数解释包结现象。 相似文献
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苯肼-α-环糊精包合物吸附行为的光谱与电化学研究 总被引:3,自引:0,他引:3
研究了水溶液体系中α环糊精(αCD)存在时盐酸苯肼(PH)的光吸收行为及电化学行为.紫外可见光谱结果表明,水溶液体系中盐酸苯肼(PH)与α环糊精(αCD)可生成1∶1包合物,经测定该包合物的包合常数(Kf)为178mol-1·dm3;与未被包合的PH相比较,PH与α环糊精生成的包合物对光及氧的敏感性质大大降低.该性质可用于改进盐酸苯肼的保存方法,并拓宽了其在医药工业中的应用范围.实验还发现水溶液体系中α环糊精存在时盐酸苯肼的电化学氧化行为得到极大的抑制. 相似文献
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β环糊精-碳纳米管/壳聚糖自组装膜修饰电极在过量抗坏血酸存在下测定多巴胺 总被引:2,自引:0,他引:2
基于β环糊精和碳纳米管可通过范德华力形成复合物, 利用壳聚糖分子以静电引力吸附富集碳纳米管-β环糊精, 采用层层自组装制备了β环糊精-碳纳米管/壳聚糖玻碳修饰电极, 并研究了多巴胺在修饰电极上的电化学行为. 在抗坏血酸和多巴胺共存体系中, 二者的氧化峰电位相差约163 mV, 据此建立了多巴胺的电化学选择性测定, 峰电流与浓度在1.0×10-6~7.0×10-5 mol/L 范围内呈良好的线性关系, 检出限为0.3 μmol/L. 相似文献
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离子液体功能化环糊精化合物(ILs-CD)兼具环糊精"内疏水、外亲水"的结构特性和离子液体的低毒性、低蒸气压、电化学窗口宽、热稳定性和化学稳定性高等特性,是一类有巨大发展潜力的新型大环化合物.本文主要根据合成的ILs-CD化合物的阳离子不同对其进行了分类,并介绍了其合成方法,同时阐述了其在电化学、环境、食品、医药、催化... 相似文献
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Complexation of morin with three kinds of cyclodextrin. A thermodynamic and reactivity study 总被引:1,自引:0,他引:1
Jullian C Orosteguis T Pérez-Cruz F Sánchez P Mendizabal F Olea-Azar C 《Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy》2008,71(1):269-275
Properties of inclusion complexes between morin (M) and beta-cyclodextrin (betaCD), 2-hydroxypropyl-beta-cyclodextrin (HPbetaCD) and Heptakis (2,6-O-di methyl) beta-cyclodextrin (DMbetaCD) such as aqueous solubility and the association constants of this complex have been determined. The water solubility of morin was increased by inclusion with cyclodextrins. The phase-solubility diagrams drawn from UV spectral measurements are of the A(L)-type. Also ORAC(FL) studies were done. An increase in the antioxidant reactivity is observed when morin form inclusion complex with the three cyclodextrin studied. Finally, thermodynamics studies of cyclodextrin complexes indicated that for DMbetaCD the inclusion is primarily enthalpy-driven process meanwhile betaCD and HPbetaCD are entropy-driven processes. This is corroborated by the different inclusion geometries obtained by 2D-NMR. 相似文献
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Julie Dutet Malika Lahiani-Skiba Ludovic Didier Soizic Jezequel Fréderic Bounoure Cécile Barbot Philippe Arnaud Mohamed Skiba 《Journal of inclusion phenomena and macrocyclic chemistry》2007,57(1-4):203-209
Purpose Ternary solid dispersions were prepared in order to estimate the effect of a double hydrophilization by cyclodextrins and
PEG 6000 on nimesulide apparent characteristics. Ternary solid dispersions of nimesulide, cyclodextrins and PEG 6000 were
characterized using DSC, FT-IR, dissolution studies and evaluating the bioavailability in rats.
Methods Ternary solid dispersions were prepared either using native powders or using a preformed inclusion complex of nimesulide and
cyclodextrin. Inclusion complexes and pure drug were used as references. Circulating nimesulide was measured out in rat plasma
after orally administration of our different products (ternary solid dispersions, inclusion complexes and pure drug).
Results An improvement of the nimesulide dissolution rate was obtained with inclusion complexes and ternary solid dispersion. In rat
plasma, inclusion complexes and ternary solid dispersion improved T
max.
Conclusions A second hydrophilization of inclusion complexes by PEG 6000 does not allow to achieve better results concerning nimesulide
concentration in rat plasma or in dissolution studies than with inclusion complexes alone. 相似文献
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A complex (C1) of tetrakis(4-hydroxylphenyl)porphyrin (THPP) and cyclodextrin-modified multi-walled carbon nanotubes (MWNTs-CD) was prepared. The UV-vis spectra show that the absorption bands of C1 are almost the same as those of THPP, implying that the electron distribution of THPP is not influenced by MWNTs-CD. On the other hand, the fluorescence of THPP is quenched, suggesting that there exists energy transfer between THPP and MWNTs-CD. In order to understand the interaction between THPP and MWNTs-CD, the electrochemical behavior of C1 was explored with cyclic voltammetry. The results display that the electrochemical behavior of C1 is similar to that of the inclusion complex of amino-modified cyclodextrin and THPP, but different from that of the MWNTs-CD. These phenomena indicate that the cyclodextrin moieties play an important role in the interaction between THPP and MWNTs-CD. 相似文献
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Thorsteinn Loftsson Dagný Hreinsdóttir Már Másson 《Journal of inclusion phenomena and macrocyclic chemistry》2007,57(1-4):545-552
Studies have shown that cyclodextrins form both inclusion and non-inclusion complexes and that several different types of
complexes can coexist in aqueous solutions. In addition, both cyclodextrins and cyclodextrin complexes are known to form aggregates
and it is thought that these aggregates are able to solubilize drugs through micellar-type mechanism. Thus, stability constants
determined from phase-solubility profiles are rarely true stability constants for of some specific drug/cyclodextrin complexes.
