首页 | 本学科首页   官方微博 | 高级检索  
相似文献
 共查询到20条相似文献,搜索用时 15 毫秒
1.
Tetrakis-, tris-, bis-, and mono salicylic acid derivatives 14 were synthesized by reaction of methyl 2-hydroxy benzoate (methyl salicylate) with 2,2-bis (hydroxymethyl) propane-1,3-diol (pentaerythritol) in the presence of sodium. Yields of different salicyloyloxy derivatives were changed by varying the molar ratios of reactants. For compounds 2 and 3, X-ray structure analysis was performed, as well as molecular energy minimization, to define their conformation in terms of their energy minima. Comparison of crystal and energy minimized structures for these two compounds (2 and 3) revealed that the intramolecular hydrogen bonds play an important role, stabilizing conformation of the most part of the molecule. The antioxidant activity and cytotoxicity of the synthesized derivatives were evaluated in a series of in vitro tests, as well as 17β-hydroxysteroid dehydrogenase type 2 inhibition potency. Tetrakis salicyloyloxy derivative 1 expressed the highest antioxidant potency, tris salicyloyloxy derivative 2 was the best inhibitor of 17βHSD2 enzyme, while bis salicyloyloxy derivative 3 showed strong cytotoxicity against prostate and breast cancer cells with no cytotoxicity against healthy cells.  相似文献   

2.
Coumarins are important and useful compounds with diverse pharmacological properties. New coumarin derivatives namely N-aminoquinoline-2-one 1, 1-((4-hydroxy-6-methyl-2-oxo-2H-pyran-3-yl)methyleneamino)quinolin-2(1H)-one 2 and 1,1′-(1E,1′E)-(1,4-phenylenebis(methan-1-yl-1-ylidene))bis(azan-1-yl-1-ylidene)diquinolin-2(1H)-one 3, were synthesized and characterized by UV–Vis, FT-IR, and NMR spectra in addition of elemental analysis. The synthesized compounds (2 and 3) show considerable anticancer activity against HEp-2 cell line. Synthesized compounds (2 and 3) were tested against selected types of microbial organisms and showed significant activities. The free-radical scavenging activity of synthesized compounds (2 and 3) have been determined by their interaction with the stable free-radical 1,1-diphenyl-2-picrilhydrazyl (DPPH) and all the compounds have shown encouraging antioxidant activities.  相似文献   

3.
Five compounds of the composition Ln(2,2′-Bipy)(C4H8NCS2)3 · 0.5CH2Cl2 (Ln = Sm (I), Eu (II), Tb (III), Dy (IV), and Tm (V); 2,2′-Bipy = 2,2′-bipyridine) are synthesized. According to the X-ray diffraction data (CIF file CCDC 986259), the crystal structure of compound I consists of molecules of the mononuclear complex [Sm(2,2′-Bipy)(C4H8NCS2)3] and solvate molecules CH2Cl2 (2 : 1). The coordination polyhedron N2S6 of the Sm atom is a distorted tetragonal antiprism. The X-ray diffraction analysis shows that compounds I–V are isostructural. The magnetic properties of compounds I–V are analyzed in the temperature range from 2 to 300 K. At 300 K compounds I and III are photoluminescent in the visible spectral range. The photoluminescence intensity of compound I considerably exceeds that of complex III.  相似文献   

4.
Two zinc(II) complexes [Zn(6,6′-dimethyl-2,2′-bipy)Cl2] n (1) and [Zn(6,6′-dimethyl-2,2′-bipy)I2] n (2) are synthesized from the reaction of the 6,6′-dimethyl-2,2′-bipy ligand with ZnCl2 and ZnI2. Zinc(II) oxide nanoparticles are synthesized by the thermolysis of [Zn(6,6′-dimethyl-2,2′-bipy)Cl2] n (1) and [Zn(6,6′-dimethyl-2,2′-bipy)I2] n (2) at two different temperatures. The ZnO nanoparticles are characterized by X-ray diffraction and scanning electron microscopy (SEM). SEM images show the average size of the ZnO nanoparticles produced of 50 nm and 60 nm in compounds 1 and 2 respectively.  相似文献   

