共查询到20条相似文献,搜索用时 46 毫秒
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Seven macrocyclic host tetraazaparacyclophanes with different hydrophobic cavity sizes were synthesized from dibromoalkanes and 4,4’-methylendianilin. Three of the tetraazacyclophanes were modified on the four nitrogen atoms by using ferrocenoyl chloride, so a new kind of enzyme model was obtained by introducing the side arms of ferrocenoyl group. And four of the tetraazacyclophanes with straight chains were also synthesized through the reaction of 1,8,22,29-tetraaza[8.1.8.1] paracyclophane with bromoalkane and alkanecarbonyl bromide. Ten of them have not ever been reported in literature. The structures were confirmed by1H NMR,13C NMR, IR, MS and elemental analysis. 相似文献
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以氰乙酸乙酯(氰乙酸)为起始原料,经酯化、缩合、氯化,然后与2-氨基-4-甲基苯并[d]噻唑反应,合成了20个新化合物4.所有化合物结构经过IR,1H NMR,13C NMR和元素分析确证.初步生物活性测试表明:在500μg·mL-1浓度下,该类化合物4具有一定的抗黄瓜花叶病毒(CMV)及抗烟草花叶病毒(TMV)室内活体治疗活性,其中化合物4b,4o,4q对CMV具有较好的活体治疗活性(抑制率分别为45.81%,43.20%,43.09%),化合物4d,4f,4h,4l对TMV具有较好的活体治疗活性(抑制率分别为45.68%,45.19%,45.86%,44.32%),对照药宁南霉素的活体治疗活性分别为56.31%,54.63%. 相似文献
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Trachylobagibberellin类似物的化学合成研究(Ⅰ)──12.16R-环赤霉低酸甲酯的合成谢文革,崔育新,马建泰,潘鑫复(兰州大学化学系,兰州大学应用有机化学国家重点实验室,兰州,730000)关键词Trachylobagibbere... 相似文献
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Cucinotta V Giuffrida A Grasso G Maccarrone G Mazzaglia A Messina M Vecchio G 《Journal of separation science》2011,34(1):70-76
The diaminotrehalose-capped derivative of β-CD, a new member of hemispherodextrins, was synthesized and characterized by NMR spectroscopy. Its protonation constants were determined by potentiometry, and the inclusion of both the enantiomers of dansyl-phenylalanine was investigated by NMR spectroscopy. Its stereoselective properties were exploited in electrokinetic chromatography by separating four enantiomeric pairs of dansyl derivatives of amino acids. 相似文献
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四种5-氟尿嘧啶二肽衍生物的合成、晶体结构和抗癌活性 总被引:2,自引:0,他引:2
合成了四种新的5-氟尿嘧啶(5-Fu)二肽衍生物, 它们的结构经过元素分析、IR、1H NMR和13C NMR的表征, 比旋光度[a]D的测定结果表明了它们之间的对映异构关系, 用X射线衍射法测定了其中一对对映异构的晶体结构3a (S)和3b (R), 生物活性测试的结果表明这四种化合物都具有一定的抑制活性, 并且R型产物比S型产物抑制率高. 研究了2a和3a与DNA在Au电极上相互作用的伏安行为, 比较了它们跟5-氟尿嘧啶与双链DNA发生相互作用的差别. 相似文献
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5-甲基-1,3,4-噻二唑-2-硫为端基的非环冠醚的合成 总被引:6,自引:0,他引:6
本文用2-巯基-5-甲基-1,3,4-噻二唑与二溴乙烷或低聚乙二醇溴化物合成了四种新的非环冠醚. 通过元素分析,UV,IR和^1H NMR波谱鉴定. 相似文献
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Sayed Alam 《Journal of Chemical Sciences》2004,116(6):325-331
Some derivatives of 2-phenyl-chromen-4-one (flavone ring) have been synthesized and tested for antibacterial and antifungal
activities along with their chalcone precursors against four human pathogenic bacteria and five plant mould fungi. The structures
of the synthesized compounds were elucidated by UV, IR and1H NMR spectroscopic techniques, and elemental analysis. The antibacterial and antifungal screens of the synthesized compounds
were performed in vitro by the filter paper disc diffusion method and the poisoned food technique. 相似文献
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Several stigamasterol saponins were concisely synthesized.Namely,four monosaccharide(glucopyranose,ga-lactopyranose,xylopyranose,2-acetamido-2-deoxy-a-D-glucopyranose),lactopyranose and chacotriose were cou-pled with 3-OH of stigmasterol.All the compounds were identified by NMR,IR and high resolusion MS. 相似文献
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3-氨基-4-氧代氰基呋咱捕获与表征 总被引:1,自引:0,他引:1
3,4-双(4-氨基呋咱-3-基)氧化呋咱由活性中间体3-氨基-4-氧代氰基呋咱分子间发生二聚获得,但3-氨基-4-氧代氰基呋咱不稳定,无法通过分离、纯化及光谱鉴定证实其存在.采用4种不同的烯烃与3-氨基-4-氧代氰基呋咱发生1,3-偶极环加成反应得到3-(4-氨基呋咱-3-基)-5-氰基-Δ2-异噁唑啉、3-(4-氨基呋咱-3-基)-5-乙酰氧基-Δ2-异噁唑啉、3-(4-氨基呋咱-3-基)-5-正丁基-Δ2-异噁唑啉及3-(4-氨基呋咱-3-基)-环己烷并-Δ2-异噁唑啉4种Δ2-异噁唑啉衍生物;采用苯甲酰氯为捕获剂,与3-氨基-4-氧代氰基呋咱反应获得了3-氨基-4-(N-苯甲酸基氨基羰基)呋咱化合物;通过红外光谱、核磁共振光谱、质谱、元素分析表征了5种新化合物的结构,提供了活性中间体3-氨基-4-氧代氰基呋咱存在的间接证据. 相似文献
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Mayya Korochkina Alessandro Casnati Arturo Arduini Rocco Ungaro Vladimir Kataev Vladimir Alfonsov 《Tetrahedron》2005,61(23):5457-5463
Novel calix[4]arene derivatives functionalized with two or four isosteviol units at the upper rim and a new calix[6]arene having six isosteviol moieties at the lower rim have been synthesized. The structures of these compounds have been confirmed by NMR and mass spectrometry data. All 1H and 13C NMR chemical shifts of isosteviol were fully assigned by extensive NMR spectroscopic methods, and used to clarify the structures and conformations of isosteviol-calixarene conjugates. 相似文献
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