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1.
Denisa Dumitrescu Sergiu Shova Constantin Draghici Marcel Mirel Popa Florea Dumitrascu 《Molecules (Basel, Switzerland)》2021,26(12)
3-Arylsydnones bearing fluorine and bromine atoms on the benzene ring were synthesized from N-nitroso-2-fluorophenylglycines and characterized by NMR spectroscopy. These were employed further in synthesis of the corresponding 1-(2-fluorophenyl)pyrazoles by 1,3-dipolar cycloaddition reaction with dimethyl acetylenedicarboxylate (DMAD) as activated dipolarophile. The sydnones as reaction intermediates were characterized by single crystal X-ray diffraction analysis showing interesting features such as halogen bonding as an important interaction in modeling the crystal structure. 相似文献
2.
T. V. Rybalova V. F. Sedova Yu. V. Gatilov O. P. Shkurko 《Journal of Structural Chemistry》2004,45(2):287-292
The crystal structures of 5-nitro- and 5-ethoxycarbonyl-substituted 6-phenyl-4-(3-fluorophenyl)-3,4-dihydro-(1H)-pyrimidin-2-ones were determined by X-ray diffraction analysis. Conformational peculiarities of the structures have been revealed and compared with data for other biologically active dihydropyrimidinones. 相似文献
3.
Synthesis,crystal and molecular structure of 2-(3-chloropropyl)-6-methyl-4-phenylquinazoline 3-oxide
The acylation of the syn isomer of the oxime of 2-amino-5-methylbenzophenone with 4-chlorobutyryl chloride gives a mixture
of the anti isomer of the 4-chlorobutyryloximine of 2-(4-chlorobutyryl)amino-5-methylbenzophenone and 2-(3-chloropropyl)-6-methyl-4-phenylquinazoline
3-oxide. The crystal and molecular structure of this oxide was established by X-ray diffraction structural analysis. The molecule
is planar. The electron impact fragmentation of 2-(3-chloropropyl)-6-methyl-4-phenylquinazoline 3-oxide was discussed.
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 7, pp. 1043–1051, July, 2007. 相似文献
4.
Condensation of Schiff"s bases (prepared from 2-hydroxy- or 2-hydroxy-5-methylacetophenones and primary amines) with ethyl polyfluoroalkanoates in the presence of LiH in THF affords 3-alkylamino-3-(2-hydroxyaryl)-1-polyfluoroalkylprop-2-en-1-ones, which undergo cyclization in acidic media into 2-polyfluoroalkyl-4H-chromen-4-iminium salts. When neutralized with aqueous ammonia, the latter give 2-polyfluoroalkyl-4H-chromen-4-imines in high yields. 相似文献
5.
2-Polyfluoroalkylchromones reacted with diethylenetriamine at 20 °C to form the corresponding 1,4,8-triazabicyclo[5.3.0]dec-4-ene derivatives. The crystal structures of 5-(2-hydroxyphenyl)-7-trifluoromethyl-1,4,8-triazabicyclo[5.3.0]dec-4-ene and 1-(2-aminoethyl)-7-(2-hydroxy-5-methoxyphenyl)-5-(1,1,2,2-tetrafluoroethyl)-2,3-dihydro-1H-1,4-diazepine were established by X-ray diffraction analysis. 相似文献
6.
The condensation of 2-aminoacetophenone with RFCO2Et (RF = CF3, CF2H, CF2CF2H) in the presence of LiH in THF or ButOK in ButOH affords either 2-polyfluoroalkyl-4-quinolones or 1-(2-polyfluoroacylaminophenyl)-3-polyfluoroalkylpropane-1,3-diones, depending on the ratio of the initial reactants. The latter are hydrolyzed in an acidic medium to produce 2-polyfluoroalkyl-4-quinolones. N-Methyl-2-trifluoromethyl-4-quinolone was synthesized from 2-aminoacetophenone, CF3CO2Et, and MeI in the presence of ButOK. 相似文献
7.
8.