5.
Two trimethylsilyl groups were introduced at 5- and 5′-positions of 2,2′-binaphthalene to improve the solubility of 2,2′-binaphthalene-based receptors. The X-ray crystallographic analysis revealed the twisted structure of 2 in the solid state. The solubility of 2 was moderately improved by 3.1-fold comparing with mother skeleton 1. As a practical example of 2, receptor 8 bearing two aza-15-crown-5 moieties was prepared and the selective binding of 8 with Ba2+ can be observed by the formation of sandwich-like complex, which shows no prevention of binding ability of the receptor by introduction of the bulky substituents.  相似文献   

6.
New luminescent heterometallic complexes of Eu3+ and Zn2+ were synthesized: Zn2Eu(NO3)(Piv)6(L)2 (Piv is pivalate anion, L = MeCN (1), 2,3-lutidine (2), 2,2′-bpy (3)) and [Zn2(Piv)3(2,2′-bpy)2][ZnEu(NO3)3(Piv)3(2,2′-bpy)] (4). In the case of 2,2′-bpy, the order of mixing of the reagents ([Zn(Piv)2] n , Eu(NO3)3·6H2O, and 2,2′-bpy) affects the composition of the final reaction product: the reaction of [Zn(Piv)2] n and Eu(NO3)3·6H2O (in the ratio Zn : Eu = 3 : 1) in MeCN affords complex 1 and the subsequent addition of 2,2′-bpy (Zn : L = 1 : 1) affords complex 3. Complex 4 is formed in the reaction of [Zn(Piv)2] n and 2,2′-bpy (Zn : L = 1 : 1) in MeCN followed by the addition of Eu(NO3)3·6H2O (Zn : Eu = 3 : 1). The luminescence spectra of compounds 1–4 (Zn : Eu = 3 : 1) exhibit metal-centered luminescence of Eu3+. The most efficient ligand-antenna is 2,2′-bpy, which is due to the optimum position of the triplet level of this ligand.  相似文献   

7.
The influence of the introduced fluorine atoms to diketonato backbone exerted on the crystal packing was studied on cobalt(II) bis(4,4,4-trifluoro-1-phenylbutane-1,3-dionato-κ 2 O,O′) compounds with pyridine (1), 2,2′-bipyridine (2) and 1,10-phenanthroline (4), and cobalt(II) bis(benzoylacetonato-κ 2 O,O′) compound with 2,2′-bipyridine (3). The solid-state structures of 14 were determined by single crystal X-ray analysis. The coordination of Co(II) is octahedral in all four compounds. The differences in crystal packing of 1 with regard to the known complexes with non-fluorinated analogue and 4,4,4-trifluoro-1-(4-fluorophenyl)butane-1,3-dionate were observed. Unit cell parameters of 2·½C7H8 and 3·½C7H8 slightly differ, but they have similar crystal packing dominated by the ππ interactions. Strong ππ interactions and weak C–H···π(arene) and C–F···π(arene) interactions are present in 24, while no significant intermolecular interactions are present in 1.  相似文献   

8.
5,6-Dihydro-4-hydroxy-6,6-dimethyl-2H-thiopyrane-2-thione (1 I) and its tautomer 2-mercapto-4H-thiopyrane-4-one (1 II) react with aliphatic aldehydes under different reaction conditions to yield mainly 5R-7,8-dihydro-2H,5H,6H-thiopyrano[2,3—b:6,5—b′]-bisthiopyran-4,6(3H)-diones2 and 2′R,4′R-5,6,6′,7′-tetrahydro-2-thioxo-spiro(4H-thiopyran-3(2H), 3′(4′H)-2′H,5′H-thiopyrano-[2,3—b]-thiopyran)-4,5′-diones3. The mechanisms of formation of the condensates2 and3 and their stereochemistry are discussed. The reaction yielding2 is analogous to the condensation of dimedone with subsequent anhydride formation.3 might be generated byDiels-Adler reaction of intermediately formed 2-thioxo-3-alkylidenethiopyranones4. An X-ray crystal structure analysis was carried out on3 b to establish its configuration and conformation.  相似文献   

