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1.
N. V. Russavskaya V. A. Grabel’nyh E. N. Deryagina N. A. Korchevin 《Chemistry of Heterocyclic Compounds》2006,42(7):868-871
The reaction of 3,3,3-trifluoro-1-(2-thenoyl)acetone with sulfur—hydrazine hydrate—alkali and hydrazine hydrate—alkali systems
is effected by reductive fission of the trifluoroacetyl group and leads to the formation of nitrogen-containing derivatives
of 2-acetylthiophene. Sodium polysulfide assists the reductive fission of 3,3,3-trifluoro-1-(2-thenoyl)acetone.
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 7, pp. 1006–1010, July, 2006. 相似文献
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A. V. Sadovoy A. E. Kovrov G. A. Golubeva L. A. Sviridova 《Chemistry of Heterocyclic Compounds》2011,46(10):1215-1223
The reaction under mild conditions of 1-alkyl-5-hydroxypyrrolidin-2-ones with different indoles having a free 3 position leads exclusively to 1-alkyl-5-(indol-3-yl)pyrrolidin-2-ones but if position 3 is occupied to 1-alkyl-5-(indol-2-yl)pyrrolidin-2-ones. 相似文献
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V. B. Sokolov T. V. Goreva T. A. Epishina A. Yu. Aksinenko 《Russian Chemical Bulletin》2007,56(11):2255-2257
Earlier unknown representatives of fluorine-containing α-chloroalkylisocyanates, viz., esters of 2-chloro-3,3,3-trifluoro-2-isocyanatopropionic acid, were obtained. Synthetic potentialities of these compounds
in the preparation of 2-substituted derivatives of 3,3,3-trifluoroalanine were demonstrated.
Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 11, pp. 2179–2181, November, 2007. 相似文献
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[reaction: see text] A concise and efficient synthesis of the novel indol-2-yl-1H-quinolin-2-one ring system found in the potent and selective KDR kinase inhibitors 1-3 is presented. 相似文献
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N. A. Anisimova E. K. Slobodchikova A. A. Kuzhaeva E. V. Stukan’ I. Yu. Bagryanskaya V. M. Berestovitskaya 《Russian Journal of Organic Chemistry》2016,52(10):1379-1384
An improved procedure was developed for the synthesis of 3,3,3-trifluoro-1-nitropropene, and a new representative of gem-bromonitroalkenes, 1-bromo-3,3,3-trifluoro-1-nitropropene, was synthesized therefrom. Its reaction with phenyl azide gave a mixture of two regioisomeric 1,2,3-triazoles, from which pure 5-nitro-1-phenyl-4-(trifluoromethyl)-1H-1,2,3-triazole was isolated. 相似文献
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T. T. Vasil'eva I. A. Fokina S. V. Vitt Y. I. Dostovalova 《Russian Chemical Bulletin》1990,39(8):1638-1641
Telomerization of 3,3,3-trifluoropropene with CCl4 was carried out in the presence of Fe(CO)5 in combination with dimethylformamide (DMF) or hexamethylphoshoric triamide (HMPA) with formation of the telomers CCl3(CH2CHCF3)nCl, n=1–3, as the main products. Chromatography-mass spectrometry showed the presence of CCl3CH2CH(CCL3)CF3, a product of recombination of the adduct radical and CCl3, in the reaction mixture, which confirms the radical nature of the process. The structure of all the reaction products was confirmed by13C NMR and (or) mass spectrometry.Translated from Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, No. 8, pp. 1807–1811, August, 1990. 相似文献
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《Tetrahedron: Asymmetry》2001,12(16):2309-2313
The selective conversion of 2,2,2-trifluoro-1-furan-2-yl-ethanone into (E)- and (Z)-oximes and oxime ethers and subsequent oxazaborolidine-catalyzed enantioselective reduction using different amino alcohols furnished both enantiomers of the important chiral building block 2,2,2-trifluoro-1-furan-2-yl-ethylamine with e.e. of up to 88%. Oxidation of the furan ring afforded both enantiomers of 3,3,3-trifluoroalanine in 91–93% yields. 相似文献
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Trifluoroethyl cyclohexyl ketone () is prepared by acylation of difluoroethylene () with cyclohexanecarboxylic acid chloride (), followed by Cl→F exchange with potassium fluoride in the presence of triethylbenzyl- ammonium chloride. Bayer-Villiger oxidation of ketone () with trifluoroperacetic acid gives cyclohexyl trifluoropropionate (). 3,3,3-trifluoropropionic acid () is obtained by treatment of () with trimethylsilyl iodide. Condensation of 2,2,2-trifluorodiazoethane () with ethyl glyoxylate () gives mainly ethyl 4,4,4-trifluoro-2-ketobutyric acid ester () which leads after hydrolysis to the corresponding acid (). 相似文献
10.
