Stochastic properties coupling between of tumor growth with non-Gaussian and Gaussian noise terms

Dynamical behavior of a tumor-growth model with coupling between non-Gaussian and Gaussian noise terms is investigated. The departure from the Gaussian noise can not only reduce the probability of tumor cells in the active state, induce the minimum of the average tumor-cell population to move toward a smaller non-Gaussian noise, but also decrease the mean first-passage time. The increase of white-noise intensity can increase the tumor-cell population and shorten the mean first-passage time, while the coupling strength between noise terms has opposite effects, and the noise correlation time has a very small effect.     

Stochastic properties of tumor growth with coupling between non-Gaussian and Gaussian noise terms

Dynamical behavior of tumor-growth model with coupling between non-Gaussian and Gaussian noise terms is investigated. The departure from the Gaussian noise can not only reduce the probability of tumor cells in the active state, induce the minimum of the average tumor-cell population to move toward a smaller non-Gaussian noise, but also decrease the mean first-passage time. The increase of white-noise intensity can increase the tumor-cell population and shorten the mean first-passage time, while the coupling strength between noise terms has opposite effects, and the noise correlation time has a very small effect.     

Transient Properties of a Bistable System with Delay Time Driven by Non-Gaussian and Gaussian Noises： Mean First-Passage Time

The mean first-passage time of a bistable system with time-delayed feedback driven by multiplicative non-Gaussian noise and additive Gaussian white noise is investigated. Firstly, the non-Markov process is reduced to the Markov process through a path-integral approach; Secondly, the approximate Fokker-Planck equation is obtained by applying the unified coloured noise approximation, the small time delay approximation and the Novikov Theorem. The functional analysis and simplification are employed to obtain the approximate expressions of MFPT. The effects of non-Gaussian parameter （measures deviation from Gaussian character） r, the delay time τ, the noise correlation time to, the intensities D and a of noise on the MFPT are discussed. It is found that the escape time could be reduced by increasing the delay time τ, the noise correlation time τ0, or by reducing the intensities D and α. As far as we know, this is the first time to consider the effect of delay time on the mean first-passage time in the stochastic dynamical system.     

Transient Properties of a Bistable System with Delay Time Driven by Non-Gaussian and Gaussian Noises: Mean First-Passage Time

The mean first-passage time of a bistable system with time-delayed feedback driven by multiplicative non-Gaussian noise and additive Gaussian white noise is investigated. Firstly, the non-Markov process is reduced to the Markov process through a path-integral approach; Secondly, the approximate Fokker-Planck equation is obtained by applying the unified coloured noise approximation, the small time delay approximation and the Novikov Theorem. The functional analysis and simplification are employed to obtain the approximate expressions of MFPT. The effects of non-Gaussian parameter (measures deviation from Gaussian character) r, the delay time τ, the noise correlation time τ₀, the intensities D and α of noise on the MFPT are discussed. It is found that the escape time could be reduced by increasing the delay time τ, the noise correlation time τ₀, or by reducing the intensities D and α. As far as we know, this is the first time to consider the effect of delay time on the mean first-passage time in the stochastic dynamical system.     

非高斯噪声激励下FHN神经元系统的定态概率密度与平均首次穿越时间

研究了非高斯噪声激励下的FHN神经元系统,应用路径积分法和统一色噪声近似得到系统的定态概率密度函数和平均首次穿越时间表达式.发现了加性噪声强度Q能够诱导非平衡相变的产生,乘性噪声强度D、偏离参数p及关联时间τ₀均不能诱导非平衡相变发生;非高斯噪声的存在缩短了细胞神经元系统静息态和激发态之间的转化时间,有利于神经元信息的传递. 关键词： FHN神经元系统 非高斯噪声 定态概率密度 平均首次穿越时间     

非高斯噪声驱动下一维双稳系统的逻辑操作

本文以成功率作为逻辑随机共振的测度, 主要研究了非高斯噪声激励下一维双稳系统的逻辑随机共振现象, 并用平均首次通过时间的方法对此现象的机理进行了解释. 研究结果表明: 只有在适当的噪声强度带或关联时间带上, 成功率才会达到共振峰值. 通过对系统参数进行优化, 提高了系统实现逻辑操作的可靠性. 关键词： 逻辑随机共振 一维双稳系统 非高斯噪声 平均首次通过时间     

Multiplicative non-Gaussian noise and additive Gaussian white noise induced transition in a piecewise nonlinear model

We study the transition problems in a piecewise nonlinear model induced by correlated multiplicative non-Gaussian noise and additive Gaussian white noise. Firstly, applying the path integral approach, the unified colored noise approximation, the analytical expression of the steady-state probability density function (SPD) is derived. Then the change regulation of the SPD is analyzed with the change of the strength and relevance of multiplicative noise and additive noise. From numerical computations we obtain some new nonlinear phenomena: the transition can be induced by the cross-correlation strength between noises, the non-Gaussian noise intensity and the Gaussian noise intensity as well as the non-Gaussian noise deviation parameter. This indicates that the effect of the non-Gaussian noise intensity on SPD is the same as that of the Gaussian noise intensity. Moreover, we also find the correlation time of the non-Gaussian noise can not induce the transition.     

