共查询到20条相似文献,搜索用时 515 毫秒
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环上取代基对苯乙酮和苯甲醛缩合反应的影响 总被引:9,自引:0,他引:9
苯乙酮衍生物与苯甲醛衍生物缩合制备各种查尔酮,报道了4种苯乙酮衍生物与9种苯甲醛之间相互缩合的结果,讨论了环上取代基对缩合反应的影响。苯甲醛环上取代基,除羟基外无论是吸电子基还是给电子基对缩合反应收率影响都不大;羟基处于醛基邻位和对位的苯甲醛与几种苯乙酮衍生物的缩合,多数没有得到预期的产物,或收率极低;苯乙酮环上的羟基对缩合反应影响很大,羟基超多,缩合越困难。提出了一种假设,试图解释羟基对缩合反应 相似文献
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5-(2-苯基-1,2,3-三唑基)-3-芳基吡唑啉衍生物的合成及其荧光性能 总被引:8,自引:0,他引:8
以2-苯基-1, 2, 3-三唑基-4-甲醛为原料, 与苯乙酮[或取代苯乙酮(1a~1d)]发生羟醛缩合, 生成相应的查尔酮(2a~2d), 再与不同的肼反应, 合成了12种新的5位含2-苯基-1, 2, 3-三唑基的吡唑啉衍生物3a~3d, 4a~4d, 5a~5d. 化合物的结构经元素分析、 IR光谱和1 H NMR谱确认, 并测定了化合物的荧光光谱. 结果显示所合成的目标化合物有荧光, 是一类新型的荧光化合物. 相似文献
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2′,4-二羟基-4′,6′-二甲氧基-二氢查尔酮的首次全合成 总被引:1,自引:0,他引:1
以2,4,6-三羟基苯乙酮和对羟基苯甲醛为起始原料,经选择性的甲基化,甲氧甲基化,羟醛缩合,还原,脱保护等反应首次完成了2′,4-二羟基-4′,6′-二甲氧基-二氢查尔酮(1)的全合成,总收率40%。1和中间体的结构经1HNMR,IR和MS表征。 相似文献
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新型查尔酮类化合物的合成及其生物活性研究 总被引:12,自引:0,他引:12
以3,5-二羟基苯甲酸为原料, 分别经酯化、甲氧甲基保护或甲基化、酰肼化、氧化、醛酮缩合、脱保护基、O-法呢基化或O-异戊烯基化等步骤, 以5.6%~46%的总收率合成了8个未见文献报道的查尔酮类化合物1a~1h, 产物通过1H NMR, 13C NMR, IR, MS进行了结构确证. 对所合成的目标化合物在3个标准活性筛选模型中进行了生物活性试验, 结果表明化合物1b在组织蛋白酶B (CAT-B)模型、化合物1e在细胞分离周期基因25表达的蛋白磷酸酶(CDC25)模型中表现出良好的活性. 相似文献
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The substituted warfarin acid chalcones have been prepared by condensation of warfarin acid and aromatic/aliphatic aldehyde using aq. NaOH as catalyst. The method is simple, cost‐effective and gives good yield in a short reaction time. All the compounds synthesized have been characterized by IR, NMR and Mass spectra. A new series of 4‐hydroxy‐3‐(3‐oxo‐1,5‐diaryl‐3‐oxo‐pent‐4‐enyl)‐chromen‐2‐ones were synthesized and submitted to biological activity. Result of the biological screening showed the compounds 3b , 3h being the most effective among the various treatments in antimicrobial screening. Compounds 3c , 3d , 3k and 3l showed moderate activity against the microorganisms tested. Compounds 3e , 3h have shown good antifungal activity. 相似文献
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Munawar Ali Munawar Muhammad Azad Hamid Latif Siddiqui Faiz‐Ul‐Hassan Nasim 《中国化学会会志》2008,55(2):394-400
The quinolinylpyrimidine derivatives were prepared by the condensation of quinolinyl chalcones with urea (or thiourea) under basic conditions by using both conventional and microwave heating. Their IR, 1H NMR, 13C NMR, mass spectra and CHN analyses confirmed the prepared compounds. The newly prepared quinolinylpyrimidine derivatives were screened for antimicrobial activities against the bacterial strains viz. S. aureus, Shigella, Salmonela, P. aeroginosa, B. Subtilus and E. coli and found considerably active against S. aureus, P. aeroginosa and E. coli. 相似文献
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Zhuya Yang Xiaoxia Ma Wenhong Tan Libin Zhou Xinying Zhuang Shude Yang 《Natural product research》2015,29(20):1909-1913
Two new chalcones, 2′,3,4,4′-tetrahydroxy-2-prenylchalcone (1) and 3-methoxy-2′,4,4′-trihydroxy-2-prenylchalcone (2), together with two known compounds, munsericin (3) and 3,4-dihydroxylonchocarpin (4), were isolated from the ethanol extract of the whole plant of Shuteria sinensis. Their structures were identified by spectroscopic analysis methods, such as 1D and 2D NMR, along with HR-MS data. Glucose metabolism activity of four compounds was tested, compounds 3 and 4 showed effect on the glucose consumption of insulin-resistant HepG2 cells. 相似文献
