Two New ent-Kaurenoids from Cacalia pilgeriana

Two new ent-kaurenoids, 19-acetyl-ent-3β, 17-dihydroxykaur-15-ene (1), 19-acetyl-ent-3β-hydroxykaur-15-en-17-al (2) were isolated from Cacalia pilgeriana. Their structures were elucidated by spectroscopic methods.     

Two New Eremophilenolides from Cacalia ainsliaeflora

Two new eremophilenolides(3β-angeloyloxy-8β,10β-dihydroxy-6β-ethoxyeremophile-nolide(1)and 3β,6β-diangeloyloxy-8α-methoxy-10α-hydroxyeremophilenolide(2)were isolated from the roots of Cacalia ainsliaeflora.Their structures were elucidated by spectroscopic methods.     

Two New Eremophilenolides from Ligularia tongolensis

Chemical investigation of L. tongolensis afforded two new eremophilenolides, which were identified as 3β-（2＇-methylbutanoyloxy）-8βH-eremophil-7（11）-en-12, 8α（14, 6α）-diolide （1）and 8βH-eremophil-3, 7（11）-dien-12, 8α （14, 6α）-diolide （2）. Their structures were established by spectroscopic methods including 2D NMR experiments.     

Two New Eremophilenolides from Ligularia sagitta

Chemical investigation of L.sagitta afforded two new eremophilenolides, which were identified as 6β-angeloyloxy-10β-hydroxy-8 β-methoxy-eremophil-7(11)-en-12, 8α-olide (1) and 6β, 8β-dimethoxy-10β-hydroxy-eremophil-7(11)-en-12, 8α-olide (2). Their structures were estab- lished by spectroscopic methods including 2D NMR experiments.     

Two New Eremophilane Sesquiterpenes from Cacalia ainsliaeflora

The root of C. ainsliaeflora has been used for curing pellagra, rheumatismal edema and insecticide1. In this paper, we report the structure elucidation of two new eremophilane sesquiterpenes (1, 2) from the roots of C. ainsliaeflora. Compound 1, colorless gum, [(]: -50 (c 0.50, CHCl3). HRESI-MS showed [M+H]+ at m/z 377.19528 (calcd for C21H29O6 377.19587), corresponding to a molecular formula C21H28O6. Its IR bands (1655, 1717, 1750cm-1) and UV absorptions (221 nm) displayed the typi…     

Eremophilenolides from Cacalia Roborowskii

ThegenusCacaliabelongstothetribesenecioneae,facelyCompositae,andcomprisesmorethan60speciesoccurringinChina,'ofwhichca.26specieslacelongbeenusedasChinesetradihonalfolkherb.2SeveralspeciesofthegenusCacahawereinvestigatedduetotheirantioxidantantiradical,andantiltistamineactivities.3Thepresenceofpyrrolizidinealkaloidsandsesquitefpenesinmanyspeciesoftribesenencioneaceiswelldocumented.'"InacontinuahonoftileStudyontilesmictureswiUIbioactivitiesfromtileCacahagenus,wereportheretheisolahonandsmictta…     

New Sesquiterpenes from Cacalia ainsliaeflora

Two new eremophilane sesquiterpenes, 3β-angeloyloxy-8-oxo-eremophil-6(7)-en-12-oic acid 1 and 3β-angeloyloxy-10β-hydroxy-8-oxo-eremophil-6(7)-en-12-oic acid 2, and a novelnor-eremophilane derivative, 3β-angeloyloxy-10β-hydroxy-8-oxo-eremophil-6(7)-en 3 were isolated from the roots of Cacalia ainsliaeflora. Their structures were elucidated by spectroscopic methods, including 2D NMR.     

Two New Eremophilenolides from Ligularia fischeri

Ligulariajischerihasl0ngbeenusedastraditi0naImedicinet0relievec0ugh,invig0ratethecircuIation0fbIo0dandst0ppain'.FromtheplantgrowinginShengnonaiia,Hubei-Chlna,t\v0neweremophiIen0lideshavebeenisolated.Comp0undlwasneedlecrystalsfrompetr0lether(60-9O'C),m.p.=148-l50'C.ItsformulawasdeterminedasC,,H,'O'by"C-NMRandDEPTspectrainaccordancewiththem0lecularionpeakm/z=280inEIMS.Thetypeofcarbonsignals(5xC,3xCH,4xCH,,4xCH,)(Table2)sh0wedithadabicyclicsesquiterpeneskeletonbearingameth0xy.ahemi-…     

A New Sesquiterpene and a New Norsesquiterpene from Cacalia deltophylla

A new sesquiterpene and a new norsesquiterpene were isolated from the whole plant of Cacalia deltophylla (Maxim) Mattf. Their structures were elucidated as deltocacalone (1) and deltonorcacalol (2) by spectroscopic methods including 2D NMR.     

