共查询到20条相似文献,搜索用时 15 毫秒
1.
Sarah J.P. Yoon-Miller 《Tetrahedron letters》2007,48(5):827-830
A three step, convergent synthesis of 4-aryl-3-pyrrolin-2-ones from a tetramic acid has been developed. The key transformation utilized a Suzuki-Miyaura cross-coupling reaction between a 4-tosyloxy-3-pyrrolin-2-one and an arylboronic acid. This work also provides access to 4-arylpyrrolidin-2-ones, cyclic analogs of γ-aminobutyric acid (GABA). Hydrogenation of 4-(4′-chlorophenyl)-3-pyrrolin-2-one proceeded smoothly to give baclofen lactam. 相似文献
2.
G. Adembri C. Anselmi A. Camparini M. G. Rossetti M. Scotton 《Journal of heterocyclic chemistry》1988,25(3):1019-1022
Preparation of some derivatives of 5-aralkylidene-3-pyrrolin-2-ones is reported. Compounds with an amino group on the phenyl ring at the 3-position of the pyrrolinone ring showed suitable properties as potential UV-A filters. Some of the compounds were quaternarized to enhance their solubility in aqueous solvents. 相似文献
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Sergio Pinheiro Ronaldo C. da Silva Júnior José Walkimar de M. Carneiro O.A.C. Antunes 《Tetrahedron letters》2009,50(20):2402-962
Short stereoselective syntheses of both 5-substituted-4-amino-pyrrolidin-2-ones and 5-substituted-4-amino-3-pyrrolin-2-ones from natural α-amino acids are described. 相似文献
5.
M. N. Armisheva N. A. Kornienko V. L. Gein M. I. Vakhrin 《Russian Journal of General Chemistry》2011,81(9):1893-1895
The reaction of 5-(4-chlorophenyl)-4-benzoyl-1-(4-hydroxyphenyl)-3-hydroxy-3-pyrrolin-2-one with aromatic amines affords the
corresponding 3-arylamino derivatives, and the reactions of 5-aryl-4-acetyl-1-(4-hydroxyphenyl)-3-hydroxy-3-pyrrolin-2-ones
with p-toluidine yield 5-aryl-4-(1-p-tolylamino)ethylene-1-(4-hydroxyphenyl)pyrrolidin-2,3-diones. 相似文献
6.
5-Aryl-4-aroyl-3-hydroxy-1-cyanomethyl-3-pyrrolin-2-ones were synthesized by a three-component reaction of methyl aroylpyruvate with a mixture of aromatic aldehyde and 2-aminoacetonitrile sulfate in glacial acetic acid in the presence of anhydrous sodium acetate. 相似文献
7.
V. L. Gein O. V. Bobrovskaya K. A. Tkachenko L. F. Gein 《Russian Journal of General Chemistry》2014,84(7):1349-1352
Depending on the reaction condition, 1-(4-aminosulfonylphenyl)-5-aryl-4-aroyl-3-hydroxy-3-pyrrolin-2-ones reacted with aromatic amines to yield 3-arylamino-3-pyrrolin-2-ones or 4-[aryl (arylamino) methylene]tetrahydropyrrole-2,3-diones. Reactions of 1-(4-aminosulfonylphenyl)-5-aryl-4-aroyl-3-hydroxy-3-pyrrolin-2-ones with hydrazine hydrate afforded pyrrolo[3,4-c]pyrazol-6-ones. 相似文献
8.
Irradiation (λ =313 nm) of the 4-pyrrolin-3-ones 1a–1c in acetone-, 3-pentanone-and cyclopentanone solution affords the title compounds 2 , formally via H-abstrac-tion by the excited ketone and recombination of the radical pair formed. 相似文献
9.
[reaction: see text] Pyrrolidine-2,4-diones (1) are naturally occurring analogues of amino acids. We herein present a facile synthesis of N-acylated, O-alkylated pyrrolin-2-ones (2) in high yield and excellent enantiopurity. Molecular mechanics calculations suggest that the resulting dipeptide analogues adopt a linear, extended conformation. 相似文献
10.
《Tetrahedron》1987,43(3):607-616
Aryl hydrazines (1) possessing an electron-withdrawing substituent on the phenyl ring, on treatment with diethyl (ethoxymethylene)malonate in ethanolic sodium ethoxide solution, have directly afforded 2-aryl-4-ethoxy-carbonyl-3-pyrazolin-5-ones (4). Spectroscopic evidence is presented to differentiate these compounds (4) from their 1-aryl isomers (3). 相似文献
11.
