共查询到20条相似文献,搜索用时 46 毫秒
1.
The direct aldol addition of malonates to aromatic, hetero-aromatic and unsaturated aldehydes leading to β-hydroxymalonates is described. The stability of these products, the trimethyl silyl protection of the hydroxyl group as well as the role of both SiCl4 and i-Pr2EtN in attaining the final products are also discussed. 相似文献
2.
Yuhki OhtsukaTetsu Yamakawa 《Tetrahedron》2011,67(12):2323-2331
Direct ethoxycarbonyldifluoromethylation of aromatic compounds by BrCF2CO2Et was investigated using Fenton reagent in dimethylsulfoxide. Various five-membered hetero-aromatic compounds, benzene derivatives and uracil having ethoxycarbonyldifluoromethyl group were obtained catalytically with the combination of ferrocene and H2O2 at room temperature. The ethoxycarbonyldifluoromethylation occurred at the position predicted by the trend of the electrophilic substitution of aromatic compounds. When para-substituted aniline derivatives were used as a substrate, the one-pot synthesis of 3,3-difluoro-2,3-dihydroindole-2-one derivatives was achieved through the ethoxycarbonyldifluoromethylation at the ortho-position to the amino group and the consecutive intramolecular amidation of the amino group and the adjacent ethoxycarbonyldifluoromethyl group. 相似文献
3.
A convenient and efficient procedure for the Friedel-Crafts acylation of aromatic compounds with carboxylic acids in the presence of P2O5/SiO2 is described. Both aromatic and aliphatic carboxylic acids reacted easily to afford the corresponding aromatic ketones. The use of non-toxic and inexpensive materials, simple and clean work-up, short reaction times and good yields of the products are the advantages of this method. 相似文献
4.
The reactive characteristics of the oxy anion radicals of sulphur, SO?2, SO?3 and SO?4 were investigated by use of the rapid-mixing flow technique coupled with electron spin resonance (ESR) which can detect the radicals having a lifetime of 5–100 msec. The SO?2 reduced the aromatic nitro compounds to the corresponding anion radicals, but did not abstract the hydrogen from the saturated compounds nor add to the unsaturated compounds. The SO?3 could add to the compounds having CC bond, but did not abstract the hydrogen from the saturated compounds nor reduce the aromatic nitro compounds. The SO?4 could abstract the hydrogen from the saturated compounds and also add to the unsaturated compounds having CC bond, but did not reduce the aromatic nitro compounds. These differences of the reactivity towards the organic substrates were discussed on the basis of the difference in the distribution of the unpaired electron density of each radical anion. 相似文献
5.
Reductive esterification of aromatic aldehydes using Zn/Ac2O/imidazole or Zn/Yb(OTf)3/(RCO)2O system
Toshikazu Hirao Sirida SanthitikulHiroki Takeuchi Akiya OgawaHidehiro Sakurai 《Tetrahedron》2003,59(51):10147-10152
Benzaldehydes are reduced by metallic zinc in the presence of Ac2O and imidazole, giving the corresponding benzyl acetates in good yields. Reductive esterification of aromatic aldehydes is also carried out via gem-diacetoxy compounds. Carbonyl compounds are readily converted to the gem-diacyloxy compounds in excellent yields on treatment with 2 molar amounts of acid anhydride and 10 mol% of Yb(OTf)3 in MeCN at room temperature. Thus-formed diacyloxy compounds derived from aromatic aldehydes are reduced in situ by metallic zinc to afford the corresponding esters. 相似文献
6.
Xiuhua Hao 《Tetrahedron letters》2005,46(15):2697-2700
In a fluorous biphase system, Hf[N(SO2C8F17)2]4 complex (1 mol %) catalyzes Friedel-Crafts acylation of aromatic compounds such as anisole, toluene and chlorobenzene, and the corresponding aromatic ketones are obtained in satisfactory to high yields. The catalyst is selectively soluble in lower fluorous phase and can be easily recovered by simple phase separation. Furthermore, the catalyst can be reused without decrease of activity in most cases. 相似文献
7.
8.
Francisco Pérez-García José G. Alvarado-Rodríguez Carlos Andrés Galán-Vidal M. Elena Páez-Hernández Noemí Andrade-López Rafael Moreno-Esparza 《Structural chemistry》2010,21(1):191-196
Treatment of KS2P(OC6H4)2 (1) with five n-alkyl halides afforded the stable n-alkyldithiophosphate compounds RS2P(OC6H4)2 (2–6). Single crystal X-ray analysis revealed that the PS2 fragment in 1 displays an isobidentate coordination pattern; compounds 2–4 display a monodentate binding pattern. The crystal packing of title compounds is stabilized by cation-π, weak hydrogen bonding
C–H---O, as well as aromatic non-bonded interactions. 相似文献
9.
Majid M. Heravi Khadijeh Bakhtiari Tina Benmorad Fatemeh F. Bamoharram Hossein A. Oskooie Maryam H. Tehrani 《Monatshefte für Chemie / Chemical Monthly》2007,41(10):449-452
The nitration of aromatic compounds was carried out in the presence of divanadium-substituted molybdophosphoric acid, H5PMo10V2O40, as catalyst and a mixture of nitric acid and acetic anhydride as nitrating agent. In the presence of this heteropolyacid
the ortho- and para-nitro compounds were obtained in good to excellent yields under mild reaction conditions. 相似文献
10.
