共查询到20条相似文献,搜索用时 31 毫秒
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《合成化学》2015,(6)
以取代苯乙酮和5-醛基-8-甲氧甲氧基-2-甲基-2-(4'-甲基-3'-戊烯基)-二氢-1-苯并吡喃为原料,经羟醛缩合反应制得两个中间体——7,2',4'-三甲氧甲氧基-6'-羟基-2-甲基-2-(4'-甲基-3'-戊烯基)-二氢-1-苯并吡喃查尔酮(3a)和7,2',4'-三甲氧甲氧基-5'-异戊烯基-6'-羟基-2-甲基-2-(4'-甲基-3'-戊烯基)-二氢-1-苯并吡喃查尔酮(3b);3a经环合和脱保护基反应合成了(±)-Malaysianone A(4a),产率12.9%;3b经脱保护基和环合反应合成了(±)-Tanariflavanones B(4b),产率5.2%。4a和4b的结构经1H NMR,13C NMR和HR-ESI-MS确证。 相似文献
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Isokotanin A是从曲霉属Aspergillus alliaceus的菌核分离出的联香豆素化合物。本文以3,5-二羟基甲苯为起始原料, 经氧化偶联, 选择性断裂醚键等八步反应, 首次成功地合成了(±)Isokotanin A, 总收率为12%。 相似文献
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《Tetrahedron letters》1994,35(3):351-354
(±)-Hymenin (1) has been synthesized by a highly efficient route involving the generation of an azafulvene intermediate and its coupling with 2-aminoimidazole. 相似文献
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Kamal Nain Singh Pushpinder Singh Arvind Kumar Sharma Paramjit Singh Satinder V. Kessar 《合成通讯》2013,43(24):3716-3720
A three step synthesis of (±)-metazocine and (±)-phenazocine starting with 3,4-lutidine is described. The key step involves Lewis acid promoted lithiation/electrophilic substitution reaction of N-alkyl-3,4-dimethyl-1,2,5,6- tetrahydropyridine. 相似文献
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对四种天然二聚二苯乙烯类化合物Shegansu B (1), Gnetuhainin F (1a), Maackin A (2)以及Cassigarol E (3)的全合成进行了研究. 以3,5-二羟基苯甲酸(4)为起始原料, 经六步反应制得异丹叶大黄素(13)和白皮杉醇(14), 在HRP/H2O2酶催化氧化体系中, 13和14分别进行自身的氧化偶联得到各自的二聚产物. 首次完成了1a, (±)-2和(±)-3的全合成, 并以较文献报道为高的氧化偶联产率合成了(±)-1. 相似文献
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Ping Yan BIE Cheng Lu ZHANG Xuan Jia PENG Xin Fu PAN* Department of Chemistry National Laboratory of Applied Organic Chemistry Lanzhou University Lanzhou 《中国化学快报》2002,13(9)
Celaphanol A was a diterpene isolated from the stems of Celastrus stephanotifolius1, which have been the subject of continued and growing interest, due to the range of biological activities shown by many members of this family2. Some have been used in traditional medicine3 or as a stimulant4 from ancient times. In order to further study the relationship between the structure and biological activity of the diterpene compound and as an extension of diterpenoid synthesis in our laboratory5, 6, … 相似文献
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We report the total synthesis of (±)-aspidophylline A, one of many complex furoindoline-containing alkaloids that has not been synthesized previously. Our route features a number of key transformations, including a Heck cyclization to assemble the [3.3.1]-bicyclic scaffold as well as a late-stage interrupted Fischer indolization to install the furoindoline and construct the natural product's pentacyclic framework. 相似文献
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A thirteen-step total synthesis of (±)-saframycin A from a tricyclic lactam intermediate is described. The key step of this total synthesis is the stereocontrolled construction of a pentacyclic saframycin framework via a modified Pictet-Spengler type cyclization generating a bis-carboxylic acid ester derivative, followed by decarboxylation. The cytotoxicity profiles are also presented. 相似文献
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Trichodiene (1), a sesquiterpene hydrocarbon, was isolated from the extract of mycelium of Trichothecium roseum. The structure of trichodiene (1) was elucidated by Nozoe and Machida in 1970 via degradation and spectroscopy.1 Trichodiene (1) has been shown to be the biogenetic precursor of the trichothecane family of sesquiterpenoids as characterized by the cytotoxic fungal metabolite (-)-trichodermin (2).2,3 The structure and absolute stereochemistry of (-)-trichodermin (2) were determined by X-ray diffraction and, therefore, the structure and absolute stereochemistry of trichodiene (1) are now firmly established.4 We wish to report a total synthesis of (±)-trichodiene (1) via previously reported lactone 3.5,6 相似文献
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Lysidicin A, which has been isolated from Lisidicie rhodostegia possesses complicated structure. A total synthesis of lysidicin A has been achieved and is described herein. The key reaction is single and cascade Claisen rearrangements. 相似文献
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A total synthesis of (±)-chloranthalactone A was completed. It features substrate-controlled epoxidation of ketone and highly diastereoselective intramolecular cyclopropanation to construct the cis, trans-3/5/6 tricyclic skeleton. 相似文献
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The total synthesis of chamobtusin A, the first diterpenoid alkaloid isolated from the whole Pinales, is described. Key features of the synthesis include a stereoselective intramolecular Michael addition to install a key stereocenter and an oxidative manipulation to prepare a 2H-pyrrole ring. 相似文献
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Summary An alternative synthesis of methyl 4,8a-dimethyl-3-oxo-trans-perhydronaphthalene-6-carboxylate is described.
Eine modifizierte Synthese von (±)-Occidentalol
Zusammenfassung Es wird eine alternative Synthese von Methyl-4,8a-dimethyl-3-oxo-trans-perhydronaphthalin-6-carboxylat beschrieben.相似文献
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