A more precise method for evaluation of the solubilizing effects of cyclodextrins is to determine their complexation efficiency
(CE). CE can be determined by measuring the solubility of a given drug at 2–3 cyclodextrin concentrations in pure water or
a medium constituting the pharmaceutical formulation such as parenteral solution or aqueous eye drop formulation. Based on
the CE value the drug:cyclodextrin ratio in the complexation medium can be determined as well as the increase in the formulation
bulk in a solid dosage form. Determination of CE is a simple method for quick evaluating the solubilizing effects of different
cyclodextrins and/or the effects of excipients on the solubilization. Here we report the CE of 43 different drugs with mainly
2-hydroxypropyl-β-cyclodextrin but also with randomly methylated β-cyclodextrin as well as few other cyclodextrins. Calculation of CE, drug:cyclodextrin molar ratio and the increase in the
formulation bulk is discussed, as well as the influence of the intrinsic solubility and drug lipophilicity on the CE. 相似文献
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N. Koen de Vries Betty Coussens Robert J. Meier Gerlie Heemels 《Journal of separation science》1992,15(8):499-504
The enantiomers of 2-chloropropionic acid methyl ester, cis-pinane, 2-bromoethylbenzene, 2-bromobutane, 2-hydroxybutane trifluoroacetyl ester, and styrene oxide have been resolved on an octakis-(3-O-butyryl-2,6-di-O-pentyl)-γ-cyclo-dextrin capillary column, and the separation of the styrene oxide enantiomers has also been studied on columns coated with octakis-(3-O-trifluoroacetyl-2,6-di-O-pentyl)-cyclodextrin, octakis-(2,3,6-tri-O-pentyl)-γ-cyclodextrin, heptakis-(3-O-trifluoroacetyl-2,6-di-O-pentyl)-β -cyclodextrin, and heptakis-(2,3,6-tri-O-methyl)-β-cyclodextrin. Thermodynamic parameters (ΔG, ΔH, and ΔS) were determined from variable temperature measurements. The inclusion complexes containing styrene oxide were also studied by molecular modeling techniques. It has been found that a combined molecular mechanics–molecular dynamics approach may be a valuable tool for rationalizing the qualitative trends observed in the experimental separation factors. For the inclusion complexes considered here it is shown that the orientation of the guest relative to the cyclodextrin host is determined by the size and polarity of the cyclodextrin. 相似文献
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Zhou H Lai WP Zhang Z Li WK Cheung HY 《Journal of computer-aided molecular design》2009,23(3):153-162
Due to the poor water solubility of andrographolide (andro), an inclusion technique has been developed to modify its physical and chemical properties so as to improve its bioavailability. In contrast with the immense experimental studies on the inclusion complexes of andro:cyclodextrin, no computational study has so far been carried out on this system. In this work, preliminary docking experiments with AutoDock were performed. Density Functional Theory (DFT) and Austin Model 1 (AM1) calculations upon the docking instances were applied to investigate the two possible modes of molecular inclusions between andro and x-cyclodextrin (xCD, where x is alpha, beta or gamma). Atoms-in-Molecules (AIM) analysis based on the B3LYP/cc-pVDZ wavefunction was applied to verify the existence of the intermolecular hydrogen bonds. It was found that the most stable complex among the six possible inclusion complexes was the one formed between andro and betaCD with andro's decalin ring moiety wrapped by CD at a ratio of 1:1. The hydrogen bonds between andro and CD were responsible for the stability of the inclusion complexes. The calculated data were found to be consistent with the experimental results. Thus, the results of this study can aid new drug design processes. 相似文献
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《Analytical letters》2012,45(4):543-560
Abstract The inclusion interactions of β‐cyclodextrin (β‐CD) and its derivative, namely hydroxypropyl‐β‐cyclodextrin (HP‐β‐CD) with clomipramine (CLOM) have been investigated. The guest molecule was clomipramine and inclusion complexes were characterized by UV, 1H NMR, 13C NMR, and 2D NMR spectroscopy. The main factors affecting the inclusion interaction were discussed in detail. The inclusion complexation behaviour of cyclodextrins with clomipramine was studied in an aqueous buffer solution of pH 4 and pH 5 at room temperature. According to the continuous variation method (Job's plot) applied to spectroscopy measurements a 1∶1 stoichiometry has been proposed for the complexes. Based on the significant enhancement of absorption intensity of clomipramine, a sensitive UV spectrophotometric methods with high sensitivity and selectivity were developed for determination of substance in bulk aqueous solution in the presence of β‐CD and HP‐β‐CD. The apparent association constant of the complex was 9.42 · 103 mol?1 L and 9.58 · 103 mol?1 L and the linear range was 17.6–70 µg mL?1 with a correlation coefficient of 0.9997 and a relative standard deviation (R.S.D.) of 0.97% and 1.02% using β‐CD and HP‐β‐CD, respectively. There was no interference from the excipients normally used in tablets and capsules. The proposed methods were successfully applied to the analysis of clomipramine in pharmaceuticals with satisfactory results. 相似文献