Two Novel Epimeric Eremophilane Sesquiterpenes from the Flower of Cacalia tangutica

Two novel epimeric eremophilane sesquiterpenes, 7β-H-3α-angeloyl-9(10)-ene-11,12-epoxy-8-oxoeremophilane (1) and 7β-H-3α-angeloyl-9(10)-ene-11, 12-epoxy-8-oxoeremophilane (2) were isolated from the methanol extract of the flower of Cacalia tangutica (Franch.) Hand-Mazz. Their structures were characterized by 1D-, 2D-NMR (^1H-^1H COSY, HMQC, HMBC, ^1H-^1H NOESY) and HRESI-MS techniques.     

Terpenoids from the Flower of Cacalia Tangutica

A thorough investigation of Cacalia tangutica (Franch.) Hand‐Mazz afforded two new epimeric eremophilane sesquiterpenoids, 7β‐ H‐3α‐angeloyloxy‐9‐ene‐11,12‐epoxy‐8‐oxoeremophilane ( 1 ) and 7α‐H‐3α‐angeloyloxy‐9‐ene‐11,12‐epoxy‐8‐oxoeremophilane ( 2 ), as well as four known sesquiterpenes, petasol ( 3 ), oplopanone ( 4 ), 4,5‐epoxy‐β‐caryophyllene ( 5 ), 4(15)‐eudesmene‐1β,6α‐diol ( 6 ), and three known monoterpenes, 1β,2α‐dihydroxy‐p‐menth‐5‐ene ( 7 ), 5α‐hydroxy‐2‐oxo‐p‐menth‐6(1)‐ene ( 8 ), 5β‐hydroxy‐2‐oxo‐p‐menth‐6(1)‐ene ( 9 ), and two known triterpenes, maniladiol 3‐O‐palmitate ( 10 ), taraxasteryl palmitate ( 11 ). The new compounds were characterized by means of spectroscopic methods including 1D, 2D NMR and HRESIMS, and the known ones were established on the basis of comparing their NMR data with those of the corresponding compounds in the literature. In addition, cytotoxicity against selected cancer cells (HL‐60, HO‐8910 and A‐549) of compounds 1 ‐ 4 , 6 , 7 , 10 were measured in vitro.     

Eremophilane Sesquiterpenes from Cacalia Roborowskii

Themajorityofphytochemicalstudiesonsenencioneace(compositae)specieshavebeenconcentratedonthepyrrolizidinealkaloidsandsesquiteIPenesbecauseoftheirpotentialbioactivitiesandCytotoalcactivities.lCacaliaroborowskii(maxim)LinginslongbeenusedasfolkremedyinnorthwestemChina.Recently,wehadisolatedseveralneweremophilenolides'fromtherootsofthisplant.Asacontinuahonofourinvestigationontillsspecies,wenowpresenttileisolationandsmicturalelucid.ltionoffouraddihonalneweremophilanesesquiterpenes.Theirsmicturesw…     

Two New Eremophilenolides from Ligularia muliensis

Many Ligularia species have long been used as traditional folk medicine for theirantibiotic, antiphlogistic and antitussive activities1, and were found to be an importantsource of eremophilane. In the course of our search for bioactive sesquiterpenoids, w…     

Separation and determination of coumarins from Cacalia tangutica by capillary zone electrophoresis

Capillary zone electrophoresis (CZE), using a 20 mmol/L borate buffer at pH 10.5, was developed for the identification and determination of three coumarins--7-hydroxy-coumarin (HC), 7-hydroxy-8-methoxy-coumarin (HMC) and 7-O-beta-D-glucosyl-coumarin (GC)--in the extracts of the flower of Cacalia tangutica. Regression equations revealed linear relationships (correlation coefficient 0.9986-0.9990) between the corrected peak area (the ratio of peak area to migration time) of each constituent and its concentration. The relative standard deviations (RSD) of the migration time and peak area were 1.45-1.52 and 2.60-3.84% (intra-day), and 1.75-2.22 and 2.90-4.04% (inter-day), respectively. The recoveries of three constituents ranged between 94.5 and 105.6%. The effects of pH value, buffer concentration and applied voltage on the migration behavior of HC, HMC and GC were investigated. The contents of the three active constituents in the flower of Cacalia tangutica were successfully determined within 6 min under the optimum conditions chosen. Moreover, the dissociation constants for three coumarins were also determined by CE.     

