Synthesis and Biological Activity of Philanthotoxin Analogs

Sodium ion channels, acetylcholine esterase and neurotransmitter receptors in insect neurons and skeletal muscles are often made as target by practical neurotoxic pesticides. But insects can create resistance after using a pesticide for a long time. So th…     

Synthesis,Crystal Structure and Antimicrobial Activity of Ethyl 2-（1-cyclohexyl-4-phenyl-1H-1,2,3-triazol-5-yl）-2-oxoacetate

A novel 1,4,5-trisubstituted 1,2,3-triazole(C18H21N3O3) was synthesized by a one-pot three component reaction of 1-azidocyclohexane, 1-copper(I) phenylethyne and ethoxalyl chloride at room temperature. The molecular structure was determined by single-crystal X-ray analysis. The compound crystallizes in the monoclinic system, space group P21/n with a = 12.8167(9), b = 8.0966(6), c = 16.7079(9) , β = 98.716(2)o, Z = 4 and V = 1713.8(2). In the crystal, the molecules are related by inversion and paired into dimers via C–H···O and C–O···C interactions involving(oxo) acetate groups. Furthermore, X-ray analysis results are compared with the optimized structure computed by using B3 LYP method with 6-311 G basis set. The calculated results showed that optimized geometry can well reproduce the crystal structure parameters. The bioassay results indicate that the compound has good antibacterial and antifungal activities.     

Design and Synthesis of New Arylsulfonamide and Arylamide Derivatives for the Platelet Aggression Inhibitor

A series of arylsulfonamide and arylamide derivatives have been prepared from anisole in good yields.The structures of those compounds were confirmed by ^H-NMR and MS analysis.Their activities against platelet aggregation were tested in vitro by using the Born test on rabbits.     

Synthesis, Structure and Biological Activity of Zn（Ⅱ） Complex with Tris（benzimidazol-2-yl-methyl）amine Ligand

A new Zn(II) mononuclear complex with tris(benzimidazol‐2‐yl‐methyl)amine (NTB) was synthesized with stoichiometry of [Zn(NTB)NO₃]NO₃ · DIPY · DMF (DIPY : 4,4′‐dipyridyl). The complex was characterized by elemental analysis, UV and IR spectra. The crystal structure was determined by using X‐ray diffraction analysis. The crystal structure indicates that four N atoms and one O atom coordinate to zinc ion to construct a distorted trigonal‐dipyramid configuration. Three nonprotonated N atoms from imidazole groups are in the equatorial plane, one alkylamino N atom and one O atom from NO₃^?_‐ in the axial directions. The biological activity assay shows that this complex presents certain biological activity by means of pyrogallol autoxidation and it can be called a model compound of superoxide dismutase (SOD).     

Synthesis and Crystal Structure of 1-（N,N-Di-（p-toluenesulfonyl））-amino- 2-（N＇-p-toluenesulfonyl）-amino-3,5-dinitrobenzene

The title compound, 1-(N,N-di-(p-toluenesulfonyl))-amino-2-(N'-p-toluenesulfonyl)-amino-3,5-dinitrobenzene, was synthesized and structurally determined by single-crystal X-ray diffraction method. It crystallizes in orthorhombic, space group Pna21 with a = 13.723(2), b =25.354(4), c = 8.6565(12)(A), V= 3011.9(8)(A)3, Z= 4, Mr = 660.68, F(000) = 1368, Dc = 1.457 g/cm3,μ = 0.309, the final R = 0.0609 and wR = 0.1042. The H atom of N2-H group, which is the unique recognition site to anion, is enveloped by two oxygen atoms and one benzene from two and one p-toluenesulfonyl moieties, respectively.     

Syntheses and Biological Activities of Novel 3-Bromo-1-（3-chloropy- ridin-2-yl）-N-hydroxy-N-aryl- 1H-pyrazole-5-carboxamides

A series of novel 3-bromo-1-（3-chloropyridin-2-yl）-N-hydroxy-N-aryl-lH-pyrazole-5-carboxamides was synthesized by the reaction of pyrazole carbonyl chloride with each of substituted phenylhydroxyamines. The latter ones were prepared in good yields by reducing substituted nitrobenzene compounds with Zn/NH4CI reductant system in alcohol. Structures of the title compounds were determined by IR, 1H NMR, and HRMS. Their insecticidal and fungicidal activities were evaluated by larvicidal test against oriental armyworm and the mycelium growth rate method, respectively.     