Mean First-Passage Time of an Asymmetric Kinetic Model Driven by Two Different Kinds of Colored Noises

The mean first-passage time （MFPT） of an asymmetric bistable system between multiplicative non-Gaussian noise and additive Gaussian white noise with nonzero cross-correlation time is investigated. Firstly, the non-Markov process is reduced to the Markov process through a path-integral approach; Secondly, the approximate Fokker Planck equation is obtained by applying the unified colored noise approximation and the.Novikov Theorem. The steady-state probability distribution （SPD） is also obtained. The basal functional analysis and simplification are employed to obtain the approximate expressions of MFPT T^±. The effects of the asymmetry parameter β, the non-Gaussian parameter （measures deviation from Gaussian character） r, the noise correlation times τ and τ2, the coupling coefficient A, the intensities D and a of noise on the MFPT are discussed. It is found that the asymmetry parameter β, the non-Gaussian parameter r and the coupling coefficient A can induce phase transition. Moreover, the main findings are that the effect of self-existent parameters （D, α, and τ） of noise and cross-correlation parameters （A, 7-2） between noises on MFPT T^± is different.     

非高斯噪声驱动下非对称双稳系统的平均首次穿越时间与随机共振研究

研究了乘性非高斯噪声和加性高斯白噪声共同激励下非对称双稳系统的平均首次穿越时间和随机共振问题. 利用路径积分法和两态模型理论,推导出平均首次穿越时间和信噪比的表达式. 研究结果表明:势阱非对称性对两个不同方向的平均首次穿越时间的影响是不同的. 信噪比是加性噪声强度和势阱非对称性的非单调函数,系统出现了随机共振现象;信噪比是乘性噪声强度的单调函数,没有共振峰出现. 这说明该系统中乘性噪声强度和加性噪声强度对信噪比的影响是不同的. 关键词： 非高斯噪声 非对称双稳系统 平均首次穿越时间 随机共振     

Stationary properties of a single-mode laser system with non-Gaussian and Gaussian noise

A single-mode laser system with non-Gaussian and Gaussian noise is investigated. The stationary mean value and the normalized variance of the laser intensity are numerically calculated under the condition that the stationary probability distribution function (SPDF) is derived. The SPDF as a function of the laser intensity exhibits a maximum. The maximum becomes smaller with the increase of the correlation intensity or the non-Gaussian parameter, where the later is a measure of the deviation from the Gaussian characteristic. The maximum becomes larger as the correlation time increases. The laser intensity stationary mean value decreases with the increase of the correlation intensity or the non-Gaussian parameter while increases with the correlation time increasing. The laser intensity normalized variance increases with the increase of the correlation intensity or the non-Gaussian parameter while decreases as the correlation time increases.     

关联高斯与非高斯噪声激励的FHN神经元系统的稳态分析

本文主要研究了关联乘性非高斯噪声和加性高斯白噪声共同激励的FHN(Fitz Hugh-Nagumo)神经元系统.利用路径积分法和统一色噪声近似,推导出该系统的定态概率密度函数表达式.通过研究发现,乘性噪声强度D、加性噪声强度Q、噪声自关联时间τ以及互关联系数λ均可以诱导系统产生非平衡相变现象,而非高斯参数q却不可以诱导系统产生非平衡相变现象.此外,我们还发现参数D和λ的增大有利于神经元系统从激发态向静息态转换,Q和τ的增大有利于神经元系统从静息态向激发态转换,q的增大会使得神经元系统停留在静息态的概率增加.     

Asymmetric stochastic resonance under non-Gaussian colored noise and time-delayed feedback

Based on adiabatic approximation theory, in this paper we study the asymmetric stochastic resonance system with time-delayed feedback driven by non-Gaussian colored noise. The analytical expressions of the mean first-passage time(MFPT) and output signal-to-noise ratio(SNR) are derived by using a path integral approach, unified colored-noise approximation(UCNA), and small delay approximation. The effects of time-delayed feedback and non-Gaussian colored noise on the output SNR are analyzed. Moreover, three types of asymmetric potential function characteristics are thoroughly discussed. And they are well-depth asymmetry(DASR), well-width asymmetry(WASR), and synchronous action of welldepth and well-width asymmetry(DWASR), respectively. The conclusion of this paper is that the time-delayed feedback can suppress SR, however, the non-Gaussian noise deviation parameter has the opposite effect. Moreover, the correlation time plays a significant role in improving SNR, and the SNR of asymmetric stochastic resonance is higher than that of symmetric stochastic resonance. Our experiments demonstrate that the appropriate parameters can make the asymmetric stochastic resonance perform better to detect weak signals than the symmetric stochastic resonance, in which no matter whether these signals have low frequency or high frequency, accompanied by strong or weak noise.     