V. B. Sokolov A. Yu. Aksinenko T. A. Epishina T. V. Goreva 《Russian Chemical Bulletin》2012,61(11):2137-2139
The behavior of methyl 3,3,3-trifluoro-2-(thiazol-2-ylimino)propionate (1) in cycloaddition and cyclocondensation reactions was studied. Cycloaddition of dimethylcyanamide to imine 1 gave a thiazolo[3,2-a][1,3,5]triazine derivative. Cyclocondensations of imine 1 with 2-aminothiazoline, N-cyclohexylbenzamidine, methyl (Z)-3-aminobut-2-enoate, and 6-amino-1-benzyluracil yielded dihydroimidazo[2,1-b]thiazol-5(6H)-one, 4,5-dihydroimidazol-5-one, 4,5-dihydro-1H-pyrrol-5-one, and dihydro-1H-pyrrolo[2,3-d]pyrimidine-2,4,6-trione derivatives, respectively. 相似文献
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Panadda ChirakulSnorri Th. Sigurdsson 《Tetrahedron letters》2003,44(36):6899-6901
Reaction of 3,3,3-trifluoropropyne with 2′-deoxy-5-iodouridine under conditions that have previously been used to prepare 5-alkynyl-2′-deoxyuridine derivatives gave 2′-deoxy-N3-(3,3,3-trifluoro-1-propenyl)uridine. This unexpected alkylation is a result of a Michael-type addition of N3 on the pyrimidine base to the electron deficient trifluoropropyne. 相似文献
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In order to access 1,2-diamines incorporating perfluorinated groups, the Michael-like addition of nitrogen nucleophiles to 3,3,3-trifluoro-1-nitropropene has been investigated using racemic and optically pure nucleophiles such as amines, amides, oxazolidin(on)es, and thiazolidin(on)es. Complete diastereoselectivity of the addition was achieved with 4-phenylthiazolidine-2-thione. 相似文献
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D. V. Vorobyeva I. E. Yagafarova T. P. Vasilyeva S. N. Osipov 《Russian Chemical Bulletin》2016,65(11):2668-2671
The efficient method for the synthesis of novel trifluoromethyl-containing hydroxy- and aminostyrenes has been developed. The reaction sequence includes the selective insertion of CF3-substituted carbene, which was catalytically derived from methyl 3,3,3-trifluoro-2-diazopropionate, into the OH- or NH-bonds of easily available o-bromophenol and o-bromoaniline derivatives followed by a bromine substitution for vinyl group via Pd-catalyzed Stille reaction. 相似文献
16.
Conclusions In the reactions of the triethylamine salt of 1,1,1-trifluoro-2-(trifluoromethyl) propionyl fluoride with nitryl chloride and with oxides of nitrogen hexafluoroacetone oxime is formed.Translated from Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, No. 12, pp. 2119–2122, December, 1966. 相似文献
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Reactions of methyl 3,3,3-trifluoro-2-(pyridin-2-ylimino)propanoates with such nucleophiles and 1,3-binucleophiles as methanol,
p-toluidine, phenylhydrazine, diethyl phosphonate, 2-aminobut-2-enenitrile, benzamidine, and 4,5-dihydro-1,3-thiazol-2-amine
led to the formation of various acyclic 2-substituted methyl 3,3,3-trifluoro-2-(pyridin-2-ylamino)propanoates and trifluoromethyl-containing
heterocyclic N-substituted 2-aminopyridine derivatives: 4,5-dihydro-1H-pyrroles, 4,5-dihydro-1H-imidazol-5-ones, and 2,3-dihydro-6Himidazo[2,1-b][1,3]thiazol-5-ones. 相似文献
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Márcia S. F. Franco Gleison A. Casagrande Cristiano Raminelli Sidnei Moura Marcelo Rossatto Frank H. Quina 《合成通讯》2013,43(6):692-701
A facile, one-pot, ultrasound-promoted synthesis of N-substituted 5-(3,3,3-trifluoro-2-oxopropylidene)pyrrolidin-2-ones from methyl 7,7,7-trifluoro-4-methoxy-6-oxohept-4-enoate and a wide range of primary alkyl(aryl)amines using ethanol as a green solvent and employing triethylamine as a base is described. 相似文献