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1.
A. R. Khomutov T. I. Oslpova E. N. Khurs K. V. Alferov R. M. Khomutov 《Russian Chemical Bulletin》1996,45(8):1961-1964
Approaches to the synthesis of 1-amino- and 2-amino-2-carboxyethylphosphinic and-phosphoric acids have been studied. A convenient method for the preparation of phosphinic acids is the reactions of ethyl diethoxymethylphosphonite with ethyl acetamidomethylenemalonate and ethyl 2-acetamidoacrylate.Translated fromIzvestiya Akademii Nauk. Seriya Khimicheskaya, No. 8, pp. 2066–2069, August, 1996. 相似文献
2.
A. V. Belyankin A. R. Khomutov Yu. N. Zhukov O. N. Kartasheva R. M. Khomutov 《Russian Chemical Bulletin》1997,46(1):133-136
The reaction of aryl and aralkyl aldoximes with hypophosphorous acid resulted in aminophosphinic acids, which were oxidized
into the corresponding aminophosphonic acids.
Translated fromIzvestiya Akademii Nauk. Seriya Khimicheskaya, No. 1, pp. 137–140, January, 1997. 相似文献
3.
Yu. N. Zhukov A. R. Khomutov T. I. Osipova R. M. Khomutov 《Russian Chemical Bulletin》1999,48(7):1348-1351
Phosphinic analogs of the key compounds of the metabolism of methionine were synthesized. The compounds obtained were selectively
oxidized either at the phosphinic group or at the sulfur-containing fragment.
Translated fromIzvestiya Akademii Nauk. Seriya Khimicheskaya, No. 7, pp. 1360–1363, July, 1999. 相似文献
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5.
Esters andN-methylamides of 2-hydroxyimino- and 2-alkoxyimino-3-(acylhydrazono)-butanoic acids were synthesized by condensation of acyl
hydrazines with the corresponding alkyl 2-hydroxyimino- and 2-alkoxyimino-3-oxobutanoates andN-methyl-2-methoxyimino-3-oxobutanamide. The compounds obtained are analogs of strobilurins, fungicidal antibiotics.
Translated fromIzvestiya Akademii Nauk. Seriya Khimicheskaya, No. 3, pp. 499–504, March, 1999. 相似文献
6.
Józef Oleksyszyn Ewa Gruszecka Paweł Kafarski Przemysław Mastalerz 《Monatshefte für Chemie / Chemical Monthly》1982,113(1):59-71
Preparation of the phosphonic analogs of -methylaspartic (4 a–d), glutamic (7 a–b) and -methylpyroglutamic (5 a–b) acids by aminoalkylation of trivalent phosphorus chlorides with ethyl esters of oxoalkyloacids and benzyl carbamate is described. The phosphonic analogs of pyroglutamic acid (8 a–b) was obtained by the cyclization of the corresponding esters (9 a–b). The stability of the phosphonic analogs of pyroglutamic acid in acidic and alkaline media was also studied.
Die Herstellung von neuen Phosphonanalogen der Asparagin- und Glutaminsäure in der Reaktion von trivalenten Phosphorchloriden mit Ethyl-acetyloacetat oder Ethyl-lävulinat bzw. Benzylcarbaminat
Zusammenfassung Es wurde die Darstellung der Phosphonanalogen der -Methylasparaginsäure (4 a–d), Glutamin- (7 a–b) und -Methylpyroglutaminsäure (5 a–b) in der Reaktion der trivalenten Phosphorchloride und der Oxoalkansäureethylester sowie des Benzylcarbaminats beschrieben. In der Ringschlußreaktion der Ester (9 a–b) erhält man Phosphonanaloge der Pyroglutaminsäure. Die Stabilität der Analogen der Pyroglutaminsäure wurde in sauren und alkalischen Medien geprüft.相似文献
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Yoann Marsac Stéphanie Legoupy Muriel Pipelier Anne-Marie Aubertin Rachid Benhida 《Tetrahedron》2005,61(32):7607-7612
Enantiomerically enriched cyclobutene compounds 13 and 24 are good precursors of several cyclobutane nucleoside analogs. The synthetic ways involve, in the key step, either hydroboration or dihydroxylation. 相似文献
9.
ZHOU Liang-Mo LIU Xue-Liang LI Zhong-Sheng WANG Qing-Hai ZHU Dao-QianDalian Institute of Chemical Physics Chinese Academy of Sciences Dalian Liaoning ChinaHU Dong-HongDepartment of Chemistry Fujian Quanzhou Teacher''''s College Quanzhou Fujian China 《中国化学》1996,14(4):348-353
A mixed stationary phase of modified β-cyclodextrin, 2,6-di-O-butyl-3-O-butyryl-β-cyclodextrin (phase A), and SE-54 (phase B) was used for enantiomeric separation of α-phenylethylami-ne, o,m,p-methyl and o,m,p-methoxy-substituted analogs. The composition of mixed phase was selected by comparison of each calculated amin(= (γm,i+1)/(γm,i))> the relative retention values of the most adjacent peaks, and γm,last, the relative retention values of the last eluting peak at each preselected ratio. Values of γm,i,α calculated by derived equations were in good agreement with the experimental results obtained with two specified mixed phases. All solutes investigated were almost baseline separated at a predicted composition of phase A and phase B in a single run within 18 minutes. 相似文献
10.