Enhancement of density divergence in an insect outbreak model driven by colored noise

The steady states and the transient properties of an insect outbreak model driven by Gaussian colored noise are studied in this paper.According to the Fokker-Planck equation in the unified colored-noise approximation,we analyse the stationary probability distribution and the mean first-passage time of this model.By numerical analysis,the effects of the self-correlation time of insect birth rate and predation rate respectively reveal a manifest population divergence on the insect density.The decrease of the mean first-passage time indicates an enhancement dynamic on the density divergency with colored noise of a large self-correlation time based on the insect outbreak model.     

非高斯噪声对惯性棘轮中粒子负迁移率的影响

利用随机模拟方法研究了惯性棘轮中非高斯噪声对负迁移率的影响. 分别模拟了绝对负迁移率(ANM), 非线性迁移率(NNM) 和负微分迁移率(NDM) 等三种反常输运现象. 计算结果表明: 1) 在不同的参数空间里, 非高斯噪声参数q 能够增强或者削弱ANM, 诱导NNM 和NDM; 2) 当q 较大时, 反常输运现象转化为正常输运; 3) 随着q 逐渐增大, 平均速度- 关联时间特性曲线朝着关联时间较小的方向移动并且其峰值逐渐减小. 关键词： 反常输运 负迁移率 非高斯噪声     

Ballistic diffusion induced by non-Gaussian noise

In this letter,we have analyzed the diffusive behavior of a Brownian particle subject to both internal Gaussian thermal and external non-Gaussian noise sources.We discuss two time correlation functions C(t) of the non-Gaussian stochastic process,and find that they depend on the parameter q,indicating the departure of the non-Gaussian noise from Gaussian behavior:for q ≤ 1,C(t) is fitted very well by the first-order exponentially decaying curve and approaches zero in the longtime limit,whereas for q 1,C(t) can be approximated by a second-order exponentially decaying function and converges to a non-zero constant.Due to the properties of C(t),the particle exhibits a normal diffusion for q ≤ 1,while for q 1 the non-Gaussian noise induces a ballistic diffusion,i.e.,the long-time mean square displacement of the free particle reads [x(t)-x(t)]2∝t2.     

Resonant-Like Activation in a Bistable System with Noise and Time Delay

A bistable system with noise and time delay is investigated. Theoretical analysis and stochastic simulation show that： （i） In the ease of a system driven only by multiplicative Gaussian white noise, the mean first-passage time for a particle to reach the other stable state from one stable state exhibits a minimum with respect to delay time, i.e., a resonant-like activation （RA） phenomenon. （ii） In the action of additive and multiplicative noise, as the additive noise intensity increases, no matter whether a correlation between the two types of noise exists or not, the RA gradually disappears. （iii） The correlation strength between the two types of noise does not influence the existence of the RA.     

Work fluctuation theorem for coloured noise driven open systems

We have studied work fluctuation behaviour in the presence of internal thermal noise as well as external coloured noise. The external coloured noise may have both Gaussian or non-Gaussian characteristics. We have investigated the dependence of position and work fluctuations on the properties of both the environments. For thermal noise driven systems, there is a maximum in the variation of mean square fluctuation of work (MSFW) as a function of damping strength at intermediate times, while at asymptotic long times MSFW monotonically increases in the same damping regime. But for external noise, MSFW monotonically decreases as a function of damping strength at intermediate times, whereas at long times it becomes almost independent of damping strength.Another interesting observation is that for the external noise driven systems, noise correlation time and damping strength have similar roles in the dynamics.     

Influence of non-Gaussian noise on a tumor growth system under immune surveillance

In this paper, the stationary probability distribution (SPD) function and the mean first passage time (MFPT) are investigated in a tumor growth model driven by non-Gaussian noise which is introduced to mimic random fluctuations in the levels of the immune system. Results demonstrate the different transitions induced by the strength of non-Gaussian noise under different immune coefficients and the dual roles of non-Gaussian noise in promoting host protection against cancer and in facilitating tumor escape from immune destruction. Additionally, it can be discovered that increases in noise strength, the degree of departure from Gaussian noise, and the immune coefficient can accelerate the extinction of tumor cells. Numerical simulations are performed, and their results present good agreement with the theoretical results.     

色交叉关联噪声作用下癌细胞增长系统的平均首通时间

研究了受色交叉关联噪声驱动的癌细胞增长系统的平均首通时间.根据Novikov定理和Fox方法得到了相应的近似Fokker-Planck方程,给出了稳态概率密度函数的表达式.运用最快下降法,得到了平均首通时间的解析式.数值结果表明:两噪声之间负关联时,平均首通时间是加性噪声强度和乘性噪声强度的减函数,是噪声关联时间的增函数;两噪声之间正关联时,平均首通时间与加性噪声强度之间的单调关系与穿越方向有关,是乘性噪声强度的非单调函数,是噪声关联时间的减函数.