Trifluoromethyl aldimines derived from α-amino esters have proven to be very good starting materials to obtain the title compounds. A Ag2O-catalyzed Mannich-type/cyclization cascade reaction starting from suitable α-isocyano acetates leads to enantiopure valuable trans-carboxylic trifluoromethyl substituted 2-imidazolines by a highly stereoselective addition without the need to add organocatalysts. 相似文献
11.
Melvyn Rowen Churchill Stuart A. Julis R. Bruce King Claude A. Harmon 《Journal of organometallic chemistry》1977,142(3):C52-C54
The reactions of the non-alternant polycyclic aromatic hydrocarbon 3,5-dimethylaceheptylene, C14H8Me2, with various transition metal carbonyls and the molecular geometry of the compounds (C14H8Me2)Mn2(CO)6 and (C14H8Me2)Fe3(CO)8 is shown. 相似文献
12.
HClO4-SiO2 catalyzed stereoselective synthesis of β-amino ketones via a direct Mannich-type reaction
The HClO4-SiO2 catalyzed three-component, one-pot Mannich reaction of ketones, aromatic aldehydes and aromatic amines is carried out in ethanol to afford the corresponding β-amino ketones in good yields and high stereoselectivities in favor of the anti-isomer. Three new compounds are reported. 相似文献
13.
A new selective brominating system Br2/SO2Cl2/zeolite, has been discovered. Partially cation-exchanged Ca2+-Y zeolite efficiently catalyzes the selective para-bromination of neat chlorobenzene (CB) by Br2/SO2Cl2 affording a CB conversion of ∼89% and a para-selectivity of ∼97%. During the bromination reaction, SO2Cl2 oxidizes HBr, prevents its accumulation within the zeolite pores and yields a more active brominating species. The Ca2+-Y catalyst was found to be stable under the bromination conditions, and can easily be regenerated by calcination. The Br2/SO2Cl2/Ca2+-Y brominating system could be applicable to other activated aromatic compounds such as o-xylene, toluene and fluorobenzene. 相似文献
14.
A variety of aromatic compounds are nitrated to parent nitro aromatic compounds under solvent-free conditions using 65% nitric acid in the presence of P2O5 supported on silica gel is described. This methodology is useful for nitration of activated and deactivated aromatic rings. 相似文献
15.
Loss of a trifluoromethyl group has been observed as an unproductive side reaction in the formation of 2-trifluoroethylbenzimidazoles. A hydrolytic mechanism for this transformation is proposed that is consistent with evidence for the identity of reaction intermediates. Cyclodehydration with POCl3 suppresses hydrolysis of the trifluoromethyl group and provides 2-trifluoroethylbenzimidazoles in good yields. 相似文献
16.
A facile, efficient and environmentally benign procedure for the synthesis of diarylmethanes via the reaction of arenes with trioxane catalyzed by InCl3·4H2O was developed. The reactions of aromatic compounds bearing electron-donating group proceeded smoothly affording the corresponding diarylmethanes in good to excellent yields. 相似文献
17.
A new, convenient and mild method for thioacetalization of heterocyclic, aromatic and aliphatic compounds catalyzed by MoCl5 or MoO2Cl2 is described. This novel method is important for the synthesis of the difficult to prepare heterocyclic thioacetals such as the pterin thioacetals and it offers significant advantages such as high conversion, short reaction times and simplicity in operation. 相似文献
18.
Min Wang Zhi-Guo Song Xin Wan Suang Zhao 《Monatshefte für Chemie / Chemical Monthly》2009,3(2):1205-1208
Abstract
SnCl2-catalyzed three-component one-pot Mannich reaction of acetophenone or p-chloroacetophenone with different aromatic aldehydes and aromatic amines in ethanol at ambient temperature gave the corresponding β-aminocarbonyl compounds in good to excellent yields. Four new compounds are reported for the first time. 相似文献19.
Substituted vanadium carbonyl compounds with η2-bonded acyl ligands (η2-RCO)V(CO)3 ( = ditertiary phosphines or arsines: dppe, dppp, dppm, diars, arphos, dpase) have been prepared by photochemical reaction of [V(CO)4] with various substituted benzoyl chlorides and cyclopropanylcarbonyl chloride.Effects of aromatic substituents and upon the thermal stability of the η2-acylcarbonylvanadium compounds are discussed. IR ν(CO) force constants and 51V NMR signals are linearly correlated with Hammett's σ constants of the aromatic substituents.The preparation of V(CO)2Cl(diars)2 is described. 相似文献
20.
Here, we report a highly effective and chemoselective method of preparing substituted indoles from (E)-2-nitropyrrolidinostyrenes via hydrogenation in the presence of a rhodium catalyst doped by additives such as Ni(NO3)2·6H2O, Fe(OAc)2 or Co(acac)3. These hydrogenation conditions may also be applied to other substrates. Aromatic nitro compounds and olefins can be selectively reduced in the presence of aromatic benzyl ethers, aromatic halides and aromatic aldehydes. 相似文献