Five new analogs 4–8 of rubiyunnanin B (1), mainly modified on the tetrapeptide subunit, were synthesized. These agents 4–8 were substituted d-Ala-l-Ala-l-Tyr(OMe)-l-Ala, d-Ala-l-Ala-l-Phe-l-Ala, d-Ala-l-Ala-l-Try-l-Ala, d-Ala-l-Ala-l-Pro-l-Ala, and d-Ala-l-Ala-l-Ala for the d-Ala-l-Ala-l-N-Me-Tyr(OMe)-l-Ala tetrapeptide subunit. Unlike the natural product, the synthetic agents 4–8 adopt only a single solution conformation, and the central peptide bond in the cyclodityrosine subunit of compounds 4–8 adopt trans stereochemistry. Cytotoxic activities of analogs 4–8 against three human cancer cell lines including A549, BGC-823, and HeLa were evaluated and all the five synthesized peptides exhibited no effects against the test cell lines. These compounds were also evaluated for their antiinsulin resistance and insulin sensitizing activities and none of them showed activity in these assays. 相似文献
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K. A. Krasnov V. G. Kartsev E. E. Santarovich 《Chemistry of Heterocyclic Compounds》2002,38(6):702-709
The reaction of barbituric, N-alkylbarbituric acids, and their 2-thio analogs with carboxybenzaldehyde and 2-carboxy-3,4-dimethoxybenzaldehyde leads to the formation of the corresponding 5-(3'-oxo-1',3'-dihydroisobenzofuran-1'-yl)barbituric and 2-thiobarbituric acids, the structures of which were studied by 1H and 13C NMR spectroscopy and mass spectrometry. In DMSO the derivatives of barbituric acid exist in the form of mixtures of the ketone and enol tautomers, while their 2-thio analogs exist in the enol form. In chloroform the tautomeric equilibrium is displaced fully toward the ketone form. 相似文献
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O. V. Dyablo A. F. Pozharskii V. V. Kuz'menko M. A. Kolesnichenko 《Chemistry of Heterocyclic Compounds》2001,37(5):567-573
The amination of 3-amino- and 3-azidoindazoles by hydroxylamine-O-sulfonic acid in an alkaline medium yields previously unreported 1,3-diamino- and 1-amino-3-azidoindazoles. These products undergo slow autoxidation in chloroform solution to give 4-aminobenzo-1,2,3-triazine. The action of formic or acetic acid on 3-amino-1-benzylideneaminoindazole leads to recyclization and formation of 3-amino-2-benzylindazole, which is also formed in the catalytic hydrogenation of 1-benzylamino-3-nitro- and 1-benzylideneamino-3-nitroindazoles. 相似文献
15.
Phosphonic acids [(HO)2P(O)C2H4CnF2n+1] (n = 4, 6) and [(HO)2P(O)C6H4-4-CnF2n+1] (n = 0, 1, 6) have been prepared in good yields. Deprotonation and reaction with cis-[PtCl2(PPh3)2] affords fluorinated platinum complexes which have been characterised by elemental analysis, mass spectrometry, IR and NMR spectroscopies. The structures of [Pt{O2P(O)C6H4-4-F}(PPh3)2], [Pt{O2P(O)C6H4-4-CF3}(PPh3)2] and [Pt{O2P(O)C2H4C6F13}(PPh3)2] have been determined by single crystal X-ray diffraction. 相似文献
16.
Reactions of 1,3-benzodioxane and 1,4-benzodioxane analogs of flavones with hydrazine derivatives are studied. The hydrazines recyclize the new flavones into 3,5-diarylpyrazoles. Their PMR spectra confirm their structures.Translated from Khimiya Prirodnykh Soedinenii, No. 1, pp. 40–41, January–February, 2000. 相似文献
17.
QIAN Hui-Fena② HUANG Weib② LI Hui-Huib YAO Chenga a 《结构化学》2006,25(10):1243-1249
1 INTRODUCTION Chiral amino acids and their versatile derivatives are very useful compounds in many fields[1]. In com- parison with well-documented chiral α and β amino acids and amino alcohols, the studies of chiral γ, δ… ω amino acids and amino alcohols deserve more attention. For example, there have been numerous reports on versatile functions of γ aminobutyric acid (GABA) produced from L-glutamic acid in the presence of L-glutamate decarboxylase (GAD)[2]. However, the stereo… 相似文献
18.
Tricyclic analogs 2a and 8 were prepared by four-step routes. The key step was an intermolecular hetero Diels-Alder reaction involving a quinone methide. 相似文献
19.
Reaction of diethyl 2,2-difluoro-3-(a-methylbenzyl)imino-4,4,4-trifluoropropanephosphonate (3) with triethylamine afforded a mixture of normal [1,3]-proton shift reaction product 5 and its HF-eliminated compound 6Z in 1 : 1 ratio. Upon hydrolysis, this reaction mixture gave solely 1,3,3,3-tetrafluoro-2-dioxypropanephosphonate (9). Reaction of 3 with DBU provided only 6, in which the ratio of E/Z forms was dependent on the reaction conditions. Aqueous hydrolysis of 6 led to 9. Catalytic hydrogenation and hydrogenolysis of 6 gave geometric isomers of 11 as expected. The reaction mechanism involved was discussed. 相似文献
20.
Meizi Wang Li Zhang Xianwei Wang Yun Ling Xiaoqing Wu Xinlu Li Yiduo Mi Xinling Yang 《中国化学快报》2018,29(9):1375-1378
Two series of peptidomimetic analogs with different substituents on the N-terminus region were designed and synthesized to explore the relationship between the structure and the inhibition activity in vitro. In addition, 3D-QSAR study was performed to highlight the structural requirements of AST analogs. 相似文献