Synthesis and Crystal Structure of 1,2-Bis-（p-nitrophenylsulfonamido）-4,5-dinitrobenzene

The title compound, 1,2-bis-(p-nitro-phenylsulfonamido)-4,5-dinitrobenzene, was synthesized and characterized by elemental analysis, IR and 1H NMR. A pale yellow prism crystal of C23H26N8O13S2 (Mr = 686.64) was obtained in DMF solution and determined by single-crystal X-ray diffraction method. It crystallizes in triclinic system, space group P1 with a = 10.346(4), b = 12.210(5), c = 12.976(5) , α = 108.220(8), β = 99.482(4), γ = 95.490(4)°, V = 1516.7(10) 3, Z = 2, Dc = 1.504 g/cm3, F(000) = 712, μ = 0.254, Mr = 686.64, the final R = 0.0561 and wR = 0.1487. One sulfonamido group of the title compound is deprotoned and forms N(3)=C(13). The crystal involves N,N-dimethylamine from the decomposition of DMF and the proton is transferred to N,N- dimethylamine. It is a strong proof for the characterization of deprotoned recognition compound by X-ray single-crystal structure.     

Synthesis,Crystal Structure and Biological Activity of 2-Chloro-N-{2-fluoro-5-[N-（phenylsulfonyl） phenyl-sulfonamido]phenyl}benzamide

2-Chloro-N-{2-fluoro-5-[N-（phenylsulfonyl）phenylsulfonamido]phenyl}benzamide was synthesized and its crystal structure was also determined by X-ray single-crystal diffraction. The title compound（C25H18ClFN2O5S2） belongs to monoclinic, space group P21/n with a=0.7377（3） nm, b=1.2036（5） nm, c=2.6846（11） nm, β=90.895（9）°, V=2.3833（16） nm3, Mr=544.98, Z=4, Dc=1.519 g/cm3, μ=0.385 mm–1, F（000）=1120, R1=0.0632, and wR2=0.1438. Its crystal structure belongs to a novel class that has not been reported yet, and its preliminary herbicidal activity was also tested. Its inhibition rate to seedling growth of barnyard grass reaches 15.1% at 100 μg/mL.     

Synthesis and Biological Activity of Tonghaosu Analogs Containing Phenoxy-phenyl Moiety

A new series of phenoxy-phenyl moieties containing tonghaosu analogs with varied B-ring 9 were synthesized and characterized by spectral studies. Their insect antifeedant activity against Pieris brassicae and insecticidal activity against Culex quinquefasciatus were investigated. Compound 9e exhibited excellent antifeeding activity.     

[反]-β-法尼烯类似物的设计、合成与生物活性研究

对[反]-β-法尼烯(EBF)类似物的骨架结构原子进行改造,引入吡虫啉系列活性基团,设计合成了13个结构新颖的EBF类似物,并对其生物活性进行了研究.结果表明,这些化合物对蚜虫具有明显的抑制活性,尤其在低浓度时活性更明显,如质量浓度为25mg/L时,I₁₀和I₁₃对蚜虫的抑制率分别为93.1%和87.1%,远高于同浓度下吡虫啉的抑制率(66.7%).     

Synthesis and Biological Activity of Novel 2,3-Dihydro-2-phenylsulfonylhydrazono-3-(2'',3'',4'',6''-tetra-O-acetyl-β-D-glucopyranosyl)thiazoles

A series of novel 2,3-dihydro-2-phenylsulfonylhydrazono-3-(2',3',4',6'-tetra-O-acetyl-β-D-glucopyranosyl)thiazoles were designed and synthesized via the reaction of thiosemicarbazide with chloroaldehyde. Their chemical structures were characterized by 1H and 13C NMR spectroscopy and elemental analysis. The bioassay results indicate that some of these compounds exhibit moderate fungicidal and herbicidal activities.     

1-(取代吡唑-4-甲酰基)吡唑类化合物的合成及生物活性研究

设计合成了25个新型1-取代吡唑甲酰基吡唑系列衍生物,化合物结构经¹HNMR、元素分析、IR和MS确证.生物活性测试结果表明,该类化合物具有一定除草活性,讨论了其结构与活性的关系.     