Synthesis of 5-methoxylated 3-pyrrolin-2-ones via the rearrangement of chlorinated pyrrolidin-2-ones
Franco Ghelfi Christian V Stevens Inge LaureynEllen Van Meenen Tina M RoggeLaurent De Buyck Kirill V NikitinRomano Grandi Emanuela LibertiniUgo M Pagnoni Luisa Schenetti 《Tetrahedron》2003,59(8):1147-1157
The reaction of N-substituted 4-methyl-2-pyrrolidinones or 4-diethoxyphosphoryl analogues, carrying at least two chlorine atoms between the C(3) and C(6) carbons, with alkaline methoxide in methanol afforded the corresponding 5-methoxylated 3-pyrrolin-2-ones, useful adducts for the preparation of agrochemicals or medicinal compounds. 相似文献
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Georgia Tsolomiti 《Tetrahedron letters》2004,45(51):9353-9355
The unexpected synthesis of N-substituted 2-acetoxy-5-arylpyrroles, from the reaction of 3-aroyl-propionamides with a large excess of refluxing acetyl chloride, and their alkaline hydrolysis to 3- and 4-pyrrolin-2-ones, is described. 相似文献
15.
Ramon Mercè Merce Pujol Josep M. Ribó Francesc R. Trull Genis Valera Asunción Vallès 《Monatshefte für Chemie / Chemical Monthly》1986,117(5):631-652
The influence of the disubstitution at the exocyclic carbon atom of 5-methylene-3-pyrrolin-2-ones upon the configurational and conformational equilibria is studied. The results obtained confirm and extend the observations reported in the literature about the factors determining the configurational and conformational equilibria in monosubstituted systems, i.e.: 5-arylmethylene-3—pyrrolin-2-ones and 5(1H)-pyrromethenones.
Zur Konfiguration und Konformation von einigen 5-Methylen-disubstituierten-3-pyrrolin-2-onen
Zusammenfassung Es wird der Einfluß der Disubstitution des exocyclischen C-Atoms von 5-Methylen-3-pyrrolin-2-onen auf das Konfigurations- und Konformationsgleich-gewicht untersucht. Die erhaltenen Resultate stehen im Einklang mit der Literatur, die sich auf monosubstituierte Verbindungen [5-Arylmethylen-3-pyrrolin-2-one, 5 (1H)-Pyrromethenone und strukturverwandte Gallenpigmente] beziehen, und vertiefen das Verständnis der Faktoren, die für diese Gleichgewichte maßgebend sind.相似文献
16.
Kanwarpal S Kochhar Holly J Carson Kimberly A Clouser John W Elling Lauren A Gramens Judith L Parry Helayne L Sherman Kevin Braat Harold W Pinnick 《Tetrahedron letters》1984,25(18):1871-1874
Acetoacetic ester is converted into 4-alkoxy-Δ3-pyrrolin-2-ones which can be hydrolyzed to give tetramic acids. 相似文献
17.
Francisco Faria M. Victoria Martín M. Carmen Paredes Amelia Tito 《Journal of heterocyclic chemistry》1987,24(5):1269-1274
Cycloaddition of diazomethane to pyrrolinones 1a,b,d,e affords only one regioisomer as a mixture of the epimeric pyrrolopyrazolines 2 and 2 ′,4-Halo derivatives 1f,g react with diazomethane to give the two possible regioisomers 2 and 3. The regio- and stereochemistry of the adducts is evidenced by the 1H-nmr data. The primary adducts originated from the halopyrrolinones suffer dehydrohalogenation to give aromatized products, which by further methylation give derivatives of type 7, 8, 10 and 11. 相似文献
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S. G. Pil’o V. M. Prokopenko V. S. Brovarets B. S. Drach 《Russian Journal of General Chemistry》2010,80(7):1345-1350
A convenient preparative procedure has been developed for the synthesis of previously unknown 2-aryl-5-arylsulfanyl-1,3-oxazole-4-carboxylic
acids and their functional derivatives from accessible multicenter substrates of the general formula Cl2C=C(NHCOR)C(O)OMe. The products turned out to be suitable for various subsequent transformations. Some oxazole-4-carboxylic
acid hydrazide derivatives containing a substituted oxazol-5-yl fragment at the N2 atom in the hydrazine moiety underwent recyclization on heating in acetic acid; as a result, one oxazole ring was converted
into 1,3,4-oxadiazole. 相似文献