S. T. Malinovskii V. P. Tashchi M. Z. Krimer A. B. Kamenskii Yu. G. Putsykin 《Russian Chemical Bulletin》1995,44(4):695-698
The synthesis and X-ray structural study of 1-(4-chlorophenyl)-3-(5-methyl-1,3-dioxan-5-yl)-(1,2), (3,4)-diepoxybutane are described.Translated fromIzvestiya Akademii Nauk. Seriya Khimicheskaya, No. 4, pp. 715–718, April, 1995. 相似文献
9.
YANG Jian-Guoa PAN Fu-Youb② a 《结构化学》2005,24(12):1403-1407
1 INTRODUCTION 2. 1 Physical measurements Azole derivatives, such as pyrazole, imidazole, All solvent and chemicals were commercial rea- triazole(including benzotriazole), tetrazole and indole, gents and used without further purification. Ele- have extensive biological activities. They have be- mental analyses were performed on a PE 1700 CHN come the central focus of studies for agricultural che- auto elemental analyzer. IR spectra were recorded on micals, medicines, plant growth regul… 相似文献
10.
G. A. Gazieva P. V. Lozhkin A. N. Kravchenko K. A. Lysenko N. G. Kolotyrkina N. N. Makhova 《Chemistry of Heterocyclic Compounds》2007,43(8):981-988
The reactions of 1,3-dialkyl-4,5-dihydroxyimidazolidin-2-ones with alkyl sulfamides have been studied and previously undescribed
1,3-dialkyl-4-(alkylaminosulfonylimino)imidazolidin-2-ones have been obtained. The structure of 1,3-dimethyl-4-(benzenesulfonylimino)imidazolidin-2-one
was investigated by X-ray structural analysis.
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 8, pp. 1159–1166, August, 2007. 相似文献
11.
1 INTRODUCTION Substituted 1,2,4-triazines represent an important class of nitrogen-containing heterocycles. The 1,2, 4-triazine core is a versatile synthetic platform to access a wide range of condensed heterocyclic ring systems via intramolecular Diels-Alder reactions with a vast array of dienophiles[1~5]. In addition, 1,2, 4-triazines have been associated with diverse activi- ties such as antihypertension and inhibition of pla- telets[6] and antiinflammatory[7], and been a key com- po… 相似文献
12.
COOEtCOCH3(CH3)2NNHNH2NNCH3OOEtNH2NH2NNCH3ONHNH2PhNCSNNCH3ONHNHCNHSOH-NNCH3NNHNPhS12345 1 INTRODUCTION A large number of 1,2,4-triazole derivatives have been synthesized in recent years[1~4]. Many of them are reported to exhibit broad spectrum biologi-… 相似文献
13.
14.
A. M. Shestopalov A. P. Yakubov D. V. Tsyganov Yu. M. Emel'yanova V. N. Nesterov 《Chemistry of Heterocyclic Compounds》2002,38(10):1180-1189
Substituted 6-aminopyrano[2,3-c]pyrazoles were synthesized by the two-component condensation of arylidenemalononitriles and substituted 5-pyrazolones or three-component condensation of aromatic aldehydes, malononitrile, and substituted 5-pyrazolones. It was established by X-ray crystallographic analysis that pyranopyrazoles exist in the 2H and not the 1H tautomeric form. 相似文献
15.
V. N. Elokhina A. S. Nakhmanovich L. I. Larina O. V. Shishkin V. N. Baumer V. A. Lopyrev 《Russian Chemical Bulletin》1999,48(8):1516-1518
1-[1-Bromo-2-benzoyl(2-thenoyl)vinyl]-1,1-dimethylhydrazinium bromides were synthesized by the reactions of 1-aroyl-2-bromoacetylenes
withN,N-dimethylhydrazine in acetonitrile at 20°C. The structure of 1-(2-benzoyl-1-bromovinyl)-1,1-dimethylhydrazinium bromide was
established by X-ray diffraction analysis.
Translated fromIzvestiya Akademii Nauk, Seriya Khimicheskaya, No. 8, pp. 1536–1538, August, 1999. 相似文献
16.