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Several 6-phenyl-3(2H)-pyridazinones bearing different alkynyl groups at position 5 have been prepared by a palladium-catalysed Sonogashira cross-coupling reaction. An interesting base-promoted electronically permitted isomerization has been observed during the coupling of 1-phenyl-2-propyn-1-ol. This rearrangement afforded the E-chalcone 6 in excellent yield. 相似文献
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联吡唑啉类化合物的合成及其荧光性能 总被引:2,自引:0,他引:2
以1-苯基-3-甲基-5-苯氧基-吡唑-4-甲醛为原料,与苯乙酮(取代苯乙酮)发生羟醛缩合,生成相应的查尔酮,再在冰醋酸中与不同的肼反应,高产率的合成出10种新的5位含1-苯基-3-甲基-5-苯氧基-吡唑基的吡唑啉类衍生物。冰乙酸既是反应溶剂,又是催化剂,产率最高可达72%。目标化合物的结构经元素分析、红外光谱和核磁共振测试技术加以确认。化合物的荧光测定证明,化合物3a~3e发射紫色荧光,λem约为377 nm,化合物4a~4e发射蓝色荧光,λem约为480 nm。在荧光光谱中,不同取代基的联吡唑啉类化合物表现出不同的荧光强度,其中化合物4e具有最强的荧光发射,其强度值可达到4694。所合成出的化合物是一类较好的联吡唑啉类荧光化合物。 相似文献
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Kai-Wei Tang Chien-Chih Ke Chih-Hua Tseng Yeh-Long Chen Cherng-Chyi Tzeng Yi-Jin Chen Chia-Chi Hsu Hsiao-Ting Tai Ya-Ju Hsieh 《Molecules (Basel, Switzerland)》2021,26(16)
Pterostilbene, a natural metabolite of resveratrol, has been indicated as a potent anticancer molecule. Recently, several pterostilbene derivatives have been reported to exhibit better anticancer activities than that of the parent pterostilbene molecule. In the present study, a series of pterostilbene derivatives were designed and synthesized by the hybridization of pterostilbene, chalcone, and cinnamic acid. The cytotoxic effect of these hybrid molecules was determined using two oral cancer cell lines, HSC-3 and OECM-1. (E)-3-(2-((E)-4-Hydroxystyryl)-4,6-dimethoxyphenyl)-1-(2-methoxyphenyl)prop-2-en-1-one (4d), with IC50 of 16.38 and 18.06 μM against OECM-1 and HSC-3, respectively, was selected for further anticancer mechanism studies. Results indicated that compound 4d effectively inhibited cell proliferation and induced G2/M cell cycle arrest via modulating p21, cyclin B1, and cyclin A2. Compound 4d ultimately induced cell apoptosis by reducing the expression of Bcl-2 and surviving. In addition, cleavage of PARP and caspase-3 were enhanced following the treatment of compound 4d with increased dose. To conclude, a number of pterostilbene derivatives were discovered to possess potent anticancer potentials. Among them, compound 4d was the most active, more active than the parent pterostilbene. 相似文献
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V. Rajeswar Rao M. Madan Mohan Reddy 《Phosphorus, sulfur, and silicon and the related elements》2013,188(2):461-471
3-acetyl coumarins on condensation with various aromatic aldehydes in the presence of piperidine gave corresponding chalcones in a solid state under solvent free conditions. These chalcones are isolated and characterized. The in-situ-formed chalcones (1) are also converted into corresponding 2-aryl-4-[2H-2-oxo[1]benzopyran-3-yl]-2,3-dihydro (3) and 2,5-dihydro-1,5-benzothiazepines (4) in one step by interacting with orthoamino thiophenol. Both the 2,3-dihydro (3) and 2,5-dihydrobenzothiazepines (4) have been converted into same tetrahydrobenzothiazepine (5). Finally, the tetrahydrobenzo thiazepine (5) is converted into its acetyl derivative (11). The structures of the title compounds have been confirmed on the basis of their microanalytical, IR, 1 H NMR, and mass spectral data. 相似文献