9.
Three oxovanadium complexes, namely [VO(NOSAA)(bpy)] (1) (NOSAA = 2-hydroxy-5-nitrosalicylidene anthranilic acid, bpy = 2,2′-bipyridyl), [VO(NOSAA)(4,4′-dimebpy)] (2) (4,4′-dimebpy = 4,4′-dimethyl-2,2′- bipyridyl), and [VO(NOSAA)(phen)] (3) (phen = 1,10-phenanthroline), have been prepared and characterized. The binding modes and strengths of these complexes with calf thymus DNA (CT-DNA) were studied using various techniques. The chemical nuclease activities and photocleavage reactions of the complexes were also tested. All three complexes interact with CT-DNA through intercalative modes, and complex 3 possesses the largest binding affinity. All three complexes can efficiently cleave pBR322 DNA upon irradiation or under physiological conditions in the presence of H2O2, and complex 3 has the best cleaving ability. In vitro experimental results showed that the three complexes are cytotoxic against myeloma (Ag8.653) and gliomas (U251) cell lines and complex 3 again showed the highest efficacy.  相似文献   

10.
New benzo-15-crown-5 derivatives containing nitro, amine and imine groups were prepared. Nitro compound (1) was prepared after the reaction?4′,5′-bis(bromethyl)benzo-15-crown-5 and o-nitrophenol in the presence of NaOH. After reduction process by using hydrazine hydrate and Pd/C amine compound (2) was formed. New crown ether imine compounds (35) were synthesized by the condensation of corresponding crown ether diamine (2) with salicylaldehyde derivatives. Sodium complexes of the crown compounds (1a5a) form crystalline 1:1 (Na+: ligand) complexes with sodium perchlorate. Nickel(II) complexes (3b5b) with 1:1 (Ni2+:ligand) stoichiometries were also been synthesized from the Schiff bases (35). The results indicated that the Schiff base ligands coordinated through the azomethine nitrogen and phenolic oxygen. The extraction ability of compounds (1, 3, 4 and 5) were also evaluated in chloroform by using several alkali and transition metal picrates such as Li+, Na+, K+, Cr3+, Mn2+, Ni2+, Cu2+, Zn2+ and Pb2+.  相似文献   

11.
A series of new compounds bearing a 1,3-benzothiazol-2-one nucleus have been synthesized using 5,6-dimethyl-3-(2-oxo-propyl)-1,3-benzothiazol-2-one (1) as a key starting compound. The reaction of 1 with some nucleophilic compounds led to the formation of compounds 2, 3, 4, 5a, b, 6 and 7a, b. The thiosemicarbazone derivatives 7a, b were treated with a number of halo ketones to produce the new heterocyclic compounds 913, while their reaction with acid anhydrides led to the formation of the derivatives 14 and 15. Also, compound 1 was condensed with different aromatic aldehydes to afford the corresponding chalcones 1822. The structures of all the novel compounds have been determined by analytical and spectral data. Some of the compounds were selected to be evaluated as anti-inflammatory and analgesic agents.  相似文献   

12.
Nanoparticles of two new coordination polymers, [Pb(5,5′-dm-2,2′-bpy)Cl2] n (1) and [Pb(5,5′-dm-2,2′-bpy)Br2] n (2), {5,5′-dm-2,2′-bpy = 5,5′-dimethyl-2,2′-bipyridine}, have been synthesized by ultrasonic assistance at different concentrations and characterized by scanning electron microscopy, X-ray powder diffraction, IR spectroscopy and elemental analyses. Metal oxide nanoparticles were prepared from thermal decomposition of compounds 1 and 2 at 600 °C under air atmosphere. Scanning electron microscopy images of the residue which are obtained from calcination of compounds 1, 2 show the formation of lead(II) oxide nanoparticles with an average diameter of about 80 and 90 nm for compounds 1 and 2, respectively.  相似文献   

13.
Heteroligand complexes Tm(L)(iso-Bu2PS2)2(NO3) (L = 2,2′-Bipy (II), Phen (III)) are synthesized. According to the X-ray phase analysis data, complex III is isostructural to mononuclear compound [Dy(Phen)(iso-Bu2PS2)2(NO3)] including, according to the X-ray diffraction data, a coordination polyhedron DyN2O2S4 (distorted dodecahedron). Single crystals of compounds [Ln(2,2′-Bipy)(iso-Bu2PS2)2(NO3)] · C6H6 (Ln = Tm (IV), Tb (V)) are obtained. An X-ray diffraction analysis shows that the crystal structures of these isostructural compounds are formed by molecules of mononuclear complexes [Ln(2,2′-Bipy)(iso-Bu2PS2)2(NO3) and uncoordinated C6H6 molecules. In complexes IV and V, the ligands [Ln(2,2′-Bipy)(iso-Bu2PS 2 ? , and NO 3 ? are bidentate-cyclic. The coordination polyhedron LnN2O2S4 is a distorted dodecahedron. Complexes II and III possess photoluminescence in the visible spectral range (λmax = 478 and 477 nm, respectively).  相似文献   