Synthesis, Crystal Structure and Biological Activity of 2-Chloro-N-{2-fluoro-5-[N-(phenylsulfonyl) phenyl- sulfonamido] phenyl} benzamide

2-Chloro-N-{2-fluoro-5-[N-(phenylsulfonyl)phenylsulfonamido]phenyl}benzamide was synthesized and its crystal structure was also determined by X-ray single-crystal diffraction. The title compound(C25H18C1FN2O5S2) belongs to monoclinic, space group P21/n with a=0.7377(3) nm, b=1.2036(5) nm, c=2.6846(11) nm, β=90.895(9)°,V=2.3833(16) nm3, Mr=544.98, Z=4, Dc= 1.519 g/cm3, μ=0.385 mm-1, F(000)=1120, R1=0.0632, and wR2=0. 1438. Its crystal structure belongs to a novel class that has not been reported yet, and its preliminary herbicidal activity was also tested. Its inhibition rate to seedling growth of barnyard grass reaches 15.1% at 100 μg/mL.     

N-(4,6-二甲氧基嘧啶-2-基)-N'-磷酰基脲类衍生物的合成及生物活性

利用二氯代磷酰基异氰酸酯与4,6-二甲氧基-2-氨基嘧啶的加成反应合成了中间体N-(4,6-二甲氧基嘧啶-2-基)-N'-二氯代磷酰基脲(Ⅰ).Ⅰ与2倍的醇或胺反应得到对称双取代磷酰基脲类化合物Ⅱa_Ⅱi;Ⅰ与1倍的胺反应得到氯代磷酰基脲类化合物Ⅲa_Ⅲe,再与1倍的醇反应则得到不对称双取代磷酰基脲类化合物Ⅳa_Ⅳg.生物活性测定结果表明,化合物Ⅱ、Ⅲ和Ⅳ均显示一定除草活性.     

一类新型酰基脲化合物的设计,合成及生物活性

设计并合成了２１个新型含呋喃环的双酰基脲化合物，经ＩＲ，＾１ＨＮＭＲ、ＭＳ和元素分析确证其结构，初步生物活性测定结果表明，该类化合物具有几丁质抑制活性。     

吡唑衍生物的合成及生物活性

以５－吡唑甲酰肼（７，８）为原料合成了４类共３０种新化合物，这些化合物的结构均经＾１Ｈ ＮＭＲ，元素分析证实，部分化合物还经过了ＭＳ、ＩＲ确证，对大部分化合物做了生物活性测试，结果表明均具有一定的杀菌和除草活性。     

2-甲基-1-(4-芳基噻唑-2-基)-苯并咪唑-6-甲酸乙酯的合成、表征及生物活性

以4-乙酰氨基苯甲酸乙酯为原料设计合成了14 种2-甲基-1-(4-芳基噻唑-2-基)-苯并咪唑-6-甲酸乙酯新化合物. 化合物结构经质谱、1H NMR、红外光谱和元素分析等确证, 并用单晶X射线衍射仪测定了化合物5a的晶体结构. 生物活性实验结果表明, 化合物5c(500 mg/L)对小麦白粉病菌抑制率达到95%; 化合物5e对辣椒疫霉病菌(25 mg/L)的抑制率为61.9%, 对油菜菌核病菌(500 mg/L) 抑制率高达97.2%; 化合物5k(25 mg/L) 对小麦赤霉病菌抑制率为55.1%.     

含硅二硫代磷酸酯的合成及生物活性

硅基甲硫醇Ｒ＾１Ｒ＾２ＣＨ３ＳｉＣＨ２ＳＨ与Ｏ，Ｏ－二烷基二硫代磷酸酯（ＲＯ）２Ｐ（Ｓ）ＳＨ及甲醛可顺利地发生类Ｍａｎｎｉｃｈ缩合反应，利用此反应和硅基甲硫醇与Ｏ，Ｏ－二乙基－Ｓ（２－溴乙基）二硫代磷酸酯的取代反应合成了３７种新的含硅二硫代到酯化合物（ＲＯ）２Ｐ（Ｓ）Ｓ（ＣＨ２）ｎＳＣＨ２ＳｉＣＨ３Ｒ＾１Ｒ＾２（ｎ＝１，２），在初筛浓度下，该类化合物具有一定的杀虫，杀螨活性。     

斯德酮类化合物的合成及生物活性研究

斯德酮类化合物的合成及生物活性研究李正名，范传文，王素华（南开大学元素有机化学研究所，元素有机化学国家重点实验室，天津，３０００７１）关键词斯德酮，合成，生物活性斯德酮（Ｓｙｄｎｏｎｅ）化合物是一类介－离子（Ｍｅｓｏ－ｉｏｎｉｃ）化合物，由于其结构有...