Yu. P. Bandera O. S. Kanishchev V. M. Timoshenko S. A. But A. M. Nesterenko Yu. G. Shermolovich 《Chemistry of Heterocyclic Compounds》2007,43(9):1138-1147
Treatment of 4-aryl(benzyl)sulfonyl-5-polyfluoroalkyl-v-triazoles with NaOCl gave the 4-aryl(benzyl)-sulfonyl-2-chloro-5-polyfluoroalkyl-v-triazole
derivatives which contain a chlorine atom only on the N(2) atom of the heterocycle. The structure of 2-chloro-5-(1,1,2,2,3,3-hexafluoropropyl)-4-(p-tolyl-sulfonyl)-2H-[1,2,3]triazole
has been established by X-ray structural investigation. The presence of a highly polarized N—Cl bond with a positive halogen
atom causes the N-chlorotriazoles to react with KCN and KF as strong acids to form the potassium salts of the triazoles and
to form 4-arylsulfonyl-2-(2-chloro-1-ethoxyethyl)-5-polyfluoroalkyl-2H-[1,2,3]triazoles with vinyl ethyl ether. It was found
that chlorination of 4-arylsulfonyl-5-polyfluoroalkyl-v-triazoles in the presence of KF gives 4-chloro-5-polyfluoroalkyl-2H-[1,2,3]triazoles.
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 9, pp. 1342–1352, September, 2007. 相似文献
17.
M. Judith Percino Víctor M. Chapela Omar Urzúa Ling-Fa Montiel Cecilia Rodríguez-Barbarín 《Research on Chemical Intermediates》2007,33(7):623-629
The novel intermediate 1-(p-fluorophenyl)-2-(2′-pyridyl)ethanol or 2-[2′-(1-hydroxy-1-(p-fluorophenyl)ethyl]pyridine and the corresponding novel dehydration compound 1-(p-fluorophenyl)-2-(2′-pyridyl)ethene or 2-[p-fluorophenylvinyl]pyridine were obtained from the condensation reaction of p-fluorophenylaldehyde and 2-picoline under catalyst-and solvent-free conditions. The intermediate 1-(p-fluorophenyl)-2-(2′-pyridyl)ethanol was obtained at 42 h reaction time and temperature of 120°C, respectively. 1H-NMR, IR spectroscopic data of the 1-(p-fluorophenyl)-2-(2-pyridyl)ethanol clearly showed the presence of the-CH2-CHOH-group. The compound was obtained as a white powder with m.p. 121–122°C and a yield of 8%. For 1-(p-fluorophenyl)-2-(2-pyridyl)ethene, the reaction conditions were similar, but the reaction temperature was increased to yield
the double bond in the 1-(p-fluorophenyl)-2-(2′-pyridyl)ethene. At the reaction temperature of 140°C, the compound was a slightly brown powder with a
m.p. of 78°C and yield of 18%. 1H-NMR, IR spectroscopic data for the 1-(p-fluorophenyl)-2-(2′-pyridyl)ethene showed the presence of a double bond in trans configuration (-CH=CH-), characteristic of a styrylpyridine. 相似文献
18.
The title compounds were synthesized and characterized by IR,1H-NMR,Mass and elementary analysis and single-crystal X-ray diffraction.In 1a,intermolecular C-H…π interactions produce a three-dimensional network.In 1b,intermolecular C-H…O hydrogen bonds generate an R22(22) ring.The hydrogen bonding is supported by C-H…π interactions. 相似文献
19.
1INTRODUCTIONManypyrazolederivativeshavebeenreportedtoshowvariousbiologicalactivitiestobeusedasbactericide[1],fungicide[2],herbicide[3],insecticide[4]andvirucide[5]agents.Inaddition,4-thiazolidinoneplaysavitalroleowingtoitswiderangeofbiologi-calactivities… 相似文献
20.
I. A. Aitov V. N. Nesterov Yu. A. Sharanin Yu. T. Strachkov 《Russian Chemical Bulletin》1996,45(2):417-419
The reaction of (4-R-benzoyl)(2-bromopyridinitim) methylides with ethoxyrnethylene-rnalononitrile is stereoselective and affords Z-1-[1-(4-R-benzoyl)-2-ethoxyvinyl]-2-dicyationietliylene-1,2-dihydropyridines. The structure of 1-[1-(4-chlorobenzoyl)-2 ethoxyvinyll-2-dicyanomethylene-1,2-dihydropyridine has been established by X-ray structural study.Translated fromIzvestiya Akademii Nauk. Seriya Khimicheskaya, No. 2, pp. 434–436, February, 1996. 相似文献