14.
N-Benzyltetrahydropyridinyl-4,6-dimethoxy phenyl-substituted 2′-hydroxychalcones SJC115 were synthesized using Claisen–Schmidt condensation, their structures confirmed by spectral analysis, and their anticancer activity evaluated. To support their biological activity, physicochemical parameters such as lipophilicity and oxidation potential were determined. To assess their relative cytotoxicity, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay was performed using MCF-7, T-47D, MDA MB-231, HepG2, and Vero cell lines. The cytotoxicity of the chalcones was found to vary with the nature of the ring B substituents. The lipophilicity of the cytotoxic compounds expressed in terms of distribution coefficient was found to lie in the range of 2.4–4.2. Further evaluation of their antioxidant potential revealed antioxidant activity by 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt (ABTS) radical scavenging assay and irreversible electrochemical reaction with oxidation potential in the range of 0.879–1.048 V. Of the 15 chalcones, SJC4, 5, 9 were selected for further in vitro studies using MCF-7. The compounds exhibited significant apoptotic effect and caused cell cycle arrest at G0/G1 and G2/M phase. Among them, two of the O-alkylated chalcones (SJC5, 9) showing promising activity against hormone-responsive breast cancer cells were evaluated for their in vivo anticancer activity using 7,12-dimethylbenz[a]anthracene (DMBA)-induced mammary tumor model. Three-week treatment with the test compounds at oral dosage of 100 mg kg?1 per day significantly improved elevated tumor parameters compared with tumor control. Treatment with chalcone SJC5 (a 2,4,5-trimethoxy derivative) exhibited anticancer effects similar to those of doxorubicin (2 mg kg?1 per week, i.p.) and was free from toxic effects observed with doxorubicin treatment.  相似文献   

15.
Photocatalysis of biscarbonylrhenium complexes cis,trans-[Re(dmbpy)(CO)2(PR3) (PR′3)]+ (dmbpy=4,4′-dimethyl-2,2′-bipyridine: R, R′=Ph (1a +); p-FPh (1b +); R=Ph, R′=OEt (1c +); R, R′=O-i-Pr (1d +)) is reported for the first time. The rhenium complexes with two triarylphosphine ligands (1a +, 1b +) efficiently photocatalyzed CO2 reduction with triethanolamine as a sacrificial donor. On the other hand, the complexes with one or two trialkylphosphite ligand(s) (1c +, 1d +) had low photocatalytic abilities under the same reaction conditions.  相似文献   

16.
Two complexes of formulas [Zn(Hfac)2(IM-IMH-Bph)] (I) and [Co(Hfac)3](IM-Bph) (II), where IM-Bph = 2,2′-bis(1′-oxyl-4′,4′,5′,5′-tetramethylimidazoline-2′-yl)-bis(2-formylphenyl) ether; Hfac = hexafluoroacetylacetonate, have been synthesized and characterized by single-crystal X-ray diffraction. The X-ray analysis demonstrates that both I and II are mononuclear complexes. In I, each zinc ion is five-coordinated with four oxygen atoms from two Hfac ligands and one oxygen atom from nitroxide. Complex II contains one Co(III) atom with six oxygen atoms from three Hfac ligands and uncoordinated IM-Bph diradical, in which the Co2+ ion and NIT-Bph biradical can undergo the redox reaction.  相似文献   