New Eremophilenolides from Senecio dianthus

From the aerial parts of Senecio dianthus, four new eremophilenolides ( 1 – 4 , resp.) and one new eremophilenolide alkaloid ( 5 ), of the relatively uncommon eremophilenoid‐type sesquiterpenoid lactones, were isolated together with three known sesquiterpenoid lactones, 10β‐hydroxyeremophil‐7(11)‐en‐12,8α‐olide ( 6 ), 8β,10β‐dihydroxyeremophil‐7(11)‐en‐12,8α‐olide ( 7 ), and 10α‐hydroxy‐1‐oxoeremophila‐7(11),8(9)‐dien‐12,8‐olide ( 8 ). On the basis of IR, MS, and NMR data, particularly 2D‐NMR analyses, the structures of the new compounds were established as: 2β‐(angeloyloxy)‐10β‐hydroxyeremophil‐7(11)‐en‐12,8α‐olide ( 1 ), 6β‐(angeloyloxy)‐10β‐hydroxyeremophil‐7(11)‐en‐12,8α‐olide ( 2 ), 2β‐(angeloyloxy)‐8β,10β‐dihydroxyeremophil‐7(11)‐en‐12,8α‐olide ( 3 ), 2β‐(angeloyloxy)‐8α‐hydroxyeremophila‐7(11),9(10)‐dien‐12,8β‐olide ( 4 ), and 8β‐amino‐10β‐hydroxyeremophil‐7(11)‐en‐12,8α‐olide ( 5 ). In addition, the relative configuration of 1 was corroborated by X‐ray diffraction analysis.     

Two New Sesquiterpenes from Ligularia macrophylla

Two new eremophilane sesquiterpenes, 15β-formic ether-6-oxo-furanoeremophilane （1） and 6α, 15β-epoxy eremophila-7（11）-en-8α, 12-olide （2） were isolation from the roots of Ligularia macrophylla. Their structures were deduced from spectroscopic methods and 2D NMR experiments.     

Two New Sesquiterpenes from Inula Japonica

Two new sesquiterpenes were isolaed from the aerial patrs of Inula Japonica.Their structures were eluicated as 1β-hydroxy-8β-acetoxyeostic acid methyl ester and 1β-hydroxy-8β-acetoxyisocostic acid mster by spectral methods.     

Two New Sesquiterpenes from Ligularia veitchiana

A new furanoeremophilane and a new eudesmane were isolated from the roots of Ligularia veitchiana .Their structures were elucidated as 1 β,10β-epoxy-6β-isobutyryloxy-9-oxo-furanoeremophilane and 8α-hydroxy-4(15),11-eudesmadiene by spectroscopic methods.     

Two New Flavone Glucosides from Serratula strangulata

Genus Serratula（Compositae）consists of about 70 species distributed throughout theworld[1]．Serratula species have been used as folk medicine to treat chickenpox,toxicosis,high cholesterol in China[2]. The phytochemical study of plant S．strangulata has not beenreported so far．In the course of our searching for biologically active substances from thisplant,two new flavone glucosides（1,2）were isolated．The present paper covers the isolationand structural elucidation of the two new compounds．     

Two New Eudesmanoildes from Sonchus transcaspicus

Two new sesquiterpene lactone glycosides were isolated from the whole plant ofSonchus transcaspicus. Their structures were elucidated as 1β--O-β-D-glucopyranosy-5α, 6βH-eudesma-3-en-12, 6αt-olide and 1β--O-β-D-glucopyranosy-15-O-(p-hydroxylphenylacetate)-5α，6β H-eudesma-3, ll(13)-dien-12, 6α-olide by spectral methods (HRMS, 1D and 2D NMR).