17.
3-(Naphthalen-1-ylmethylene)-5-phenylfuran-2(3H)-one 1 was prepared and converted into a variety of heterocyclic systems of synthetic and biological importance. Benzylamine was reacted with furanone 1 to afford compounds 2 and 3 according to the reaction conditions. Butanamide 2 was reacted with thionyl chloride or thiourea to give derivatives 4 and 5, respectively. Compound 3 was reacted with ethyl cyanoacetate to give the corresponding pyrrolopyridine derivative 6. Treatment of 1 with hydrazine hydrate afforded compounds 7 and 8 according to the reaction conditions. Also, compound 1 was reacted with phenyl hydrazine, hydroxyl amine, malononitrile or thiourea to give compounds 912, respectively. Cyclization of 7 with ethoxymethylene-malononitrile, ethyl-(ethoxymethylene)cyanoacetate, carbon disulphide or acetylacetone afforded the corresponding compounds 1316, respectively. Condensation of 7 with p-nitrobenzaldehyde gave the corresponding hydrazone 17, which was treated with thioglycolic acid or chloroacetyl chloride to give compounds 18 and 19, respectively. Also, most of the prepared products were tested for anti-avian influenza virus and revealed promising antiviral activity against H5N1 virus [A/Chicken/Egypt/1/2006 (H5N1)] by determination of both TC 50 and ED 50 and confirmed by plaque reduction assay on MDCK cells. Compounds 7, 8, 11, 12 and 13 showed the highest effect compared with the other tested compounds.  相似文献   

18.
Quantum mechanical and Rice-Ramsperger-Kassel-Marcus (RRKM) calculations are carried out to study the thermal unimolecular decomposition of oxetane (1), 2-methyloxetane (2), and 2,2-dimethyloxetane (3) at the MPW1PW91/6-311 + G** level of theory. The results of the calculations reveal that decomposition reaction of compounds 1?C3 yields formaldehyde and the corresponding substituted olefin. The predicted high-pressure-limit rate constants for the decomposition compounds 1?C3 are represented as 6.61 × 1013exp(?32472/T), 9.33 × 1013exp(?29873/T), and 4.79 × 1013exp(?27055/T) s?1, respectively. The fall-off pressures for the decomposition of compounds 1?C3 are found to be 9.42 × 10?2, 3.67 × 10?3, and 7.26 × 10?4 mm Hg, respectively. As the fall-off pressure of the decomposition process of compounds 1?C3 are in the following order: P 1/2(1) > P 1/2(2) > P 1/2(3); therefore the decomposition rates are as follow: rate(1) < rate(2) < (3).  相似文献   

19.
A series of d-homo lactones 4?C10 from dehydroepiandrosterone 1 via 16-hydroximino derivatives 2 and 3 were synthesized. The d-homo lactone 4 was transformed by the Oppenauer oxidation to obtain compound 5. The (Z)-2-hydroxymethylene-4-en-3-one compound 6, was obtained through reaction of 4-en-3-one compound 5 with ethyl formate and sodium hydride. The epoxides 8 and 9 were prepared from compound 7 by oxidation with m-chloroperbenzoic acid. Compound 10 was obtained by treating epoxides 8 and 9 with chromium(VI)-oxide. The structure of compounds 6 and 10 were confirmed by X-ray structural analysis. These derivatives were screened for antitumor activity against three tumor cell lines (human breast adenocarcinoma ER+, MCF-7, human breast adenocarcinoma ER?, MDA-MB-231, prostate cancer AR?, PC-3), and one human non-tumor cell line, MRC-5. Compounds 4, 7, 8, and 10 exhibited significant antitumor activity against MDA-MB-231 cells, while compound 5 showed strong cytotoxicity against MDA-MB-231. No compounds displayed toxicity against MRC-5 cells.  相似文献   

20.
Guanidine reacts with cyclohexanone, cycloheptanone, acetone and 3-pentanone, resp., in a molar ratio 2∶1 to give the 1,3,5-triazaspiro[5.5]undeca-and [5.6]dodeca-1,3-dien-2,4-diamines3 a and3 b resp. and the 6,6-dimethylresp. diethyl-1,6-dihydro-1,3,5-triazin-2,4-diamines3 d and3 e resp. On the contrary, action of guanidine on cyclopentanone yields not3 c, but the 1′,5′,7′-tetrahydrospiro[cyclopentane-1,4′-cyclopentapyrimidine]-2′(3′H)-imines2 c, 5 c and6 c resp., which are 1∶2- and 1∶3-condensates. Phenylacetone is transformed by guanidine (1∶2) to give 6-phenyl-2,4-pyrimidindiamine (8 f). The structure of the compounds cited is proved by NMR-, IR-, and (partially) mass spectra. The different courses of the formation of3 a, b, d, e, 2 c, 5 c and6 c resp. and8 f are also discussed. The structural formulae of some additional bases, which were synthesized from guanidine and cyclopentanone, 3-pentanone and phenylacetone resp. could not be established.  相似文献   

设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号